Digital Commons Network^™

Diet And Lifetyle Factors Associated With Mirna Expression In Colorectal Tissue, Martha L. Slattery, Jennifer S. Herrick, Lila E. Mullany, John R. Stevens, Roger K. Wolff

Mathematics and Statistics Faculty Publications

MicroRNAs (miRNAs) are small non-protein-coding RNA molecules that regulate gene expression. Diet and lifestyle factors have been hypothesized to be involved in the regulation of miRNA expression. In this study it was hypothesized that diet and lifestyle factors are associated with miRNA expression. Data from 1,447 cases of colorectal cancer to evaluate 34 diet and lifestyle variables using miRNA expression in normal colorectal mucosa as well as for differential expression between paired carcinoma and normal tissue were used. miRNA data were obtained using an Agilent platform. Multiple comparisons were adjusted for using the false discovery rate q-value. There were 250 …

Et Tu, Android?: Regulating Dangerous And Dishonest Robots, Woodrow Hartzog

Faculty Scholarship

Consumer robots like personal digital assistants, automated cars, robot companions, chore-bots, and personal drones raise common consumer protection issues, such as fraud, privacy, data security, and risks to health, physical safety, and finances. They also raise new consumer protection issues, or at least call into question how existing consumer protection regimes might be applied to such emerging technologies. Yet it is unclear which legal regimes should govern these robots and what consumer protection rules for robots should look like.

This paper argues that the FTC's grant of authority and existing jurisprudence are well-suited for protecting consumers who buy and interact …

A Single Dose Of Epidermicin Ni01 Is Sufficient To Eradicate Mrsa From The Nares Of Cotton Rats, Samantha Halliwell, Peter Warn, Abdul Sattar, Jeremy P. Derrick, Mathew Upton

School of Biomedical Sciences

No abstract provided.

Applying Text Mining To Analyze The Performance Of Pbos On The Basis Of Their Obligatory Annual Activity Statements, Tomasz Dyczkowski

European Management Studies

The paper’s aims is to investigate if the level of detail and selection of particular performance-related information by public benefit organizations (PBOs) in their obligatory annual activity statements can stimulate individual donations. The research encompassed 177 randomly selected Polish PBOs. It applied text mining methodologies and a laboratory experiment. The results obtained allowed the identification of nine key groups of topics that PBOs focus on the narrative parts of their obligatory annual activity statements. Moreover, it was proven that organizations that potential donors would like to support with their 1% tax write-off discuss their performance in more detail and focus …

Discontinuous Finite Element Mechanistic Water Quality Model For The Simulation Of Adsorptive Pollutants Transport In River Systems., F. P. Fiengo, L. Sweeck, M. Elskens, W. Bauwens

Open Water Journal

The close interaction between humans, animals and the river system requires to have control about the concentration of different pollutants in the water column in order to avoid damage to the environment. Due to the fact that the measurements are time consuming, expensive and in most of the cases very local, it is required to develop tools in order to predict the spatial and temporal distribution of the pollutants in the system.

Once pollutant effluents are discharged in waters, part of them is transported in liquid phase and the rest is attached to the suspended sediments and to the bed …

Parallel Session: A Study Of Buyers' And Sellers' Perception Of Organic Foods In Pakistan: Towards A More Effective Marketing Mix (Green Field Marketing), Sara Khan

International Conference on Marketing

Issues of food safety, nutritional value as well as environmental and ecological damage as a result of agricultural abuse have acquired global significance. Many people are looking for equitable, less cruel and sustainable answers to these problems. Organic foods / products are one such solution to people's food and agricultural needs. Looking at the viewpoints of both consumers (including prospective consumers) and producers, this research undertakes to study the marketing mix of the organic foods / products market in Pakistan and explores marketing solutions to enhance its development (research objective). Using qualitative interviews and thematic analysis, respondents' answers are coded …

Parallel Session: Trends On Green Consumer Behaviors (Gcb): A Viewpoint From Developed And Developing Countries, Siti Aisyah Asrul

International Conference on Marketing

Green consumers are those who purchase and consume green products and the one who persevere the environment with being green. The effort of these green consumers is with regards to their awareness of how the environment has been savagely polluted and they are working hard to reduce the pollution by saving the environment. They play their role as one of the living mechanism with purchasing and consuming eco-friendly products and even influence their family and peers to be part of it. Green behaviour has been well-developed by the consumers all around the continents, be it from developing country or developed …

Parallel Session: Moving Towards Sustainable Consumption: A Study Of Reduce, Reuse And Recycle (3rs) Adoption Among Malaysians, Regina Yan Ginny, Yusniza Kamarulzaman

