Digital Commons Network^™

Methods And Matrices: Approaches To Identifying Mirnas For Nasopharyngeal Carcinoma, Jordan L. Plieskatt, Gabriel Rinaldi, Yanjung Feng, Paul H. Levine, Samantha Easley, Elizabeth Martinez, Salman Hashmi, Nader Sadeghi, Paul J. Brindley, Jeffrey M. Bethony, Jason Mulvenna

Microbiology, Immunology, and Tropical Medicine Faculty Publications

We tested two miRNA discovery workflows on two sample sources for miRNAs associated with NPC. In the first workflow, we assumed that NPC tumor tissue would be enriched for miRNAs, so we compared miRNA expression in FFPE from NPC cases and controls using microarray and RNA-Seq technologies. Candidate miRNAs from both technologies were verified by qPCR in FFPE and sera from an independent NPC sample set. In a second workflow, we directly interrogated NPC case and control sera by RNA-Seq for c-miRNAs associated with NPC, with candidate c-miRNAs verified by qPCR in the sera from the same independent NPC sample …

Value Associations Of Emotional Faces Can Modify The Anger Superiority Effect: Behavioral And Electrophysiological Evidence, Shuxia Yao, Cody Ding, Senqing Qi, Dong Yang

Education Sciences and Professional Programs Faculty Works

Although several paradigms have shown that threatening faces are processed preferentially, no study to date has investigated whether this preferential processing can be manipulated by value associations. Using schematic faces, this study was divided into three phases in order to investigate the effects of associating high values with happy faces and low values with angry faces. The baseline phase, in which elicited a shorter RT and a larger N2pc for angry faces than for happy faces, demonstrated that the preferential processing of angry faces could be obtained in the discrimination task. After the training phase, which established associations between different …

Faculty Senate Agenda, January 6, 2014, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Council on Teacher Education Annual Report -Francine Johnson
• EPC Items for December –Larry Smith
• Code Revision Process, Policy Manual 202
• Updates of code revision to 405.12 Post-Tenure Review Process
• PRPC Section 402.4.3 changes to wording in FS meeting order of business(Second Reading) - Stephen Bialkowski
• PRPC Section 405.6.1 changes to wording in role statement and role assignment(Second Reading) - Stephen Bialkowski
• PRPC word changes from ASUSU to USUSA to 400 all sections(Second Reading) - Stephen Bialkowski
• PRPC Section 402.12.5(1) addition of sentence referring to policies in Section 202(First Reading) - Stephen Bialkowski

Year In Review: Gardner-Webb University’S Top 13 Stories Of 2013, Office Of University Communications

Gardner-Webb NewsCenter Archive

With the dawn of a new year at hand, the year 2013 has quietly slipped into the annals of history. Many important events and milestones helped make 2013 a year that will not be quickly forgotten. In an effort to offer a tribute to 2013, we have assembled a list of the top 13 stories (and a few notable honorable mentions) within the University this past year.

Energy Input Is Primary Controller Of Methane Bubbling In Subarctic Lakes, Martin Wik, Brett F. Thornton, David Bastviken, Sally Macintyre, Ruth K. Varner, Patrick M. Crill

Faculty Publications

Emission of methane (CH4) from surface waters is often dominated by ebullition (bubbling), a transport mode with high‐spatiotemporal variability. Based on new and extensive CH4 ebullition data, we demonstrate striking correlations (r2 between 0.92 and 0.997) when comparing seasonal bubble CH4 flux from three shallow subarctic lakes to four readily measurable proxies of incoming energy flux and daily flux magnitudes to surface sediment temperature (r2 between 0.86 and 0.94). Our results after continuous multiyear sampling suggest that CH4 ebullition is a predictable process, and that heat flux into the lakes is the dominant driver of gas production and release. Future …

