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Articles 16051 - 16080 of 817988
Full-Text Articles in Entire DC Network
Nuestro Testimonio: The Experiences And Testimonios Of Early-Career World Language Educators In An Urban High School, Bonny Guadalupe
Nuestro Testimonio: The Experiences And Testimonios Of Early-Career World Language Educators In An Urban High School, Bonny Guadalupe
Theses and Dissertations
Research shows that teaching Spanish language and culture often reinforces biases, stereotypes, and suffers from limited economic and institutional support (Avendaño, 1979; Carter, 2014; Heredia & Altarriba, 2001; Potowski, 2002; Quan, 2021; Randolph Jr., 2017). These challenges restrict the social and academic mobility of Spanish-speaking students, especially in urban areas like New York City. This qualitative narrative inquiry addresses two questions: how do early-career high school World Language educators decolonize the AP Spanish Language and Culture curriculum, and how does engagement in Sealy-Ruiz’s Archeology of Self framework influence their teaching? The study examines the intersections of personal identity, professional growth, …
Using High Speed Kinematics To Investigate Kinematic Variation Across Populations Of Astyanax Mexicanus, Agniva Sinha
Using High Speed Kinematics To Investigate Kinematic Variation Across Populations Of Astyanax Mexicanus, Agniva Sinha
Theses and Dissertations
Kinematic analysis pipelines now provide temporal and geometric resolution for determining a variety of body movement. These machine-learning trained programs allow behavioral neuroscientists to dissect complex behaviors and relate changes in those movements to conserved neural assemblages. These analyses are common in model organisms, but a lack of ethologically driven kinematic work in non-models has hampered our understanding of how evolution shapes behavior through sensorimotor circuits. Astyanax Mexicanus is a unique model organism that allows us to understand how evolutionary divergence as a result of adaptation to environmental conditions leads to genotypic and associated phenotypic changes in brain development and …
The Relation Between Referral Source And Completion Of Trauma-Specific Assessment And Therapy In A Community-Based Training Clinic, Olivia Fiallo
The Relation Between Referral Source And Completion Of Trauma-Specific Assessment And Therapy In A Community-Based Training Clinic, Olivia Fiallo
Theses and Dissertations
In the United States, more than 60% of youth experience at least one trauma by age 16, and about one-third develop a trauma-related disorder. Evidence-based trauma-specific cognitive behavioral therapies (TS-CBTs) exist, yet fewer than 20% of trauma-exposed youth receive trauma-focused treatment, with dropout rates as high as 75% after treatment initiation. Referral sources are gatekeepers to TS-CBTs and may be a key system-level factor shaping barriers to starting and staying in treatment. This study examined whether referral source was associated with entry into and completion of a full TS-CBT service delivery pathway in a community-based trauma clinic. Participants were 346 …
Beliefs And Recommendations Of Parents And Teachers For Internalizing Vs. Externalizing Disorders: A Thematic Analysis, Kyle Macdonald
Beliefs And Recommendations Of Parents And Teachers For Internalizing Vs. Externalizing Disorders: A Thematic Analysis, Kyle Macdonald
Theses and Dissertations
The prevalence of mental health disorders among school-aged children continues to rise, underscoring the importance of effective collaboration between families and schools. This qualitative study explored how parents (N=11) and teachers (N=11) perceive the causes, severity, and most appropriate interventions for internalizing (e.g., anxiety, depression) and externalizing (e.g., ADHD, conduct) disorders. Using vignette-based interviews and thematic analysis, six central themes emerged: (1) causal attributions (biological vs. environmental), (2) links between causes, symptom permanence, and intentionality, (3) intervention preferences, (4) importance of collaboration, (5) perceptions of severity, and (6) gendered interpretations of symptoms. 12 of the 22 participants (5 parents, 7 …
Interference Under Pressure: Task-Switching And Cognitive Control In Adhd, Rocio Belen Varela
Interference Under Pressure: Task-Switching And Cognitive Control In Adhd, Rocio Belen Varela
Theses and Dissertations
