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2015

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The Role Of Ribosome Biogenesis In Exercise-Induced Skeletal Muscle Anabolism In Aging, Michael Stec Jan 2015

The Role Of Ribosome Biogenesis In Exercise-Induced Skeletal Muscle Anabolism In Aging, Michael Stec

All ETDs from UAB

Numerous chronic medical conditions, as well as normal aging result in a significant loss of skeletal muscle mass. This has profound effects on quality of life and can increase the risk of all-cause mortality. Currently, the most potent treatment for reversing the loss of muscle mass is resistance exercise training (RT); however, the human muscle fiber growth (hypertrophy) response to this treatment is quite variable, and older adults do not respond as favorably to this treatment as younger adults. The focus of this dissertation is to elucidate the role that ribosome biogenesis plays in regulating the RT-induced hypertrophic response. We …

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The Role Of Mammalian Tribbles Homolog 3 (Trb3) In Macrophage Biology; Evidence For Reciprocal Regulation Of Macrophage Function In Foam Cell Formation, Dennis Steverson Jan 2015

The Role Of Mammalian Tribbles Homolog 3 (Trb3) In Macrophage Biology; Evidence For Reciprocal Regulation Of Macrophage Function In Foam Cell Formation, Dennis Steverson

All ETDs from UAB

Atherosclerosis is disease characterized by dysregulated lipid metabolism and chronic inflammation. Macrophages are critical to the progression of the disease and are involved in the pathophysiology at all stages of the disease. In the early stages, macrophages are responsible for fatty streak formation by becoming foam cells through lipid uptake. In the later stages, macrophages contribute to the degradation of the fibrous cap and are largely responsible for chronic inflammation in atherosclerotic plaques. Tribbles homolog 3 (TRB3) is a pseudokinase that inhibits Akt activation by blocking its phosphorylation site. TRB3 is expressed on numerous cell types in the body (pancreatic …

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Closing The University/School Divide: A Grounded Theory Approach To Preparation Of Early Childhood/Elementary Education Teacher Candidates, Jennifer L. Summerlin Jan 2015

Closing The University/School Divide: A Grounded Theory Approach To Preparation Of Early Childhood/Elementary Education Teacher Candidates, Jennifer L. Summerlin

All ETDs from UAB

The purpose of this grounded theory study was to explore the most significant experiences in preparation for becoming early childhood/elementary educators, as perceived by teacher candidates and recent graduates of one southeastern university, school of education. This research study, conducted from a constructivist theoretical lens, and using a grounded theory methodology, sought to answer three research questions. First, what are the significant experiences, as perceived by recent graduates, from one southeastern school of education, in preparation for the multifaceted role of today's early childhood/elementary generalist? Secondly, what are the most significant experiences, as perceived by current teacher candidates involved in …

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Deleterious Effects Of Hyperglycemia On Cognitive Functioning In The Cardia Study Cohort, Michele Holland Talley Jan 2015

Deleterious Effects Of Hyperglycemia On Cognitive Functioning In The Cardia Study Cohort, Michele Holland Talley

All ETDs from UAB

DELETERIOUS EFFECTS OF HYPERGLYCEMIA ON COGNITIVE FUNCTIONING IN THE CARDIA STUDY COHORT MICHELE LYN HOLLAND TALLEY SCHOOL OF NURSING ABSTRACT With an aging society, maintaining cognitive functioning into older age is becoming more important. Because of the impact cognitive functioning has on daily activities, any disruption may inhibit the ability to perform such daily activities successfully. To prevent disruptions, determinants of cognitive functioning must be considered. Such determinants may or may not be modifiable. Some predictors may be demographic, metabolic, or inflammatory in nature. In addition, predictors or determinants may differ based on genetic predisposition to Alzheimer’s disease. As part …

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Just Past The Trestle, Gentry Chance Turner Jan 2015

Just Past The Trestle, Gentry Chance Turner

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JUST PAST THE TRESTLE GENTRY CHANCE TURNER MASTER OF ARTS ENGLISH ABSTRACT The fall of the Old South is the backdrop for this chronicle of one family's descent and resurrection throughout the violent upheaval of the twenty-first century. Several generations of Turner men are examined in this tale of power, hatred and the collateral damage of arrested development. The following chapters give a truncated vision of a lifetime of competing forces and the pain of escaping from "loved" ones.

