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The College Of Pharmacy, South Dakota State University

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

[Page] 2 Student Organizations Throughout the history of the college, student organizations have played a strong part in what the college has become.
[Page] 8 Academic and athletic success Numerous students participate as members of the Jackrabbits’ athletics teams.
[Page] 10 Relationships matter Johns Hopkins researcher works with State on breast cancer and delivers second annual Francis Miller Lecture.
[Page] 12 Celebration of Excellence By playing a prominent role in interprofessional education, Debra Farver is named the college’s outstanding scholar.
[Page] 14 Pharmacist of the Year Associate professor Tadd Hellwig honored by South Dakota Society of Health-System Pharmacists.
[Page] 15 …

News & Notes Summer 2014, Isabelle Farrington College Of Education

News & Notes

No abstract provided.

External/Internal Optical Adapter For Ftir Spectrophotometer, Zhi Xu

UMSL Patents

A Fourier Transfer Infrared (FTIR) spectrophotometer having reduced baseline noise. The system and method include internal or external optical adapters having a moveable beamsplitter for splitting the source light beam into a reference beam and a sample beam, and may include a variable bandpass filter, variable preamplifier and reversed biased photodiodes.

For the most up-to-date information about these patents, including the availability of Certificates of Correction, be sure to check the United States Patent and Trademark Office's free, publicly accessible database: Patent Public Search https://ppubs.uspto.gov/pubwebapp/static/pages/landing.html

[Accepted Article Manuscript Version (Postprint)] Auxin Input Pathway Disruptions Are Mitigated By Changes In Auxin Biosynthetic Gene Expression In Arabidopsis, Gretchen Spiess, Amanda Hausman, Peng Yu, Jerry Cohen, Rebekah Rampey, Bethany Zolman

Biology Department Faculty Works

Auxin is a phytohormone involved in cell elongation and division. Levels of indole-3-acetic acid (IAA), the primary auxin, are tightly regulated through biosynthesis, degradation, sequestration, and transport. IAA is sequestered in reversible processes by adding amino acids, polyol or simple alcohols, or sugars, forming IAA conjugates, or through a two-carbon elongation forming indole-3-butyric acid. These sequestered forms of IAA alter hormone activity. To gain a better understanding of how auxin homeostasis is maintained, we have generated Arabidopsis (Arabidopsis thaliana) mutants that combine disruptions in the pathways, converting IAA conjugates and indole-3-butyric acid to free IAA. These mutants show phenotypes indicative …

Cytosolic Phosphorylating Glyceraldehyde-3-Phosphate Dehydrogenases Affect Arabidopsis Cellular Metabolism And Promote Seed Oil Accumulation, Xuemin Wang, Liang Guo, Fangfang Ma, Fang Wei, Brian Fanella, Doug Allen

Biology Department Faculty Works

The cytosolic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPC) catalyzes a key reaction in glycolysis, but its contribution to plant metabolism and growth are not well defined. Here, we show that two cytosolic GAPCs play important roles in cellular metabolism and seed oil accumulation. Knockout or overexpression of GAPCs caused significant changes in the level of intermediates in the glycolytic pathway and the ratios of ATP/ADP and NAD(P)H/NAD(P). Two double knockout seeds had ∼3% of dry weight decrease in oil content compared with that of the wild type. In transgenic seeds under the constitutive 35S promoter, oil content was increased up to 42% …

The Search, The Jackson Laboratory

Search Magazine

No abstract provided.

