Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2015

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 141391 - 141420 of 146280

Full-Text Articles in Entire DC Network

Benefit Finding Among Caregivers Of Childhood Cancer Survivors, Molly Gardner Jan 2015

Benefit Finding Among Caregivers Of Childhood Cancer Survivors, Molly Gardner

All ETDs from UAB

With improved survival rates for children diagnosed with cancer brings a focus on the psychological adjustment of both children and caregivers. Benefit finding, defined as positive change in the face of adversity, has been documented among caregivers of children with cancer and other chronic illness conditions. The first manuscript is a comprehensive literature review of studies investigating benefit finding among caregivers of children with chronic illness conditions, including caregiver demographic and psychosocial, and child demographic and medical predictors, as well as outcomes of benefit finding. The second manuscript reports on predictors of benefit finding in a sample of caregivers of …

Go to article

The Role Of The Teacher In Family Involvement: A Multiple Case Study, Terri Garrison Jan 2015

The Role Of The Teacher In Family Involvement: A Multiple Case Study, Terri Garrison

All ETDs from UAB

The purpose of this qualitative multiple case study was to explore the teacher's role in family involvement in preschool classrooms. Family involvement has been a relevant topic for early childhood educators for many years (Hoover-Dempsey & Sandler, 1995). When families are involved in their child's school experience, it has added a positive benefit to the child's development (Chavkin, 2005; Swick, 2004; Marcon, 1999). Regardless of this widely held belief, many families face barriers that prevent involvement from occurring (Gallimore & Goldenberg, 2001; Lamb-Parker, Piotrkowski, Baker, Kessler-Sklar, Clark, & Peay, 2001). This multiple case study was designed to answer the following …

Go to article

Safety Culture And Patient Harm, Alfonso Gatmaitan Jan 2015

Safety Culture And Patient Harm, Alfonso Gatmaitan

All ETDs from UAB

SAFETY CULTURE AND PATIENT HARM EVENTS: A CONTINGENCY THEORY PERSPECTIVE IN THE CONTEXT OF COMPLEX ADAPTIVE SYSTEMS ALFONSO GATMAITAN ADMINISTRATION-HEALTH SERVICES ABSTRACT This study examines the correlation between a Culture of Patient Safety as measured by hospital staff surveys and actual patient harm attributed to hospital performance. It is generally accepted by health care management leaders that the presence of a strong culture of patient safety has become a critical component in reducing patient harm. However, little empirical evidence within multiple hospitals over time exists to support this belief. Healthcare managers can utilize this evidence in formulating patient safety improvement …

Go to article

A Redescription Of The Cretaceous Marine Turtle Ctenochelys Acris Zangerl, 1953 And A Systematic Revision Of The 'Toxochelyid'-Grade Taxa Using Cladistic Analysis, Andrew Douglas Gentry Jan 2015

A Redescription Of The Cretaceous Marine Turtle Ctenochelys Acris Zangerl, 1953 And A Systematic Revision Of The 'Toxochelyid'-Grade Taxa Using Cladistic Analysis, Andrew Douglas Gentry

All ETDs from UAB

Within this thesis are two separate articles, each representing a distinct chapter. The first chapter is a redescription of the ‘toxochelyid’-grade marine turtle Ctenochelys acris Zangerl, 1953. This redescription, based on several nearly complete specimens from the early Campanian Mooreville Chalk of Alabama, reveals multiple previously undescribed autapomorphic characteristics of this species and contributes significantly to our understanding of ‘toxochelyid’ alpha taxonomy. The second chapter is comprised entirely of the results of multiple cladistic analyses of the ‘toxochelyid’-grade taxa that produce a hypothesized phylogenetic system of classification for this clade. 108 characters from the cranium, carapace, plastron, and appendicular skeleton …

Go to article

On Fire Or Burnt Out? The Social Psychological Health Of United Methodist Pastors, Philip Gibson Jan 2015

On Fire Or Burnt Out? The Social Psychological Health Of United Methodist Pastors, Philip Gibson

All ETDs from UAB

This study examines the social processes and structures that shape the social psychological health of United Methodist pastors. These individuals play a central role in a religious institution that is in a state of decline in the 21st century United States. In addition, burnout, a state of compromised social psychological health related to work involving relationships, is a salient issue among clergy. Using a qualitative approach based in grounded theory methodology, 31 semi-structured interviews were conducted with current and former United Methodist pastors, including those in a supervisory role within the Church hierarchy. Using grounded theory coding practices, data from …