The Role Of Bioactive Lipids In Stem Cell Mobilization And Homing: Novel Therapeutics For Myocardial Ischemia, Yuri M. Klyachkin, Anush V. Karapetyan, Mariusz Z. Ratajczak, Ahmed Abdel-Latif

Saha Cardiovascular Research Center Faculty Publications

Despite significant advances in medical therapy and interventional strategies, the prognosis of millions of patients with acute myocardial infarction (AMI) and ischemic heart disease (IHD) remains poor. Currently, short of heart transplantation with all of its inherit limitations, there are no available treatment strategies that replace the infarcted myocardium. It is now well established that cardiomyocytes undergo continuous renewal, with contribution from bone marrow (BM)-derived stem/progenitor cells (SPCs). This phenomenon is upregulated during AMI by initiating multiple innate reparatory mechanisms through which BMSPCs are mobilized towards the ischemic myocardium and contribute to myocardial regeneration. While a role for the SDF-1/CXCR4 …

The Psychology Of Judicial Betrayal, Carly P. Smith, Jennifer M. Gomez, Jennifer J. Freyd

Roger Williams University Law Review

No abstract provided.

Transcriptional Analysis Of Reciprocal Tumor-Microenvironment Interactions In Glioblastoma, Michael Brooks

All Theses and Dissertations (ETDs)

In the last twenty years both computational biology and cancer biology have made great strides and in the last 5 years the merger of the two has helped to revolutionize our knowledge of personalized targeted therapy and the diversity of cancer. In cancer, cell-to-cell interactions between tumor cells and their microenvironment are critical determinants of tumor tissue biology and therapeutic responses. Interactions between glioblastoma (GBM) cells and endothelial cells (ECs) establish a purported stem cell niche. We hypothesized that genes that mediate these interactions would be important, particularly as therapeutic targets. Using a novel computational approach to deconvoluting expression data …

Spatial Frequency Analysis Of Anisotropic Drug Transport In Tumor Samples, Stewart Russell, Kimberley S. Samkoe, Jason R. Gunn, P Jack Hoopes, Thienan A. Nguyen, Milo J. Russell, Robert R. Alfano, Brian W. Pogue

Dartmouth Scholarship

Directional Fourier spatial frequency analysis was used on standard histological sections to identify salient directional bias in the spatial frequencies of stromal and epithelial patterns within tumor tissue. This directional bias is shown to be correlated to the pathway of reduced fluorescent tracer transport. Optical images of tumor specimens contain a complex distribution of randomly oriented aperiodic features used for neoplastic grading that varies with tumor type, size, and morphology. The internal organization of these patterns in frequency space is shown to provide a precise fingerprint of the extracellular matrix complexity, which is well known to be related to the …

The Mammalian Neocortex New Pyramidal Neuron: A New Conception, Miguel Marín-Padilla

Dartmouth Scholarship

The new cerebral cortex (neocortex) and the new type of pyramidal neuron are mammalian innovations that have evolved for operating their increasing motor capabilities while essentially using analogous anatomical and neural makeups. The human neocortex starts to develop in 6-week-old embryos with the establishment of a primordial cortical organization, which resembles the primitive cortices of amphibian and reptiles. From the 8th to the 15th week of age, new pyramidal neurons, of ependymal origin, are progressively incorporated within this primordial cortex forming a cellular plate that divides its components into those above it (neocortex first layer) and those below it (neocortex …

Comparison Of Antibodies That Mediate Hiv Type 1 Gp120 Antibody-Dependent Cell-Mediated Cytotoxicity In Asymptomatic Hiv Type 1-Positive Men And Women, Mariana M. Mata, Joyce R. Iwema, Shanna Dell, Leslie Neems, Beth D. Jamieson, John Phair, Mardge H. Cohen, Kathryn Anastos, Linda L. Baum

Open Access Publications

No abstract provided.

