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Articles 27751 - 27763 of 27763
Full-Text Articles in Entire DC Network
Septin-Dependent Assembly Of The Exocyst Is Essential For Plant Infection By Magnaporthe Oryzae, Yogesh K. Gupta, Yasin F. Dagdas, Ana Lilia Martinez-Rocha, Michael J. Kershaw, George R. Littlejohn, Lauren S. Ryder, Jan Sklenar, Frank Menke, Nicholas J. Talbot
Septin-Dependent Assembly Of The Exocyst Is Essential For Plant Infection By Magnaporthe Oryzae, Yogesh K. Gupta, Yasin F. Dagdas, Ana Lilia Martinez-Rocha, Michael J. Kershaw, George R. Littlejohn, Lauren S. Ryder, Jan Sklenar, Frank Menke, Nicholas J. Talbot
School of Biological and Marine Sciences
No abstract provided.
Adverse Outcome Pathways Can Drive Non‐Animal Approaches For Safety Assessment, N Burden, F Sewell, Me Andersen, A Boobis, Jk Chipman, Mtd Cronin, Th Hutchinson, I Kimber, M Whelan
Adverse Outcome Pathways Can Drive Non‐Animal Approaches For Safety Assessment, N Burden, F Sewell, Me Andersen, A Boobis, Jk Chipman, Mtd Cronin, Th Hutchinson, I Kimber, M Whelan
School of Geography, Earth and Environmental Sciences
AbstractAdverse Outcome Pathways (AOPs) provide an opportunity to develop new and more accurate safety assessment processes for drugs and other chemicals, and may ultimately play an important role in regulatory decision making. Not only can the development and application of AOPs pave the way for the development of improved evidence‐based approaches for hazard and risk assessment, there is also the promise of a significant impact on animal welfare, with a reduced reliance on animal‐based methods. The establishment of a useable and coherent knowledge framework under which AOPs will be developed and applied has been a first critical step towards realizing …
Parasites And Personality In Periwinkles (Littorina Littorea): Infection Status Is Associated With Mean-Level Boldness But Not Repeatability., Ben Seaman, Mark Briffa
Parasites And Personality In Periwinkles (Littorina Littorea): Infection Status Is Associated With Mean-Level Boldness But Not Repeatability., Ben Seaman, Mark Briffa
School of Biological and Marine Sciences
We demonstrate the presence of animal personality in an inter-tidal gastropod, Littorina littorea, both in a sample of individuals infected by the trematode Cryptocotyle lingua and in an uninfected sample. On average infected individuals behaved more cautiously than individuals free of infection, but the parasite did not affect repeatability. Although the parasite is not associated with greater diversity of behaviour amongst infected individuals, infection might be associated with state-dependent personality differences between infected and non-infected individuals.
Predictive Habitat Suitability Models To Aid Conservation Of Elasmobranch Diversity In The Central Mediterranean Sea, V. Lauria, M. Gristina, M. J. Attrill, F. Fiorentino, G. Garofalo
Predictive Habitat Suitability Models To Aid Conservation Of Elasmobranch Diversity In The Central Mediterranean Sea, V. Lauria, M. Gristina, M. J. Attrill, F. Fiorentino, G. Garofalo
School of Biological and Marine Sciences
No abstract provided.
Predicting Frequent Copd Exacerbations Using Primary Care Data, D Price, M Kerkhof, D Freeman, R Jones, A Chisholm
Predicting Frequent Copd Exacerbations Using Primary Care Data, D Price, M Kerkhof, D Freeman, R Jones, A Chisholm
Peninsula Medical School
No abstract provided.
The H50q Mutation Induces A 10-Fold Decrease In The Solubility Of Α-Synuclein, Riccardo Porcari, Christos Proukakis, Christopher A. Waudby, Benedetta Bolognesi, P. Patrizia Mangione, Jack F.S. Paton, Stephen Mullin, Lisa D. Cabrita, Amanda Penco, Annalisa Relini, Guglielmo Verona, Michele Vendruscolo, Monica Stoppini, Gian Gaetano Tartaglia, Carlo Camilloni, John Christodoulou, Anthony H.V. Schapira, Vittorio Bellotti
The H50q Mutation Induces A 10-Fold Decrease In The Solubility Of Α-Synuclein, Riccardo Porcari, Christos Proukakis, Christopher A. Waudby, Benedetta Bolognesi, P. Patrizia Mangione, Jack F.S. Paton, Stephen Mullin, Lisa D. Cabrita, Amanda Penco, Annalisa Relini, Guglielmo Verona, Michele Vendruscolo, Monica Stoppini, Gian Gaetano Tartaglia, Carlo Camilloni, John Christodoulou, Anthony H.V. Schapira, Vittorio Bellotti
Peninsula Medical School
No abstract provided.
