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Spectrum, Volume 55, Issue 4, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Second Annual P.I.E.R. Conference -- Laudato Si’ Initiative Expands to Office -- PRSSA Prepares Students for Real-World Success -- Fall Festivities at SHU -- TAP Presents “A Midsummer Night’s Dream” -- Sacred Heart Hockey Ranked First in Preseason Polls

Fatal Cases Of Poisoning Diagnosed In Medicolegal Directorate Of Baghdad, Ahmed Ghadhban, Nabeel Hashim

Iraqi Postgraduate Medical Journal

Abstract: Background: Poisoning is a significant contributor to morbidity and mortality throughout the world. Providing accurate statistical data is essential to understand the different aspects of poisoning cases for the seek of diagnosis particularly at the medicolegal side, and also for the seek of better management. Objective: To investigate the epidemiological characteristics, and the postmortem findings of fatal poisoning cases referred to the medicolegal directorate of Baghdad. To identify the most common toxic agents, and the manner of death, in addition to demonstrate the demographic factors for the purpose of prevention and management.Materials and Methods: Retrospective study analyzing autopsy records …

Irf6 Regulates Adherens Junction Proteins And Inflammatory Cytokines In Salivary Acinar Cells And Its Expression Is Elevated In Sjӧgren’S Syndrome, Vi Pham, Antonio Hernandes Chaves Neto, Julia Zheng, Mary Elmeniawi, Krishna Kumar Kookal, Muhammad F Walji, Mary C Farach-Carson, Walid D Fakhouri

Faculty, Staff and Student Publications

Objective: To investigate the mechanism of Interferon Regulatory Factor 6 (IRF6) function in regulating adherens junction proteins and inflammatory cytokines in human salivary acinar cells and Sjögren's syndrome biopsies.

Design: We used mouse model, salivary cell lines, and human salivary gland (SG) biopsies to investigate IRF6 function in SG cellular integrity and immunomodulation.

Results: In Irf6-null mice, we observed myoepithelial cell detachment from acinar cells of major SGs, and the acini were remarkably disorganized compared to wild-type littermates. At the molecular level, the acinar differentiation markers E-cadherin and MIST1 were markedly reduced in Irf6-null embryonic SG, while the proinflammatory cytokines, …

Assessing Cognitive Abilities In Students With Hearing Loss And Specific Learning Disabilities, Pooja Gupta, Corinna V. Cole, William H. Blackwell

Journal of Human Services: Training, Research, and Practice

This literature review synthesizes approximately 30 years of research on students from kindergarten through 12th grade with hearing impairments who are suspected of having a specific learning disability (SLD). Assessing SLDs in these students presents significant challenges, particularly when evaluating cognitive abilities using the Cattell-Horn-Carroll (CHC) theory of intelligence. This theory encompasses seven broad cognitive domains that influence academic success in reading, mathematics, and writing, including crystallized intelligence, fluid and sequential reasoning, long-term and short-term memory, visual processing, auditory processing, and processing speed. Since auditory processing is inherently affected in students with hearing impairments, this review excludes it from discussion. …

An Animal Interest Approach Method As A Gateway To A One Health Educated Pipeline, Meghan C. Wulster-Radcliffe, Sarah A. Reed, James N. Macleod, Rebekah B. Epps, J. Scott Radcliffe, Robert J. Coleman, Steven A. Zinn

Animal and Food Sciences Faculty Publications

No abstract provided.

The Role Of Prelimbic Projections To The Rostromedial Tegmnetal Nucleus In Cue Discrimination, Emma Lane Carlson

Theses and Dissertations

Maladaptive decision-making, such as persistent reward seeking despite negative consequences, is a hallmark of substance use disorder (SUD) and related psychiatric conditions. These behaviors are thought to arise from impairments in aversive learning and disrupted neural signaling that normally supports behavioral inhibition. The prelimbic cortex (PL) plays a critical role in encoding cue–outcome associations and exerting top-down control over behavior, while the rostromedial tegmental nucleus (RMTg) serves as a GABAergic inhibitor of midbrain dopamine neurons in response to aversive stimuli. Although both structures have been implicated in reward and avoidance processes, little is known about how direct PL-RMTg projections contribute …