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Difference In Recommended-To-Actual Nurse Staffing And Patient Falls, Shawn Ulreich Jan 2015

Difference In Recommended-To-Actual Nurse Staffing And Patient Falls, Shawn Ulreich

All ETDs from UAB

Patient falls are a serious safety concern in hospitals. Injuries from falls can be devastating to patients and are now subject to reimbursement penalties from the Center for Medicare and Medicaid Services. Patient falls have been identified by the American Nurses Association as a nursing sensitive indictor suggesting that improvements in the quality or quantity of nurses may impact this outcome. Moreover, the literature suggests that nurse staffing levels have an impact on various patient outcomes such as patient falls. Therefore, identifying appropriate nurse staffing levels to minimize patient falls is critically important to hospitals. A variety of staffing metrics …

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Characterization Of The Gtpase Rac1 As An Electrophilic-Sensitive Protein In Vascular Cells, Stephanie Brook Wall Jan 2015

Characterization Of The Gtpase Rac1 As An Electrophilic-Sensitive Protein In Vascular Cells, Stephanie Brook Wall

All ETDs from UAB

The GTPase Rac1 is a protein which has been shown to be dysregulated in the context of a number of inflammatory diseases including atherosclerosis. Rac1 responds to extracellular signals and is involved in cellular cytoskeletal rearrangement, reactive oxygen species generation and cell cycle progression. When activated Rac1 interacts with effector proteins on the plasma membrane. This activation has recently been shown to be modulated by redox signaling via an active site cysteine. However, it is not known whether other redox signaling compounds can modulate Rac1 activity. An important redox signaling mediator is the electrophilic lipid, 15-deoxy-Δ12,14-prostaglandin J2 (15dPGJ2). This lipid …

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Decoding Nf1 Intragenic Copy-Number Changes, Meng-Chang Hsiao Jan 2015

Decoding Nf1 Intragenic Copy-Number Changes, Meng-Chang Hsiao

All ETDs from UAB

Genomic rearrangements may cause both Mendelian and complex disorders. Currently, several major mechanisms causing genomic rearrangements have been proposed such as non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ), fork stalling and template switching (FoSTeS) and microhomology-mediated break-induced replication (MMBIR). However, to what extent these mechanisms contribute to gene-specific pathogenic copy-number changes (CNCs) remains understudied. Furthermore, only few studies resolved these pathogenic alterations at the nucleotide-level. Accordingly, our aim was to explore which mechanisms contribute to a large, unique set of locus-specific non-recurrent genomic rearrangements causing the genetic neurocutaneous disorder neurofibromatosis type 1 (NF1). Through breakpoint-spanning PCR as well as …

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A Bio-Inspired Hybrid Nanosack For Pancreatic Islet Transplantation In The Omentum, Patrick Tj Hwang Jan 2015

A Bio-Inspired Hybrid Nanosack For Pancreatic Islet Transplantation In The Omentum, Patrick Tj Hwang

All ETDs from UAB

Pancreatic islet transplantation (PIT) has demonstrated consistent and sustained reversal of type 1 diabetes, generating optimism for its wider application as a potential cure for type 1 diabetes. However, the clinical efficacy is still lacking because of a substantial loss of islets during or shortly after transplant to the implantation site. The liver has been widely used as an implantation site for PIT, but it has serious risks for islet loss, such as massive islet destruction by instant blood-mediated inflammatory reaction, progressive attrition of islet cells due to exposure to the toxic environment. The omentum has gained significant attention as …

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A Comprehensive Assessment Of Possible Links Between Digital Advertising Billboards And Traffic Safety, Md Mozahidul Islam Jan 2015

A Comprehensive Assessment Of Possible Links Between Digital Advertising Billboards And Traffic Safety, Md Mozahidul Islam

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Advertising billboards are a common roadside object and a very efficient medium of outside advertising. For years, static billboards have been adopted by the billboard advertising companies. Most recently, a sizeable portion of the regular (static) billboards have been digitized to convey more information to the drivers, thus raising questions about their potential impact on traffic safety. Frequently changing images on digital advertising billboards may compel more glances, and sequential messages may hold drivers' gazes longer until the entire message is read. Earlier studies sponsored by billboard advertising companies did not report statistically significant correlations between the crash occurrences and …

