Digital Commons Network^™

The Multivariate Ewma Model And Health Care Monitoring, Xia Pan, Jeffrey E. Jarrett

College of Business Faculty Publications

We introduce the construction of MEWMA (Multivariate exponentially weighted movingaverage) process control in the field of bio surveillance. Such introduction will both improve the reliability of data collected in bio surveillance, better interpretation of the results,improvement in the quality of results and standardization of results when more than two variables are involved. We propose sensitivity ratios as a measure of the effects of the mean shift and dispersion shift in processes under study. Using these sensitivity measures, we designed the optimal exponential weighting factor, which is consistent to results reported in control chart applications. Although ARL (average run length) is …

Targeting Grp78 In Cancer With Nucleic Acid Bioconjugates, Pradeepkumar L. Patel

Seton Hall University Dissertations and Theses (ETDs)

Nucleic acid bioconjugates have gained widespread use in medicinal chemistry research programs aimed at fighting human malignancies such as cancer, diabetes, genetic and infectious diseases. Their popularity stems from their ability to accelerate the drug development process by conjugating chemical functionality that may improve the pharmacology of a bioactive nucleoside. Moreover, this strategy has been proven to be effective with small molecule nucleoside analogs and those derived from lengthy oligonucleotide sequences. Considering these fruitful applications, my research and this thesis aims to explore the synthesis, characterization and therapeutic potential of novel classes of nucleic acid bioconjugates.

These are based on, …

Sociology Doctoral Student Earns Fellowship Grant From Nih, Staff

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No abstract provided.

Kennedy Keeps Things Running Smoothly, Natalie Wade

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No abstract provided.

Comparisons Of Intensity-Duration Patterns Of Physical Activity In The Us, Jamaica And 3 African Countries, Lara R. Dugas, Pascal Bovet, Terrence E. Forrester, Estelle V. Lambert, Jacob Plange-Rhule, Ramon A. Durazo-Arvizu, David Shoham, Jacolene Kroff, Guichan Cao, Richard S. Cooper, Soren Brage, Ulf Ekelund, Amy Luke

Faculty Publications

Background: This difference in how populations living in low-, middle or upper-income countries accumulate daily PA, i.e. patterns and intensity, is an important part in addressing the global PA movement. We sought to characterize objective PA in 2,500 participants spanning the epidemiologic transition. The Modeling the Epidemiologic Transition Study (METS) is a longitudinal study, in 5 countries. METS seeks to define the association between physical activity (PA), obesity and CVD risk in populations of African origin: Ghana (GH), South Africa (SA), Seychelles (SEY), Jamaica (JA) and the US (suburban Chicago).

Three-Year Change In The Wellbeing Of Orphaned And Separated Children In Institutional And Family-Based Care Settings In Five Low- And Middle-Income Countries, Kathryn Whetten, Jan Ostermann, Brian W. Pence, Rachel A. Whetten, Lynne C. Messer, Sumedha Ariely, Karen O'Donnell, Augustine I. Wasonga, Vanroth Vann, Dafrosa Itemba, Misganaw Eticha, Ira Madan, Nathan M. Thielman, The Positive Outcomes For Orphans (Pofo) Research Team

Faculty Publications

Background With more than 2 million children living in group homes, or “institutions”, worldwide, the extent to which institution-based caregiving negatively affects development and wellbeing is a central question for international policymakers.

Methods A two-stage random sampling methodology identified community representative samples of 1,357 institution-dwelling orphaned and separated children (OSC) and 1,480 family-dwelling OSC aged 6–12 from 5 low and middle income countries. Data were collected from children and their primary caregivers. Survey-analytic techniques and linear mixed effects models describe child wellbeing collected at baseline and at 36 months, including physical and emotional health, growth, cognitive development and memory, and …

Three-Year Change In The Wellbeing Of Orphaned And Separated Children In Institutional And Family-Based Care Settings In Five Low- And Middle-Income Countries, Kathryn Whetten, Jan Ostermann, Brian W. Pence, Rachel A. Whetten, Lynne C. Messer, Sumedha Ariely, Karen O'Donnell, Augustine L. Wasonga, Vanroth Vann, Dafrosa Itemba, Misganaw Eticha, Ira Madan, Nathan M. Thielman, Positive Outcomes For Orphans (Pofo) Research Team

Community Health Faculty Publications and Presentations

Background: With more than 2 million children living in group homes, or "institutions", worldwide, the extent to which institution-based caregiving negatively affects development and wellbeing is a central question for international policymakers.