Anthropomorphism In Language And Thought: The Effect Of Agentive Linguistic Framing On Readers’ Perceptions Of Ai Animacy, Dawson Petersen

Theses and Dissertations

Over the past decade, deep learning AI systems have gone from academic obscurity to near cultural centrality in the developed world. As these technologies become increasingly integrated into daily life, there is growing cause for concern about AI anthropomorphism—i.e., the perception of AIs as more human than they really are. Despite the potential risks, AI developers continue to market their technologies using agentive language that seems to be designed to encourage anthropomorphism. The current dissertation utilizes behavioral and eye-tracking methods to examine the relationship between agentive linguistic framing and AI anthropomorphism in both controlled judgments and automatic inferences. The results …

Behind The Gens: A Bioarchaeological Study Of Kinship Structure And Social Change In Iron Age Latium, Italy, Andrea Noemí Acosta Caballero

Theses and Dissertations

The cemetery of Osteria dell’Osa is the only completely published Iron Age cemetery from Latium. Its research legacy continues as dietary, mobility, and biological affinity patterns were reconstructed through carbon, nitrogen, oxygen, and strontium isotope analyses and biodistance analysis using bone and dental samples for this dissertation project. The main hypotheses tested are:

a) The diet of people buried at Osteria dell’Osa during the Iron Age likely consisted of mostly grains like wheat and barley, which may yield low carbon isotope signatures;

b) The protein consumption of the diet of people at Osteria dell’Osa was mainly composed of terrestrial protein …

Development Of A Strategy To Neutralize Ccl8 Activity And Ablate Ccl8 Cellular Targets, Bernardo Chavez

Theses and Dissertations

The chemokine CCL8 (monocyte chemoattractant protein-2) is a versatile signaling molecule involved in tumor progression, immune cell recruitment, and therapeutic resistance. Through activation of receptors including CCR1, CCR2B, and CCR5, CCL8 promotes leukocyte trafficking, epithelial–mesenchymal transition, and the establishment of immunosuppressive tumor microenvironments. In breast cancer and inflammatory diseases, elevated CCL8 levels correlate with poor clinical outcomes, making it a promising therapeutic target.

A strategy was developed to block CCL8 activity and selectively ablate CCL8 receptor expressing cells. A neutralizing monoclonal antibody, 1G3E5, was identified from a panel of murine candidates based on high affinity CCL8 binding. Sequencing revealed two …

Multi-Layer Decision Making For Long-Term Autonomous Mission Based On Dual Process Theory, Shruti Jadhav

Theses and Dissertations

Unmanned aerial vehicles (UAVs) are increasingly used in precision agriculture, where extended autonomous operation is required for monitoring, intervention, and field management. However, achieving long-term autonomy remains challenging due to battery constraints, environmental uncertainty, and the need to balance exploration with event-driven tasks. To address these challenges, a multi-layer decision-making framework inspired by Dual Process Theory (DPT) is developed. The framework combines reactive return-tobase strategies, exploratory navigation, and directional bias from prior missions, with a conflict-monitoring mechanism that adapts system behavior based on real-time conditions. The approach is implemented in a simulated agricultural grid environment, demonstrating improved adaptability and coverage …

A Qualitative Study Of Middle School Teachers’ Experiences Integrating Computer Coding Into Mathematics Classrooms, George William Austin Iii

Theses and Dissertations

As computers become more accessible in schools nationwide, teachers are embracing them to impact achievement positively (Brudno, 2013; Cetin, 2016). As a result, computer coding instruction has gained attention as a strategy for providing students with skills that will serve them both pre and post-graduation (Burke & Kafai, 2013; Yadav et al., 2016; Ng, 2017). Computer coding is the process of providing instructions for a computer to follow. In 2017, the South Carolina State Board of Education approved Computer Science and Digital Literacy standards for all K-8 public schools in the state of South Carolina (South Carolina Department of Education, …

Ursinus Magazine, Fall 2025, Gundolf Graml, Steve Thomas, Jennifer L. Post-Whisted, Alyssa Kratz, Brad Drexler, Connor Donohue, Michelle Yurko

