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Esophageal Replacement By Hydroxylated Bacterial Cellulose Patch In A Rabbit Model, Changlai Zhu, Fang Liu, Wenbo Qian, Yingjie Wang, Qingsheng You, Tianyi Zhang, Feng Li

Turkish Journal of Medical Sciences

Background/aim: To repair esophageal defects by hydroxylated and kombucha -synthesized bacterial cellulose (HKBC) patch in a rabbit model. Materials and methods: Semicircular esophageal defects 1 cm in length of the cervical esophagus were initially created in 18 Japanese big-ear rabbits and then repaired with HKBC patch grafts. The clinical outcomes including survival rate, weight change, food intake, and hematological and radiologic evaluation were observed. After X-ray evaluation, the rabbits were sacrificed sequentially at 1, 3, and 6 months for histopathologic analysis with light microscopy and scanning electron microscopy. Results: Survival rate during the first month was 88.9% (n = 16). …

Alzheimer Disease And Anesthesia, Gözde İnan, Zerri̇n Özköse Şatirlar

Turkish Journal of Medical Sciences

Alzheimer disease (AD) is one of the most common neurodegenerative diseases and the most prevalent form of dementia. Some factors in the development of AD, age being the best-known one, have been suggested; however, no causes have been found yet. The pathophysiology of the disease is highly complex, current therapies are palliative, and a cure is still lacking. Adverse effects of anesthetics in the elderly have been reported since the 1950s; however, awareness of this old problem has recently gained importance again. Whether exposure to surgery and general anesthesia (GA) is associated with the development of AD has been questioned. …

Immunogenicity Of Conserved Cork And Ss-Barrel Domains Of Baumannii Acinetobactin Utilization Protein In An Animal Model, Yaqub Hajiaghatabar Sangroodi, Iraj Rasooli, Shahram Nazarian, Walead Ebrahimizadeh, Fatemeh Sefid

Turkish Journal of Medical Sciences

Background/aim: The uptake of the ferric-acinetobactin complex into the periplasmic space relies on the baumannii acinetobactin utilization (BauA) protein. BauA is composed of cork and the β-barrel domains. We constructed a recombinant protein from conserved antigenic domains of cork and the β-barrel of BauA to evaluate their immunogenic role in an animal model. Materials and methods: The selected bauA domains were amplified from a purified genome of Acinetobacter baumannii ATCC 19606. The domains were then cloned into pET28a and the proteins expressed in E. coli BL21 (DE3) were purified using nickel nitrilotriacetic acid chromatography. Mice and rabbits were immunized with …

(In)Visible, Federico Cuatlacuatl

School of Art Graduate Exhibitions, Portfolios, and Theses

No abstract provided.

Enhancement Of Copd Biological Networks Using A Web-Based Collaboration Interface, Stephanie Boue, Brett Fields, Julia Hoeng, Jennifer Park, Manuel C. Peitsch, Walter K. Schlage, Vladimir Bondarenko

College of Osteopathic Medicine (TUN) Publications and Research

The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease. Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease of the airways for which therapeutic options currently are limited after diagnosis, even in its earliest stage. COPD network models are important tools to better understand the biological components and processes underlying initial disease development. With the increasing amounts of literature that are now available, crowdsourcing approaches offer new forms of collaboration for researchers to review biological findings, which can be applied to the construction and verification …

Captain Beefheart, Monica Berger

Publications and Research

No abstract provided.