Go to article

Kinomic Profiling And Drug Screening Of Three-Dimensional Glioblastoma Microtumors As A Potential Comparative Model To Orthotopic Xenolines, Ashley Nichole Gilbert Jan 2015

Kinomic Profiling And Drug Screening Of Three-Dimensional Glioblastoma Microtumors As A Potential Comparative Model To Orthotopic Xenolines, Ashley Nichole Gilbert

All ETDs from UAB

Glioblastoma multiforme (GBM), the most common form of primary malignant brain cancer in adults, is a devastating disease for which effective treatment has remained elusive for over 75 years. A likely reason for the minimal progress during this time is the lack of accurate preclinical models to represent the patient in vivo environment, causing a disconnect in drug therapy effectiveness between the laboratory and clinic. Our proposed solution to address this disconnect and the issues of traditional preclinical modeling is to use innovative HuBiogel-based MicroTumors as a three-dimensional (3D) drug screening model for GBM. Six subcutaneous patient-derived xenografts (PDXs) prepared …

Go to article

Role Of Macrophages In The Cardiomyopathy Associated With Obesity And Type 2 Diabetes, Mehak Goel Jan 2015

Role Of Macrophages In The Cardiomyopathy Associated With Obesity And Type 2 Diabetes, Mehak Goel

All ETDs from UAB

Obesity is a state of chronic low-grade systemic inflammation that, along with type 2 diabetes (T2D), increases the risk of developing cardiovascular disease (CVD). Despite the wealth of information on the link between macrophages and cytokines in adipose tissue and peripheral insulin resistance, their role in the pathogenesis of diabetic cardiomyopathy and cardiac diastolic dysfunction is unclear. We hypothesized that activated immune cell mediators, in particular monocytes and macrophages, are fundamental drivers of diet-induced obesity and diabetic cardiomyopathy. Herein, firstly, a diet-induced model of diabetic cardiomyopathy was developed in C57BL/6 mice by feeding a high fat diet (HFD, 45% kcal …

Go to article

Consequences Of Trps1 Deficiency On Dentinogenesis, Morgan Goss Jan 2015

Consequences Of Trps1 Deficiency On Dentinogenesis, Morgan Goss

All ETDs from UAB

Dentinogenesis is a complex process of dentin formation. It involves differentiation of odontoblasts, the cells that make dentin, and the formation of a unique extracellular matrix, known as dentin. Dentin is ultimately produced through the interaction of collagen fibers, non-collagenous proteins and hydroxyapatite (HA) crystals. Odontoblasts are cranial neural crest (CNC) ectomesenchymal derived cells. Trps1 is a novel transcription factor believed to play an important role in both tooth formation and the mineralization process. TRPS1 gene mutations are known to result in dental and skeletal abnormalities manifested in humans as tricho-rhino-phalangeal syndrome (TRPS) and Ambras syndrome. Trps1 expression varies throughout …

Go to article

Unmanned Ground Vehicle Terrain/Road Mobility Foundation And Its Algorithmic Formalization For Wheel Power Management To Improve Leader And Follower Capabilities, Jeremy P. Gray Jan 2015

Unmanned Ground Vehicle Terrain/Road Mobility Foundation And Its Algorithmic Formalization For Wheel Power Management To Improve Leader And Follower Capabilities, Jeremy P. Gray

All ETDs from UAB

The implementation of the autonomy-enabled technologies to improve soldier safety and battlefield distribution for the Ground Distribution fleet, by using semi-autonomous leader and follower capabilities, has begun. The need for tactical and operational mobility and agility is a key element in this process. Their success significantly depends on mobility of the convoy vehicles in terrain and road conditions. Although, existing methods have successfully improved vehicle mobility, those methods have exhausted their potential. There is a need for a new technological paradigm that would lead to a breakthrough in vehicle and convoy mobility research and engineering. Mobility strongly depends on the …

Go to article

County-Level Homicide In The United States: An Analysis From A Social Disorganization Perspective, Julien Grayer Jan 2015

County-Level Homicide In The United States: An Analysis From A Social Disorganization Perspective, Julien Grayer

