Digital Commons Network^™

Unh Recognized For University Research Farms In National Ranking, Lori Tyler Gula

UNH Today Archive

No abstract provided.

Prostate Cancer And Li-Fraumeni Syndrome: Implications For Screening And Therapy., Colleen K Spees, Kelly J Kelleher, Ronney Abaza, Steven K Clinton

Oncology Articles

Li-Fraumeni Syndrome (LFS) is an autosomal dominant genetic disorder associated with mutations in the TP53 gene and characterized by a propensity to develop a variety of malignancies resulting in a shortened lifespan. We report a case of prostate cancer in a 50 year old male with LFS. Experimental studies suggest that TP53 mutations in prostate cancer are associated with therapeutic resistance to radiation, chemotherapy, and anti-androgens, implying that LFS men may experience more aggressive cancer biology with implications for therapeutic decisions. The potential of prostate cancer to develop earlier in LFS favors institution of screening at earlier ages.

February 5 And 6, 2015- Board Of Trustees Meeting Minutes, Regular And Special Meetings, Central Washington University Central Washington University

Board of Trustees Meeting Minutes

Meeting minutes for the Regular Meeting of the Board of Trustees at Central Washington University, February 5 and 6, 2015

Sonia Schorr Sloan, Sonia Sloan, Kelsey Duinkerken

First Women at Jefferson Oral Histories

Ms. Sonia Schorr Sloan received her Bachelor of Science degree from Syracuse University in 1949. Upon graduation she went to Jefferson Medical College to pursue a Master of Science degree in Microbiology, where she became the first woman to receive any degree from the University. From Jefferson Ms. Sloan went to teach in the Department of Microbiology at Temple Medical School for two years before being hired as the first woman to work in the Central Research Department at DuPont. From the 1950s onward Ms. Sloan has been involved with a variety of community and political organizations, many of them …

Prenatal And Neighborhood Correlates Of Oppositional Defiant Disorder (Odd), Andrea A. Russell, Claire L. Johnson, Arwa Hammad, Kelly I. Ristau, Sandra Zawadzki, Luz Del Alba Villar, Kendell Coker

Psychology Faculty Publications

This study investigates the link between prenatal exposure to alcohol and drugs, parental perceptions of neighborhood safety and support, and the diagnosis of oppositional defiant disorder (ODD) among a nationally representative sample of youth. A subset of variables from a larger study, the 2001–2004 National Comorbidity Survey-Adolescent Supplement (NCS-A), as well as its supplemental parental surveys, was analyzed in this study. This study used a specific selection of 5,924 adolescents and their parents from the NCS-A. Results suggest a correlation between prenatal caffeine use and a subsequent ODD diagnosis in female adolescents. Overall correlations between neighborhood drug use/sales and minority …

Political Science & Economics Alum Named To Dynavax Board, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

New Distributional Records For Pleasing Lacewings (Neuroptera: Dilaridae, Nallachius Spp.) In The Americas, David E. Bowles, Atilano Contreras-Ramos, Mariza A. Sarmiento-Cordero, Michael L. Ferro

Insecta Mundi

We report on collections of seven species of pleasing lacewings (Neuroptera: Dilaridae) from the Americas. New country distributional records are reported for Nallachius pulchellus (Banks) from Honduras and Trinidad, and Nallachius phantomellus Adams from Ecuador. Nallachius ovalis Adams and Nallachius prestoni (McLachlan) are reported from Brazil representing the second reported collections of those species. Additional state records and in-country distributional information are presented for the other species. Two species could not be identifi ed with certainty.