Ursinus Magazine, 1995–Present

Introducing Interim President Gundolf Graml • Transfer agreement signed with DCCC • New Native American and Indigenous Studies minor • Students get front-row seat to optical innovation • Study abroad expands in Ireland • Alumna earns fellowship from French government • Softball roots, Phillies dreams • New Spirit Store now open • Ursinus' youngest student: Making headlines worldwide • Alumna earns Fulbright award • Ursinus, America250PA support PA scholars • Alumni join Ursinus Board of Trustees • When generosity meets vision • Ursinus named to Phi Theta Kappa Transfer Honor Roll • Field hockey team explores South Africa • Rankings …

Montana Folk Festival 2025, Butte, Montana, Rachel Baer, Ava Worbets, Kika Bradford

Institute for Tourism and Recreation Research Publications

This study was conducted for the Montana Folk Festival to provide insight into the characteristics of attendees of the 2025 Montana Folk Festival. 968 attendees from the event completed the survey. Results show that 80% of respondents were residents of Montana, of which 37% were from Butte-Silver Bow County. Out-of-county respondents spent an average of 4.5 nights in Montana, reporting a total spending of $263,194.25, mostly in hotel/motel/bed and breakfasts and restaurants/bars. Results provide event organizers with useful data for future event planning, making improvements to the event, event marketing/promotion, and understanding the visitor spending associated with the event.

Hungry Minds: Analyzing The Impact Of Food Insecurity And Food Assistance Programs On Neurocognitive Development And Childhood Mental Health, Kayla A. Davenport

Senior Theses

Introduction: Food insecurity affects millions of children in the United States and is increasingly recognized as a significant risk factor for poor nutritional intake and adverse health outcomes. However, less is known about how the experience of food insecurity disrupts healthy development and well-being, particularly among American youth. This thesis had two aims: (1) to examine the relationship between household food insecurity and children’s neurocognitive and mental health outcomes and (2) to evaluate how major food assistance programs address, or fail to address, these developmental risks.

Methods: This thesis uses a mixed-methods approach, integrating a narrative literature review, a cross-sectional …

Carotenoids As Neuroprotective Agents In Multiple Sclerosis: Pathways, Mechanisms, And Clinical Prospects, Elham Nadimi, Shirin Jamal Omidi, Mahshad Ghasemi, Mohammad Hashem Hashempur, Aida Iraji

Faculty, Staff and Student Publications

Multiple sclerosis (MS) is a chronic autoimmune andneurodegenerative disorder affecting the central nervous system (CNS), characterized by demyelination and neuroinflammatory responses, oxidative stress, and immune dysregulation. The global incidence of MS is rising, demonstrating the necessity for new therapeutic agents against its complex pathophysiology. Carotenoids, naturally pigments with strong antioxidant, anti-inflammatory, immunomodulatory, and neuroprotective activities, have been recognized as promising candidates to target MS.The antioxidant effect of astaxanthin, lycopene, β-carotene, crocin, and lutein resulted from the deactivation of reactive oxygen species (ROS), preservation of mitochondrial integrity, and prevention of lipid peroxidation. Additionally, carotenoids regulate inflammatory pathways by suppressing NF-κB activation, …

Cervical And Tumor-Associated Microbiomes In Botswana Women With And Without Hiv With Carcinoma Of The Cervix Before And After Definitive Chemoradiation, Travis T Sims, Kyoko Yoshida-Court, Molly B El Alam, Pleasure Ramatlho, Rebecca Ketlametswe, Matthew S Ning, Erle S Robertson, Kathleen M Schmeler, Lauren E Colbert, Ann H Klopp, Surbhi Grover

Faculty, Staff and Student Publications

Purpose: Cervical cancer remains a significant public health concern globally and particularly in sub-Saharan Africa, where high rates of HIV infection exacerbate cervical cancer incidence. Understanding the cervical microbiome and its role in cancer progression is essential, especially in regions where both cervical cancer incidence and HIV prevalence are high. This study aimed to characterize the cervical microbiome in women living with HIV (WLWH) and HIV-negative women with squamous cell carcinoma of the cervix in Botswana, compare the microbiome between before and after chemoradiation therapy (CRT) in WLWH, and assess the prognostic value of specific microbial taxa for overall survival …

Site-Specific Drug Release Of Monomethyl Fumarate To Treat Oxidative Stress Disorders, Thomas D Avery, Jiahe Li, Dion J L Turner, Mohd S U Rasheed, Fisher R Cherry, Damian L Stachura, Fátima Rivera-Escalera, David M Ruiz, Michael J Lacagnina, Caitlyn M Gaffney, Clarissa Aguilar, Jingxian Yu, Yang Wang, Huan Xie, Dong Liang, Andrew J Shepherd, Andrew D Abell, Peter M Grace