Collisional Dynamic Elements Of The Pyrazine - N2o System:Middle And Low J States, La Moyne Tyler Mix

Theses and Dissertations

Unimolecular reactions based on the Lindemann - Hinchelwood mechanism are important to understanding combustion and atmospheric processes. The main feature of this mechanism is the energy transfer probability distribution function, P(E',E). We have chosen to study P(E',E) through gas phase collisional dynamics probed with IR transient absorption spectroscopy. Post-collision absorption line widths for the pyrazine-N2O system are used to calculate lab frame translational temperatures. The translational temperatures reveal that collisions with large rotational energy transfer also transfer large amounts of translational energy. For J states >47 the relationship is linear indicating a constant impact parameter. Line widths for J=47 through …

Soluble Apoe/Aβ Complex: Mechanism And Therapeutic Target For Apoe4-Induced Ad Risk, Leon M. Tai, Shipra Mehra, Varsha Shete, Steven Estus, G. William Rebeck, Guojun Bu, Mary Jo Ladu

Sanders-Brown Center on Aging Faculty Publications

The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for Alzheimer's disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a soluble oligomeric form (oAβ), is considered a proximal cause of neurodegeneration in AD. Emerging data indicate that levels of soluble oAβ are increased with APOE4, providing a potential mechanism of APOE4-induced AD risk. However, the pathway(s) by which apoE4 may increase oAβ levels are unclear and the subject of continued inquiry. In this editorial review, we present the hypothesis that apoE isoform-specific interactions with Aβ, namely apoE/Aβ complex, modulate Aβ levels. Specifically, we …

Metabotropic Glutamate Receptor-1 Contributes To Progression In Triple Negative Breast Cancer, Malathi Banda, Cecilia L. Speyer, Sara N. Semma, Kingsley O. Osuala, Nicole Kounalakis, Keila E. Torres Torres, Nicola J. Barnard, Hyunjin J. Kim, Bonnie F. Sloane, Fred R. Miller, James S. Goydos, David H. Gorski

Department of Surgery

TNBC is an aggressive breast cancer subtype that does not express hormone receptors (estrogen and progesterone receptors, ER and PR) or amplified human epidermal growth factor receptor type 2 (HER2), and there currently exist no targeted therapies effective against it. Consequently, finding new molecular targets in triple negative breast cancer (TNBC) is critical to improving patient outcomes. Previously, we have detected the expression of metabotropic glutamate receptor-1 (gene: GRM1; protein: mGluR1) in TNBC and observed that targeting glutamatergic signaling inhibits TNBC growth both in vitro and in vivo. In this study, we explored how mGluR1 contributes to TNBC …

Traversing Swanton Road, 14th Ed., James A. West

Academic, Government & Associated Organizational Research Resources

Situated at the northwest end of Santa Cruz County and occupying circa 30 square miles of sharply contrasted terrain, the Scott Creek Watershed concentrates within its geomorphological boundaries, at least 10-12% of California's flora, both native and introduced. Paradoxically, the use/abuse that the watershed has sustained over the past 140+ years, has not necessarily diminished the biodiversity and perhaps parallels the naturally disruptive but biologically energizing processes (fire, flooding, landslides and erosion), which have also been historically documented for the area for +60 years. This is an early edition of an extensive document by James A. West. Please visit the …

Sjsu Erfa News, Summer 2014, San Jose State University, Emeritus And Retired Faculty Association

Emeritus and Retired Faculty Association (ERFA) Newsletter

Volume 28, Number 1

Understanding The Mechanism Of Glucose-Induced Relief Of Rgt1-Mediated Repression In Yeast, Adhiraj Roy, David Jouandot, Kyu Hong Cho, Jeong-Ho Kim

Biochemistry and Molecular Medicine Faculty Publications

The yeast Rgt1 repressor inhibits transcription of the glucose transporter (HXT) genes in the absence of glucose. It does so by recruiting the general corepressor complex Ssn6-Tup1 and the HXT corepressor Mth1. In the presence of glucose, Rgt1 is phosphorylated by the cAMP-activated protein kinase A (PKA) and dissociates from the HXT promoters, resulting in expression of HXT genes. In this study, using Rgt1 chimeras that bind DNA constitutively, we investigate how glucose regulates Rgt1 function. Our results show that the DNA-bound Rgt1 constructs repress expression of the HXT1 gene in conjunction with Ssn6-Tup1 and Mth1, and that …

Citizen Litigants Citizen Regulators: Four Cases Where Citizen Suits Drove Development Of Clean Water Law, Karl S. Coplan

Colorado Environmental Law Journal

No abstract provided.