Using Nd Isotopes To Understand Changes In Continental Weathering Flux In Mid-Pennsylvanian (Desmoinesian) Carbonate Cycles, Phil Ragonese

Earth and Planetary Sciences ETDs

Decades of study on Phanerozoic sedimentary deposits indicates that changes in Earth's orbital parameters are one of the main drivers of climate change on the 104-105 yr time scales, however understanding the relationships between climate change on coeval marine and continental deposits is difficult due to post-depositional erosion and tectonic processes. Nd isotopes measured in marine carbonates are a proxy for regional-scale continental weathering flux (CWF) and can help resolve these difficulties because its short residence time (less than ocean mixing times). This study focuses on cyclic Middle Pennsylvanian (Desmoinesian) marine successions from the Pedregosa (Arizona) and Bird Spring (southern …

A Win-Win On Agricultural Lands: Creating Wildlife Habitat Through Agroforestry, Gary Bentrup

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

With increasing demands from society for limited resources, agroforestry will likely be one source of solutions as people find it increasingly necessary to achieve multiple social, economic, and ecological objectives on the same plot of land. Indications are that this is a growing field, so wildlife biologists of the future may want to consider incorporating agroforestry into their career development.

Engagement In A Community-Based Integral Practice Program Enhances Well-Being, Cassandra Vieten, Mica Estrada, Adam B. Cohen, Dean Radin, Marilyn M. Schlitz, Arnaud Delorme

International Journal of Transpersonal Studies

This project examined associations between engagement in a community-based integral practice program and measures of health and well-being. In this prospective withinsubjects uncontrolled cohort study, 53 participants of Integral Transformative Practice (ITP), a program that incorporates movement, nutritional and exercise recommendations, affirmations, contemplative introspection, theory and philosophy, and group discussions and activities, were followed over one year. Participants completed online questionnaires upon enrollment, at six months, and one year later. Repeated measures analyses showed that participants reported improved overall health and reduced symptoms of ill health, as well as increased psychological well-being, vitality, and quality of life over the course …

Implications And Consequences Of Post-Modern Philosophy For Contemporary Transpersonal Studies Iii. Deleuze And Some Related Phenomenologies Of Felt Meaning: Psychosis And Mysticism As Inherent “Structures Of Thought”, Harry Hunt

International Journal of Transpersonal Studies

There is a surprising confluence in the philosopher Deleuze, the psychoanalyst Bion, and phenomenological psychologist Gendlin on what Deleuze terms the immediate “sense” of understanding and Gendlin calls “felt meaning.” Beneath its more differentiated propositional articulations, all three understand this phenomenon as a felt sense of constantly shifting coherence and incoherence, and based in often tacit metaphoric, figural, and/or synesthetic processes. For Deleuze and Bion, in particular, psychotic thought disorder is understood as the exaggeration of this incoherence potential within all felt meaning. Correspondingly, the expansion or enhancement of the felt coherence aspect of ordinary thought becomes the basis for …

Making Ketamine Work In The Long Run, Terrence S. Early

International Journal of Transpersonal Studies

Treatments such as ketamine psychotherapy face substantial financial and regulatory obstacles to dissemination into widespread use. Newly patented medications are able to generate enough capital to pay for studies required for FDA approval, personnel to apply for coverage on insurance plans, and marketing to establish a successful launch. Ketamine is an older drug with considerable evidence of efficacy for treatment resistant depression, and almost 50 years of data concerning safety as an anesthetic agent. However, it can no longer be patented, so there is no incentive for pharmaceutical companies to help get it into widespread use. In this paper we …

Ketamine Psychedelic Psychotherapy: Focus On Its Pharmacology, Phenomenology, And Clinical Applications, Eli Kolp, Harris L. Friedman, Evgeny Krupitsky, Karl Jansen, Mark Sylvester, M. Scott Young, Anna Kolp

International Journal of Transpersonal Studies

Meant to be an authoritative guide for psychiatrists and others interested in understanding and applying ketamine psychedelic psychotherapy (KPP), this paper focuses on its pharmacology, phenomenology, and clinical applications. Ketamine is a dissociative anesthetic widely used by physicians and veterinarians in the United States. In addition to its anesthetic and dissociative properties, ketamine also has a multitude of other psychological and pharmacological properties, which include analgesic, sedative, neuroprotective, anxiolytic, antidepressant, stimulant, euphoriant, and hallucinogenic effects. The literature on the clinical application of KPP is comprehensively reviewed, practical advice for using KPP is given, and the pharmacology and phenomenology of ketamine-induced …

Regarding The Transpersonal Nature Of Ketamine Therapy: An Approach To The Work, Jeffrey Becker