Big Data - A 21st Century Science Maginot Line? No-Boundary Thinking: Shifting From The Big Data Paradigm, Xiuzhen Huang, Steven F. Jennings, Barry Bruce, Alison Buchan, Liming Cai, Pengyin Chen, Carole L. Cramer, Weihua Guan, Uwe K.K. Hilgert, Hongmei Jiang, Zenglu Li, Gail Mcclure, Donald F. Mcmullen, Bindu Nanduri, Andy Perkins, Bhanu Rekepalli, Saeed Salem, Jennifer Specker, Karl Walker, Donald Wunsch, Donghai Xiong, Shuzhong Zhang, Yu Zhang, Zhongming Zhao, Jason H. Moore

Graduate School of Oceanography Faculty Publications

Whether your interests lie in scientific arenas, the corporate world, or in government, you have certainly heard the praises of big data: Big data will give you new insights, allow you to become more efficient, and/or will solve your problems. While big data has had some outstanding successes, many are now beginning to see that it is not the Silver Bullet that it has been touted to be. Here our main concern is the overall impact of big data; the current manifestation of big data is constructing a Maginot Line in science in the 21st century. Big data is not …

Convergence Of Soil Nitrogen Isotopes Across Global Climate Gradients, Joseph M. Craine, Andrew J. Elmore, Lixin Wang, Laurent Augusto, W. Troy Baisden, E. N. J. Brookshire, Michael D. Cramer, Niles J. Hasselquist, Erik A. Hobbie, Ansgar Kahmen, Keisuke Koba, J. Marty Kranabetter, Michelle C. Mack, Erika Marin-Spiotta, Jordan R. Mayor, Kendra K. Mclauchlan, Anders Michelsen, Gabriela B. Nardoto, Rafael S. Oliveira, Steven S. Perakis, Pablo L. Peri, Carlos A. Quesada, Andreas Richter, Louis A. Schipper

Faculty Publications

Quantifying global patterns of terrestrial nitrogen (N) cycling is central to predicting future patterns of primary productivity, carbon sequestration, nutrient fluxes to aquatic systems, and climate forcing. With limited direct measures of soil N cycling at the global scale, syntheses of the 15N:14N ratio of soil organic matter across climate gradients provide key insights into understanding global patterns of N cycling. In synthesizing data from over 6000 soil samples, we show strong global relationships among soil N isotopes, mean annual temperature (MAT), mean annual precipitation (MAP), and the concentrations of organic carbon and clay in soil. In both hot ecosystems …

A Versatile Microparticle-Based Immunoaggregation Assay For Macromolecular Biomarker Detection And Quantification, Haiyan Wu, Yu Han, Xi Yang, George G. Chase, Qiong Tang, Chen-Jung Lee, Bin Cao, Jiang Zhe, Gang Cheng

Chemical, Biomolecular, and Corrosion Engineering Faculty Research

The rapid, sensitive and low-cost detection of macromolecular biomarkers is critical in clinical diagnostics, environmental monitoring, research, etc. Conventional assay methods usually require bulky, expensive and designated instruments and relative long assay time. For hospitals and laboratories that lack immediate access to analytical instruments, fast and low-cost assay methods for the detection of macromolecular biomarkers are urgently needed. In this work, we developed a versatile microparticle (MP)-based immunoaggregation method for the detection and quantification of macromolecular biomarkers. Antibodies (Abs) were firstly conjugated to MP through streptavidin-biotin interaction; the addition of macromolecular biomarkers caused the aggregation of Ab-MPs, which were subsequently …

A Versatile Microparticle-Based Immunoaggregation Assay For Macromolecular Biomarker Detection And Quantification, Haiyan Wu, Yu Han, George G. Chase, Qiong Tang, Chen-Jung Lee, Bin Cao, Jiang Zhe, Gang Cheng

Mechanical Engineering Faculty Research

The rapid, sensitive and low-cost detection of macromolecular biomarkers is critical in clinical diagnostics, environmental monitoring, research, etc. Conventional assay methods usually require bulky, expensive and designated instruments and relative long assay time. For hospitals and laboratories that lack immediate access to analytical instruments, fast and low-cost assay methods for the detection of macromolecular biomarkers are urgently needed. In this work, we developed a versatile microparticle (MP)-based immunoaggregation method for the detection and quantification of macromolecular biomarkers. Antibodies (Abs) were firstly conjugated to MP through streptavidin-biotin interaction; the addition of macromolecular biomarkers caused the aggregation of Ab-MPs, which were subsequently …