“Man? Where’S A Man? Don’T Let Him Go!”: Molina’S Trans/Gender Web In Interpretation And Performance, Bella V. Smith

Calvert Undergraduate Research Awards

Using perspectives typical of English and theatrical fields of study, this capstone project interprets Molina from Manuel Puig’s 1976 novel Kiss of the Spider Woman as a heterosexual transgender woman and then investigates why such an interpretation does not exist in performance adaptations. Although Molina has been called a transgender woman in recent criticism, there is a conflation of gender and sexuality that has been uninvestigated in this text. It has not been addressed how Molina constructs her identity or how this interpretation might be employed in performance, which this essay seeks to confront. The first half of the project …

Mcnair Research Journal - Summer 2015, Kelly Abuali, Starr Bailey, Krystal Courtney D. Belmonte, Brittaney Benson-Townsend, Jennifer Bolick, Mihaela A. Ciulei, Ashley Crisp, Daniel N. Erosa, Richard V. Foster, Gisele Braga Goertz, Michael A. Langhardt, Kara Osborne, Julienne Jochel Paraiso, Shawn M. Rosen, Bella V. Smith, Jeevake Attapattu, Ernesto H. Bedoy, Michael G. Curtis, Wanda Inthavong, Marielle Leo, Primrose Martin, Tamieka Meadows, Rosa Perez, Jessica Recarey, Shea Silver, Linda Tompkins

McNair Journal

Journal articles based on research conducted by undergraduate students in the McNair Scholars Program

Table of Contents

Biography of Dr. Ronald E. McNair

Statements:

Dr. Neal J. Smatresk, UNLV President

Dr. Juanita P. Fain, Vice President of Student Affairs

Dr. William W. Sullivan, Associate Vice President for Retention and Outreach

Mr. Keith Rogers, Deputy Executive Director of the Center for Academic Enrichment and Outreach

McNair Scholars Institute Staff

Ebola Viral Disease: What Should Be Done To Combat The Epidemic In 2014?, Ali̇ye Baştuğ, Hürrem Bodur

Turkish Journal of Medical Sciences

Ebola virus disease (EVD) was defined first in 1976. Since then, more than 24 epidemics have been reported from Africa, predominantly with the Zaire species. On 21 March 2014, the current West Africa outbreak was reported by the World Health Organization, the largest one ever recorded. The Congo epidemic was reported in July 2014. It was considered that the two epidemics had unrelated origins with 96.8% identical genomic sequence of the virus. EVD outbreaks occurred in areas with limited resources but it has a potentially global effect due to the possibility of imported infection and the potential misuse of the …

Gastrointestinal System Lesions In Children Due To The Ingestion Of Alkali And Acid Corrosive Substances, Kaan Demi̇rören, Hali̇l Kocamaz, Yaşar Doğan

Turkish Journal of Medical Sciences

To examine esophageal and gastric lesions in children due to the ingestion of alkali and acid corrosive substances and to emphasize all related complications. Materials and methods: The reports of 103 children who ingested or were suspected to have ingested corrosive substances and who then underwent upper gastrointestinal endoscopic inspections were evaluated retrospectively. Results: Of the patients, the mean age was 41 ± 3.6 months, and 57.3% were male. Vomiting was the most common symptom (44.7%). Eighteen different commercial products were defined as corrosive substances: 59.2% of them were alkali, 39.8% were acids, and 1% had a neutral pH. These …

The Effects Of Chanellization And Channel Restoration On Aquatic Habitat And Biota Of The Pecos River, New Mexico, Darrel J. Mecham

Electronic Theses and Dissertations

River channelization has been shown to negatively impact riverine ecosystems by degrading aquatic habitat conditions, decreasing diversity of both fish and aquatic invertebrate assemblages and impairing fish recruitment. As knowledge of the negative impacts of channelization has increased, so have channel restoration efforts. We evaluated a recent channel restoration project on the Pecos River, New Mexico by comparing abiotic and biotic conditions among five reaches of river, including the restored reach, an unchannelized reach and a channelized reach all prone to streamflow intermittence and an unchannelized reach and channelized reach more perennial in nature. Our first objective was to assess …

Development Programs And Livelihood Strategies Of Residents In Altos De La Florida, Colombia, Andres Felipe Florez

Graduate Research Theses & Dissertations

Colombia has a long history of internal displacement due to an ongoing armed conflict. Millions of Internally Displaced Persons (IDPs) have made their way to urban areas around the country seeking safety and a new start. The municipality of Soacha, a suburb of Bogota, is the largest receptor area for IDPs in the country, and many Non-Governmental Organizations have set up operations to aid the residents of the area. Within Soacha the most vulnerable residents live in an informal settlement called Altos de la Florida Sector 3. This area has no infrastructure and a large portion of the residents are …

