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Material Biocompatibility And Applications In Metabolic Monitoring, Michail Kastellorizios

Doctoral Dissertations

The present dissertation focuses and expands on the optimization and application of poly(lactic-co-glycolic acid) (PLGA)/polyvinyl alcohol (PVA) composite coatings and initiates metabolic studies in small animals to identify novel biomarkers to be utilized in exhaustion prediction. The composites are used to coat implantable biosensors and improve their biocompatibility. The objectives of the work are: i) investigate species differences related to the foreign body reaction (FBR) between small and large animals; ii) develop composite coatings to prevent the FBR in large animals; iii) develop composites loaded with combinations of dexamethasone, vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) …

Ring-Opening Polymerization Of Ε-Caprolactone Initiated By Ganciclovir (Gcv) For The Preparation Of Gcv-Tagged Polymeric Micelles, Alicia J. Sawdon, Ching-An Peng

Michigan Tech Publications, Part 1

Ganciclovir (GCV) is a nucleoside analogue with antiviral activity against herpes viral infections, and the most widely used antiviral to treat cytomegalovirus infections. However, the low bioavailability and short half-life of GCV necessitate the development of a carrier for sustained delivery. In this study, guanosine-based GCV was used as the initiator directly in ring-opening polymerization of ε-caprolactone (ε-CL) to form hydrophobic GCV-poly(caprolactone) (GCV-PCL) which was then grafted with hydrophilic chitosan to form amphiphilic copolymers for the preparation of stable micellar nanoparticles. Successful synthesis of GCV-PCL and GCV-PCL-chitosan were verified by ¹H-NMR analysis. Self-assembled micellar nanoparticles were characterized by dynamic …

Incentivizing The Ordinary User, Gaia Bernstein

Florida Law Review

Disputes regarding the effectiveness of the patent system focus on the appropriate scope of patent rights. This Article departs from the traditional debate and looks instead at the players regulated by the patent system. This Article shows that the patent system fails to effectively encourage technological dissemination because it focuses on the patent owner and his competitors but largely ignores a crucial player: the ordinary user.

The user, in his everyday decisions of whether to adopt a technology, plays a critical role in determining whether a new technology will be disseminated. Yet patent law contains an overly simplistic view of …

Urban Ecology & Conservation Symposium 2015: 13th Annual (Abstracts), Urban Ecosystem Research Consortium Of Portland/Vancouver

Urban Ecosystem Research Consortium of Portland/Vancouver

The UERC is a consortium of people from various universities and colleges, state and federal agencies, local governments, non-profit organizations and independent professionals interested in supporting urban ecosystem research and creating an information-sharing network of people that collect and use ecological data in the Portland/Vancouver area.

UERC Mission Statement:

To advance the state of the science of urban ecosystems and improve our understanding of them, with a focus on the Portland/Vancouver metropolitan region, by fostering communication and collaboration among researchers, managers and citizens at academic institutions, public agencies, local governments, non-profit organizations, and other interested groups.

The principal organizers span …

Rapid Effects Of A Protective O-Polysaccharide-Specific Monoclonal Iga On Vibrio Cholerae Agglutination, Motility, And Surface Morphology, Magdia De Jesus

Biomedical Sciences Faculty Scholarship

2D6 is a dimeric monoclonal immunoglobulin A (IgA) specific for the nonreducing terminal residue of Ogawa O-polysaccharide (OPS) of Vibrio cholerae. It was previously demonstrated that 2D6 IgA is sufficient to passively protect suckling mice from oral challenge with virulent V. cholerae O395. In this study, we sought to define the mechanism by which 2D6 IgA antibody protects the intestinal epithelium from V. cholerae infection. In a mouse ligated-ileal-loop assay, 2D6 IgA promoted V. cholerae agglutination in the intestinal lumen and limited the ability of the bacteria to associate with the epithelium, particularly within the crypt regions. In vitro fluorescence …

Grand Valley Forum, Volume 039, Number 20, February 09, 2015, Grand Valley State University

2014-2015, Volume 39

Grand Valley Forum is Grand Valley State's faculty and staff newsletter, published from 1976 to the present.

