Digital Commons Network^™

Neonatal Sepsis In Rural Ghana: A Case Control Study Of Risk Factors In A Birth Cohort, Mate Siakwa, Dzigbodi Kpikpitse, Sylvia C. Mupepi, Mohamed Semuatu

Peer Reviewed Articles

Neonatal sepsis poses a major challenge to achieving the MDG-4 due to lack of facilities to implement proposed management guidelines. Identifying risk factors of neonatal sepsis will help put strategies in place to prevent sepsis. This prospective case control study investigated risk factors of neonatal sepsis in the Asutifi District a typical rural setting of the Brong Ahafo Region of Ghana. A semi-structured check list was used to collect clinical and demographic data from 196 neonates (96 with sepsis as case and 100 without sepsis as control) and respective mothers. Maternal factors that were significantly associated with neonatal sepsis were …

Bioo 475.00: Mammalogy, David Paul Hendricks

University of Montana Course Syllabi

No abstract provided.

Influence Of Resource Levels, Organic Compounds And Laboratory Colonization On Interspecific Competition Between The Asian Tiger Mosquito Aedes Albopictus (Stegomyia Albopicta) And The Southern House Mosquito Culex Quinquefasciatus, D.W. Allgood, Donald A. Yee

Faculty Publications

The mosquitoes Aedes albopictus (Stegomyia albopicta) (Skuse) and Culex quinquefasciatus (Say) (Diptera: Culicidae) are common inhabitants of tyres and other artificial containers, which constitute important peridomestic mosquito breeding habitats. We tested the hypotheses that interspecific resource competition between the larvae of these species is asymmetrical, that the concentration of chemicals associated with decomposing detritus affects the competitive outcomes of these species, and that wild and colonized strains of Cx. quinquefasciatus are affected differently by competition with Ae. albopictus. We conducted two laboratory competition experiments wherein we measured survivorship and estimated population growth (λ′) in both species under …

Baylisascaris Procyonis Prevalence And Impact In Raccoon (Procyon Lotor) Populations, Matthew Ingle

Loma Linda University Electronic Theses, Dissertations & Projects

Baylisascaris procyonis is a nematode parasite that infects the small intestines of raccoons (Procyon lotor). Raccoons are the definitive host for this parasite, which can have both an indirect and direct life cycle. In intermediate hosts, the parasite causes serious pathology resulting from larvae migrating through host tissue to the brain. Infection via exposure to B. procyonis eggs is fatal in over 90 vertebrate species that serve as intermediate hosts, including humans. The zoonotic potential of B. procyonis makes understanding factors that impact prevalence and pathology in raccoons important for management strategies. Alimentary canals from 226 raccoons trapped in nine …

Death Before The Fall: Biblical Literalism And The Problem Of Animal Suffering (Book Review), Joel Duff

Pro Rege

Reviewed Title: Osborn, Ronald E. Death Before the Fall: Biblical Literalism and the Problem of Animal Suffering, Downers Grove, IL: InterVarsity Press, 2014. 197 pages, paperback. ISBN: 978-0-8308-4046-5.

Adobe Medicus 2014 5 September-October, Health Sciences Library And Informatics Center

adobe medicus

No abstract provided.

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Against the Grain

No abstract provided.

Troublesome Women And The Nanny State: Drawing Boundaries And Legislating Bifurcated Belonging In Patriarchal Singapore, Eugene K. B. Tan

Research Collection Yong Pung How School Of Law

Singapore was and remains an immigrant society. The immigration of newcitizens and temporary workers has become the primary means by which thepopulation is replenished and right-sized for its economic and demographicrequirements. More than one in three persons (or 38.6 percent) living inSingapore are foreigners (non-citizens, including permanent residents) in2013.[2] Of the 3.45 million working population in Singapore, about 38 percent(or about 1,296,800 persons are foreigners.[3] The vast majority of theseforeigners are transient workers (migrant workers) on short-term work permits.Of these, about 211,000—all women—are employed as domestic help (or ‘maids’ inlocal parlance) as of June 2013.