The Silent Dimension Of A Healthcare Narrative: How Patients Perceive Practitioners’ Nonverbal Cues, Sarah Steele

Communication & Leadership Dissertations and Theses

This study examines patient perceptions of medical practitioners’ nonverbal behavior. The philosophical framework is based on Buber’s (1923/1958) work on “dialogic ethics,” and grounded in Giles’ (1987) communication accommodation theory. Both quantitative and qualitative data were gathered by means of survey research, and examined through correlational and content analysis. Results show a significant positive correlation between patient perceptions of practitioner nonverbal immediacy and subsequent satisfaction. Analysis of survey comments revealed listening as the nonverbal behavior most valued and noted by patients. These findings serve to inform medical professionals on how to maximize patient satisfaction and care through effective use of …

Into The Wild: A Case Study Of The Intersection Of Archaeology And Federal Wilderness Policy, Erika S. Blecha

Graduate Student Theses, Dissertations, & Professional Papers

Cultural resource specialists working with and for Federal land management agencies have voiced their concern about the perception of cultural sites within federally recognized wilderness areas. However, as a whole, professionals working within the discipline of archaeology have remained relatively absent in the debates on wilderness with regards to human occupation in these designated areas. This thesis introduces the concept of wilderness, its history, perceptions, management, laws, and issues relevant to archaeology. It also draws attention to the paucity of archaeological research and the relaxed nature of cultural resource compliance mandates [National Historic Preservation Act (NHPA) Sections 106 and 110] …

Non-Coding Rnas Of The Q Fever Agent, Coxiella Burnetii, Indu Ramesh Warrier

Graduate Student Theses, Dissertations, & Professional Papers

Coxiella burnetii is an obligate intracellular bacterial pathogen that undergoes a biphasic developmental cycle, alternating between a small cell variant (SCV) and a large cell variant (LCV). Despite the remarkable niche and life cycle of C. burnetii, little is known about its modes of regulation and the roles that non-coding RNAs play in its growth and development. One such element is the intervening sequence (IVS); a 444-nt RNA element that is inserted within helix 45 of CoxiellaÆs precursor 23S rRNA. C. burnetii may have acquired IVS through horizontal transfer, and it has been subsequently maintained by all strains of C. …

Run To The Hills - Partial Migration In Large Herbivores, Wibke Peters

Graduate Student Theses, Dissertations, & Professional Papers

Partially migratory populations in which some individuals move to allopatric ranges during one season while others remain on their shared range, offer a unique opportunity to understand which factors shape the realized niche of individuals with plastic movement behaviors. For ungulates, forage and its spatiotemporal variability, risk (predation, humans) and density have been suggested to be the main determinants for the probability, distance and timing of migration. Roe deer (Capreolus caproelus), a small browsing ungulate with a high ecological plasticity and a wide distribution, present an ideal model species to test hypotheses on migration plasticity.

Optimising Motor Learning Of Infants At High Risk Of Cerebral Palsy Using Goal-Oriented And Environmental Interventions, Catherine Morgan

Theses

Background and aims: Cerebral palsy (CP) is the most common physical disability of childhood occurring in 1 in 500 live births in developed countries. Although CP starts in infancy because of a lesion in the developing brain, it is usually not diagnosed until about 19 months. The problem with late detection has meant that early neurorehabilitation is not accessed until motor impairment is evident. Consequently the dose of active intervention during the critical period for brain plasticity is often inadequate. Little evidence exists for the effectiveness of early intervention (EI) protocols for infants with CP. In particular, interventions that take …

It's A Small World: Biogeography And Invasion In The Mouse Intestine, Ellen Lark

Graduate Student Theses, Dissertations, & Professional Papers

Host associated systems are of particular interest to many microbiologists because invasion of these systems can lead to disease. One important host-associated systems is the intestinal microbiome, but in many studies, including those on pathogenesis, this system is represented by samples from one location (generally the feces or cecum). This body of work was initiated in part because I wondered why a large and diverse ecosystem was being was being represented by samples from only one habitat.