Attention-Deficit/Hyperactivity Disorder (ADHD) is a widespread neurodevelopmental condition associated with significant academic difficulties, often resulting in students scoring a year below average on standardized examinations (Lawrence et al., 2020; Mohammadi et al., 2019). A proposed core feature of the disorder involves impairments in working memory (WM), specifically the Central Executive component responsible for attentional control (Alderson et al., 2013; Kofler et al., 2008). These WM operations are governed by two cognitive control modalities: proactive control (sustained, anticipatory maintenance) and reactive control (cue-driven, on-demand processing) (Braver et al., 2007). This quasi-experimental study investigated whether a natural tendency toward reactive control grants …
Program Evaluation: A Study To Evaluate A Traditional Suspension Program Versus An Alternate Suspension Program, Ruth Desronvil
Program Evaluation: A Study To Evaluate A Traditional Suspension Program Versus An Alternate Suspension Program, Ruth Desronvil
Theses and Dissertations
In the United States, millions of students face out-of-school suspensions from public schools each year. Black and Hispanic students, in particular, are suspended at higher rates than their white peers (Cobb-Clark et al., 2015). Students miss class time and valuable learning, which widens the achievement gap between Black, Hispanic, and White students. Suspended students also face additional consequences, such as social alienation from schools and a higher likelihood of engagement in delinquency. Several programs seek to improve the effects of suspensions on students’ outcomes. In this dissertation response, I examine the effectiveness of one such program: an alternative suspension educational …
Don’T Hit Mommy! Associations Between Harsh Parenting And Aggression In Toddlerhood: The Moderating Role Of Temperament, Serah Betancourt
Don’T Hit Mommy! Associations Between Harsh Parenting And Aggression In Toddlerhood: The Moderating Role Of Temperament, Serah Betancourt
Theses and Dissertations
Physical aggression is known to be particularly common in toddlerhood. Further, harsh parenting practices and certain temperament traits in children have been found to be associated with aggressive behaviors. Recently, aggression has been demonstrated to be differentiated between provoked and unprovoked aggression. The current study examined early aggression and explored the mechanisms by which harsh parenting practices and temperament traits may predict different types of aggression and how that may also change depending on the stage of development in toddlerhood. That is, we proposed that harsh parenting would be more strongly associated with provoked aggression among toddlers with higher negative …
Vulnerable Narcissism In Borderline Personality Disorder: Impact On Emotion Dysregulation, Identity Disturbance, And Rejection Sensitivity In Psychiatric Inpatients, Lauren Baker Lloveras
Vulnerable Narcissism In Borderline Personality Disorder: Impact On Emotion Dysregulation, Identity Disturbance, And Rejection Sensitivity In Psychiatric Inpatients, Lauren Baker Lloveras
Theses and Dissertations
Borderline personality disorder (BPD) is a severe personality disorder frequently seen in clinical settings due to high service utilization. It is characterized by emotion dysregulation, identity disturbance, suicidal behavior, fear of abandonment, and impulsive or risky behavior. BPD is categorized as a Cluster B personality disorder, alongside narcissistic personality disorder (NPD), which is defined by grandiosity, attention-seeking, and a lack of empathy. NPD can be further conceptualized across two subtypes: grandiose narcissism and vulnerable narcissism (VN). Unlike grandiose narcissism, VN has been largely neglected in research – despite overlapping features with personality and mood disorders, especially BPD. These shared features …
Umbralisib Antagonizes Multidrug Resistance In Abcb1- Overexpressing Cancer Cells, Letao Bo
Umbralisib Antagonizes Multidrug Resistance In Abcb1- Overexpressing Cancer Cells, Letao Bo
Theses and Dissertations
Overexpression of ATP-binding cassette (ABC) transporters, particularly ABCB1, is a major mechanism of multidrug resistance (MDR) and contributes to chemotherapy failure by reducing intracellular drug accumulation. Umbralisib is a dual inhibitor of phosphoinositide 3-kinase delta (PI3Kδ) and casein kinase 1 epsilon (CK1ε) that was developed for the treatment of hematologic malignancies; however, it was later withdrawn due to safety concerns. In the present study, we found that umbralisib has the potential to reverse ABCB1-mediated MDR. The MTT assay demonstrated that umbralisib significantly sensitized ABCB1-overexpressing KB-C2 and SW620/Ad300 cells, as well as ABCB1-transfected HEK293 cells. Mechanistic assays revealed that umbralisib enhanced …
Prevention Of Inflammation-Associated Neurodegeneration: Assessing The Efficacy Of N,N-Dimethylacetamide (Dma) In Lipopolysaccharide (Lps)-Induced Neuroinflammation Using C57bl/6 Mice, Teeshavi Devi Acosta
Prevention Of Inflammation-Associated Neurodegeneration: Assessing The Efficacy Of N,N-Dimethylacetamide (Dma) In Lipopolysaccharide (Lps)-Induced Neuroinflammation Using C57bl/6 Mice, Teeshavi Devi Acosta
