Digital Commons Network^™

Can Simple Rules Control Development Of A Pioneer Vertebrate Neuronal Network Generating Behavior?, A Roberts, D Conte, M Hull, R Merrison-Hort, Et Al

School of Engineering, Computing and Mathematics

How do the pioneer networks in the axial core of the vertebrate nervous system first develop? Fundamental to understanding any full-scale neuronal network is knowledge of the constituent neurons, their properties, synaptic interconnections, and normal activity. Our novel strategy uses basic developmental rules to generate model networks that retain individual neuron and synapse resolution and are capable of reproducing correct, whole animal responses. We apply our developmental strategy to young Xenopus tadpoles, whose brainstem and spinal cord share a core vertebrate plan, but at a tractable complexity. Following detailed anatomical and physiological measurements to complete a descriptive library of each …

Health Law And Policy In The News, Jake Harper, Krista Maier, Kristen Tullia, Gary Norman

Health Law and Policy Brief

No abstract provided.

Application Of H And G Indices To Quantify Scientific Productivity Of Physicists At Jnu, India, Manisha Singh, Shailendra Kumar

Library Philosophy and Practice (e-journal)

The study aims to quantify the scientific productivity of Physicists using Scientometric h-index and g-index indicators. Paper also identifies that h and g are complementary to each other and g ≥h (1.5 times of h). The most productive and highly cited physicists and their average citation per item at JNU are identified. Also the study enlists the best ten high impact papers published during 2007-2011. Questionnaire was used to know research papers published (2007-2011) by the physicists at JNU. These papers were cross checked for originality, accuracy and completeness from web of science, Scopus, and by visiting journals online. Quantification …

A Scientometric Analysis Of Global Forensic Science Research Publications, John Jeyasekar Jesubright, Saravanan P Dr.

Library Philosophy and Practice (e-journal)

A scientometric study of forensic science literature from the year 1975 to 2011 is carried out to find out the growth in forensic science literature, authors’ productivity, the top ranking source journal and the country-wise productivity. The data for the study is obtained from the SCOPUS database. The 13626 number of results retrieved are analysed using excel worksheets. Google Scholar database is used as a data source for citation analysis of the authors who are found highly productive in the SCOPUS data. Publish or Perish (PoP) software is used for the citation analysis. It is found forensic science literature has …

Control Of Ltr Transcription By Swi/Snf Baf And Pbaf Complexes, Irene Guendel, Rachel Van Duyne, Fatah Kashanchi

Microbiology, Immunology, and Tropical Medicine Posters and Presentations

No abstract provided.

Fall 2013 Registration And Revenue Analysis - Excluding Law, University Of Southern Maine

Direction Package

No abstract provided.

A Unique Covalent Bond In Basement Membrane Is A Primordial Innovation For Tissue Evolution, Aaron L. Fidler, Roberto M. Vanacore, Sergei V. Chetyrkin, Vadim K. Pedchenko, Gautam Bhave, Viravuth P. Yin, Cody L. Stothers, Kristie Lindsey Rose, W. Hayes Mcdonald, Travis A. Clark, Dorin-Bogdan Borza, Robert E. Steele, Michael T. Ivy, The Aspirnauts, Julie K. Hudson, Billy G. Hudson

Biology Faculty Research

We recently discovered that the collagen IV scaffolds of bovine, mouse, and Drosophila melanogaster tissues are stabilized by sulfilimine chemical bonds (S = N) (20⇓–22). The bond is a covalent cross-link between methionine-93 (Met93) and lysine-211 or hydroxylysine-211 (Lys211/Hyl211) residues that stabilizes the noncollagenous (NC1) interface of adjoining triple helical protomers (Fig. 1A). Peroxidasin, an animal heme peroxidase embedded in basement membrane, forms these sulfilimine cross-links by producing hypohalous acids as intermediates for Met93 oxidization (21, 22). Here, we explored whether the sulfilimine cross-link of collagen IV is a fundamental requirement in the genesis and evolution of tissues in Eumetazoa. …

The Utah Statesman, January 7, 2014, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Redox Pioneer: Professor Joe M. Mccord, David M. Schnell, Daret K. St Clair