Current, February 09, 2015, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

A&S Departments Share Advising Goals For 2014-15, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Statesman, V. 58, I. 18, Stony Brook University

Stony Brook Statesman-Sucolian

v. 58, i. 18

The Daily Gamecock, Monday, February 9, 2015, University Of South Carolina, Office Of Student Media

February

No abstract provided.

Stand Dynamics, Humus Type And Water Balance Explain Aspen Long Term Productivity Across Canada, Kenneth A. Anyomi, Francois Lorenzetti, Yves Bergeron, Alain Leduc

Aspen Bibliography

This study examined the relative importance of soil, stand development and climate hypotheses in driving productivity for a species that is widely distributed in North America. Inventory plots, 3548 of such, either dominated by aspen or made up of species mixture of which aspen occurs in dominant canopy position were sampled along a longitudinal gradient from Quebec to British Columbia. Site index (SI), was used as a measure of productivity, and soil, climate and stand attributes were correlated with site index in order to determine their effects on productivity. Results show a decline in productivity with high moisture deficit. Soil …

Seminar: Role Of Slit Tumor Suppressor Gene In Neural Crest Delamination, Feb 9, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Daily Eastern News: Feburary 09, 2015, Eastern Illinois University

February

No abstract provided.

The Collegian (2015-02-09), Jesus Sanchez

UTB/TSC Archives - The Collegian [Newspaper]

Vol. 67, No. 19

Panther- February 2015 - Vol. Xcv, No.3, Prairie View A&M University

PV Panther Newspapers

No abstract provided.

A Novel Chemosynthetic Peptide With Β-Sheet Motif Efficiently Kills Klebsiella Pnuemoniae In A Mouse Model, Shirui Tan, Changpei Gan, Rongpeng Li, Yan Ye, Shuang Zhang, Xu Wu, Yi Yan Yang, Weimin Fan, Min Wu

Chemistry Faculty Publications

Klebsiella pneumoniae (Kp) is one of the most common pathogens in nosocomial infections and is increasingly becoming multiple drug resistant. However, the molecular pathogenesis of Kp in causing tissue injury and dysregulated host defense remains elusive, further dampening the development of novel therapeutic measures. We have previously screened a series of synthetic antimicrobial beta-sheet forming peptides and identified a peptide (IRIKIRIK; ie, IK8L) with a broad range of bactericidal activity and low cytotoxicity in vitro. Here, employing an animal model, we investigated the antibacterial effects of IK8L in acute infection and demonstrated that peritoneal injection of IK8L to mice down-regulated …

Lanthorn, Vol. 49, No. 42, February 9, 2015, Grand Valley State University

Volume 49, July 7, 2014 - June 1, 2015

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

The Bifunctional Alcohol And Aldehyde Dehydrogenase Gene, Adhe, Is Necessary For Ethanol Production In Clostridium Thermocellum And Thermoanaerobacterium Saccharolyticum, Jonathan Lo, Tianyong Zheng, Shuen Hon, Daniel G. Olson, Lee Lynd

Dartmouth Scholarship

Thermoanaerobacterium saccharolyticum and Clostridium thermocellum are anaerobic thermophilic bacteria being investigated for their ability to produce biofuels from plant biomass. The bifunctional alcohol and aldehyde dehydrogenase gene, adhE, is present in these bacteria and has been known to be important for ethanol formation in other anaerobic alcohol producers. This study explores the inactivation of the adhE gene in C. thermocellum and T. saccharolyticum. Deletion of adhE reduced ethanol production by >95% in both T. saccharolyticum and C. thermocellum, confirming that adhE is necessary for ethanol formation in both organisms. In both adhE deletion strains, fermentation products shifted from ethanol …

Uab Pathologist Gene Siegal Wins Distinguished Educator Award, Jeff Hansen

Browse All News

No abstract provided.

