Digital Commons Network^™

Ilp-2 Modeling And Virtual Screening Of An Fda-Approved Library:A Possible Anticancer Therapy, Saeed Khalili, Hemn Mohammadpour, Mahideh Shokrollahi Barough, Parviz Kokhaei

Turkish Journal of Medical Sciences

Background/aim: The members of the inhibitors of apoptosis protein (IAP) family inhibit diverse components of the caspase signaling pathway, notably caspase 3, 7, and 9. ILP-2 (BIRC-8) is the most recently identified member of the IAPs, mainly interacting with caspase 9. This interaction would eventually lead to death resistance in the case of cancerous cells. Therefore, structural modeling of ILP-2 and finding applicable inhibitors of its interaction with caspase 9 are a compelling challenge. Materials and methods: Three main protein modeling approaches along with various model refinement measures were harnessed to achieve a reliable 3D model, using state-of-the-art software. Thereafter, …

The Consequences Of Aluminium Intake On Reproductive Function In Male Rats:A Three-Generation Study, Florin Muselin, Romeo Teodor Cristina, Violeta Igna, Eugenia Dumitrescu, Diana Brezovan, Alexandra Trif

Turkish Journal of Medical Sciences

Background/aim: The effects of aluminium exposure on reproductive biomarkers in male rats were followed in a three-generation study. Materials and methods: Forty Wistar male rats (F0) were divided into the following groups: control (C), receiving only tap water, and three experimental (E) groups, receiving aluminium sulphate (AS) (E1: 200 ppb, E2: 400 ppb, and E3: 1000 ppb) in drinking water for a 6-month exposure period. To obtain F1, three males from each group were mated with previously unexposed females (1:2 sex ratios) that during gestation and lactation were exposed to the same AS levels as males. The F1 generation male …

Effectiveness Of A Single Versus Repeated Administration Of Trimetazidine In The Protection Against Warm Ischemia/Reperfusion Injury Of Rat Liver, Asma Mahfoudh Boussaid, Rabi Selmi, Mohamed Bejaoui, Kaouther Hadj Ayed, Mohamed Amine Zaouali, Hassen Ben Abdennebi

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare the effects of single and repeated trimetazidine (TMZ) administration against warm hepatic ischemia/reperfusion (I/R) injury and to explore the possible mechanisms affected by TMZ. Materials and methods: Wistar rats were divided into 4 groups (n = 6). Sham: rats were subjected to dissection. I/R: rats were subjected to 60 min of partial hepatic ischemia followed by 24 h of reperfusion. TMZ1: Same as I/R group but rats were pretreated with a single dose of TMZ (10 mg/kg, intraperitoneal injection) 30 min before warm ischemia. TMZ3: Same as I/R but rats were …

The Efficacy Of Oral Ribavirin On Clinical And Laboratory Parameters Incrimean?Congo Hemorrhagic Fever: An Observational Study From Turkey*, Günay Ertem, Meli̇ha Çağla Sönmezer, Fati̇h Temoçi̇n, Çi̇ğdem Ataman Hati̇poğlu, Necla Tülek, Behi̇ç Oral

Turkish Journal of Medical Sciences

Background/aim: In this observational study, the effects of oral ribavirin on clinical and laboratory parameters and blood products use in patients with Crimean-Congo hemorrhagic fever (CCHF) were evaluated. Materials and methods: CCHF patients (n = 100) who were hospitalized between 2007 and 2010 were included. Oral ribavirin was administered to 56 patients with symptom duration less than 5 days. Forty-four patients did not receive ribavirin (control group). The patients that received ribavirin in the first 3 days following the initiation of symptoms were designated as Group 1 (n = 29) and the others were designated as Group 2. Results: Ribavirin-treated …

The Effects Of Sebum Configuration On Demodex Spp. Density, Hati̇ce Gamze Demi̇rdağ, Hamdi̇ Özcan, Şule Gürsoy, Gülçi̇n Beker Akbulut

Turkish Journal of Medical Sciences

Background/aim: Demodex spp. are ectoparasites living in the pilosebaceous units, which feed on the host's sebum and cellular proteins. The protective barrier of the skin consists of sebum secretion, moisture, and the acid mantle. In this study, we aimed to determine the effects of skin sebum, moisture, pH levels, and sebum configuration on Demodex spp. density Materials and methods: Forty-five patients who had demodicosis were enrolled in the study group, while the control group consisted of 40 subjects without demodicosis. Body fat percentage, serum triglyceride and cholesterol levels, skin sebum, moisture, and pH levels were measured. Demodex spp. density was …

Genotypic Analysis Of Escherichia Coli Strains That Cause Urosepsis In The Aegean Region, Betül Gi̇ray, Füsun Bahri̇ye Uçar, Sabi̇re Şöhret Aydemi̇r