Faculty, Staff and Student Publications

Treatment of diseases of oxidative stress through activation of the antioxidant nuclear factor E2-related factor 2 (NRF2) is limited by systemic side effects. We chemically functionalize the NRF2 activator monomethyl fumarate to require Baeyer-Villiger oxidation for release of the active drug at sites of oxidative stress. This prodrug reverses chronic pain in mice with reduced side effects and could be applied to other disorders of oxidative stress.

First Experience With Third-Party Validations: A Robust Calibration And Qa Procedure For Proton Flash Delivery, Chih-Chiang Chang, Balaji Selvaraj, Xingyi Zhao, Jacob Rembish, Paige A Taylor, Alexander Bookbinder, Chingyun Cheng, J Isabelle Choi, Charles B Simone, Haibo Lin, Minglei Kang

Faculty, Staff and Student Publications

Background: Proton FLASH radiotherapy, delivering ultra-high dose rates, shows promise in reducing normal tissue toxicity while maintaining tumor control. However, accurate dosimetry and quality assurance (QA) for FLASH remain challenging due to the extreme dose rates involved. Developing reliable calibration and QA procedures is crucial for advancing FLASH towards clinical implementation.

Purpose: To present an effective routine calibration and QA procedure for proton FLASH delivery to ensure high-quality dosimetry performance for preclinical and clinical delivery.

Methods: A high temporospatial resolution strip ionization chamber array (SICA) detector was mounted to the treatment nozzle, which was calibrated using an Advanced Markus ion …

Tofacitinib Ameliorates Campylobacter-Induced Intestinal Pathology By Suppressing Ifnγ Producing Ilcs And T Cells, Anna A Korchagina, Sergey A Shein, Wayne T Muraoka, Justin Nguyen, Qiangxing Chen, Anna A Tumanova, Austin W Todd, Carlos E Rivera, Rita Tamayo, Paolo Casali, Ekaterina Koroleva, Alexei V Tumanov

Faculty, Staff and Student Publications

Patients with autoimmune diseases are more susceptible to foodborne infections, which can be exacerbated by immunosuppressive therapy. Tofacitinib, a JAK/STAT pathway inhibitor, was recently approved for the treatment of ulcerative colitis, yet its effects on the pathogenesis of intestinal infections remain unclear. Here, we examined the impact of oral tofacitinib treatment in a mouse model of Campylobacter jejuni (C. jejuni) infection. Our results show that early tofacitinib administration attenuates intestinal pathology without affecting bacterial colonization. Specifically, tofacitinib suppressed CXCL1, CXCL2, CCL2 chemokine expression by intestinal epithelial cells, limiting recruitment of monocytes and neutrophils to the gut. In addition, JAK/STAT inhibition …

Epigenetic Age Acceleration Mediates Treatment Effects On Cardiometabolic And Cardiovascular Risk In Childhood Cancer Survivors, Xiaoxi Meng, Tiffany Eulalio, Yoonji Kim, John Easton, Heather L Mulder, Emily Walker, Geoffrey Neale, Nan Song, Kyla Shelton, Rebecca M Howell, Mengqi Xing, Sedigheh Mirzaei, Deo Kumar Srivastava, Bonnie Ky, Stephanie B Dixon, Melissa M Hudson, Kirsten K Ness, Gregory T Armstrong, Zhaoming Wang

Faculty, Staff and Student Publications

BACKGROUND: Childhood cancer survivors are at increased risk for epigenetic age acceleration (EAA) and subsequent morbidities, including cardiometabolic risk factors (CMRFs) and cardiovascular diseases, because of prior genotoxic treatments.

OBJECTIVES: The aim of this study was to evaluate the mediating role of EAA in the relationship between cancer treatment exposures and risk for CMRFs and cardiovascular diseases.