International Journal of Transpersonal Studies

Recent evidence has shown that ketamine treatment can facilitate psychological insight and symptom resolution in various psychiatric disorders. To aid this process, psychotherapeutic support should be considered a fundamental aspect of treatment. The psychedelic experience produced by ketamine can be a deeply meaningful source of enduring change and personal growth. The author has repeatedly observed a rapid realignment of self-perception away from shame, fear, and dread toward authentic self-acceptance and gratitude, offering patients opportunity for insight and the consideration of new potentialities. The experience produced by ketamine is similar in quality to transpersonal experiences described by Jung and induced by …

Ketamine For Depression: A Mixed-Methods Study, Philip E. Wolfson

International Journal of Transpersonal Studies

Prior studies have reported variously on the presence or absence of dissociative effects at subanesthtetic doses of ketamine administered for treatment-resistant depression. This mixedmethods study emulated the protocol used for the studies in question, with IV administration of 0.5mg/kg over 40 minutes with eight experienced ketamine users. Quantitative measures were generally insignificant since this was not a population reporting depression; blood pressure increased as expected by 20-30mm systolic and 6-20mm diastolic, falling rapidly by 20 minutes after completion of the infusion. Individual qualitative reports reports of relaxation, pleasant sensation, decreased cognitive function, and some disabling of ordinary capacities. As experienced …

Psychedelic Experiential Pharmacology: Pioneering Clinical Explorations With Salvador Roquet (How I Came To All Of This: Ketamine, Admixtures And Adjuvants, Don Juan And Carlos Castaneda Too): An Interview With Richard Yensen, Philip E. Wolfson

International Journal of Transpersonal Studies

Richard Yensen was a research fellow at the Maryland Psychiatric Research Center from 1972 to 1976. He studied psychedelic psychotherapy with Stanislav Grof, M.D. and other senior staff. During this time he treated patients with substance abuse disorders, cancer, neurosis, and other health professionals seeking a training experience. Dr. Yensen did his Ph.D. dissertation on the use of MDA in psychotherapy with neurotic outpatients and conducted his research at the MPRC. Through many years of experience in governmentsanctioned psychedelic research, he has evolved a non-drug shamanistic psychotherapy called Perceptual Affective Therapy. In the 1990’s Richard was co-holder of IND 3250, …

Improvements On Segment Based Contours Method For Dna Microarray Image Segmentation, Yang Li

Doctoral Dissertations

DNA microarray is an efficient biotechnology tool for scientists to measure the expression levels of large numbers of genes, simultaneously. To obtain the gene expression, microarray image analysis needs to be conducted. Microarray image segmentation is a fundamental step in the microarray analysis process. Segmentation gives the intensities of each probe spot in the array image, and those intensities are used to calculate the gene expression in subsequent analysis procedures. Therefore, more accurate and efficient microarray image segmentation methods are being pursued all the time.

In this dissertation, we are making efforts to obtain more accurate image segmentation results. We …

Discovery, July 2014, Office Of Vice President For Research

Research and Discovery News

• Discovery communities
• Discovery experts, July 31 deadline
• $1.4 million HHMI grant
• Sustainability award from second nature
• Diversity change initiative grant RFP
• $4 million for autism
• Facilities & administrative cost rates

Endothelial Progenitor Cells: From Senescence To Rejuvenation, Michael S. Goligorsky

NYMC Faculty Publications

Discovered more than 15 years ago, endothelial progenitor cells attract both basic and translational researchers. It has become clear that they represent a heterogeneous population of endothelial colony-forming cells, early or late outgrowth endothelial cells, or blood outgrowth endothelial cells, each characterized by differing proliferative and regenerative capacity. Scattered within the vascular wall, these cells participate in angiogenesis and vasculogenesis and support regeneration of epithelial cells. There is growing evidence that this cell population is impaired during the course of chronic cardiovascular and kidney disease when it undergoes premature senescence and loss of specialized functions. Senescence-associated secretory products released by …

Mass And Nutrient Loss In Decaying Hardwood Boles At Hubbard Brook, Chris E. Johnson

Civil and Environmental Engineering - All Scholarship

No abstract provided.