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to characterize strains genotypically, to determine their phylogenetic relationships, to investigate the presence of the papG gene, and to compare their antibiotic susceptibility test results. Materials and methods: Seventy pathogenic E. coli strains were isolated from both urine and blood cultures of patients with the preliminary diagnosis of urosepsis who were referred to the Ege University Faculty of Medicine, Bacteriology Laboratory of Medical Microbiology Department in İzmir. All of these strains were examined for the papG gene and phylogenetic groups with the multiplex polymerase chain reaction technique. Pulsed-field gel electrophoresis and multilocus sequence …

The Protective Effects Of Hydrogen On Ho-1 Expression In The Brainafter Focal Cerebral Ischemia Reperfusion In Rats, Xifeng Wang, Lianshuang Zhang, Wei Zhao, Tongshen Liu

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate whether a hydrogen administration can produce neuroprotective effects after brain ischemia reperfusion in rats. Materials and methods: A brain ischemia reperfusion injury was induced by a 2-h left middle cerebral artery occlusion (MCAO) using an intraluminal filament, followed by 46 h of reperfusion. A hydrogen-rich saline (1 mL/kg body weight i.p.) was administered at the beginning of reperfusion. Saline (1 mL/kg)-treated animals were used as the control. Sham-operated animals were also used. Subsequently, 48 h after the MCAO, histological alternations, heme oxygenase-1 (HO-1) expression, and levels of malondialdehyde (MDA) and superoxide …

Effect Of Methylprednisolone Injection On Interleukin-4 And Interferon-Gamma Expression Following Hepatitis B Vaccination In Mice, Peter Ughachukwu, Paul Okonkwo, Prince Unekwe, John Ogamba

Turkish Journal of Medical Sciences

Background/aim: The prevalence of hepatitis B infection is high worldwide with liver cirrhosis and hepatocellular carcinoma as important complications. Immunosuppression, especially from corticosteroids, is often cited as a cause of poor immune response and there is documented evidence of irrational administration of glucocorticoids to children and adults. Decreased expression of interleukin-4 and interferon-gamma is an indication of poor humoral and cellular immune responses, respectively. Therefore, we decided to find out if methylprednisolone injection decreases interleukin-4 and interferon-gamma expression following hepatitis B vaccination in mice. Materials and methods: Mice were randomly divided into 2 groups. Daily intramuscular injections of methylprednisolone (15 …

Analysis Of Diabetes-Related Cerebellar Changes In Streptozotocin-Induced Diabetic Rats, Nuri̇ye Güzi̇n Özdemi̇r, Feray Akbaş, Tuğba Koti̇l, Adem Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Diabetic peripheral neuropathy has been extensively studied and reported, but the number of studies that have investigated diabetes-related changes in the central nervous system are limited, with even fewer studies on the cerebellum. The aim of this experimental study was to perform a histologic analysis of the diabetes-related changes in the cerebellums of diabetic rats. Materials and methods: Twenty Sprague Dawley rats weighing between 200 and 220 g were included in the study. Diabetes was induced in 14 of these rats by a single intraperitoneal injection of 65 mg/kg streptozotocin dissolved in saline, while 6 animals constituted the control …

Going Online On Behalf Of Others: An Investigation Of ‘Proxy’ Internet Consumers, Neil Selwyn, Nicola Johnson, Selena Nemorin, Elizabeth Knight

Research outputs 2014 to 2021

A range of Australians find themselves acting as ‘proxy internet users’ – i.e. using online services and applications on behalf of other adults who otherwise make limited use of the internet. It is rare for those adults being supported by proxies to be absolute non-users of the internet. Apart from extreme cases of physical/intellectual incapacity, most people covered by our research were making some use of the internet, if only through smartphones and Apps. Proxy internet assistance often takes place within families – notably elderly parents being helped by their adult sons and daughters. Other proxy users include people acting …

The Effect Of Low Let (Linear Energy Transfer) Ionizing Radiation To Catalase Activity Of Wistar’S Submandibular Gland, Nevy T. Putri, Sarianoferni, Endah Wahjuningsih

Journal of Dentomaxillofacial Science

No abstract provided.

Collective Action And Decision Making: An Analysis Of Economic Modeling And Environmental Free-Riding, Thomas Miller 16

Honor Scholar Theses

No abstract provided.