International Conference on Marketing

Over the last decade, rapid globalization, industrial development, economic growth and technological advancement has resulted in population growth and unprecedented changes to the social and cultural lifestyle in Malaysia. One of the dramatic increase was witnessed in the consumption of goods and services due to the rising household income and progressive consumption-oriented lifestyles. On one hand, it helps to stimulate economic activities, but on the other hand, it poses threat to the diversity and stability of the natural environment in various ways. Hence, the key purpose of this study is to identify the factors that affects Reduce, Reuse and Recycle …

Art-Integration Through Making Dioramas Of Women Mathematicians’ Lives Enhances Creativity And Motivation, Audrey C. Rule, Dana L. Atwood-Blaine, Clayton M. Edwards, Mindy M. Gordon

Journal of STEM Arts, Crafts, and Constructions

Creativity is essential for solving problems in the workplace, natural environment, and everyday life, necessitating that creativity be nurtured in schools. Identification of factors that intrinsically motivate students to learn difficult or initially unappealing content is also important. This project, in which 24 racially diverse fifth grade girls created dioramas of the lives of diverse successful women mathematicians, explored the girls’ reactions to art integration into mathematics through a phenomenological qualitative analysis of their products, essays, and responses to questionnaires. The project supported the Next Generation Science Standard for engineering design, Standard 3-5-ETS1-1 and two National Core Arts Standards for …

Three- And Four-Year Olds Learn About Gears Through Arts Incorporation, Dessy Stoycheva, Leann M. Perkins

Journal of STEM Arts, Crafts, and Constructions

This research paper explores art integration into a science lesson unit that follows the Next Generation Science Standards (K-PS2-1) and focuses on the effects on memory retention of key concepts along with levels of enjoyment. An experiment was conducted with children ages 3 and 4 teaching scientific concepts about gears while incorporating student-made art products. The children were assigned to alternating experimental (art-integrated) or control (no art) conditions during the four stages of the lesson. The results did not show statistically significant differences at the alpha = 0.05 level between conditions in the amount of information retained based on the …

Fourth Graders Make Inventions Using Scamper And Animal Adaptation Ideas, Mahjabeen Hussain, Anastasia Carignan

Journal of STEM Arts, Crafts, and Constructions

This study explores to what extent the SCAMPER (Substitute, Combine, Adapt, Modify, Put to another use, Eliminate, and Rearrange) technique combined with animal adaptation ideas learned through form and function analogy activities can help fourth graders generate creative ideas while augmenting their inventiveness. The sample consisted of 24 fourth grade students (14 female, 10 male) ages 9-10 at a suburban Midwestern elementary school. A repeated-measures design involving all participants alternately in the two conditions measured students under each treatment condition. In the experimental condition, students used SCAMPER charts with animal adaptation ideas to generate ideas to improve a product using …

Who Moved Those Rain Clouds To Town? Making Windbirds To Learn About The Power Of Wind, Deepanee Samarakoon, Latisha L. Smith

Journal of STEM Arts, Crafts, and Constructions

In this practical article, a kindergarten teacher shares a lesson designed to teach students about the power of wind. To address the Next Generation Science Standards engineering standards, students discussed the negative and positive aspects of wind and made daily weather observations (K-ESS2-1). Students constructed bird-shaped windsocks, called windbirds, to explore how the shape of the object allowed it to move in the wind (K-2-ETS1-2). To address the National Core Arts Standards, creative arts were integrated as students designed cylindrical windbirds of colorful materials. The windbirds were used to observe the effects of wind in the students’ outdoor environment at …

Using Creativity From Art And Engineering To Engage Students In Science, Mason Albert Kuhn, Scott Greenhalgh, Mark Mcdermott

Journal of STEM Arts, Crafts, and Constructions

STEAM education, referring to integrated Science, Technology, Engineering, Art, and Mathematics, is a contemporary buzzword that is popular in many schools. In particular, many elementary school teachers who have been tasked to incorporate STEM teaching, because of the requirements of the Next Generation Science Standards, attempt to apply the arts in their science curriculum because they feel more comfortable using instructional approaches that incorporate creative activities such as crafts, drawing, and model construction than the core practices of STEM disciplines. Teachers can use the creative arts activities in two ways to enhance the STEM learning environment: 1) Using creative processes …

Spatial Thinking Skills And Stem Connections: How Does This Issue Address Them?, Audrey C. Rule

Journal of STEM Arts, Crafts, and Constructions

In this editorial, the Editor considered the importance of spatial thinking skills to STEM careers, provided examples of ways scientists use spatial thinking, noted sex and socioeconomic differences in spatial skill proficiency, and reviewed ways that activities included in articles in this issue involved spatial thinking. Brief summaries and preview images were provided for the articles in the issue. The four-component spatial thinking classification scheme with categories of intrinsic-static, intrinsic-dynamic, extrinsic-static and extrinsic dynamic was applied to the activities from this issue of the Journal of STEM Arts, Crafts, and Constructions. All categories of this classification scheme were addressed, providing …

Parallel Technical Sessions Schedule, Institute Of Business Administration

International Conference on Marketing

No abstract provided.