Biomechanical Model For Evaluation Of Pediatric Upper Extremity Joint Dynamics During Wheelchair Mobility, Alyssa J. Schnorenberg, Brooke A. Slavens, Mei Wang, Lawrence Vogel, Peter Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Pediatric manual wheelchair users (MWU) require high joint demands on their upper extremity (UE) during wheelchair mobility, leading them to be at risk of developing pain and pathology. Studies have examined UE biomechanics during wheelchair mobility in the adult population; however, current methods for evaluating UE joint dynamics of pediatric MWU are limited. An inverse dynamics model is proposed to characterize three-dimensional UE joint kinematics and kinetics during pediatric wheelchair mobility using a SmartWheel instrumented handrim system. The bilateral model comprises thorax, clavicle, scapula, upper arm, forearm, and hand segments and includes the sternoclavicular, acromioclavicular, glenohumeral, elbow and wrist joints. …

The Inclusive Dynamics Of Islamic Universalism: From The Vantage Point Of Sayyid Qutb's Critical Philosophy, Andrea Mura

Comparative Philosophy

This article pursues a topological reading of Milestones, one of the most influential books in the history of Islamism. Written by Muslim thinker Sayyid Qutb, the general interest in this crucial text has largely remained restricted to the fields of Islamic Studies and Security Studies. This article aims to make the case for assuming a philosophical standpoint, relocating its significance beyond the above-mentioned fields. A creative and topological reading of this text will allow the spatial complexity of Qutb’s eschatological vision to be fully exposed, while also unpacking the way in which antagonistic relations have variously been articulated by this …

Money, Meet Mouth: The Era Of Regulation And Prescription Drug Importation/Reimportation, Aaron James Wong

Health Law and Policy Brief

No abstract provided.

Reexamining Models On Disability And Applying Rationality, Morality, And Ethics To Support Disability Rights In Context Of Genetics, Gary C. C. Norman

Health Law and Policy Brief

No abstract provided.

Parts Of The Whole: Only Connect, Dorothy Wallace

Numeracy

This is the first of several columns that will focus on the mechanisms by which new ideas become accepted by a culture, offering some familiar examples, deriving basic principles from these examples, and applying them to the problem of promoting quantitative literacy in an educational system. In this essay we describe how new concepts become embedded in a culture through their connections to existing ideas, and use this principle to suggest strategies of discourse about numeracy that promote it among various constituencies in the culture.

Sjsu Erfa News, Fall 2014, San Jose State University, Emeritus And Retired Faculty Association

Emeritus and Retired Faculty Association (ERFA) Newsletter

Volume 28, Number 2

Mcb Seminar | Martin Schmerr Invited Guest Seminar, Feb 18, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Philosophy Of Science Why Genetics Succeeds An Epistemology Of Scientific Practice, Feb 21, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Seminar | The Virtual Pig Head As A Teaching Resource In 200 300 400 Level Courses, Feb 21, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Federal Wild Lands Policy In The Twenty-First Century: What A Long, Strange Trip It's Been, Michael C. Blumm, Andrew B. Erickson

Colorado Environmental Law Journal

No abstract provided.

Pbio Colloquium | Integrated Omics Approach To Harness Natural Variation Underlying Complex Traits In Maize, Feb 7, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Science Café | Endangered Species Of Amphibians Why Their Survival Is Vital To Our Health, Feb 19, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.