New Insights Into Landslide Processes Around Volcanic Islands From Remotely Operated Vehicle (Rov) Observations Offshore Montserrat, S. F.L. Watt, M. Jutzeler, P. J. Talling, S. N. Carey, R. S.J. Sparks, M. Tucker, A. J. Stinton, J. K. Fisher, D Wall‐Palmer, V. Hühnerbach, S. G. Moreton
New Insights Into Landslide Processes Around Volcanic Islands From Remotely Operated Vehicle (Rov) Observations Offshore Montserrat, S. F.L. Watt, M. Jutzeler, P. J. Talling, S. N. Carey, R. S.J. Sparks, M. Tucker, A. J. Stinton, J. K. Fisher, D Wall‐Palmer, V. Hühnerbach, S. G. Moreton
School of Geography, Earth and Environmental Sciences
AbstractSubmarine landslide deposits have been mapped around many volcanic islands, but interpretations of their structure, composition, and emplacement are hindered by the challenges of investigating deposits directly. Here we report on detailed observations of four landslide deposits around Montserrat collected by Remotely Operated Vehicles, integrating direct imagery and sampling with sediment core and geophysical data. These complementary approaches enable a more comprehensive view of large‐scale mass‐wasting processes around island‐arc volcanoes than has been achievable previously. The most recent landslide occurred at 11.5–14 ka (Deposit 1; 1.7 km3) and formed a radially spreading hummocky deposit that is morphologically similar to many …
Uncoupling Protein-2 Attenuates Palmitoleate Protection Against The Cytotoxic Production Of Mitochondrial Reactive Oxygen Species In Ins-1e Insulinoma Cells., Jonathan Barlow, Jensen V Hirschberg, Charles Affourtit
Uncoupling Protein-2 Attenuates Palmitoleate Protection Against The Cytotoxic Production Of Mitochondrial Reactive Oxygen Species In Ins-1e Insulinoma Cells., Jonathan Barlow, Jensen V Hirschberg, Charles Affourtit
School of Biomedical Sciences
High glucose and fatty acid levels impair pancreatic beta cell function. We have recently shown that palmitate-induced loss of INS-1E insulinoma cells is related to increased reactive oxygen species (ROS) production as both toxic effects are prevented by palmitoleate. Here we show that palmitate-induced ROS are mostly mitochondrial: oxidation of MitoSOX, a mitochondria-targeted superoxide probe, is increased by palmitate, whilst oxidation of the equivalent non-targeted probe is unaffected. Moreover, mitochondrial respiratory inhibition with antimycin A stimulates palmitate-induced MitoSOX oxidation. We also show that palmitate does not change the level of mitochondrial uncoupling protein-2 (UCP2) and that UCP2 knockdown does not …
The Expression Of Toll-Like Receptor 4, 7 And Co-Receptors In Neurochemical Sub-Populations Of Rat Trigeminal Ganglion Sensory Neurons, M. P. Helley, W. Abate, S. K. Jackson, J. H. Bennett, S. W.N. Thompson
The Expression Of Toll-Like Receptor 4, 7 And Co-Receptors In Neurochemical Sub-Populations Of Rat Trigeminal Ganglion Sensory Neurons, M. P. Helley, W. Abate, S. K. Jackson, J. H. Bennett, S. W.N. Thompson
School of Biomedical Sciences
No abstract provided.