A Tool-Free Calibration Method For Turntable-Based 3d Scanning Systems, Xufang Pang, Rynson W.H. Lau, Zhan Song, Shengfeng He, Shengfeng He

Research Collection School Of Computing and Information Systems

Turntable-based 3D scanners are popular but require calibration of the turntable axis. Existing methods for turntable calibration typically make use of specially designed tools, such as a chessboard or criterion sphere, which users must manually install and dismount. In this article, the authors propose an automatic method to calibrate the turntable axis without any calibration tools. Given a scan sequence of the input object, they first recover the initial rotation axis from an automatic registration step. Then they apply an iterative procedure to obtain the optimized turntable axis. This iterative procedure alternates between two steps: refining the initial pose of …

Towards A Science Of Security Games, Thanh Hong Nguyen, Debarun Kar, Matthew Brown, Arunesh Sinha, Albert Xin Jiang, Milind Tambe

Research Collection School Of Computing and Information Systems

Security is a critical concern around the world. In many domains from counter-terrorism to sustainability, limited security resources prevent full security coverage at all times; instead, these limited resources must be scheduled, while simultaneously taking into account different target priorities, the responses of the adversaries to the security posture and potential uncertainty over adversary types.Computational game theory can help design such security schedules. Indeed, casting the problem as a Bayesian Stackelberg game, we have developed new algorithms that are now deployed over multiple years in multiple applications for security scheduling. These applications are leading to real-world use-inspired research in the …

Examining The Potential Clinical Value Of Curcumin In The Prevention And Diagnosis Of Alzheimer's Disease, K. G. Goozee, T. M. Shah, Hamid R. Sohrabi, Stephanie Rainey-Smith, B. Brown, Guiseppe Verdile, Ralph Martins

Research outputs 2014 to 2021

Curcumin derived from turmeric is well documented for its anti-carcinogenic, antioxidant and anti-inflammatory properties. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties that may help delay or prevent neurodegenerative diseases, including Alzheimer’s disease (AD). Currently, clinical diagnosis of AD is onerous, and it is primarily based on the exclusion of other causes of dementia. In addition, phase III clinical trials of potential treatments have mostly failed, leaving disease-modifying interventions elusive. AD can be characterised neuropathologically by the deposition of extracellular β amyloid (Aβ) plaques and intracellular accumulation of tau-containing neurofibrillary tangles. Disruptions in Aβ metabolism/clearance contribute to …

Reading-Specific Flexibility Moderates The Relation Between Reading Strategy Use And Reading Comprehension During The Elementary Years, Emily K. Gnaedinger, Alycia M. Hund, Matthew S. Hesson-Mcinnis

Faculty Publications – Psychology

The goal was to test whether cognitive flexibility moderates the relation between reading strategy use and reading comprehension during the elementary years. Seventy-five second through fifth grade students completed a think aloud task and a metacognitive questionnaire to measure reading strategies, two card-sorting tasks to measure general and reading-specific cognitive flexibility, and one standardized measure of reading comprehension, as well as measures of oral reading fluency and vocabulary. As expected, oral reading fluency and vocabulary predicted reading comprehension, as did reading-specific flexibility. Importantly, reading-specific flexibility had a significant moderating effect, over and above the other effects. Specifically, weak reading-specific flexibility …

Biodiversity Of Insect Populations In The Springfield Bog Metropark In Summit County, Ohio: A Secondary Succession Site, Cynthia Perkovich

Department of Entomology: Distance Master of Science Projects

An initiative has been taken up by many environmental agencies for the conservation and restoration of endangered wetland habitats. These unique ecosystems are being depleted of resources and acreage due to industrialization and extensive anthropogenic activities. Bogs are a unique subgroup that are diminishing worldwide. The Springfield Metropark Bog is a newly established conservation area in Summit County, Ohio, in the United States. Insect populations were recorded over four seasons, starting in March 2015 and concluding in February 2016. Samples were taken from 3 different sites within the conserved habitat including field site, forested area, and a manufactured pond. Using …

Insect Pest Introduction Into Florida: Surveillance And Detection Efforts By Government Agencies, Gangadai Azore

Department of Entomology: Distance Master of Science Projects

Today, Florida’s most important crops such as corn, peppers, and snow beans owe their existence to constant vigilance by the Florida Department of Agriculture (FDACS), United States Department of Agriculture (USDA), and Customs & Border Protection Agricultural Specialists (CBP); all three agencies work together to keep many dangerous pests out of the state. Diligent inspectors working alongside the Customs officers, meet all arriving vessels that arrive by land, sea, or air. The officers inspect cargo and passengers’ baggage, the holds of vessels, cabins, crew’s quarters, and storerooms of vessels themselves to keep out potential insects hitch-hiking on commodities or on …

Technique For: Determination Of Insect Prey Selection By Insectivorous Bats, Merrill Tawse

Department of Entomology: Distance Master of Science Projects

Utilizing Fecal Pellet Analysis to Determine Prey Selection by Insectivorous Bats: For my Graduate Project I examined culled exoskeleton parts from bat fecal pellets (guano) to determine identifications of the insects preyed upon by a group of bats to their order and often family levels. Culled insect parts were permanently fixed on microscope slides and viewed under a dissection microscope to determine identifications and to quantify the percentage composition that they represented in the bat’s diet. Comparisons were made of prey selected by the different bat species that were foraging at the same location and at the same time. Comparisons …