“The Battle-Fortune Of Marshal Hindenburg Is Not Bound Up With The Possession Of A Hill”: The Germans And Vimy Ridge, April 1917, Holger Herwig

Canadian Military History

On 9 April 1917 four Canadian divisions and one British division of 170,000 men broke through the “Vimy Group” of German Sixth Army of some 40,000 men. By late afternoon, the Germans had been driven off the Ridge. That day, as Brigadier-General Alexander Ross famously put it, constituted “the birth of a nation.” Rivers on ink have been spilled in the Canadians’ actions that day, but little attention has been paid to “the other side of the hill.” Which German units defended the Ridge? What was the quality of their leadership? Why did the defence collapse so quickly? Why did …

Sirt1 Regulates Glial Progenitor Proliferation And Regeneration In White Matter After Neonatal Brain Injury., Beata Jablonska, Marcin Gierdalski, Li-Jin Chew, Teresa Hawley, Mackenzie Catron, Arturo Lichauco, Juan Cabrera-Luque, Tracy Yuen, David Rowitch, Vittorio Gallo

Pediatrics Faculty Publications

Regenerative processes in brain pathologies require the production of distinct neural cell populations from endogenous progenitor cells. We have previously demonstrated that oligodendrocyte progenitor cell (OPC) proliferation is crucial for oligodendrocyte (OL) regeneration in a mouse model of neonatal hypoxia (HX) that reproduces diffuse white matter injury (DWMI) of premature infants. Here we identify the histone deacetylase Sirt1 as a Cdk2 regulator in OPC proliferation and response to HX. HX enhances Sirt1 and Sirt1/Cdk2 complex formation through HIF1α activation. Sirt1 deacetylates retinoblastoma (Rb) in the Rb/E2F1 complex, leading to dissociation of E2F1 and enhanced OPC proliferation. Sirt1 knockdown in culture …

Act On The Registration And Evaluation Of Chemicals (K-Reach) And Replacement, Reduction Or Refinement Best Practices, Soojin Ha, Troy Seidle, Kyung-Min Lim

Legal Regulation of Animal Research Collection

Objectives - Korea’s Act on the Registration and Evaluation of Chemicals (K-REACH) was enacted for the protection of human health and the environment in 2015. Considering that about 2000 new substances are introduced annually across the globe, the extent of animal testing requirement could be overwhelming unless regulators and companies work proactively to institute and enforce global best practices to replace, reduce or refine animal use. In this review, the way to reduce the animal use for K-REACH is discussed. Methods - Background of the enforcement of the K-REACH and its details was reviewed along with the papers and regulatory …

The Murray Ledger And Times, December 19, 2016, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Usa V. Anthony Robinson

2016 Decisions

USDC for the Eastern District of Pennsylvania

Advances And Perspectives In Genetics Of Congenital Thyroid Disorders Associated With Thyroglobulin Gene Mutations, Héctor M. Targovnik, Cintia E. Citterio, Sofi Siffo, Carina M. Rivolta

Pharmacy Faculty Articles and Research

Dyshormonogenesis due to thyroglobulin (TG) gene mutations is a rare cause of congenital hypothyroidism with an estimated incidence of approximately 1 in 100,000 newborns. The TG gene is organized in 48 exons, spanning over 270 kb on human chromosome 8q24. The human TG mRNA is 8.5 Kb long and the preprotein monomer is composed of a 19 amino acids signal peptide followed by a 2749 residues polypeptide. Until now, one hundred seventeen deleterious mutations in the human TG gene have been identified and characterized, originating structural changes in the protein that alter the normal protein folding, assembly and …

A Neuronal Network Of Mitochondrial Dynamics Regulates Metastasis., M. Cecilia Caino, Jae Ho Seo, Angeline Aguinaldo, Eric Wait, Kelly G. Bryant, Andrew V. Kossenkov, James E. Hayden, Valentina Vaira, Annamaria Morotti, Stefano Ferrero, Silvano Bosari, Dmitry I. Gabrilovich, Lucia R. Languino, Andrew R. Cohen, Dario C. Altieri

Department of Cancer Biology Faculty Papers

The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and power the membrane machinery of cell movements. When expressed in tumours, SNPH inhibits the speed and distance travelled by individual mitochondria, suppresses organelle dynamics, and blocks chemotaxis and metastasis, in vivo. Tumour progression in humans is associated with downregulation or loss of SNPH, which correlates with shortened patient survival, increased mitochondrial trafficking to the cortical cytoskeleton, greater …