All ETDs from UAB

The United States has the highest rates of homicide among industrialized nations. The analysis of variations in the homicide rate lends itself to interpretation through various theoretical frameworks, one of which is social disorganization. Social disorganization is commonly used as a means to discuss crime in the context of neighborhoods and communities. The argument of social disorganization is that criminal activity is curbed by collective efficacy. That collective efficacy is affected by structural variables such as poverty, residential stability, and heterogeneity. The question then became whether social disorganization could be utilized for county-level analysis. The results showed that social disorganization …

Go to article

The Effect Of Applied Stress On Knowledge Retention In A Multiwall Virtual Environment, David Wayne Brown Jan 2015

The Effect Of Applied Stress On Knowledge Retention In A Multiwall Virtual Environment, David Wayne Brown

All ETDs from UAB

While the science of medicine continues to grow as new discoveries in the treatment of disease are made, the education of existing procedures has not evolved with the growth of new technology. The training of doctors and nurses is still, primarily, one of classrooms and presentations. In addition, this training is predominately focused on treating the patient once they have reached the hospital, with limited thought given to out of hospital emergencies. Simulation labs are present at most schools, but these are limited in their ability to deliver identical scenarios across the entire student population due to variances in personnel …

Go to article

Lab-On-A-Brane: A Novel Physiologically Relevant Planar Arterial Model To Study Transendothelial Transport, Karim I. Budhwani Jan 2015

Lab-On-A-Brane: A Novel Physiologically Relevant Planar Arterial Model To Study Transendothelial Transport, Karim I. Budhwani

All ETDs from UAB

The tremendous quality of life impact notwithstanding, cardiovascular diseases and Cancer add up to over US$ 700bn each year in financial costs alone. Aging and population growth are expected to further expand the problem space while drug research and development remain expensive. However, preclinical costs can be substantially mitigated by substituting animal models with in vitro devices that accurately model human cardiovascular transport. Here we present a novel physiologically relevant lab-on-a-brane that simulates in vivo pressure, flow, strain, and shear waveforms associated with normal and pathological conditions in large and small blood vessels for studying molecular transport across the endothelial …

Go to article

Effects Of Transcranial Direct Current Stimulation (Tdcs) On Symptoms Of Binge Eating Disorder (Bed) And Sub-Threshold Bed, Emilee Elizabeth Burgess Jan 2015

Effects Of Transcranial Direct Current Stimulation (Tdcs) On Symptoms Of Binge Eating Disorder (Bed) And Sub-Threshold Bed, Emilee Elizabeth Burgess

All ETDs from UAB

The present study investigated the efficacy of a single administration of transcranial direct current stimulation (tDCS) to reduce binge eating symptoms, namely food consumption, food cravings, and binge urges, in individuals clinically diagnosed with BED and sub-threshold BED. The study used a within-subjects crossover design whereby each participant received both a real and a sham condition of tDCS in counterbalanced order. Results indicated that tDCS significantly reduced caloric intake of specifically preferred foods during an in-lab eating test, decreased food cravings induced by food photo images, and decreased binge desire on the same day as treatment, compared to sham stimulation. …

Go to article

Exploring The Relationship Between Study Abroad And Emotional Intelligence, Michael Joshua Carter Jan 2015

Exploring The Relationship Between Study Abroad And Emotional Intelligence, Michael Joshua Carter

All ETDs from UAB

EXPLORING THE RELATIONSHIP BETWEEN STUDY ABROAD AND EMOTIONAL INTELLIGENCE MICHAEL JOSHUA CARTER EDUCATIONAL LEADERSHIP ABSTRACT Given the increased interest in the academic and behavioral impact of university study abroad programs, the possible relationship between study abroad and emotional intelligence was evaluated. A paper-based survey packet consisting of a researcher-developed demographic questionnaire and the Bar-On EQ-i: 2.0 Emotional Intelligence Quotient Inventory (EQi) was administered to a convenience sample of 144 undergraduate students, ages 19-25, at the University of Alabama at Birmingham. The total sample consisted of two groups: (1) a sample group of undergraduate students who participated in the university study …

Go to article

The Adaptive Significance Of Phenotypic Plasticity In The Wild: An Experimental Test Using The Brown Anole Lizard (Anolis Sagrei), Corey Dale Cates Jan 2015

The Adaptive Significance Of Phenotypic Plasticity In The Wild: An Experimental Test Using The Brown Anole Lizard (Anolis Sagrei), Corey Dale Cates