METHODS: This study included 2,939 5-year survivors from SJLIFE (St. Jude Lifetime Cohort) who underwent DNA methylation profiling using peripheral blood mononuclear cells. EAA was calculated using 3 established epigenetic clocks: DunedinPACE, PCPhenoAge, and GrimAge2. Treatment data, including body region-specific radiotherapy (RT) and …

Mapping Cardiac Electrical Abnormalities In Rodents, Ashish Kapoor, Peter A Doris

Faculty, Staff and Student Publications

No abstract provided.

Cancer-Associated Fibroblasts As Mediators Of Tissue Microenvironment Remodeling In Cancer, Fernanda G Kugeratski, Emily J Kay, Sara Zanivan

Faculty, Staff and Student Publications

Cancer-associated fibroblasts (CAFs) are a multifunctional cell population of solid tumors that substantially remodel the tumor microenvironment (TME). The combination of single-cell and spatial technologies with elegant mouse models and analysis of patient samples is enabling unprecedented advances in the characterization of CAF origins, heterogeneity, and functions within the TME. As such, the field is now evolving to delineate tissue-specific subpopulations of CAFs, their markers, and the biological context in which each subset presents with a tumor-promoting or a tumor-restraining function. In this timely review, we discuss recent advances in CAF biology in the context of emerging areas of interest …

Cancer-Induced Nerve Injury Promotes Resistance To Anti-Pd-1 Therapy, Erez N Baruch, Frederico O Gleber-Netto, Priyadharsini Nagarajan, Xiayu Rao, Shamima Akhter, Tuany Eichwald, Tongxin Xie, Mohammad Balood, Adebayo Adewale, Shorook Naara, Hinduja N Sathishkumar, Shajedul Islam, William Mccarthy, Brandi J Mattson, Renata Ferrarotto, Michael K Wong, Michael A Davies, Sonali Jindal, Sreyashi Basu, Karine Roversi, Amin Reza Nikpoor, Maryam Ahmadi, Ali Ahmadi, Catherine Harwood, Irene Leigh, Dennis Gong, Paulino Tallón De Lara, Derrick L Tao, Tara M Davidson, Nadim J Ajami, Andrew Futreal, Kunal Rai, Veena Kochat, Micah Castillo, Preethi Gunaratne, Ryan P Goepfert, Sharia D Hernandez, Nikhil I Khushalani, Jing Wang, Stephanie S Watowich, George A Calin, Michael R Migden, Mona Yuan, Naijiang Liu, Yi Ye, William L Hwang, Paola D Vermeer, Nisha J D'Silva, Yuri L Bunimovich, Dan Yaniv, Jared K Burks, Javier Gomez, Patrick M Dougherty, Kenneth Y Tsai, James P Allison, Padmanee Sharma, Jennifer A Wargo, Jeffrey N Myers, Sebastien Talbot, Neil D Gross, Moran Amit

Faculty, Staff and Student Publications

Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types1, yet its mechanism remains unclear. Here we provide clinical and mechanistic insights into the role of PNI and cancer-induced nerve injury (CINI) in resistance to anti-PD-1 therapy. Our study demonstrates that PNI and CINI of tumour-associated nerves are associated with poor response to anti-PD-1 therapy among patients with cutaneous squamous cell carcinoma, melanoma and gastric cancer. Electron microscopy and electrical conduction analyses reveal that cancer cells degrade the nerve fibre myelin sheets. The injured neurons respond by autonomously initiating IL-6- and type I interferon-mediated …

Phi 172 Contemporary Moral Issues, Naomi Zack Phd

Open Educational Resources

An ethical situation or an ethical aspect to something involves human harm or well-being or life or death. Human well-being and life are universally considered important and valuable. This course will present classical ethics writings in Philosophy, contemporary moral/ethical topics, and tools for reading, thinking, speaking, and writing about ethics. In order to apply ethics to current issues, we need to know what Philosophy has contributed to ethical/moral thinking. This course develops that knowledge. Included are: philosophical moral systems of virtue ethics, deontology, utilitarianism and existentialism. Contemporary issues include animal rights, the life of the mind in college, upward social …

Design And Development Of An Intervention To Improve The Quality And Safety Of Pediatric Dental Sedation: A Human-Centered Design Approach, Kawtar Zouaidi, Jan Yeager, Suhasini Bangar, Sayali Tungare, Urvi Mehta, Janelle Urata, Alfa-Ibrahim Yansane, Thomas Tanbonliong, Jungsoo Kim, Emily Sedlock, Krishna Kumar Kookal, Yan Xiao, Tokede Oluwabunmi, Heiko Spallek, Amy Franklin, Gregory W Olson, Joel White, Elsbeth Kalenderian, Muhammad F Walji

Faculty, Staff and Student Publications

Background: There are gaps in understanding the experiences of children, parents, and providers during dental conscious sedation. This study aimed to capture and analyze these experiences to identify opportunities for improvement and enhance the quality and safety of pediatric dental conscious sedation.