Methods: A two-stage random sampling methodology identified community representative samples of 1,357 institutional dwelling orphaned and separated children (OSC) and 1,480 family-dwelling OSC aged 6–12 from 5 low and middle income countries. Data were collected from children and their primary caregivers. Survey-analytic techniques and linear mixed effects models describe child wellbeing collected at baseline and at 36 months, including physical and emotional health, growth, cognitive development and memory, …

Establishing A Translational Research Center In California's San Joaquin Valley: Principles, Partnerships, And Initial Steps, Rachel R. Cox

Master's Projects and Capstones

The Great Valley Center seeks to promote the social, economic, and environmental well-being of California's Central Valley. UC Merced's Health Sciences Research Institute (HSRI) was established in 2012 to engage in collaborative, multidisciplinary research with a community emphasis in order to rapidly develop, test, and disseminate new ways to improve health. To address the numerous health disparities present in the San Joaquin Valley, HSRI began working toward the development of a regional Translational Research Center, to allow San Joaquin Valley residents access to the latest and most effective interventions and translate findings into community actions. The attached paper is a …

New York City Hiv Testing Initiatives, Marie Bernadette S. Villanueva

Master's Projects and Capstones

My culminating fieldwork experience took place at the New York City Department of Health and Mental Hygiene’s Health Research Training Program where I completed over 300 hours of practical experience in working with the HIV Diagnostics Unit in the Bureau of HIV/AIDS Prevention and Control. While my work focused on a variety of public health interventions, for the purpose of my final paper, I have chosen to detail my work on the application of data analysis, program planning/evaluation, and community engagement in the New York City HIV Testing Initiatives Program. The USF MPH Program coursework and commitment to social justice …

Reducing Obesity And Obesity-Related Diseases In Richmond, California: Understanding The Importance Of Partnerships In Community-Based Health Education, Arlette Hernandez

Master's Projects and Capstones

In the United States obesity has become a major public health issue. Over the past two decades, the prevalence of obesity has doubled in adults and children. In the city of Richmond, California, adults and children are experiencing the highest rates of obesity and obesity-related diseases in comparison to other residents of West Contra Costa County. In an effort to reduce the rates of obesity in Richmond, two non-profit organizations have partnered up to provide innovative community-based health education to combat obesity and type II diabetes.

This paper will explore and summarize the 300-hour fieldwork the author experienced and completed …

Prevention Of Hiv Mother-To-Child-Transmission In Sub-Saharan Africa, Sidik Abdul-Mumuni

Master's Projects and Capstones

The transmission of HIV infection from an HIV-positive mother to her child during labor, pregnancy, breastfeeding or delivery is termed as mother-to-child HIV transmission (WHO, 2013 report on HIV). A range of 15-45% infection transmissions are possible when no intervention strategies are put into place. Globally, goals and initiatives have been set to combat this issue as well as speeding up the interventions and achieve possible transmission rates of levels less than 5% and total elimination of new infant HIV infections by 2015 (WHO, 2013 report on HIV). In 2011, 57% of pregnant women living with HIV in low and …

Extraction And Sensitive Detection Of Toxins A And B From The Human Pathogen Clostridium Difficile In 40 Seconds Using Microwave-Accelerated Metal-Enhanced Fluorescence, Lovleen Tina Joshi, Buddha L. Mali, Chris D. Geddes, Les Baillie

Peninsula Dental School

No abstract provided.