All ETDs from UAB

The conditions that embryos experience during development have substantial effects on offspring phenotypes and fitness. Although plastic responses to developmental environments are widespread, whether they are adaptive is unknown in most cases. Developmental plasticity is often thought to be adaptive in heterogeneous environments, but it can also enhance fitness when environments experienced by embryos provide cues for the conditions they will eventually experience later in life. Under the latter scenario, early embryonic conditions could program an individual’s physiology to appropriately deal with predictable future conditions. This hypothesis has received support in the ecological and medical literature on diverse organisms. However, …

Go to article

Intra-Oral Scanning Devices Compared To Traditional Digital Impressions, Terpsithea Christou Jan 2015

Intra-Oral Scanning Devices Compared To Traditional Digital Impressions, Terpsithea Christou

All ETDs from UAB

The aim of this study is to review the state of art concerning 3D optical acquisition techniques and devices currently used in Orthodontics, and determine whether a commercial intra-oral scanner is as accurate as traditional impressions for orthodontic purposes. Materials and Methods: Records of 30 subjects were prospectively acquired and digital models were obtained using an intra-oral scanner, LythosTM by Ormco, and an extra-oral scanner, GOM ATOS Triple Scan II by GOM. Seven parameters indicating linear measurements from predetermined landmarks were measured and analyzed. Paired t tests, plots and bars and Bland and Altman Analysis were used to compare and …

Go to article

The Impact Of Student Loans On Homeownership, Matthew Eric Click Jan 2015

The Impact Of Student Loans On Homeownership, Matthew Eric Click

All ETDs from UAB

This thesis examines the relationship between student loan debt and homeownership. I hypothesize that a negative relationship exists, and control for a respondent’s age, household income, household size, race, gender, marital status, and level of education. Using a binary logistic regression model to examine data from the 2012 National Financial Capability Study (NFCS) and the 2014 Survey of Household Economic Decisions (SHED), I model the odds-ratios and predicted probabilities of homeownership for respondents with and without student loans. I find a decrease in the predicted probability of homeownership by 8.4% and 9.3% in the NFCS and SHED datasets, respectively. While …

Go to article

The Utilization Of Blue - Green Algae Lyngbya Recovered From Local Ponds As Natural Reinforcement Of Composite Materials, Ninfa Alejandra Constante Perez Jan 2015

The Utilization Of Blue - Green Algae Lyngbya Recovered From Local Ponds As Natural Reinforcement Of Composite Materials, Ninfa Alejandra Constante Perez

All ETDs from UAB

The abundance of blue - green algae (BGAs) has created a social and industrial problem. The overgrowth of algae blooms in water bodies across the U.S. reduces the quality of water for ecological and recreational purposes. The production of algae biofuels is forecasted to exponentially grow in the coming years, but waste residual algal biomass represents a challenge to biofuel producers. This work explores possible avenues for the utilization of BGAs as an effective reinforcement of natural fiber composites. Natural fiber composites (NFCs) are of great importance for the automotive industry in applications such as interior door panels, headliners, and …

Go to article

Upper Incisors Position Changes After Orthodontic Treatment In Class I, Ii And Iii Malocclusions, Konstantinos Bakos Jan 2015

Upper Incisors Position Changes After Orthodontic Treatment In Class I, Ii And Iii Malocclusions, Konstantinos Bakos

All ETDs from UAB

Objective: The purpose of this study was to evaluate the maxillary central incisor position changes after orthodontic treatment in Class I, II and III malocclusions. Material and Methods: This retrospective cohort study evaluated nighty non extraction orthodontic Class I, II and III cases which were collected randomly from the Orthodontic clinic at the University of Alabama at Birmingham and the Institutional Review Board of the University of Alabama at Birmingham approved the study. All the chosen cases were treated with fixed appliances and according to the standards of American Board of Orthodontics. All the lateral cephalo-metric radiographs were taken using …

Go to article

Interlayer Utilization (Including Metal Borides) For Subsequent Deposition Of Nsd Films Via Microwave Plasma Cvd On 316 And 440c Stainless Steels, Jared Ballinger Jan 2015

Interlayer Utilization (Including Metal Borides) For Subsequent Deposition Of Nsd Films Via Microwave Plasma Cvd On 316 And 440c Stainless Steels, Jared Ballinger