Graduate Center for Nutritional Sciences Faculty Publications

Dr. Joe McCord (Ph.D. 1970) is recognized here as a Redox Pioneer because he has published at least three articles on antioxidant/redox biology as first/last author that have been cited over 1000 times and has published at least 37 articles each cited over 100 times. Dr. McCord is known for the monumental discovery of the antioxidant superoxide dismutase (SOD) while a graduate student under fellow redox pioneer Irwin Fridovich and demonstrating its necessity to aerobic life. Beyond this, McCord's career is distinguished for bridging the gap from basic science to clinical relevance by showing the application of SOD and superoxide …

Compositions Including Triciribine And Trastuzumab And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti

USF Patents

This application relates to combination therapies including triciribine and related compounds and trastuzumab or a salt thereof and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

Volume Exclusion Agent To Enhance Formation Of Extracellular Matrix, David E. Birk, John Hassell, Bradley Kane, La Tia Etheredge

USF Patents

A method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert procollagen to collagen. In contrast, normal extracellular matrix deposition involves procollagen processing to collagen, fibril assembly and deposition into the cell layer to form a collagenous extracellular matrix. The addition of certain growth factors and the addition of a thin layer of a certain volume exclusion agent on top of the cells dramatically enhances the conversion of procollagen to collagen and will increase the amount of collagen and extracellular …

Materials And Methods For Treatment Of Respiratory Allergic Diseases, Shyam S. Mohapatra

USF Patents

The present invention pertains to a method for treatment of allergic diseases by administering a natriuretic hormone peptide (NHP), or a nucleic acid sequence encoding NHP, to a patient in need thereof. In another aspect, the present invention concerns an expression vector comprising a nucleic acid sequence encoding NHP. In another aspect, the present invention concerns a host cell genetically modified with a nucleic acid sequence encoding NHP. In another aspect, the present invention concerns a pharmaceutical composition comprising NHP or a nucleic acid sequence encoding NHP and a pharmaceutically acceptable carrier. In another aspect, the present invention pertains to …

Redox-Dependent Stability, Protonation, And Reactivity Of Cysteine-Bound Heme Proteins, Fangfang Zhong, George P. Lisi, Daniel P. Collins, John H. Dawson, Ekaterina V. Pletneva

Dartmouth Scholarship

Cysteine-bound hemes are key components of many enzymes and biological sensors. Protonation (deprotonation) of the Cys ligand often accompanies redox transformations of these centers. To characterize these phenomena, we have engineered a series of Thr78Cys/Lys79Gly/Met80X mutants of yeast cytochrome c (cyt c) in which Cys78 becomes one of the axial ligands to the heme. At neutral pH, the protonation state of the coordinated Cys differs for the ferric and ferrous heme species, with Cys binding as a thiolate and a thiol, respectively. Analysis of redox-dependent stability and alkaline transitions of these model proteins, as well as comparisons to Cys …

Children's Eyewitness Memory: The Influence Of Cognitive And Socio-Emotional Factors , Gail S. Goodman, Deborah A. Goldfarb, Jia Y. Chong, Lauren Goodman-Shaver

Roger Williams University Law Review

No abstract provided.

A Life History Perspective On Skin Cancer And The Evolution Of Skin Pigmentation, Daniel L. Osborne, Raymond B. Hames

Department of Anthropology: Faculty Publications

The ancestral state of human skin pigmentation evolved in response to high ultraviolet radiation (UVR) stress. Some argue that pigmentation evolved to limit folate photolysis, therein limiting neural tube defects. Pigmentation also protects against sunburn which decreases the efficiency of sweating and potentiates skin infection. Pigmentation increases the efficacy of skin as a barrier to infection. Skin cancer has been rejected or minimized as a selective pressure because it is believed to have little or no effect on mortality during reproductive years. This argument ignores evidence of human longevity as a derived life history trait and the adaptive value of …

Strengthening Forensic Alcohol Analysis In California Dui Cases: A Prosecutor's Perspective, Christopher Boscia

Santa Clara Law Review

No abstract provided.

