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Evaluation Of Small Molecules On The Excitatory Amino Acid Transporter 3 (Eaat3) For The Treatment Of Ocd, Emmanuel Zubia

Open Access Theses & Dissertations

We seek to discover new drug candidates for the excitatory amino acid transporter 3 (EAAT3) for the treatment of Obsessive Compulsive Disorder (OCD). We hypothesize that decreasing the glutamatergic transmission via EAAT3 intervention will create an amelioration of the symptoms of OCD. For this we have prepared in-silico binding calculations to identify a better compound that can stimulate EAAT3 and decrease glutamatergic transmission. This research will help us further understand and elucidate the role of glutamate in the neural mechanisms of this illness, which to date remain inconclusive. Those areas of study are significant because, until now, there is no …

The Contribution Of Mild Traumatic Brain Injury/Concussion To The Development Of Post-Traumatic Stress Disorder Symptoms, Kylie Lauren Marshall

Open Access Theses & Dissertations

A controversial issue is whether TBI is a necessary precursor to the development of PTSD symptoms, or if the two variables are mutually exclusive. Recent rodent-models reveal that a stressful environment cannot cause PTSD symptoms directly without TBI, yet it is unknown if PTSD symptoms can develop following a TBI. This study provides a potential analogue to study this relationship by evaluating the effects of sports-related concussion. Purpose: This study investigated two questions, 1) Is there a significant difference in the frequency of PTSD symptoms reported by athletes at baseline (BL) testing and post-concussion (PC) testing over time? 2) Is …

Posture Affects How Robots And Infants Map Words To Objects., Af Morse, Vl Benitez, T Belpaeme, A Cangelosi, Lb Smith

School of Engineering, Computing and Mathematics

For infants, the first problem in learning a word is to map the word to its referent; a second problem is to remember that mapping when the word and/or referent are again encountered. Recent infant studies suggest that spatial location plays a key role in how infants solve both problems. Here we provide a new theoretical model and new empirical evidence on how the body - and its momentary posture - may be central to these processes. The present study uses a name-object mapping task in which names are either encountered in the absence of their target (experiments 1-3, 6 …

Experimental Approaches To Derive Cd34+ Progenitors From Human And Nonhuman Primate Embryonic Stem Cells, Qiang Shi, John L. Vandeberg

School of Medicine Publications

Traditionally, CD34 positive cells are predominantly found in the umbilical cord and bone marrow, thus are considered as hematopoietic progenitors. Increasing evidence has suggested that the CD34+ cells represent a distinct subset of cells with enhanced progenitor activity; CD34 is a general marker of progenitor cells in a variety of cell types. Because the CD34 protein shows expression early on in hematopoietic and vascular-associated tissues, CD34+ cells have enormous potential as cellular agents for research and for clinical cell transplantation. Directed differentiation of embryonic stem cells will give rise to an inexhaustible supply of CD34+ cells, creating an exciting approach …

Normative And Standardized Data For Cognitive Measures In The Mexican Health And Aging Study, Silvia Mejia-Arango, Rebeca Wong, Alejandra Michaels-Obregón

School of Medicine Publications

Objective: To describe the cognitive instrument used in the Mexican Health and Aging Study (MHAS) in Mexican individuals aged 60 and over and to provide normative values for the Cross Cultural Cognitive Examination test and its modified versions (CCCE).

Materials and methods: The CCCE was administered to 5,120 subjects as part of a population-based sample free of neurologic and psychiatric disease from the MHAS 2012 survey. Normative data were generated by age and education for each test in the cognitive instrument as well as for the total cognition score. Pearson correlations and analysis of variance were used to examine the …