All ETDs from UAB

Diamond thin films have promising applications in numerous fields due to the extreme properties of diamonds in conjunction with the surface enhancement of thin films. Biomedical applications are numerous including temporary implants and various dental and surgical instruments. The unique combination of properties offered by nanostructured diamond films that make it such an attractive surface coating include extreme hardness, low obtainable surface roughness, excellent thermal conductivity, and chemical inertness. Regrettably, numerous problems exist when attempting to coat stainless steel with diamond generating a readily delaminated film: outward diffusion of iron to the surface, inward diffusion of carbon limiting necessary surface …

Go to article

On The Simplest Lamination Of A Given Identity Return Triangle, Brandon Lee Barry Jan 2015

On The Simplest Lamination Of A Given Identity Return Triangle, Brandon Lee Barry

All ETDs from UAB

Laminations are models for locally connected Julia sets of complex polynomials. This paper is concerned with laminations associated with degree 3 polynomials. We introduce and discuss simplest laminations and prove that subject to certain conditions a finite collection C of periodic polygons is associated with a simplest lamination L_C. This lamination is unique with respect to some collection of pullback schemes. We apply this result to the case where the collection C consists of the orbit of a periodic chord. We then introduce and characterize simple Fatou gaps by their boundary leaves and discuss the relationship between simple Fatou gaps …

Go to article

Mechanisms Of Npy-Induced Phase Shifts And Gsk3 Modulation Of Rhythmic Molecular Clock Gene Expression, Neurophysiological Function, And Memory., Rachel Besing Jan 2015

Mechanisms Of Npy-Induced Phase Shifts And Gsk3 Modulation Of Rhythmic Molecular Clock Gene Expression, Neurophysiological Function, And Memory., Rachel Besing

All ETDs from UAB

The current set of studies addresses three main hypotheses. We first tested the hypothesis that NPY-induced phase advances are accompanied by persistent suppression of core circadian clock gene PER2 and are mediated by long-term depression of neuronal excitability in a phase-specific manner. We found that NPY induced phase advances in PER2::LUC cultures, as well as decreased neuronal firing in SCN slices, are largest when NPY is given in the early part of the day and PER2::LUC phase advances were blocked by depolarization with potassium chloride, suggesting that NPY-induced phase advances are mediated by long-term depression of neuronal excitability. The second …

Go to article

Synthesis And Characterization Of A Collagen Based Biodegradable Polymer Initiated By Hydroxyapatite Nanoparticle For Bone Regeneration, Didarul B. Bhuiyan Jan 2015

Synthesis And Characterization Of A Collagen Based Biodegradable Polymer Initiated By Hydroxyapatite Nanoparticle For Bone Regeneration, Didarul B. Bhuiyan

All ETDs from UAB

Synthetic bone graft biomaterials are considered as a potential alternative to the conventional use of bone grafts, due to their limitless supply and lack of disease transmission. Current synthetic bone graft materials generally lack the necessary combination of biological and mechanical properties for use as a bone graft substitute. Bone is a dynamic tissue that serves biological, chemical and mechanical purpose in the body and it is unlikely that a single component synthetic biomaterial can provide the appropriate combination of mechanical integrity and biological stimulation to replace bone. Multicomponent biomaterials need chemical bonding between the components to prevent phase separation …

Go to article

Exploring First-Semester Medical Student Academic Self-Efficacy: A Mixed Methods Investigation, Deborah J. Blackstone Jan 2015

Exploring First-Semester Medical Student Academic Self-Efficacy: A Mixed Methods Investigation, Deborah J. Blackstone

All ETDs from UAB

Academic self-efficacy has been empirically demonstrated to be related to academic performance over a wide range of grade levels and academic settings, but little research exists examining this relationship in medical school. This study sought to fill this gap by investigating academic self-efficacy in first-semester medical students using a sequential mixed methods approach. In the first, quantitative strand, 81 first-semester medical students completed an academic self-efficacy survey during the first science-based course and again at the end of the semester. Academic self-efficacy for out of class academic tasks decreased over the semester; academic self-efficacy for in class academic tasks was …

Go to article

Women Manufacturing Methamphetamine: Gender In The Context Of Shake And Bake Cooking In Alabama, Jessica Rae Deitzer Jan 2015

Women Manufacturing Methamphetamine: Gender In The Context Of Shake And Bake Cooking In Alabama, Jessica Rae Deitzer