Origin And Evolution Of European Community-Acquired Methicillin-Resistant Staphylococcus Aureus, Marc Stegger, Thierry Wirth, Paal S. Andersen, Robert L. Skov, Anna De Grassi, Lance B. Price, +23 Additional Authors

Environmental and Occupational Health Faculty Publications

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) was recognized in Europe and worldwide in the late 1990s. Within a decade, several genetically and geographically distinct CA-MRSA lineages carrying the small SCCmec type IV and V genetic elements and the Panton-Valentine leukocidin (PVL) emerged around the world. In Europe, the predominant CA-MRSA strain belongs to clonal complex 80 (CC80) and is resistant to kanamycin/amikacin and fusidic acid. CC80 was first reported in 1993 but was relatively rare until the late 1990s. It has since been identified throughout North Africa, the Middle East, and Europe, with recent sporadic reports in sub-Saharan Africa. While …

Today - August 26, 2014, Loma Linda University Health

TODAY

Inside this issue:

-- Adventist hospitals stay open despite Ebola crisis
-- EXSEED challenges and inspires math and science educators
-- School of Public Health dean appointed to national accrediting council
-- LLUH physician inducted as president of SBC Medical Society
-- Students showcase biomedical research at 14th annual Health Disparities Symposium
-- One Loma Linda resident's active and spiritual workout toward wholeness
-- LLUMC-Murrieta named 'Most Wired' by American Hospital Association
-- Critical event course creates interprofessional experience to mimic disaster response
-- Weismeyer Conference Room officially named and dedicated
-- School of Public Health launches smoking cessation website …

The Statesman, V. 58, I. 02, Stony Brook University

Stony Brook Statesman-Sucolian

v. 58, i. 02

Cama Newsletter - August, 2014, Civil Aviation Medical Association

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A twelve page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.

My News

My News (2014-2020)

• Georgia Southern University Celebrates New $8.65 Million Communication Arts Building
• Georgia Southern Makes History with Inaugural Degree Program
• Engineering Programs Receive National Accreditation
• Paint the Town Blue
• School of Nursing Receives $2.2 Million in Grant Funding
• A Season of Firsts: Meet New Women's Golf Coach Emily Kuhfeld
• Auxiliary Services Opens New Grocer & Sandwich Shop
• HIV Conference to Bring New Strategies to Rural Health Care
• New Exhibit On Display

Genome Sequence Analysis Of In Vitro And In Vivo Phenotypes Of Bunyamwera And Ngari Virus Isolates From Northern Kenya, Collins Odhiambo, Marietjie Venter, Konongoi Limbaso, Robert Swanepoel, Rosemary Sang

All Peer-Reviewed Publications

Biological phenotypes of tri-segmented arboviruses display characteristics that map to mutation/s in the S, M or L segments of the genome. Plaque variants have been characterized for other viruses displaying varied phenotypes including attenuation in growth and/or pathogenesis. In order to characterize variants of Bunyamwera and Ngari viruses, we isolated individual plaque size variants; small plaque (SP) and large plaque (LP) and determined in vitro growth properties and in vivo pathogenesis in suckling mice. We performed gene sequencing to identify mutations that may be responsible for the observed phenotype. The LP generally replicated faster than the SP and the difference …

Disrupted Human–Pathogen Co-Evolution: A Model For Disease, Nuri Kodaman, Rafal S. Sobota, Robertino Mera, Barbara G. Schneider, Scott M. Williams

Dartmouth Scholarship

A major goal in infectious disease research is to identify the human and pathogenic genetic variants that explain differences in microbial pathogenesis. However, neither pathogenic strain nor human genetic variation in isolation has proven adequate to explain the heterogeneity of disease pathology. We suggest that disrupted co-evolution between a pathogen and its human host can explain variation in disease outcomes, and that genome-by-genome interactions should therefore be incorporated into genetic models of disease caused by infectious agents. Genetic epidemiological studies that fail to take both the pathogen and host into account can lead to false and misleading conclusions about disease …

Analysis On The Issue Of Ship Sewage In Terms Of Pollution, Discharge And Reception In The Minjiang Inland Port With Countermeasures, Binsong Zheng

Maritime Safety & Environment Management Dissertations (Dalian)

No abstract provided.

The Management Status And Research Of Pollution Prevention Of Ships For Jingtang Port Areas, Chengwei Wang

Maritime Safety & Environment Management Dissertations (Dalian)

No abstract provided.

Editorial Comment: Temporal Trends In Preparedness Capacity, Gulzar H. Shah

Frontiers in Public Health Services and Systems Research

In view of the critical role local health departments (LHDs) play among agencies responsible for responding to natural and man-made emergencies, Bevc et al. examined the LHDs’ emergency preparedness and capacity. They compared LHDs in North Carolina with those across the country for preparedness along eight domains. Significant declines in emergency preparedness were noted from 2010 to 2012 for five out of eight domains, raising questions about our national priority concerning this important function of public health agencies. These findings have numerous implications, some of which are covered in this commentary.