Safety Of Celecoxib And Nonselective Nonsteroidal Anti-Inflammatory Drugs In Juvenile Idiopathic Arthritis: Results Of The Phase 4 Registry, Rachel E. Sobel, Daniel J. Lovell, Hermine I. Brunner, Jennifer E. Weiss, Paula W. Morris, Beth S. Gottlieb, Elizabeth C. Chalom, Lawrence K. Jung, Karen B. Onel, Lisa Petiniot, Donald P. Goldsmith

Pediatrics Faculty Publications

Background

This study aimed to assess long-term safety and developmental data on juvenile idiopathic arthritis (JIA) patients treated in routine clinical practice with celecoxib or nonselective nonsteroidal anti-inflammatory drugs (nsNSAIDs).

Methods

Children aged ≥2 to <18 years with rheumatoid-factor–positive or –negative polyarthritis, persistent or extended oligoarthritis, or systemic arthritis were enrolled into this prospective, observational, multicenter standard-of-care registry. Eligible patients were newly or recently prescribed (≤6 months) an nsNSAID or celecoxib. Enrolled patients were followed to the end of the study, whether they remained on the original NSAID, switched, or discontinued therapy altogether. All adverse events (AEs) regardless of severity were captured in the database.

Results

A total of 274 patients (nsNSAID, n = 219; celecoxib, n = 55) were observed for 410 patient-years of observation. Naproxen, meloxicam, and nabumetone were the most frequently used nsNSAIDs. At baseline, the celecoxib group was older, had a numerically longer median time since diagnosis, and a numerically higher proportion of patients with a history of gastrointestinal-related NSAID intolerance. AEs reported were those frequently …

Ketamine—Its History, Uses, Pharmacology, Therapeutic Practice, And An Exploration Of Its Potential As A Novel Treatment For Depression, Philip E. Wolfson

International Journal of Transpersonal Studies

NA

Connections, July 2014, University Of Montana--Missoula. Mansfield Library

Connections

No abstract provided.

Near Real-Time Measurement Of Forces Applied By An Optical Trap To A Rigid Cylindrical Object, Joseph Glaser, David Hoeprich, Andrew Resnick

Physics Faculty Publications

An automated data acquisition and processing system is established to measure the force applied by an optical trap to an object of unknown composition in real time. Optical traps have been in use for the past 40 years to manipulate microscopic particles, but the magnitude of applied force is often unknown and requires extensive instrument characterization. Measuring or calculating the force applied by an optical trap to nonspherical particles presents additional difficulties which are also overcome with our system. Extensive experiments and measurements using well-characterized objects were performed to verify the system performance.

Granivory Of Invasive, Naturalized, And Native Plants In Communities Differentially Susceptible To Invasion, B. M. Connolly, Dean Pearson, R. N. Mack

Biological Sciences Faculty Publications

Seed predation is an important biotic filter that can influence abundance and spatial distributions of native species through differential effects on recruitment. This filter may also influence the relative abundance of nonnative plants within habitats and the communities’ susceptibility to invasion via differences in granivore identity, abundance, and food preference. We evaluated the effect of postdispersal seed predators on the establishment of invasive, naturalized, and native species within and between adjacent forest and steppe communities of eastern Washington, USA that differ in severity of plant invasion. Seed removal from trays placed within guild-specific exclosures revealed that small mammals were the …

Morphological Variability In Tree Root Architecture Indirectly Affects Coexistence Among Competitors In The Understory, Erik T. Aschehoug, Ragan M. Callaway

Biological Sciences Faculty Publications

Interactions between plants can have strong effects on community structure and function. Variability in the morphological, developmental, physiological, and biochemical traits of plants can influence the outcome of plant interactions and thus have important ecological consequences. However, the ecological ramifications of trait variability in plants are poorly understood and have rarely been tested in the field. We experimentally tested the effects of morphological variation in root architecture of Quercus douglasii trees in the field on interactions between understory plants and community composition. Our results indicate that variability among Q. douglasii tree root systems initiates a striking reversal in the competitive …