All ETDs from UAB

Researchers of women in the drug economy have been divided, with some portraying women involved in drug manufacturing, dealing, and trafficking as limited participants, and others acknowledging women’s use of agency and gender to successfully accomplish higher roles in drug economies. Additionally, some suggest that the context of the local community and drug market has a strong influence on the roles women occupy within the drug economy. In this study, I examine women’s roles within a particular style of meth cooking (shake and bake) to determine the various opportunities and constraints they face as women meth cooks. To do so, …

Go to article

The Effects Of Inter-Age Class Competition On Habitat Use In A Territorial Lizard, David Michael Delaney Jan 2015

The Effects Of Inter-Age Class Competition On Habitat Use In A Territorial Lizard, David Michael Delaney

All ETDs from UAB

All organisms have specific habitat requirements that allow them to properly function in the environment. However, optimal habitats often differ across age classes, and accordingly, juveniles shift habitat choice as they age. Field observations of the brown anole lizard (Anolis sagrei) suggest that juveniles perch in open-canopy areas on low vegetation whereas adults reside in forest edges on higher vegetation. I hypothesized that this age-specific habitat variation is because adults force juveniles to less preferred habitat. To address these issues, I conducted a series of experiments to examine the role of inter-age class competition in driving variation in perch use …

Go to article

Hiv-1 Adaptation To T-Cell Responses During Infection, Victor Yimin Du Jan 2015

Hiv-1 Adaptation To T-Cell Responses During Infection, Victor Yimin Du

All ETDs from UAB

recommended vitamin D intake, and perceived barriers to adequate calcium intake

Go to article

The Adhd Medication Process Model: A Qualitative Investigation Of Teaching Pedagogies, Ideal Student Behavior, Labeling Processes, And Attitudes Towards Adhd Medication., Zachary Robert Simoni Jan 2015

The Adhd Medication Process Model: A Qualitative Investigation Of Teaching Pedagogies, Ideal Student Behavior, Labeling Processes, And Attitudes Towards Adhd Medication., Zachary Robert Simoni

All ETDs from UAB

The number of children diagnosed with and medicated for ADHD has increased within the last decades. In this study, I assert that ADHD is a serious mental health issue with a biological etiology which in many cases is alleviated by the use of medication. However, I also argue that powerful socio-cultural forces are important to understanding ADHD and medication use in the American Educational system. Physicians and psychiatrists are responsible for assigning medication as a treatment for ADHD. Nevertheless, teachers are at the front lines of the ADHD issue and handle it on a daily basis. Despite this fact, very …

Go to article

The Influence Of Personal, Interpersonal, And Community Factors On The Parenting Self-Efficacy Of First-Time Mothers, Tamika L. Smith Jan 2015

The Influence Of Personal, Interpersonal, And Community Factors On The Parenting Self-Efficacy Of First-Time Mothers, Tamika L. Smith

All ETDs from UAB

The Social Ecological Model (SEM) allows for examining human behavior and the factors that influence behavior change in totality. In addition, the model offers guidance in identifying the factors that may lead to a change in or explanation of behavior. This study utilizes SEM to identify factors at the personal, interpersonal, and community level in order to determine the relationship between specific ecological factors and parenting self-efficacy. Furthermore, the study examines the predictive quality of the ecological factors on parenting self-efficacy. Data collected from the Parenting for the First-time Project (PFT) was used. PFT is a multi-site longitudinal study of …

Go to article

Exploiting The Glioblastoma Tumor Microenvironment For Enhanced Oncolytic Herpes Simplex Virus Therapy, Tyrel Talbert Smith Jan 2015

Exploiting The Glioblastoma Tumor Microenvironment For Enhanced Oncolytic Herpes Simplex Virus Therapy, Tyrel Talbert Smith

All ETDs from UAB

Gliomas are the most common and fatal malignancy of the adult central nervous system. The need for new therapeutic options is clear, as standard of care therapies only extend median survival 12-14 months beyond diagnosis. Conditionally replication-competent oncolytic herpes simplex type-1 viruses (oHSV) have emerged as promising therapeutics for treating malignant gliomas. However, two factors that contribute to the dismal prognosis of malignant gliomas, immunosuppression and invasive growth, are also thought to limit virotherapeutic efficacy. We examined these factors in tumor microenvironments to explore novel strategies to treat malignant gliomas with oHSV for improved therapeutic response. In a Phase 1b …

Go to article

First Prev Next Last