Theses and Dissertations
Neurological function is closely linked to both longevity and quality of life. While some degree of neurodegeneration occurs naturally with aging, pathological neurodegeneration leads to devastating functional decline. The mechanisms underlying these processes remain incompletely understood; however, neuroinflammation is recognized as a key driver of neuronal dysfunction and death. Emerging evidence indicates that neuroinflammatory cascades can precede and potentiate hallmark features of neurodegenerative diseases, including synaptic loss and cognitive decline observed in Alzheimer’s disease (AD). Activation of the NF-κB signaling pathway contributes to amyloid beta (Aβ) peptide production, further amplifying a cycle of inflammation and neuronal injury. Preclinical work from …
2026-2027 Catalog, Governors State University
2026-2027 Catalog, Governors State University
Catalogs
The 2026-2027 Governors State University Undergraduate and Graduate Catalog is a comprehensive listing of current information regarding:
Degree Requirements
Course Offerings
Undergraduate and Graduate Rules and Regulations
Effectiveness Of Walleye Stocking In Winter Kill Lakes, Tyler Haus
Effectiveness Of Walleye Stocking In Winter Kill Lakes, Tyler Haus
Journal of Earth and Life Science
Winter kill events, marked by extensive fish mortality due to hypoxic conditions under the ice, are a common phenomenon in shallow eutrophic lakes, especially in the northern lakes in the northern United States. These events can drastically alter fish communities and often result in the elimination of top predators. Though these lakes will typically slowly bounce back to what they were in a couple of years. This study evaluates the effectiveness of walleye, Sander vitreus, stocking in lakes after a winter kill. For this study, four known winter kill lakes that are consistently stocked with walleye were studied. Pre- …
Assessing Urban–Rural Differences In Largemouth Bass Abundance In Minnesota, Jonathan Gates
Assessing Urban–Rural Differences In Largemouth Bass Abundance In Minnesota, Jonathan Gates
Journal of Earth and Life Science
Urbanization can significantly alter freshwater ecosystems and influence sport fish populations. This study examined differences in largemouth bass Micropterus nigricans catch-per-unit-effort (CPUE) between urban and rural lakes in Minnesota and evaluated temporal changes between 2000–2010 and 2011–2021. Forty lakes (20 urban, 20 rural) were selected using Minnesota Department of Natural Resources fisheries survey data. Lakes were classified using NLCD 2019 land cover data, with ≥10% developed land designated as urban. Nonparametric analyses (Wilcoxon rank-sum and signed-rank tests) were used to assess spatial and temporal differences in CPUE. Results showed that rural lakes had consistently higher median CPUE than urban lakes …
Statewide Northern Pike Response To Minnesota’S 2018 Regulation Change, Elijah Wozniak
Statewide Northern Pike Response To Minnesota’S 2018 Regulation Change, Elijah Wozniak
Journal of Earth and Life Science
Management of northern pike (Esox lucius) is challenging because it attempts to balance ecological sustainability with angler interests. Northern pike often stunt their own growth by diminishing the size and abundance of prey fish, their food source. Anglers are often displeased when small pike occur in high population densities. In response to populations of small northern pike, the DNR implemented a new, statewide northern pike regulation in 2018. The objective of this study was to determine whether the regulation successfully changed the mean weight, length, and CPUE of northern pike in Minnesota. The secondary objective was to test …
Neonicotinoid Bioaccumulation In Bluegill And Bullhead Within Lake Julia And Lake Zumwalde, Jake Stuber
Neonicotinoid Bioaccumulation In Bluegill And Bullhead Within Lake Julia And Lake Zumwalde, Jake Stuber
Journal of Earth and Life Science
Brown Bullhead Ameiurus nebulosus, Yellow Bullhead Ameiurus natalis, and Bluegill Lepomis macrochirus are unique in their stark differences. Bullhead are scaleless bottom feeders that can tolerate high pollution and low O2 conditions. In contrast, Bluegill are scaled, aggressive nesters and are less tolerant of high pollutants or low-oxygen conditions. Among these pollutants include a class of chemicals called neonicotinoids (hereafter referred to as neonics). Neonics are a class of insecticides primarily used within agriculture and pest management. Due to the effectiveness, application has escalated on a global scale. They have been well documented by many toxicology assessments. …
Comparison Of Calcified Structures To Estimate Ages Of Northern Pike Esox Lucius In Various Lakes, Kaed Rauk