The biogeography of living organisms has an impact on landscape ecology studies, including those in the field of invasion ecology. Despite several studies …

Synthesis, Surface Functionalization, And Biological Testing Of Iron Oxide Nanoparticles For Development As A Cancer Therapeutic, Stanley E. Gilliland Iii

Theses and Dissertations

Iron oxide nanoparticles are highly researched for their use in biomedical applications such as drug delivery, diagnosis, and therapy. The inherent biodegradable and biocompatible nanoparticle properties make them highly advantageous in nanomedicine. The magnetic properties of iron oxide nanoparticles make them promising candidates for magnetic fluid hyperthermia applications. Designing an efficient iron oxide nanoparticle for hyperthermia requires synthetic, surface functionalization, stability, and biological investigations. This research focused on the following three areas: optimizing synthesis conditions for maximum radiofrequency induced magnetic hyperthermia, designing a simple and modifiable surface functionalization method for specific or broad biological stability, and in vitro and in …

Mitochondrial Therapeutics During Ischemia-Reperfusion; Modulation Of Complex I: Effect Of Metformin., Shawn Y. Sunu

Theses and Dissertations

The modulation of the electron transport during ischemia-reperfusion has been shown to be protective. We hypothesized that metformin, a Complex I inhibitor, may exhibit characteristics of a pharmacological agent that could achieve long-term therapeutic intervention against ischemia-reperfusion injury. Mitochondria were harvested from adult male mice and incubated with or without metformin at 30^oC for 15 minutes, while being shaken at 300 rpm. Metformin decreased Complex I oxidative phosphorylation and Complex I activity. However, metformin also increased injury and decreased the maximum membrane potential. Even though there was a decrease in maximum membrane potential, the proton motive force (PMF) …

Hif-Independent Responses In Hypoxia, Divya Padmanabha

Theses and Dissertations

The adaptive response to hypoxia is accompanied by widespread transcriptional changes that allow for prolonged survival in low oxygen. Many of these changes are directly regulated by the conserved hypoxia-inducible factor-1 (HIF-1) complex; however, even in its absence, many oxygen-sensitive transcripts in Caenorhabditis elegans are appropriately regulated in hypoxia. To identify mediators of these non-HIF-dependent responses, I established a hif-1 mutant reporter line that expresses GFP in hypoxia or when worms are treated with the hypoxia mimetic cobalt chloride (cobalt chloride). The reporter is selective and HIF-independent, in that it remains insensitive to a number of cellular stresses, but is …

Heterosandwich Assay Of Nicotinic Acetylcholine Receptors, Augustine J. Pagan Iv

Theses and Dissertations

Using the technology afforded by Winschel et al., cyclen-1, a high affinity, strong complexation agent for 8-hydroxypyrene-1,3,6 trisulfonate and derivatives, a new assay has been developed for fluorescently labeling proteins of interest (POIs). Ligation of the endogenous ligand for nicotinic acetylcholine receptors (nAChRs), acetylcholine, using click chemistry afforded the triazole derivative of an alkynyl-acylcholine (compound 1) with 8-azidopyrene-1,3,6 trisulfonate (compound 2). Liposomes encapsulated with Rhodamine B were used to strengthen the initial fluorophore response of compound 2, using an anchored form of cyclen-1 complex. Using a palmitoyl tail as the lipophilic moiety for liposomal amplification, the …

For Those On Glass Cliffs: The Nature Of Women In Power As Explored Through Frozen, The Abramson Effect, And "Let It Go, Raelissa Glennon-Zukoff

sprinkle: an undergraduate journal of feminist and queer studies

This paper seeks to explore the link made by Deborah Spar in her recently published piece The Ambramson Effect: Tales of Women Who Topple From Power between the effects of the glass ceiling and glass cliff effects on women in the topmost positions in American businesses, organizations, and corporations and the ascension to power of Queen Elsa in the Disney motion picture Frozen. By incorporating media reports on merchandising and animation, as well as scholarly research, this paper places Spar's theory into a more accessible space. Furthermore, by referencing the lyrics to the feature power ballad from the animated film, …