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Mechanisms Of Heme Oxygenase-1-Mediated Protection Against Tissue Injury, Travis David Hull Jan 2015

Mechanisms Of Heme Oxygenase-1-Mediated Protection Against Tissue Injury, Travis David Hull

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Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in the catabolism of heme, which is released by necrotic cells in injured tissue. HO-1 expression is protective in cardiac and renal injury because it coordinates the degradation of pro-oxidant heme with the generation of equimolar quantities of iron (Fe2+) and the cytoprotective mole-cules carbon monoxide and biliverdin. While many studies have demonstrated that HO-1 expression is protective in numerous disease states, relatively few have examined the specific cellular compartment(s) through which HO-1 expression confers its protective effects. Our objective was to define the cellular compartments in which HO-1 expression is critical to …

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Mechanisms Of Resistance To Oncolytic Herpes Simplex Viruses In Malignant Peripheral Nerve Sheath Tumors, Joshua Douglas Jackson Jan 2015

Mechanisms Of Resistance To Oncolytic Herpes Simplex Viruses In Malignant Peripheral Nerve Sheath Tumors, Joshua Douglas Jackson

All ETDs from UAB

Malignant peripheral nerve sheath tumors (MPNSTs) are rare but highly aggressive cancer of the peripheral nervous tissue. Median patient survival is approximately two years following diagnosis due in part to the ineffective options for treatment. As an alternative therapeutic approach to conventional radio- and chemotherapy, oncolytic herpes simplex viruses type-1 (oHSVs) have been proposed to treat MPNSTs. These oHSVs have been shown safe in clinical trials with associated tumor regression. However, there is evidence that resistance to the therapy should be anticipated in a subset of patients. Therefore, the goal of this dissertation has been to identify the primary obstacles …

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Zebrafish Wnt9b Patterns The First Pharyngeal Arch Into D-I-V Domains And Promotes Anterior-Medial Outgrowth, Henry Jackson Jan 2015

Zebrafish Wnt9b Patterns The First Pharyngeal Arch Into D-I-V Domains And Promotes Anterior-Medial Outgrowth, Henry Jackson

All ETDs from UAB

The secondary mouth and its associated face and jaws were an important evolutionary adaptation in the vertebrate lineage. The secondary mouth is formed from facial prominences including the fronto-nasal prominence and the 1st pharyngeal-arch derived maxillary and mandibular prominence. Cranial neural crest cells within these prominences give rise to the connective tissues of face and jaws, and strict spatio-temporal regulation of cranial neural crest cell fate patterning and subsequent prominence outgrowth is vital to normal facial development. Oral-facial clefting (OFC) is a common morbid human birth disorder characterized by disrupted oral and craniofacial morphogenesis. Our previous studies demonstrate that a …

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Hospital Community Orientation: Predictors And Performance Outcomes, J'Aime Jennings Jan 2015

Hospital Community Orientation: Predictors And Performance Outcomes, J'Aime Jennings

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The three publishable manuscripts contained within this dissertation examine the predictors and performance outcomes of hospital community orientation. Community orientation is the customization of hospital services to meet identified community health needs. Together, these papers fill gaps in the literature regarding the factors that assist or hinder hospitals from being community-oriented, as well as the effects of community orientation. The first paper uses longitudinal data to examine the organizational and environmental factors that may influence how engaged hospitals are in a community orientation strategy based on the number of activities performed. The remaining papers consider the performance outcomes of community …

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Exploring Body Image And The Association Between Body Image Dissatisfaction And Waist Circumference Among Overweight And Obese Rural African American Women Participating In A Weight Loss Program, Erica Rayshelle Johnson Jan 2015

Exploring Body Image And The Association Between Body Image Dissatisfaction And Waist Circumference Among Overweight And Obese Rural African American Women Participating In A Weight Loss Program, Erica Rayshelle Johnson