Comparison Of Calcified Structures To Estimate Ages Of Northern Pike Esox Lucius In Various Lakes, Kaed Rauk
Journal of Earth and Life Science
Northern pike Esox lucius are a dominant predatory fish in many aquatic systems. They can have significant impacts on the ecosystems they inhabit and are also a popular game fish among anglers. However, northern pike are a difficult species to age accurately. This study aimed to compare calcified aging structures to identify trends and determine which structure provides the most accurate age estimates. A total of 119 northern pike were sampled, and multiple structures from each fish were independently aged by two readers. The coefficient of variation (CV) was calculated for each structure to assess precision. Sectioned sagittal otoliths exhibited …
Indigenous Land Seizure & Environmental Injustice: Impacts Of Settler Colonialism, Lydia Moorman
Indigenous Land Seizure & Environmental Injustice: Impacts Of Settler Colonialism, Lydia Moorman
Journal of Earth and Life Science
The fields of conservation and environmentalism prioritize ecosystem health, yet both emerged from western frameworks that displaced and criminalized Indigenous land stewardship. The idealization of “pristine wilderness” narratives served to justify the removal of Indigenous peoples from their homelands and erased millennia of sustainable land stewardship that had maintained ecological balance long before western conservation existed. These narratives not only misrepresented Indigenous relationship with land but also constructed a false dichotomy between humans and nature that positioned Indigenous presence as a threat rather than a source of ecological knowledge. Simultaneously, anthropogenic expansion; such as pipelines, mining, railroads, and other extractive …
Powering The Machine, Draining The Planet: Whether U.S. Environmental Law Is Equipped To Regulate The Energy And Water Demands Of Ai Data Centers, Michael Marcu
Journal of Earth and Life Science
Artificial intelligence (AI) data centers have become one of the United States' fastest-growing and least-regulated sources of environmental stress. In 2024 alone, U.S. data centers consumed 183 terawatt-hours (TWh) of electricity more than the entire nation of Pakistan and consumed an estimated 17 billion gallons of water (IEA, 2025; Berkeley Lab, 2024). By 2030, electricity demand from these facilities is projected to reach 426 TWh, a 133% increase in six years (Pew Research Center, 2025). This paper examines whether the existing U.S. environmental regulatory framework put by the National Environmental Policy Act (NEPA), the Clean Water Act (CWA), and the …
Size Structure Comparison Of Bluegill In Lakes With And Without Special Regulations, Jenna Lawin
Size Structure Comparison Of Bluegill In Lakes With And Without Special Regulations, Jenna Lawin
Journal of Earth and Life Science
Lots of individuals have mixed feelings about special regulations for all sorts of game fish species such as northern pike Esox lucius, crappie Pomoxis spp., sunfish Lepomis spp., and so on. One species commonly sought after by many is bluegill Lepomis macrochirus. Bluegill are often deemed easy to find, catch, and clean. This study looks at three different categories of lakes (all lakes contain bluegill populations). The three categories are lakes with a five sunfish limit, lakes with a ten sunfish limit, and lakes without any special regulations. This study provides valuable insight into the size …
Distal Adding-On As A Complication Of Posterior Spinal Fusion In Adolescent Idiopathic Scoliosis: A Scoping Review Of Contemporary Evidence, Hussein Hashem, Hassan Abou Adma, Joseph Hayek, Ali Rezazadeh Shirazi, Karim Gaber, Waleed Kishta
Distal Adding-On As A Complication Of Posterior Spinal Fusion In Adolescent Idiopathic Scoliosis: A Scoping Review Of Contemporary Evidence, Hussein Hashem, Hassan Abou Adma, Joseph Hayek, Ali Rezazadeh Shirazi, Karim Gaber, Waleed Kishta
Western Journal of Orthopaedics
Distal adding-on (DAO) is a complication of spinal fusion characterized by postoperative deformity progression distal to the fusion construct. DAO after posterior spinal fusion for adolescent idiopathic scoliosis (AIS) is variably defined and inconsistently managed. This scoping review synthesizes evidence on DAO detection, management, and outcomes. A PRISMA-ScR–guided search identified relevant studies. Thirty-one studies (2,998 patients; median follow-up, 30 months) met inclusion criteria. Reported DAO incidence ranged from 3.5% to 62.5%, reflecting heterogeneity in definitions, patient factors, surgical constructs, and follow-up duration. Revision surgery was infrequent and typically delayed. When performed, it was most often prompted by progressive coronal decompensation …