Marginalia No. 35, Merrill-Cazier Library

Marginalia

Marginalia no.35 Summer 2014

Happy Trails... Farewell to Richard W. Clement, Dean of Libraries at USU

17^th Annual May Swenson Poetry Award goes to Luisa A. Igloria

2013 Arrington Writing Award Winners: Scott Marianno, Chad Nielsen, and Joshua Hortin

Merrill Cazier Faculty Award goes to Patricia Moyer-Packenham

Library Service Award to USU’s Composition Program

Friends Spring Lecture: Students and the Art of Research by Prof. Leonard Rosenband

10^th Annual Research Week: Library hosts lectures, symposia, workshops, and receptions

“Goodbye, she said. I’m off to join the Gypsies” … Ann Buttars (Special Collections & Archives) and Cheryl Walters (Head …

College Of Arts And Sciences E-News Issue 15: July 2014, College Of Arts And Sciences

College of Arts and Sciences news

• WMU to receive $4 million to boost autism research and training
• Dr. Keith Hearit named new CAS associate dean
• Twenty-two CAS faculty celebrated during Board of Trustees luncheon
• Sean Laraway '03 wins Teaching Excellence Award from San Jose State University
• Bob Hercules '79 producing and co-directoring documentary on Maya Angelou
• Koty Neelis '11 goes viral with her top ten lists
• PhD student, Becky Straples named editor of The Hilltop Review
• Mallinson Institute for Science Education international students share their experiences

‘No One Should Destroy The Forest': Using Photo-Based Vignette Interviews To Understand Kenyan Teachers' Views Of The Environment, Cassie Quigley, Zachary D. Miller, James Dogbey, S Megan Che, Jeffrey Hallo

Publications

In the midst of the current environmental crisis, scientists, academics, authors, and politicians worldwide are urging citizens to create sustainable communities. However, there is little capability to build a sustainable society without an informed, active, and engaged populous. This requires more than just environmentally knowledgeable citizens. It requires a society that understands the principles of the environment and can also exemplify them in daily life. In order to create a more environmentally literate world, there has been a push for environmental education integrated into schools. This qualitative study sought to examine Kenyan teachers’ perspectives on the human–nature interaction by conducting …

Ua77/1 Wku Spirit, Wku Alumni Relations

WKU Administration Documents

WKU's alumni magazine. Contents:

• Ransdell, Gary. President’s Letter
• Downing University Center
• All 4 WKU Nominees Recognized by Goldwater Scholarship Program
• Michael McClellan Named Diplomat-in-Residence at WKU
• WKU Meteorology Major Awarded Internship with NASA Program – Victoria Hampton
• WKU Youth in Government Chapter Honored at National Assembly
• WKU Ties for 2^nd in Overall Hearst Competition
• WKU Earns Tree Campus USA Recognition for 4^th Straight Year
• WKU Forensics Team Sweeps Major Championships
• 2013 Talisman Wins Gold Crown
• Record 6 WKU Students Awarded Critical Language Scholarships
• Gift Supports Nursing & Honors Life of Bowling Green Nurse – Helen Turner
• Farhad Ashrafzadeh …

Targeting The Extracellular Matrix: Matricellular Proteins Regulate Cell-Extracellular Matrix Communication Within Distinct Niches Of The Intervertebral Disc, Jake Bedore, Andrew Leask, Cheryle A. Séguin

Paediatrics Publications

The so-called "matricellular" proteins have recently emerged as important regulators of cell-extracellular matrix (ECM) interactions. These proteins modulate a variety of cell functions through a range of interactions with cell-surface receptors, hormones, proteases and structural components of the ECM. As such, matricellular proteins are crucial regulators of cell phenotype, and consequently tissue function. The distinct cell types and microenvironments that together form the IVD provide an excellent paradigm to study how matricellular proteins mediate communication within and between adjacent tissue types. In recent years, the role of several matricellular proteins in the intervertebral disc has been explored in vivo using …