All ETDs from UAB

African American (AA) women are disproportionately burdened by obesity, an epidemic with implications that reach beyond physiological consequences. Given that perceptions of body image may impact health-promoting behaviors and weight management efforts, we sought to evaluate the presence and magnitude of body image dissatisfaction (BID) and explore its relationship with waist circumference (WC), independent of weight among overweight and obese treatment-seeking rural AA women. Participants referred to images from the Pulvers Figure Rating Scale that included nine body silhouettes to answer: “How I think I look now” (i.e., current body image) and “How I would like to look” (i.e., desired …

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Prevalence And Determinants Of High Risk Human Papillomavirus (Hpv) Among Wives Of Migrant Workers - A Study In Far - West Nepal, Derek Johnson Jan 2015

Prevalence And Determinants Of High Risk Human Papillomavirus (Hpv) Among Wives Of Migrant Workers - A Study In Far - West Nepal, Derek Johnson

All ETDs from UAB

This dissertation research focuses on the risk factors associated with high-risk HPV infection (HR-HPV) and abnormal cervical cytology in Nepali women residing in Nepal’s Far-West district of Achham. The first part of this dissertation assesses the HR-HPV test concordance of self-collected vs. clinician-collected cervico-vaginal specimens. Of 261 women with both clinician- and self-collected cervical samples, 25 tested positive for HR-HPV, resulting in an overall HR-HPV prevalence of 9.6% (95% Confidence Interval [CI]: 6.3 – 13.8). The overall Kappa value for clinician- and self-collected tests was 0.64 (95% CI: 0.48 – 0.84), indicating a “good” level of agreement. The second part …

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Towards An Understanding Of Patient Satisfaction In The Military Health System, Alan Alexander Jones Jan 2015

Towards An Understanding Of Patient Satisfaction In The Military Health System, Alan Alexander Jones

All ETDs from UAB

The Military Health System (MHS) is the most expansive health care system in the world. The MHS provides health care services to 9.7 million eligible beneficiaries spread across six continents. The MHS budget exceeded $52 billion in 2013 or 10 percent of the total 2013 Defense budget. The cost of health care in the MHS is of great concern to the Department of Defense and the US Congress. The MHS needs a strong framework to measure the value of the health care it provides. The purpose of this study was to develop a framework to better understand Patient Satisfaction in …

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Joining And Assembly With Long Fiber Thermoplastic Composites, Danila Kaliberov Jan 2015

Joining And Assembly With Long Fiber Thermoplastic Composites, Danila Kaliberov

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Thermoplastic composites are used extensively in automotive, mass transit, aerospace and other commercial industries. Current industry usage is typically limited to short fiber composites formed by injection molding processes, and continuous fiber reinforced composites through processes such as autoclave molding, filament winding etc. Long fiber thermoplastics (LFT) are a class of composites known for their specific strength, corrosion resistance, impact and damping properties, as well as high production rates, recyclability, and ability for complex part fabrication. The overall objective of this research was to investigate viability of joining and assembly with long fiber thermoplastic composites. This research deals with (1) …

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Simulation Of Bridge Responses To Heavy Vehicles, Rahul Kalyankar Jan 2015

Simulation Of Bridge Responses To Heavy Vehicles, Rahul Kalyankar

All ETDs from UAB

The main objective of this dissertation is to simulate dynamic heavy vehicle bridge interaction using advanced numerical models of heavy vehicle and bridges for the Next Generation Bridge Weigh in Motion (B-WIM) system. The traditional B-WIM system uses a simplified approach where the bridge is considered as a beam and the heavy vehicle is considered as a stable mass moving with constant speed. On the contrary, the moving heavy vehicle consists of a series of complex parts such as tire assembly, springs and dampers, rigid bodies, and types of materials. Along with the complexities of the heavy vehicle, the bridge …

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Examining The Interplay Of Diet Composition, Cardiometabolic Diseases, And Economics, Kenneth Patton Kell Jan 2015

Examining The Interplay Of Diet Composition, Cardiometabolic Diseases, And Economics, Kenneth Patton Kell

All ETDs from UAB

Despite the invaluable contributions that both randomized controlled trials and longitudinal studies have made to our understanding of the relationships between diet and cardiovascular disease (CVD), a comprehensive understanding of these relationships does not yet exist from birth to death. Furthermore, the longest running of these longitudinal studies have not included a representative portion of racial minority participants. Lastly, given the financial impacts of CVD, as well as how socioeconomic status (SES) can influence diet, the interplay between these three merits consideration. Therefore, the objective of this dissertation was to evaluate the associations between diet and cardiovascular disease (CVD): 1) …