The Ins And Outs Of The Pesticide Registration Process And Why It's Important To The End-User, Linda Johns

Department of Entomology: Distance Master of Science Projects

The US EPA registration process evaluates pesticides through legal, administrative and scientific procedures that encompass the pesticide ingredients (inert and active); the crop or site pertaining to where the pesticide will be used; the amount, timing and frequency of the pesticide to be used; the disposal and storage practices for the pesticide; and the potential human health and environmental effects that could be associated with the pesticide. The US EPA evaluates and approves all label language that appears on a pesticide label, thus ensuring proper use patterns and that safety measures have been met to reduce any potential risks. All …

A Survey Of The Insect Orders Present In The Gypsum Dunes Of The White Sands National Monument, Zell Zanarkand

Department of Entomology: Distance Master of Science Projects

•Introduction Video to White Sands National Monument (WSNM) •Facts and History •Insects Orders and Families Found in WSNM •Introduction Video to Theories Regarding Lighter Coloration •Three Theories on Color Change •Insects in WSNM depicting lighter coloration •Conclusion Video

The Role Of Host Genotypes In The Susceptibility To Porcine Circovirus Associated Diseases, Ashley Fejfar

UCARE: Research Products

Porcine Circovirus 2 (PCV2) is a small (1.7kb), circular, single-stranded DNA virus. Infected pigs become seropositive between 6-18 weeks of age with 5-15% eventually displaying clinical signs of Porcine Circovirus Associated Diseases (PCVAD). Vaccination is costly given the small percentage of affected pigs. • PCVAD is usually expressed between 90-120 days of age and commonly manifests as Post-weaning Multi-systemic Wasting Syndrome (PMWS), Porcine Dermatitis and Nephropathy Syndrome, Porcine Respiratory Disease Complex, enteritis, reproductive failure and enlarged lymph nodes / lymphoid depletion. • Previous research using genome wide association analysis uncovered two SNPs that explain 12.4% (SSC12) and 3.7% (SSC7) of …

An Investigation Of Multimedia Instruction, The Modality Principle, And Reading Comprehension In Fourth-Grade Classrooms, Laura Angela Sandoval

Doctoral Dissertations

Elementary-school teachers are faced with the responsibility of finding the most effective ways to educate their students using multimedia approaches. The use of instruction with visuals and audio has resulted in positive learning outcomes on retention and transfer tasks for junior-high and high-school students. This approach that results in the modality principle has been tested less frequently in elementary-aged students.

The purpose of this study was to examine two different multimedia instructional approaches to investigate which condition offers beneficial learning outcomes through recall and transfer assessments during a lesson on different types of energy in fourth-grade classrooms using a Powerpoint® …

Training In Summarizing Notes: Effects Of Teaching Students A Self-Regulation Study Strategy In Science Learning, Michelle Mendoza Nebres

Doctoral Dissertations

The last two decades of national data assessments reveal that there has been a sharp decline in nationwide standardized test scores. International assessment data show that in 2012 a very low amount of American students were performing at proficiency or above in science literacy. Research in science literacy education suggests that students benefit most when they are self-regulated (SR) learners. Unfortunately, SR poses a challenge for many students because students lack these skills. The effects of having learned few SR strategies at an early age may lead to long term learning difficulties—preventing students from achieving academic success in college and …

Muscle Memory: Stories, Hannah N. Bradley 16

Honor Scholar Theses

No abstract provided.

In The Light Of Evolution: Human Nature, Political Behavior, And Making Sense Of Our Social Identity, Corby F. Burger 16

Honor Scholar Theses

No abstract provided.

Strategies Independent Coffee Shop Owners Require To Survive Beyond Five Years, Bruce Higdon

Walden Dissertations and Doctoral Studies

Successful independent coffee shop owners in Washington struggle to compete with the larger coffee shop chains. The purpose of this qualitative multiple case study was to investigate what strategies owners of independent coffee shops in Washington use to survive beyond the first 5 years. Five independent coffee shop owners in Washington participated in the study and shared their practices and observations. Systems theory directed the study exploring the perspectives of successful independent coffee shop owners in Washington. Using communication skills and personal availability to answer questions and remain in contact throughout the research process built a rapport with participants. Data …

Gender And Power In Waiting For Godot, Ryan Wright

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

The Reader's Complicity: Universality In Waiting For The Barbarians, The Laramie Project, And The Laramie Project: Ten Years Later, Aubrey Kosa

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Blind With Superstition, Cursed With Illusions: Masculinity And War In Bierce’S “Chickamauga”, Salina Patterson

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.