Calculating The Methan-Matics Of Our Future, Victoria Salinas

Op-Eds from ENSC230 Energy and the Environment: Economics and Policies

In the first two decades after its release, methane, a green house gas, is 84 times more potent than carbon dioxide. Historically, atmospheric concentrations of methane remained fairly stable at around 750 ppb, significantly less than today’s levels of 1,800 ppb. Unfortunately, agricultural activity accounts for about one-fifth of total global greenhouse gas emissions, while the current production of ruminants contributes nearly 80% of these emissions due to their large populations, body size and appetites, and the anaerobic microbial fermentation that occurs during digestion. Because of methane’s severe impact on the climate, methane emissions, specifically due to the production of …

Giving Credit Where Credit Is Due: Reducing Inequality With A Progressive State Tax Credit, Eric Kades

Louisiana Law Review

The article focuses on the income inequality entirely within the control of governments with the unfair taxation across every state in one fell swoop with the progressive state tax credit (PSTC) and federal income tax deduction for state tax payments and tax policy of constitutional law.

An Exploratory Study On The Possible Effect Of Hydraulic Fracturing Activities On Air Quality In The Eagle Ford Shale Region Of Texas., Laura B. Fimibama

Electronic Theses and Dissertations

Eagle Ford Shale (EFS) play is one out of five major oil and gas formations in Texas, found in the South-Eastern region with approximately 30 counties. In addition to natural gas, it produces crude oil and petroleum liquids which in recent times has resulted in a surge in drilling due to a new drilling technology – hydraulic fracturing that injects massive quantities of water along with sand and chemical additives into a well to create tiny hairline cracks in rock formations. The success of this technology has made gas extraction more economically feasible. However, this technique has generated an array …

Rat Elbow Project, Wilson Roen, Spencer Lake

Mechanical Engineering and Materials Science Independent Study

Current methods for treating post-traumatic joint stiffness (PTJS), a common clinical problem following elbow surgeries which causes functional impairment of the limb, have proven insufficient.1 The main factors that expose the elbow joint to this complication are a high degree of congruence, the complexity of the joint surfaces and the high tissue sensitivity to trauma, especially the joint capsule.1 As a result, the Lake laboratory is working with elbow tissue to determine how the injury presents itself. With a deeper understanding of the injury, the lab hopes to develop more effective prevention and treatment methods for PTJS. Before the fall …

Skull Shape Affects Susceptibility To Traumatic Brain Injury, Kashyap Arcot, Guy M. Genin

Mechanical Engineering and Materials Science Independent Study

Rapid deformation of brain matter caused by skull acceleration is one of the most significant causes of concussion and severe traumatic brain injury (TBI). Despite substantial research being conducted in this area of study, very little is understood regarding the mechanics of the brain when exposed to rapid acceleration. As a result, the biomechanics of TBI remain ambiguous. In the present study, we apply a new strain estimation algorithm that enables the tracking of strains on the periphery of an image onto data obtained from tagged gel phantom and human MR-images. We use this new method to quantify strain concentrations …

The Hif/Phf8/Ar Axis Promotes Prostate Cancer Progression., D Tong, Q Liu, G Liu, W Yuan, L Wang, Y Guo, W Lan, Dianzheng Zhang, S Dong, Y Wang, H Xiao, J Mu, C Mao, J Wong, J Jiang

PCOM Scholarly Works

Recent studies provide strong evidence that the androgen receptor (AR) signaling pathway remains active in castration-resistant prostate cancer (CRPC). However, the underlying mechanisms are not well understood. In this study, we demonstrate that plant homeo domain finger protein 8 (PHF8 )interacts with and functions as an essential histone demethylase activity-dependent AR coactivator. Furthermore, we demonstrate that the expression of PHF8 is induced by hypoxia in various prostate cancer cell lines. Knockdown of either hypoxia-inducible factor HIF2α or HIF1α almost completely abolished hypoxia-induced PHF8 expression. Importantly, we observed that PHF8 is highly expressed in clinical androgen deprived prostate cancer samples and …

Bjc Today

BJC Today

No abstract provided.

Role Of The Endocannabinoid System And Medical Cannabis, Sabrina Jarvis, Sean Rasmussen, Blaine Winters

Student Works

Our bodies produce substances called endocannabinoids which attach to receptors within the endocannabinoid system (ECS) impacting physiological processes on a daily basis. The cannabis plant contains over 100 different cannabinoids which also manipulate the ECS. Knowledge about these interactions have led to an increase in cannabis based pharmacological studies. Providers should have a basic understanding about how the ECS works and how cannabis is being used to treat certain illnesses. This article presents what is currently known about the ECS and how cannabis based medicines impact it, as well as the current laws providers need know regarding cannabis use.