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The Influence Of State Politics On State Rainy Day Funds, Nathaniel Franklin Kelley Jan 2015

The Influence Of State Politics On State Rainy Day Funds, Nathaniel Franklin Kelley

All ETDs from UAB

States often find themselves facing fiscal hardships due to such issues as their own revenue volatility or through federal recessions. The methods taken by the states have varied over the years, but rainy day funds are becoming one of the leading mechanisms for coping with economic disparity. As more state officials look to rainy day funds as a solution, the field for research regarding rainy day funds has expanded. The existing studies have focused on the best way to build and maintain these types of funds, but there has been little information put forth that helps understand how they work. …

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Automated Processing Of Continuous Glucose Monitor (Cgm) Data To Study Onset Of Diabetes, Aman Khatri Jan 2015

Automated Processing Of Continuous Glucose Monitor (Cgm) Data To Study Onset Of Diabetes, Aman Khatri

All ETDs from UAB

Diabetes is a long term condition that causes high levels of blood glucose, and it is necessary to get a complete picture of glucose levels which can lead to better treatment decision and better glucose control. The advent of Continuous Glucose Monitoring (CGM) is helping researches to track the blood glucose levels continuously and to understand the effects of impaired glucose levels on human body which in turn can lead to better treatment of diabetes. Current CGM systems process enormous amounts of data and have limitations in regards to data accuracy, precision, and reliability of raw glucose data. The inaccuracy …

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Regulation Of Cks1 Protein Turnover In Cancer Cells, Vinayak Khattar Jan 2015

Regulation Of Cks1 Protein Turnover In Cancer Cells, Vinayak Khattar

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Cks1 is a crucial cell cycle regulator which plays pleiotropic roles in cancer cell growth and is highly expressed at both the protein, and mRNA levels, in cancer cells. In contrast, normal cells exhibit barely detectable levels of this protein, even though they express substantial Cks1 mRNA. One reason for high Cks1 protein in cancers appears to be its stabilization in these cells. Cks1 is known to be ubiquitinated and degraded by the proteasome. Coordinated ubiquitination dependent proteasomal degradation of cell cycle proteins is a major mechanism that regulates their activity. Therefore aberrant accumulation of Cks1, frequently observed in cancer, …

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Evaluation Of Sample Size Re-Estimation Procedures For Non-Inferiority Designs With Time-To-Event Outcomes, Hwasoon Kim Jan 2015

Evaluation Of Sample Size Re-Estimation Procedures For Non-Inferiority Designs With Time-To-Event Outcomes, Hwasoon Kim

All ETDs from UAB

Study designs that allow sample size review may potentially save a study by identifying misspecified assumptions, modifying the planned sample size, and reinforcing the study’s power. Most sample size re-estimation (SSR) methods in non-inferiority trials have been developed for continuous or binary outcomes. In many medical domains studying cancer, heart failure, and other chronic diseases, most phase III trials use censored endpoints (e.g. survival or event-free survival). Non-inferiority designs have inherent complexity by the introduction of the non-inferiority margin and therefore understanding of strategies in these methods is essential. In our first paper, we detail the issues related to misspecification …

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Impairment Of The Gliovascular Unit In Neurological Disease, Ian Kimbrough Jan 2015

Impairment Of The Gliovascular Unit In Neurological Disease, Ian Kimbrough

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Cerebral blood flow is regulated by vasoactive molecules released by astroglial cell processes that ensheath the entire cerebrovasculature. This regulation of blood flow in response to neuronal activity is a process known as functional hyperemia. Astrocytes, along with their associated neurons and microvessels, are organized into a functional system called the gliovascular unit (GVU). The astroglial component of the GVU is integral in both regulation of blood flow and maintenance of the blood-brain barrier (BBB). In disease, this system can be disrupted. We found that glioma cells displace astrocytic processes, called endfeet, and prevent their communication with associated vessels, leading …

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The Impact Of Cultural Competency On Patient Experience Of Care, Emily Lane Koudelka Jan 2015

The Impact Of Cultural Competency On Patient Experience Of Care, Emily Lane Koudelka

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The impact of hospitals’ cultural competency on inpatient experience of care will be examined. Enhanced patient experience of care may alter an individual’s willingness to use health services, thereby increasing access and decreasing health disparities. As a result, to the extent that cultural competency influences patient experience of care, the integration of cultural competency into healthcare organizations has emerged as a critical issue for researchers, industry leaders, and policymakers. Findings from this study will inform policies, practices, and processes across the broad spectrum of healthcare industry stakeholders.