Predicting Protein Interface Residues Using Easily Accessible On-Line Resources, Surabhi Maheshwari, Michal Brylinski

Faculty Publications

© The Author 2015. Published by Oxford University Press. It has beenmore than a decade since the completion of the Human Genome Project that provided us with a complete list of human proteins. The next obvious task is to figure out how various parts interact with each other. On that account, we re- view 10methods for protein interface prediction, which are freely available as web servers. In addition, we comparatively evaluate their performance on a common data set comprising different quality target structures. We find that using experi- mental structures and high-quality homology models, structure-basedmethods outperformthose using only protein se- …

Nurturing Young Learners In Practice: A Case Study Of Key Teacher Dispositions That Support Child Centered Practice In An Urban Preschool Environment, Lorraine Ricchezza

Theses and Dissertations

This dissertation examines an educator's disposition to positively impact children's cognitive and social emotional development in the preschool setting as evidenced in child centered practices that arouse curiosity, foster social interaction, and promote children's learning as expressed in interpersonal interactions that affirm differences among young children in an urban preschool setting. Through examination and interpretation, this study delineates educator perspectives on child differences and reciprocal relationships as integral to developmentally appropriate practice. Seven female educators at the ABC Elementary School in Urban City, New Jersey participated in this study. This study involved key data sources. During 8 months of data …

Parkinson’S Disease-Related Circulating Microrna Biomarkers - A Validation Study, David Petillo, Stephen Orey, Aik Choon Tan, Lars Forsgren, Sok Kean Khoo

Peer Reviewed Articles

Parkinson’s disease (PD) is the second most common neurodegenerative disease. One of the major challenges in studying this progressive neurological disorder is to identify and develop biomarkers for early detection. Recently, several blood-based microRNA (miRNA) biomarkers for PD have been reported. However, follow-up studies with new, independent cohorts have been rare. Previously, we identified a panel of four circulating miRNA biomarkers for PD (miR-1826, miR-450b-3p, miR-505, and miR-626) with biomarker performance of 91% sensitivity and 100% specificity. However, the expression of miR-450b-3p could not be detected in a new, independent validation set. In our current study, we improved the detection …

Biofluid-Based Microrna Biomarkers For Parkinson’S Disease: An Overview And Update, Sapana Shinde, Sayantoni Mukhopadhyay, Ghada Mohsen, Sok Kean Khoo

Peer Reviewed Articles

Parkinson’s disease (PD) is a highly debilitating motor disorder and is the second most common neurodegenerative disease after Alzheimer’s disease. Its current method of diagnosis mainly relies on subjective clinical rating scales in the presence of clinical motor features. Early detection of PD is a known challenge as neuronal cell death may range from 50% to 80% when a patient is first diagnosed with PD. Therefore, there is an urgent need to identify and develop biomarkers for early detection of this progressive disease. This mini review focuses on the recent developments of biofluid-based microRNAs (miRNAs) as molecular biomarkers for PD. …

The Stoichiometry Of Metal Assisted Etching (Mae) Of Si In V2o5 + Hf And Hooh + Hf Solutions, Kurt W. Kolasinski, William B. Barclay, Yu Sun, Mark Aindow

Chemistry Faculty Publications

No abstract provided.

Évaluation De L’Exposition Des Travailleurs Aux Sous-Produits De Désinfection En Piscine Intérieure Au Québec, Robert Tardif, Cyril Catto, Sami Haddad, Manuel Rodriguez

Rapports de recherche scientifique

Les sous-produits de désinfection (SPD) par chloration sont le résultat inévitable des réactions chimiques survenant entre le chlore ajouté à l’eau des piscines et les matières organiques et/ou azotées qui y sont naturellement présentes ou introduites par le biais des baigneurs.