Third-Generation Cephalosporin Resistance Conferred By A Chromosomally Encoded Blacmy-23 Gene In The Escherichia Coli St131 Reference Strain Ec958., Minh Duy Phan, Kate M. Peters, Sohinee Sarkar, Brian M. Forde, Alvin W. Lo, Mitchell Stanton-Cook, Leah W. Roberts, Mathew Upton, Scott A. Beatson, Mark A. Schembri
Third-Generation Cephalosporin Resistance Conferred By A Chromosomally Encoded Blacmy-23 Gene In The Escherichia Coli St131 Reference Strain Ec958., Minh Duy Phan, Kate M. Peters, Sohinee Sarkar, Brian M. Forde, Alvin W. Lo, Mitchell Stanton-Cook, Leah W. Roberts, Mathew Upton, Scott A. Beatson, Mark A. Schembri
School of Biomedical Sciences
OBJECTIVES: Escherichia coli ST131 is a globally disseminated MDR clone originally identified due to its association with the blaCTX-M-15 gene encoding an ESBL. It is thus assumed that blaCTX-M-15 is the major determinant for resistance to β-lactam antibiotics in this clone. The complete sequence of EC958, a reference strain for E. coli ST131, revealed that it contains a chromosomally located blaCMY-23 gene with an upstream ISEcp1 element as well as several additional plasmid-encoded β-lactamase genes. Here, we examined the genetic context of the blaCMY-23 element in EC958 and other E. coli ST131 strains and investigated the contribution of blaCMY-23 to …
Antibiotic-Resistant St38, St131 And St405 Strains Are The Leading Uropathogenic Escherichia Coli Clones In Riyadh, Saudi Arabia., Majed F. Alghoribi, Tarek M. Gibreel, Garry Farnham, Johani Sm Al, Hanan H. Balkhy, Mathew Upton
Antibiotic-Resistant St38, St131 And St405 Strains Are The Leading Uropathogenic Escherichia Coli Clones In Riyadh, Saudi Arabia., Majed F. Alghoribi, Tarek M. Gibreel, Garry Farnham, Johani Sm Al, Hanan H. Balkhy, Mathew Upton
School of Biomedical Sciences
OBJECTIVES: We investigated the molecular epidemiology of uropathogenic Escherichia coli (UPEC) from a tertiary care hospital in Riyadh, Saudi Arabia, revealing, for the first time, the population structure of UPEC in the region. METHODS: A total of 202 UPEC isolates were recovered from hospital and community patients with urinary tract infection in December 2012 and January 2013. Strains were characterized by MLST, antibiotic susceptibility determination and virulence gene detection. RESULTS: The most common lineages were ST131 (17.3%), ST73 (11.4%), ST38 (7.4%), ST69 (7.4%), ST10 (6.4%), ST127 (5.9%), ST95 (5.4%), ST12 (3.5%), ST998 (3.5%) and ST405 (3%). ST131 and ST405 isolates …
Molecular Characterization Of A Multidrug Resistance Incf Plasmid From The Globally Disseminated Escherichia Coli St131 Clone., Minh Duy Phan, Brian M. Forde, Kate M. Peters, Sohinee Sarkar, Steven Hancock, Mitchell Stanton-Cook, Zakour Nl Ben, Mathew Upton, Scott A. Beatson, Mark A. Schembri
Molecular Characterization Of A Multidrug Resistance Incf Plasmid From The Globally Disseminated Escherichia Coli St131 Clone., Minh Duy Phan, Brian M. Forde, Kate M. Peters, Sohinee Sarkar, Steven Hancock, Mitchell Stanton-Cook, Zakour Nl Ben, Mathew Upton, Scott A. Beatson, Mark A. Schembri
School of Biomedical Sciences
Escherichia coli sequence type 131 (E. coli ST131) is a recently emerged and globally disseminated multidrug resistant clone associated with urinary tract and bloodstream infections. Plasmids represent a major vehicle for the carriage of antibiotic resistance genes in E. coli ST131. In this study, we determined the complete sequence and performed a comprehensive annotation of pEC958, an IncF plasmid from the E. coli ST131 reference strain EC958. Plasmid pEC958 is 135.6 kb in size, harbours two replicons (RepFIA and RepFII) and contains 12 antibiotic resistance genes (including the blaCTX-M-15 gene). We also carried out hyper-saturated transposon mutagenesis and multiplexed transposon …
Aspergillus Nidulans Protein Kinase A Plays An Important Role In Cellulase Production, Assis Lj De, Laure Nicolas Annick Ries, Marcela Savoldi, Reis Tf Dos, Neil Andrew Brown, Gustavo Henrique Goldman
Aspergillus Nidulans Protein Kinase A Plays An Important Role In Cellulase Production, Assis Lj De, Laure Nicolas Annick Ries, Marcela Savoldi, Reis Tf Dos, Neil Andrew Brown, Gustavo Henrique Goldman
School of Biomedical Sciences
No abstract provided.