Methods: A human-centered design approach was used to examine the conscious sedation experience in 2 US advanced education pediatric dental clinics. Researchers conducted field observations, interviews with providers and parents, and providers focus groups to explore experiential factors. Data were transcribed and analyzed using content thematic analysis. Insights from the data were used to explore and generate new …

Scottish Workers’ Stories Of Life And Labour During Covid-19 From The Workers’ Stories Project, Hailey Maxwell, Ruth Gilbert, Suki Sangha, Ewan Gibbs

Studies in Scottish Literature

This article explores how Scottish workers narrated the impact of the COVID-19 pandemic on their life and work, by analysing 55 fifty-five submissions to the Workers' Stories Project. Between 2020 and 2022, the project creative reflections on the pandemic from workers across Scotland, drawing on the tradition of workers' inquiry and workers' education that encouraged critical reflection and the embrace of worker creativity. Submissions were overwhelmingly literary in form, primarily short prose supplemented by poetry, with three key themes emerging: intimacy and alienation; insecurity and status; and a slower living pace. Cumulatively, the stories underline how COVID-19 magnified workplace injustices …

Burying Weapons Under The White Pine Tree: Reducing Nuclear Weapons And Using The Monetary Savings To Compensate Native Peoples Injured By The U.S. Nuclear Weapons Complex, William Y. Chin

Cardozo Journal of Equal Rights & Social Justice

No abstract provided.

Exudation Entomology, John Buchanan

Department of Entomology: Distance Master of Science Projects

My master's project is exudation entomology. I propose a new area of entomology that will renew and reshape the science, answer questions that have been explored, and open new questions that have yet to be asked.

Exudation entomology is the study of exudates from arthropods. This includes (but is not limited to) honey, saliva, silk, secretions, venom, pheromones, paper, wax, and more. Other properties, such as bioluminescence, sounds, and odors, are also included. Exudation entomology will explore the chemical makeup of exudates, the anatomical mechanisms for how the arthropod produces the exudate, why the exudate is essential for arthropods and …

Flies: Nature’S Hidden Helpers, A Science Literacy Project Exploring Beneficial And Pest Insects, Natalie Johnston

Department of Entomology: Distance Master of Science Projects

A science literacy project for elementary learners exploring beneficial and pest insects with a focus on flies, nature's hidden helpers.

This project demonstrates that science literacy can be cultivated through experiential and interdisciplinary teaching. Future developments could include digital tools for compost monitoring, citizen science participation, or expanded studies of other decomposer species. Cross-curricular collaboration with language arts and art education can further strengthen the integration of creativity and evidence-based reasoning.

Ultimately, this work reaffirms that even small organisms—like flies—can inspire big learning outcomes. By integrating science literacy with sustainability education, we prepare students to think critically about ecological relationships …

Experimental Insights Into High Background Radiation: Reduced Cancer Risks In A Murine Model Study, S. M.J. Mortazavi, M. Arshadi, B. F. Baha'addini Baigy Zarandi, J. S. Welsh, H. Mozdarani, M. Haghani, N. Jooyan, S. Nematollahi, Negar Azarpira, Lembit Sihver

Informatics and Engineering Systems Faculty Publications

Background: Natural background radiation varies geographically and has potential implications for cancer development. High-level natural radiation areas (HLNRAs), like Ramsar, Iran, offer unique opportunities to study the biological effects of radiation exposure. This study investigates the relationship between high background radiation and tumor progression in a murine model. Materials and Methods: Thirty-two C57BL/6 mice were exposed to varying levels of natural radiation (0.097 μSv/h to 9.24 μSv/h) for two months, simulating conditions in Ramsar. Mice were divided into four groups based on radiation intensity. After exposure, 1106 B16-F10 melanoma cells were injected subcutaneously, and tumor growth was monitored for 24 …