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An Nphp-4 Enhancer Mutagenesis Screen For Modifiers Of Cilia Phenotypes Reveals Novel Mks Alleles, Uncovers, A Specific Genetic Interaction Between Osm-3 And Nphp-4, And A Novel Ciliary Calcium Channel., Dawn Landis Jan 2015

An Nphp-4 Enhancer Mutagenesis Screen For Modifiers Of Cilia Phenotypes Reveals Novel Mks Alleles, Uncovers, A Specific Genetic Interaction Between Osm-3 And Nphp-4, And A Novel Ciliary Calcium Channel., Dawn Landis

All ETDs from UAB

Nephronophthisis (NPHP) is a ciliopathy with diverse clinical features likely caused by genetic modifiers. To identify NPHP modifiers, a screen was conducted on nphp-4(tm925) mutant C. elegans to reveal mutations that exacerbate the NPHP ciliary defects. Ten loci were generated, five of which have now been identified. Three are mutations in ciliopathy genes mks-1, mks-2, and mks-5. The fourth allele (yhw66) is a missense mutation (S316F) in OSM-3, a kinesin required for cilia distal segment assembly. As in osm-3 null mutants, nphp-4(tm925);osm-3(yhw66) mutants lack distal segments, are dye-filing defective (Dyf), and have osmotic avoidance defects (OSM). The osm-3(yhw66) mutant alone …

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14-3-3 Proteins Regulate Mutant Lrrk2 Kinase Activity And Neurite Shortening, Nicholas Lavalley Jan 2015

14-3-3 Proteins Regulate Mutant Lrrk2 Kinase Activity And Neurite Shortening, Nicholas Lavalley

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Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of inherited Parkinson’s disease (PD), and LRRK2 is a risk factor for idiopathic PD. How LRRK2 function is regulated is not well understood. Recently, the highly-conserved 14-3-3 proteins, which play a key role in many cellular functions including cell death, have been shown to interact with LRRK2. In this study, we investigated whether 14-3-3s can regulate mutant LRRK2-induced neurite shortening and kinase activity. In the presence of 14-3-3θ overexpression, neurite length of primary neurons from BAC transgenic G2019S-LRRK2 mice returned back to wildtype levels. Similarly, 14-3-3θ overexpression …

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Changes In The Frontal Soft Tissue Of The Lower Face By Age And Sex, Maggie Law Jan 2015

Changes In The Frontal Soft Tissue Of The Lower Face By Age And Sex, Maggie Law

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The purpose of this study is to determine age-related changes of the lower face by age and by gender. The secondary purpose of this study is to stress the importance of the clin-ical exam for orthodontic patients in the frontal view, the way most patients perceive themselves. Also, individualized treatment planning with age-appropriate incisor display is crucial for esthetic outcomes. Materials and Methods: Specific dimensions of the lower face were measured at patients initial clinical exam before starting orthodontic treatment. All patients were from Dr. David Sarver's private practice in Vestavia Hills, AL collected from 1/1/2002-11/4/2014. The following parameters were …

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Gene Replacement Therapy For Sickle Cell Disease, Chao Li Jan 2015

Gene Replacement Therapy For Sickle Cell Disease, Chao Li

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Sickle Cell Disease (SCD) is a devastating inherited disorder resulting from a single DNA base pair (bp) mutation in the sixth codon of the β-globin gene. It causes severe tissue damage that can result in strokes, splenic infarction, kidney failure, liver and lung disorders, painful crises, and other complications. Currently, the only cure for the disease is allogenic stem cell transplantation, which is only available to limited patients with histocompatible donors. In order to overcome this limitation, CRISPR/Cas enhanced gene correction in sickle patient iPS and CD34+ hematopoietic stem/progenitor cells as a therapy strategy was explored. Keratinocytes from skin biopsies …

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