Seeking To Emerge From Slavery's Long Shadow: The Interplay Of Tribal Sovereignty And Federal Oversight In The Context Of The Recent Disenrollment Of The Cherokee Freedmen, Sepideh Mousakhani

Santa Clara Law Review

No abstract provided.

Denying A Class Of Adopted Children Equal Protection, Katherine A. West

Santa Clara Law Review

No abstract provided.

N-Substituted 5-Amino-6-Methylpyrazine-2,3-Dicarbonitriles: Microwave-Assisted Synthesis And Biological Properties, Aidan Coffey, Jiahui Guo, Et. Al.

Department of Biological Sciences Publications

In this work a series of 15 N-benzylamine substituted 5-amino-6-methyl-pyrazine-2,3-dicarbonitriles was prepared by the aminodehalogenation reactions using microwave assisted synthesis with experimentally set and proven conditions. This approach for the aminodehalogenation reaction was chosen due to its higher yields and shorter reaction times. The products of this reaction were characterized by IR, NMR and other analytical data. The compounds were evaluated for their antibacterial, antifungal and herbicidal activity. Compounds 3 (R = 3,4-Cl), 9 (R = 2-Cl) and 11 (R = 4-CF3) showed good antimycobacterial activity against Mycobacterium tuberculosis (MIC = 6.25 µg/mL). It was found that the lipophilicity is …

Executive Committee - Agenda, 1/7/2014, Academic Senate

Academic Senate Agendas

No abstract provided.

Light And Affects From A Comparative Point Of View, Kyle Takaki

Comparative Philosophy

Light metaphors occurring in Chinese philosophy and Stoicism are of special interest for the unique ways they channel potentialities of the self. In this paper I apply ideas from cognitive linguistics to examine selected structural features of these metaphors. I also build on these ideas by presenting a framework regarding affects to assist in disclosing what is at stake for differing Chinese and Stoic technologies of the self. The paper adopts a high-level perspective to see these broad philosophical implications, interleaving discussions of Chinese philosophy (mainly views associated with Daoism), Stoicism (bringing into relief important differences from these views), and …

Measurement Issues With Couple-And Family-Level Data, Dean M. Busby, Franklin O. Poulsen

Faculty Publications

Early in my (D.B.) training as a family therapist, I did some co-therapy with a clinical psychology student who wanted to learn how to work with couples. The couple we were working with was quite volatile, and it was not uncommon for the dialogue between the spouses to get heated. While it was challenging enough to keep the interactions between the partners moving in a productive direction, my co-therapist was quite uncomfortable with conflict and would emotionally "check out" of the session as soon as things became intense. Each time a session was challenging and conflict became intense, my co-therapist …

Counselor Confirmation Bias: Can The Internet Serve As A Debiasing Tool?, George Gharibian Gharghani

Electronic Theses and Dissertations Archive

Among laymen and professionals the growing use of the Internet for easy access to information to make decisions has made it important to examine how this easy access could impact the decision making processes. More specifically this research study examined the impact of easy access to the information through the Internet on counselors’ tendency to preferentially note confirmatory information when testing a client hypothesis.In this study 31 participants from master’s and doctoral level counseling programs were asked to select pieces of information from a client narrative that they felt were important in testing a particular client hypothesis. Since participants in …

The Anti-Tumor Histone Deacetylase Inhibitor Saha And The Natural Flavonoid Curcumin Exhibit Synergistic Neuroprotection Against Amyloid-Beta Toxicity, Jia Meng, Yan Li, Cynthia Camarillo, Yue Yao, Yina Zhang, Chun Xu, Lihong Jiang

Health & Biomedical Sciences Faculty Publications

With the trend of an increasing aged population worldwide, Alzheimer’s disease (AD), an age-related neurodegenerative disorder, as one of the major causes of dementia in elderly people is of growing concern. Despite the many hard efforts attempted during the past several decades in trying to elucidate the pathological mechanisms underlying AD and putting forward potential therapeutic strategies, there is still a lack of effective treatments for AD. The efficacy of many potential therapeutic drugs for AD is of main concern in clinical practice. For example, large bodies of evidence show that the antitumor histone deacetylase (HDAC) inhibitor, suberoylanilidehydroxamic acid (SAHA), …

