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Uncertainty Estimates And Prediction Interval Development For Internal Strain Gage Balance Calibration Systems, Kenneth G. Toro

Mechanical & Aerospace Engineering Theses & Dissertations

Currently, there is a lack of the use of mathematically rigorous methods to evaluate the performance of multivariate force measurement systems. The specific problem addressed in the research stems from the practical issues faced by test engineers when wind tunnel models with internal strain gage balances are readied for test. Check loads are applied and the question that needs to be answered is whether or not the balance is reading within acceptable limits. These systems tend to be difficult to characterize uncertainty, primarily due to their multivariate nature, but also due to the desire for an estimate on the explanatory …

De Novo Protein Structure Modeling And Energy Function Design, Lin Chen

Computer Science Theses & Dissertations

The two major challenges in protein structure prediction problems are (1) the lack of an accurate energy function and (2) the lack of an efficient search algorithm. A protein energy function accurately describing the interaction between residues is able to supervise the optimization of a protein conformation, as well as select native or native-like structures from numerous possible conformations. An efficient search algorithm must be able to reduce a conformational space to a reasonable size without missing the native conformation. My PhD research studies focused on these two directions.

A protein energy function—the distance and orientation dependent energy function of …