Les SPD se déclinent en de nombreuses catégories et en bien plus de composés encore (>600), ce qui suscite, à l’échelle internationale, les préoccupations des législateurs et des scientifiques au regard de l’impact sanitaire de ces substances sur les travailleurs. Les problèmes d’irritation associés à l’exposition aux chloramines (CAM) qui polluent l’air ambiant sont les plus souvent pointés …

First Record Of The Invasive Asian Fish Tapeworm Bothriocephalus Acheilognathi In Honduras, Central America, Guillermo Salgado-Maldonado, Wilfredo A. Matamoros, Brian R. Kreiser, Juan Manuel Caspeta-Mandujano, Edgar F. Mendoza-Franco

Faculty Publications

This paper provides the first report of the invasive Asian fish tapeworm, Bothriocephalus acheilognathi Yamaguti, 1934, in Honduras. The cestode was found in Profundulus portillorum (Cyprinodontiformes: Profundulidae), which represents a new host record, and which is a member of a genus faced with a variety of conservation challenges, now potentially complicated by the presence of this pathogenic cestode. Nearly complete sequence data from the ITS-1 5.8S and ITS-2 regions corroborate the determination based on morphological characteristics. Several species of carp were introduced to Honduras for aquaculture purposes in the early 1980s and the presence of the Asian fish tapeworm in …

Unh Manchester To Launch The Region’S Only On-Campus, Undergrad Analytics Degree Program, Beth Brosnan

UNH Today Archive

No abstract provided.

Biological Control Via "Ecological" Damping: An Approach That Attenuates Non-Target Effects, Rana D. Parshad, Kelly Black, Emmanuel Quansah, Matthew Beauregard

Faculty Publications

In this work we develop and analyze a mathematical model of biological control to prevent or attenuate the explosive increase of an invasive species population in a three-species food chain. We allow for finite time blowup in the model as a mathematical construct to mimic the explosive increase in population, enabling the species to reach “disastrous” levels, in a finite time. We next propose various controls to drive down the invasive population growth and, in certain cases, eliminate blow-up. The controls avoid chemical treatments and/or natural enemy introduction, thus eliminating various non-target effects associated with such classical methods. We refer …

Clemson Trustees Minutes, 2015 February 6, Clemson University Board Of Trustees

Minutes

No abstract provided.

Design And Synthesis Of Bioactive Peptidomimetics, Yaogang Hu

USF Tampa Graduate Theses and Dissertations

Protein-Protein Interactions (PPIs) play a very important role in biological functions and therefore the inhibition of specific Protein-Protein Interactions has a huge therapeutic value. The most successful small molecular PPIs inhibitors do not fit with the prevalent `Rule of Five' drug profile. To overcome the disadvantages of small molecular PPIs inhibitors, peptide based PPIs inhibitors were developed. Herein we describe the development of a new class of peptidomimetics AA-peptides. The AApeptides were designed based on chiral PNA backbone. Substitution of nucleobases yields AApeptides that are resistant to proteolysis and capable of mimicking peptides. Two types of AApeptides were discussed in …

A High-Density Linksage Map For Astyanax Mexicanus Using Genotyping-By-Sequencing Technology, Brian M. Carlson, Samuel W. Onusko, Joshua B. Gross

KIP Articles

The Mexican tetra, Astyanax mexicanus, is a unique model system consisting of cave-adapted and surface-dwelling morphotypes that diverged >1 million years (My) ago. This remarkable natural experiment has enabled powerful genetic analyses of cave adaptation. Here, we describe the application of next-generation sequencing technology to the creation of a high-density linksage map. Our map comprises more than 2200 markers populating 25 linksage groups constructed from genotypic data generated from a single genotyping-by-sequencing project. We leveraged emergent genomic and transcriptomic resources to anchor hundreds of anonymous Astyanax markers to the genome of the zebrafish (Danio rerio), the most closely related model …