Fibula Strut Allograft With Proximal Tibia Autograft For Treatment Of Humerus Nonunion: A Case Report And Review Of Oligotrophic Nonunion Management, Paul Wilson, Naomi Kelley, Samer Kakish
Fibula Strut Allograft With Proximal Tibia Autograft For Treatment Of Humerus Nonunion: A Case Report And Review Of Oligotrophic Nonunion Management, Paul Wilson, Naomi Kelley, Samer Kakish
Western Journal of Orthopaedics
Due to their high incidence and frequent need for reoperation, nonunions of the humerus present a significant challenge in orthopaedics. Using fibular struts to treat nonunions have demonstrated excellent results. While fibular autografts provide both biologic and structural benefit, high donor site morbidity must be considered. Although their application in midshaft humeral nonunions remains limited, fibular allografts avoid donor site morbidity. Enhancing fibular strut allografts with biological components offers a promising strategy for treating fractures that have failed prior revisions. This case study presents a 36-year-old woman with an aseptic oligotrophic midshaft humeral nonunion who had an unsuccessful revision surgery. …
Spe 1200 - Interpersonal Communication Syllabus Redesigned For Use With Oer, Gordon Alley-Young
Spe 1200 - Interpersonal Communication Syllabus Redesigned For Use With Oer, Gordon Alley-Young
Open Educational Resources
This document is a syllabus for an Interpersonal Communication course that has been redesigned to be used with open educational resources (OERs). The class outlined in the syllabus is for first and second year college students.
Competitive And Priority Effects Of Native Cool-Season Grasses On Invasive Bromus Species In The Northern Great Plains, Tyler Michael Geltmacher
Competitive And Priority Effects Of Native Cool-Season Grasses On Invasive Bromus Species In The Northern Great Plains, Tyler Michael Geltmacher
Electronic Theses and Dissertations
Native grasslands and restoration sites in the Northern Great Plains face pressure from invasive cool-season grass species, such as smooth brome (Bromus inermis) and cheatgrass (Bromus tectorum). Native cool-season grass species may compete in the same niche as the invaders and provide resistance to invasion of existing or restored grasslands. Green needlegrass (Nassella viridula) and junegrass (Koeleria macrantha) were evaluated in this study for competitive effect and priority effect against invasive bromes to inform management decisions. Greenhouse studies were conducted to evaluate competitive ability of the two native species as well as how priority influences competition. In my first chapter, …
Primary Avian Tracheal Cell Models For The Isolation Of Emerging Avian Metapneumovirus Strains, Tricia Serrao
Primary Avian Tracheal Cell Models For The Isolation Of Emerging Avian Metapneumovirus Strains, Tricia Serrao
Electronic Theses and Dissertations
The emergence of avian metapneumovirus (aMPV) subgroups A and B in the United States poultry industry has created an urgent need for standardized, host-specific diagnostic platforms. Historically, reliance on continuous, multi-species cell lines has limited the primary isolation of field strains and introduced potential adaptation artifacts. To address these challenges, this research first established and characterized a reproducible primary cell culture system derived from the tracheal tissues of 1-day-old turkey poults. This system was maintained in an optimized DMEM/F-12 formulation supplemented with 5% FBS, EGF, and ITS, with early-passage cultures achieving 90% confluence within 24 to 48 hours. Morphological and …
Finite Mixture Modeling Towards Applications In Material Science And Biomedical Data, Jason Hasse
Finite Mixture Modeling Towards Applications In Material Science And Biomedical Data, Jason Hasse
Electronic Theses and Dissertations
This dissertation contains three chapters on different applications of mixture regression models, broadly in materials science and public health. We begin with a basic application of finite mixture models and regression mixture models. The materials science analysis was performed entirely using data from finite element simulations of the additive manufacturing process via powder bed fusion. Visualization of the clustering solution as applied to the additive manufacturing designs highlighted the intuitive patterns that could be found. These patterns simultaneously yield the regression coefficients and subgroups of the geometric regions, providing a way to predict stresses and strains in a new geometry …
Understanding Motor Competence In Autism And Developmental Coordination Disorder: From Everyday Performance To Underlying Postural Control Mechanisms, Crystal E. Alvarez
Understanding Motor Competence In Autism And Developmental Coordination Disorder: From Everyday Performance To Underlying Postural Control Mechanisms, Crystal E. Alvarez
Kinesiology Dissertations