The Emerging Role Of Oxylipins In Thrombosis And Diabetes., Benjamin E Tourdot, Intekhab Ahmed, Michael Holinstat

Division of Endocrinology, Diabetes and Metabolic Diseases Faculty Papers

The prevalence of cardiovascular disease (CVD), the leading cause of death in the US, is predicted to increase due to the shift in age of the general population and increase in CVD risk factors such as obesity and diabetes. New therapies are required to decrease the prevalence of CVD risk factors (obesity and diabetes) as well as reduce atherothrombosis, the major cause of CVD related mortality. Oxylipins, bioactive metabolites derived from the oxygenation of polyunsaturated fatty acids, play a role in the progression of CVD risk factors and thrombosis. Aspirin, a cyclooxygenase-1 inhibitor, decreases atherothrombotic associated mortality by 25%. These …

Investigation And Characterization Of Pt-Modified Au Catalysts And Polymer Composites By Electrochemistry, Raman And Surface Enhanced Raman Spectroscopy (Sers), Ranjani Muralidharan

USF Tampa Graduate Theses and Dissertations

This dissertation thesis consists of six chapters. The main focus of this study is the need for understanding the reaction mechanism and intermediates formed on Pt-modified Au surface as anode catalysts in the formic acid fuel cells. Chapter 1 gives an introduction to formic acid and methanol fuel cells, an overview of the current catalysts employed at the anode of the fuel cells, specifically the Pt-modified Au electrodes as potential catalysts and the different deposition methods for preparing this catalytic surface. Information about different electrochemical methods used like cyclic voltammetry and potential step method along with other characterization methods and …

A Field Guide To Genomics Research, Andrea H. Bild, Jeffrey T. Chang, W. Evan Johnson, Stephen R. Piccolo

Faculty Publications

High-throughput technologies are enabling scientists to profile genomes, transcriptomes, proteomes, and metabolomes at an unprecedented scale [1]. All this “-omics” research (let's call it genomics for simplicity) is exciting—and game changing—but it's also fraught with dangers for the tenderfoot. Here, we've put together a brief “field guide” for those wishing to visit the genomics frontier, in which we use caricatures to illustrate various pitfalls that can beset those who inhabit this new territory. By documenting the behaviors of these common types, we hope to guide researchers in their quest to apply sound practices when designing genomics experiments and analyzing …

2matrix: A Utility For Indel Coding And Phylogenetic Matrix Concatenation, Nelson R. Salinas, Damon P. Little

Publications and Research

Premise of the study: Phylogenetic analysis of DNA and amino acid sequences requires the creation of files formatted specifically for each analysis package. Programs currently available cannot simultaneously code inferred insertion/deletion (indel) events in sequence alignments and concatenate data sets.

Methods and Results: A novel Perl script, 2matrix, was created to concatenate matrices of non-molecular characters and/or aligned sequences and to code indels. 2matrix outputs a variety of formats compatible with popular phylogenetic programs.

Conclusions: 2matrix efficiently codes indels and concatenates matrices of sequences and non-molecular data. It is available for free download under a GPL (General Public License) open …

2014-01-06 Bio 498 Teaching Practicum In Biological Sciences, Michael Cerbo

Library Impact Statements

This is the Library Impact Statement for BIO 498 Teaching Practicum in Biological Sciences. No new library resources are need to support this course.

Renal Recovery, Stuart L. Goldstein, Lakhmir S. Chawla, Claudio Ronco, John A. Kellum

Anesthesiology and Critical Care Medicine Faculty Publications

Acute kidney injury (AKI) research in the past decade has mostly focused upon development of a standard AKI definition, validation of early novel biomarkers to predict AKI prior to serum creatinine rise and predict AKI severity, and assessment of aspects of renal replacement therapies and their impact on survival. Given the independent association between AKI and mortality in the acute phase, such focus makes imminent sense. More recently, the recognition that AKI is associated with subsequent development of chronic kidney disease and end-stage renal disease, with the attendant increase in mortality, has led to interest in the clinical epidemiology and …