Measuring The Acute Physiological Effects Of Leptin In The Carotid Body, Richard Laurence Pye

Browse all Theses and Dissertations

Obesity is the healthcare crisis of our generation. Circulating levels of the adipokine leptin are proportional to adiposity and in addition to its role as a satiety factor leptin has been shown to have a host of pleiotropic effects. Among these effects is its role as a respiratory stimulant where it has been shown to have both whole body and central stimulatory effects on breathing. Porzionato et al. (2011) showed that leptin and leptin receptors are selectively expressed in the chemosensing type I cells of the carotid body. Carotid bodies are small chemosensitive organs that act as the primary peripheral …

The Guinea Pig Model For Organophosphate Toxicology And Therapeutic Development, Christopher Daniel Ruark

Browse all Theses and Dissertations

Organophosphates (OPs) are highly toxic insecticides and nerve agents that have been designed to inhibit the hydrolysis of acetylcholine by binding to the serine active site of acetylcholinesterase (AChE). They are one of the most common causes of human poisoning worldwide and are frequently intentionally used in suicides in agricultural areas. For this reason, there is a need for therapeutics to rescue those from intoxication. Obvious ethical concerns prevent humans from being subjected to OP exposure for therapeutic efficacy and safety testing. Therefore, animal surrogates for humans must be appropriately selected. A new paradigm, described herein, incorporating both in silico …

Sky Lifting His Skirts, Thaddeus Harmon

Graduate Thesis Collection

An imbecilic invocation uttered by glass-fingered mannequins jaggedly gesticulating forgotten ballet moves in a future where skin is optional, and computers sneeze.

3d-Printed Hand Controlled By Arm Gestures To Verify The Robustness And Reliability Of A Low Cost Surface Electromyography System, Ma. Erika Manlapaz, Marie Perrot, Gabrielle Villavicencio, Bryan Lao, Rosula Sj Reyes

Electronics, Computer, and Communications Engineering Faculty Publications

The study focuses on the development of a low-cost surface electromyography and 3D-printed hand gesture-recognition system. The complete system captures four (4) channels of EMG data through sEMG amplifier circuits interfaced to an Arduino prototyping board. This data is sent to a workstation wherein the graphical user interface shows the pre-processed signal. The gestures are used as control for the movements of the 3D-printed arm.

Front Matter And Faculty Notes

Transactions: The Tennessee Journal of Business Law

No abstract provided.

Automated Essay Evaluation And The Computational Paradigm: Machine Scoring Enters The Classroom, Catherine M. Barrett

Open Access Dissertations

Grading papers is a "tedious, repetitive, and time-consuming" undertaking, one that invites the sort of sympathies one might receive upon the "death of a pet' (Baker, 2014, p. 36). Perhaps, though, the only thing more distasteful for an English professor than having to grade hundreds of essays each semester is having to hand the job over to the likes of a mindless software program. Automated Essay Evaluation (AEE), the process of scoring essays by computer, was developed in the 1960s but has mostly aroused suspicion and derogation from the composition community.

The parable of the blindfolded villagers describing the same …

Tax Law Within The Larger Legal System, J. Scott Wilkie, Peter W. Hogg

Osgoode Hall Law Journal

Tax law may be viewed as occupying its own universe, even though tax funds the implementation of public policies that animate Canadian society. This article reminds us that tax law must respond to basic rule-of-law norms in spite of overarching and well-meaning policy goals. It adopts reference points featured in recent cases. One is the Charter, which limits penalties that can be imposed on non-compliant taxpayers and tax advisers without adhering to due process safeguards. Another is the impact of international arrangements among countries in a global business environment to guide consistent regulatory responses and to identify and share information. …