Metabolism-Oriented Lead Optimization Of Propargyl-Linked Dhfr Inhibitors, Wangda Zhou

Doctoral Dissertations

Dihydrofolate reductase (DHFR), a key enzyme within folate biosynthetic pathway, has been a popular drug target for over six decades. Trimethoprim (TMP) is the only FDA approved antibacterial DHFR inhibitor and remains clinically important. However, acquired resistance by point mutations and natural enzymatic insensitivity limit its use.

A library of novel propargyl-linked antifolates targeting DHFR from MSRA, Candida and Klebsiella species was developed. Early lead propargyl-linked antifolates were proven potent antibacterial and antifungal agents. Much effort was placed on evaluating the metabolism properties. A strategy of incorporating crystallographic insight and experimental evaluation of structure-activity relationships (SAR) to guide new compound …

Infection With Mers-Cov Causes Lethal Pneumonia In The Common Marmoset, Darryl Falzarano, Emmie De Wit, Friederike Feldmann, Angela L. Rasmussen, Atsushi Okumura, Xinxia Peng, Matthew J. Thomas, Neeltje Van Doremalen, Elaine Haddock, Lee Nagy, Rachel Lacasse, Tingting Liu, Jiang Zhu, Jason S. Mclellan, Dana P. Scott, Michael G. Katze, Heinz Feldmann, Vincent J. Munster

Dartmouth Scholarship

The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV has been established, the lack of uniform, severe disease in this model complicates the analysis of countermeasure studies. Modeling of the interaction between the MERS-CoV spike glycoprotein and its receptor dipeptidyl peptidase 4 predicted comparable interaction energies in common marmosets and humans. The suitability of the marmoset as a MERS-CoV model was tested by inoculation via combined intratracheal, intranasal, oral and ocular routes. Most of the marmosets developed a progressive severe pneumonia …

New York: Public Health Implications Of The 'Soda Ban' Ruling, Andrew Geltman

Homeland Security Publications

No abstract provided.

Anemia Research In India: A Bibliometric Analysis Of Publications Output During 1993–2013., Jeyshankar -. Ramalingam -, Vellai Chamy A

Library Philosophy and Practice (e-journal)

This study is made an attempt to make the quantitative study of research output on anemia disease. Data of the present study is obtained from Scopus (http:// www.scopus.com) online multidisciplinary database for the period 1993–2013.The study reveals that 5085 papers were published during the period under study. The highest number of papers (739) is published in the year 2013 but it received 178 citations only. The minimum number (47) of papers is published in the year of 1996, but they have received 3245 citations. The study reveals that lowest number (0.56%) of citations received in the year 2013. The study …

Protect Yourself Against Infectious Disease, Here And Abroad, Traci Bratton

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No abstract provided.

Attitudes Towards Latino Immigrants Expressed In The Online Media, Jordan Mcclain

Honors Theses

The language used towards Latino immigrants expressed in the online media is a prevalent occurrence that warrants a more detailed analysis. I used a total of fifty-four articles from Fox New, CNN, MSNBC, Southern Poverty Law Center, National Immigration Law Center, Immigration Advocates, Networks Liberty News, Minuteman Project, and American Immigration Control Council. I analyzed the wording used by each source when they referred to Latino immigrants. I analyzed my data further by distinguishing it into five categories: Affirmative language, negative language, avoidance language, the use of linguistic devices, and a category dedicated to the special circumstances around the recent …

Mathematical Modeling And Simulation Of Multialleic Migration-Selection Models, Chad N. Vidden

Journal of Undergraduate Research at Minnesota State University, Mankato

Population ecology is concerned with the growth and decay of specific populations. This field has a variety of applications ranging from evolution and survival at the environmental level to the spread of infectious disease at the cellular and molecular levels. Many ecological circumstances require the use of mathematical methods and reasoning in order to acquire better knowledge of the issue at hand. This study considered and analyzed multiple different mathematical models of population dynamics along with their purposes. This foundation was then applied in order to explore the migration of populations from one isolated region to another along with the …

Bjc Today

BJC Today

No abstract provided.