Motor competence plays a foundational role in children’s participation, physical activity, adaptive behavior, and overall quality of life. Although motor difficulties are highly prevalent in autism spectrum disorder (autism) and developmental coordination disorder (DCD), these challenges are frequently under-identified and insufficiently characterized, particularly in autistic populations. Existing research demonstrates substantial overlap in motor challenges across autism and DCD; however, relatively little work has integrated caregiver perceptions, standardized motor assessment, and mechanistic postural control measures within the same investigation. Therefore, the purpose of this dissertation was to examine motor competence and postural control in autistic children, children with DCD, and neurotypical …
Drone Dichotomy: Investigating The Application Of Unmanned Aerial Systems For Offensive And Defensive Chemical, Biological, Radiological, And Nuclear-Related Tasks, Evan Jacob Martinovitch
Drone Dichotomy: Investigating The Application Of Unmanned Aerial Systems For Offensive And Defensive Chemical, Biological, Radiological, And Nuclear-Related Tasks, Evan Jacob Martinovitch
Graduate Theses/Dissertations
This thesis investigates the application of unmanned aerial systems (UAS) for both offensive and defensive chemical, biological, radiological, and nuclear (CBRN) tasks to determine if they serve as a force multiplier on the modern battlefield. As CBRN weapons reemerge as realistic threats alongside the rapid proliferation of UAS, the intersection of these fields presents unique challenges and opportunities. Through a methodology that examines the history of the UAS-CBRN intersection, military doctrine, and the status of UAS technology, this research evaluates the capability of current and emerging UAS against specific CBRN delivery, reconnaissance and surveillance, and decontamination tasks. The analysis conducted …
Small Mammal Communities Within And Land Coverage Around Southwestern Missouri Prairies, Kaitlyn J. Bebensee
Small Mammal Communities Within And Land Coverage Around Southwestern Missouri Prairies, Kaitlyn J. Bebensee
Graduate Theses/Dissertations
Land alterations can reduce the amount of suitable habitat necessary for persistence of an associated species. Within such constrained habitats, limited resources may elicit competition, which could cause shifts in abundance and occurrence of species. Missouri prairies have been declining in size, making it imperative to collect reference data on mammal populations within and land use types around remnants. For this study, I trapped small mammals in Southwestern Missouri prairies because they can be indicators of environmental health and can vary in abundance between prairies. I focus on the diet of two dominant small mammals, Peromyscus maniculatus and Microtus ochrogaster …
Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales
Gene Editing And The Accessibility Of Bioterrorism: Rethinking Global Biosecurity In The Post-Covid-19 Era, Nicholas Morales
Graduate Theses/Dissertations
COVID‑19 demonstrated how a single biological event can strain health systems, disrupt supply chains, undermine national security, and erode public trust. This shock occurred as biotechnology became dramatically more accessible: gene editing and synthetic biology tools once limited to specialized laboratories are now widely available through inexpensive equipment, open‑source data, and decentralized expertise.
This expanded access accelerates innovation but also broadens the threat landscape. The ability to reconstruct pathogens using publicly available sequences and mail‑order DNA shows that complex biological synthesis is no longer confined to state programs. These risks are amplified by opaque biotechnology activities in China, Russia, and …
Perfluorooctane Sulfonate (Pfos)-Induced Disruption Of Mitochondrial Activity And Cell Adhesion In Liver Cells, Phuong Dam Nam Tran
Perfluorooctane Sulfonate (Pfos)-Induced Disruption Of Mitochondrial Activity And Cell Adhesion In Liver Cells, Phuong Dam Nam Tran
Graduate Theses/Dissertations
Perfluorooctane sulfonate (PFOS) is a persistent environmental pollutant associated with potential hepatoxic effects and other health risks. Despite its widespread distribution, the mechanisms underlying its toxicities remain to be fully understood. To investigate PFOS toxicology, my study utilized HepG2 and THLE-2 human hepatic cell models to replicate conditions reflecting PFOS accumulation in the liver. Cell viability, cell stress, and cell death assays were conducted to assess the toxicological influence of the chemical on both cell lines. Total RNA extraction was performed, followed by cDNA sequencing, and RT-qPCR. The XTT viability assay revealed a dose-dependent decrease in number of viable cells …