Upregulation Of Mir21 And Repression Of Grhl3 By Leptin Mediates Sinusoidal Endothelial Injury In Experimental Nonalcoholic Steatohepatitis, Sahar Pourhoseini, Ratanesh K. Seth, Suvarthi Das, Diptadip Dattaroy, Maria B. Kadiiska, Guanhua Xie, Gregory A. Michelotti, Mitzi Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee

Faculty Publications

Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinusoidal injury by decreasing functionally active nitric oxide synthase 3 (NOS)3 via miR21. Using rodent models of NASH, and transgenic mice lacking leptin and leptin receptor, results showed that hyperleptinemia caused a 4-5 fold upregulation of hepatic miR21 as assessed by qRTPCR. The upregulation of miR21 led to a time-dependent repression of its target protein Grhl3 levels as shown by western blot analyses. NOS3-p/NOS3 ratio which is controlled …

The Pervasive Role Of Biological Cohesion In Bedform Development., Jonathan Malarkey, Jaco H. Baas, Julie A. Hope, Rebecca J. Aspden, Daniel R. Parsons, Jeff Peakall, David M. Paterson, Robert J. Schindler, Leiping Ye, Ian D. Lichtman, Sarah J. Bass, Alan G. Davies, Andrew J. Manning, Peter D. Thorne

School of Geography, Earth and Environmental Sciences

Sediment fluxes in aquatic environments are crucially dependent on bedform dynamics. However, sediment-flux predictions rely almost completely on clean-sand studies, despite most environments being composed of mixtures of non-cohesive sands, physically cohesive muds and biologically cohesive extracellular polymeric substances (EPS) generated by microorganisms. EPS associated with surficial biofilms are known to stabilize sediment and increase erosion thresholds. Here we present experimental data showing that the pervasive distribution of low levels of EPS throughout the sediment, rather than the high surficial levels of EPS in biofilms, is the key control on bedform dynamics. The development time for bedforms increases by up …

A New Genus And Four New Species Of False Click Beetles (Coleoptera: Eucnemidae) From Southeast Asia, Robert L. Otto

Insecta Mundi

A new genus and four new species of false click beetle (Coleoptera: Eucnemidae) are described. Bermilloides new genus is described from Bornean Malaysia. New species are: Calyptocerus iridis new species (Philippines), Bermilloides lumawigi new species (Malaysia), Spinifornax elongatus new species (Malaysia) and Ceratus antennatus new species (Thailand). Dorsal and ventral habitus, as possible, for each species are illustrated. Male aedeagi are illustrated for Calyptocerus iridis and Ceratus antennatus. A new key is provided for Calyptocerus species in Southeast Asia.

Collection And Transportation Of Municipal Solid Waste In Prishtina Municipality, Linda Shuku

Theses

After many years of efforts Prishtina municipality for improving the waste collection, there are still many problems associated with it. Uncontrolled dumping has resulted in spread of diseases, flooding, and unpleasant smells. The lack of financial resources for improving the waste collection services is part of the problem. Considering this situation, the goal of this project was to identify and analyze the waste collection and transportation process. The city planning and service fees were identified as important aspects for ensuring a well maintained and clean environment.

The research showed that with only 63% of overall collection of the fees, the …

Student Criminality: The Influence Of Strain, Family And Peers, Annie Cvetan

Theses and Dissertations

General strain theory suggests that a number of conditioning factors affect who is more likely to respond to strain with crime. Research has also demonstrated that an individual's self-complexity plays a role in how an individual responds to strain. Self-complexity refers to (1) the number of identities individuals perceive as important to themselves; and (2) the varied characteristics they ascribe to these identities. This research study analyzed if college students were committing crime, whether the crimes were major or minor in nature, and if criminality was a new behavior or an imported one. This study also looked at who, if …

Pollock Recognized By Aps For Excellence In Research, Mentoring, Kendra Carter

Browse All News

No abstract provided.

The Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University for February 5-11, 2015. Vol. 99, No. 4.