‘Toads Prefer To Bound, Not Hop’, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Biology Alum Joins Medical Group In Nevada, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Regulatory Function Of Sphingosine-1-Phosphate Signaling Axis On Regulatory T Cells In Colorectal Cancer, Andrew V. Nguyen, Yuan-Yuan Wu, Elaine Y. Lin

Publications and Research

In tumors associated with inflammation such as inflammatory bowel disease (IBD) and colorectal cancer (CRC), high numbers of regulatory T cells (Tregs) are associated with both favorable and poor prognoses. The functions of Tregs in CRC remain elusive and have yet to be clearly defined. With new evidence supporting many subsets of Tregs, the research on the development and functions of these cells has begun to come to fruition. The sphingosine 1 phosphate (S1P) pathway was recently reported to regulate the development and function of regulatory T cells. This pathway may shine new light into the pleiotropic nature of these …

Identifying And Analyzing Rna Pseudoknots Based On Graph-Theoretical Properties Of Dual Graphs: A Partitioning Approach, Louis Petingi

Publications and Research

In this paper we propose the study of properties of RNA secondary structures modeled as dual graphs, by partitioning these graphs into topological components denominated blocks. We give a full characterization of possible topological configurations of these blocks, and, in particular we show that an RNA secondary structure contains a pseudoknot if and only if its corresponding dual graph contains a block having a vertex of degree at least 3. Once a dual graph has been partitioned via computationally-efficient well-known graph-theoretical algorithms, this characterization allow us to identify these sub-topologies and physically isolate pseudoknots from RNA secondary structures and analyze …

Undergraduate Research In Biology Iii: Causes Of Avian Mortality, Eric Walters

Undergraduate Research Symposium

No abstract provided.

Undergraduate Research In Biology Ii: Aquatic Ecology, David Gauthier

Undergraduate Research Symposium

No abstract provided.

Medicine And World War I, Annette Finley-Croswhite

Undergraduate Research Symposium

No abstract provided.

Undergraduate Research In Biology I: Understanding Pathogens And Their Vectors, Dayle Daines

Undergraduate Research Symposium

No abstract provided.

Poster Session, Honors College, Old Dominion University

Undergraduate Research Symposium

Poster Session features 21 posters in Biology, Chemistry, Park, Recreation & Tourism, Psychology, Computer Science, Electrical and Computer Engineering, Biochemistry, Political Science, Bioelectrics, Geology, Counseling and Human Services.

“For It Acordeth Noght To Kinde”: Remediating Gower’S Confessio Amantis In Machinima, Sarah L. Higley

Accessus

Visual adaptation of a medieval text, as tempting as it is in film of any kind, is never an easy conversion, and all the more so if the original is as formally structured as John Gower’s Confessio Amantis. This essay examines the philosophy and difficulties of making a “medieval motion picture” (animated and narrated by the author) reflect the message of three of Gower’s tales (“The Travelers and the Angel,” “Canace and Machaire,” “Florent”) as well as the multimedia properties of the manuscripts that house them, their illuminations beckoning us into colorful virtual worlds. In referencing theories of adaptation, …

Herbivore Impacts On Two Morphologically Similar Bloom-Forming Ulva Species In A Eutrophic Bay, Michele Guidone, Carol S. Thornber, Kathryn L. Van Alstyne

Biological Sciences Faculty Publications

Herbivore impacts on macrophyte growth vary with the identity of the herbivores and macrophytes, as well as under different abiotic conditions. This interaction is further complicated by anthropogenic alterations to the environment, such as eutrophication. In this study, we utilized in situ herbivore exclusion experiments and mesocosm feeding preference assays to examine the impacts of different herbivores on the growth of two morphologically similar, co-occurring macroalgal bloom Ulva species in a nutrient-rich environment. We found that herbivory had a measurable impact on Ulva biomass, though the rate of consumption rarely surpassed growth for either Ulva species. We determined that the …