Natural Infections Of Tetrathyridia Of Mesocestoides Species In Deer Mice, Peromyscus Maniculatus, From New Mexico, John E. Ubelaker, Nora Abdullah, Aya Mouhaffel, Rashmi Ananadampillair, Caitlyn Emigh, Scott Lyell Gardner

Papers in Parasitology

At Southern Methodist University campus about 6 miles south of Taos, New Mexico, we recovered tetrathyridia of Mesocestoides in five Peromyscus maniculatus in the summers of 2008 (3 of 129, 0.023%), 2009 (0 of 98, 0%), 2010 (1 of 112, 0.008%), 2011 (0 of 88, 0%), and 2012 (1 of 86, 0.011%). Tetrathyridia from the body cavity of one of the five infected mice were injected into the peritoneal cavity of laboratory white mice, Mus musculus. Our later examination of the laboratory mice revealed heavy infections of tetrathyridia continuing to reproduce asexually. Here we provide important new information on …

Natural Infections Of Tetrathyridia Of Mesocestoides Species In Deer Mice, Peromyscus Maniculatus, From New Mexico, John E. Ubelaker, Norah Abdullah, Aya Mouhaffel, Rashmi Ananadampillair, Caitlyn Emigh, Scott Lyell Gardner

Harold W. Manter Laboratory of Parasitology: Faculty Publications

At Southern Methodist University campus about 6 miles south of Taos, New Mexico, we recovered tetrathyridia of Mesocestoides in five Peromyscus maniculatus in the summers of 2008 (3 of 129, 0.023%), 2009 (0 of 98, 0%), 2010 (1 of 112, 0.008%), 2011 (0 of 88, 0%), and 2012 (1 of 86, 0.011%). Tetrathyridia from the body cavity of one of the five infected mice were injected into the peritoneal cavity of laboratory white mice, Mus musculus. Our later examination of the laboratory mice revealed heavy infections of tetrathyridia continuing to reproduce asexually. Here we provide important new information on the …

Prevalence Of Oral And Peri-Oral Lesions Among A Group Of Saudi Hiv-Infected Patients, Safia A. Al-Attass

Saudi Medical Journal

OBJECTIVES: To investigate the prevalence of oral and peri-oral lesions among a group of Saudi human immunodeficiency virus (HIV)-infected patients. METHODS: A cross-sectional controlled study was conducted on 50 HIV-infected Saudi patients from King Fahad Armed Forces Hospital, and 100 healthy individuals recruited from Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia between November 2012 to June 2013. All subjects underwent conventional oral examinations to identify mucosal lesions according to the EC-Clearinghouse/World Health Organization classifications. RESULTS: The findings revealed that 68% of the HIV group exhibited HIV-related lesions compared with 4% in the control group. The most commonly observed …

Seroprevalence Of Toxoplasma Gondii In Women In Najran City, Saudi Arabia, Ismail S. El-Shahawy, Mokhtar I. Khalil, Mosa M. Bahnass

Saudi Medical Journal

OBJECTIVES: To evaluate the seroprevalence of Toxoplasma gondii among Saudi pregnant women in Najran City, as well as to measure the performance of the diagnostic tests used. METHODS: A total of 96 women attending prenatal special clinics (Oteafyn special clinic) in Najran Province, Saudi Arabia, over a one year period, from September 2012 to September 2013 were screened for the presence of Toxoplasma antibody in their blood serum using an indirect hemagglutination assay (IHA). Specific immunoglobulin (Ig) G and IgM antibodies were evaluated using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Out of the 96 samples of sera tested using IHA, …

Treatment Of Postoperative Purulent Pericarditis And Streptococcal Toxic Shock Syndrome By Intensive Blood Purification, Xin Lin, Xian-Qing Shi, Yan Zha

Saudi Medical Journal

[No abstract available]

Virus-Host Mucosal Interactions During Early Siv Rectal Transmission, Wuxun Lu, Fangrui Ma, Alexander Churbanov, Yanmin Wan, Yue Li, Guobin Kang, Zhe Yuan, Dong Wang, Chi Zhang, Jianqing Xu, Mark Lewis, Qingsheng Li

Nebraska Center for Biotechnology: Faculty and Staff Publications

To deepen our understanding of early rectal transmission of HIV-1, we studied virus-host interactions in the rectal mucosa using simian immunodeficiency virus (SIV)-Indian rhesus macaque model and mRNA deep sequencing. We found that rectal mucosa actively responded to SIV as early as 3 days post-rectal inoculation (dpi) and mobilized more robust responses at 6 and 10 dpi. Our results suggests that the failure of the host to contain virus replication at the portal of entry is attributable to both a high-level expression of lymphocyte chemoattractant, proinflammatory and immune activation genes, which can recruit and activate viral susceptible target cells into …

Event Analytics, Jin Song Dong, Jun Sun, Yang Liu, Yuan-Fang Li

Research Collection School Of Computing and Information Systems

The process analysis toolkit (PAT) integrates the expressiveness of state, event, time, and probability-based languages with the power of model checking. PAT is a self-contained reasoning system for system specification, simulation, and verification. PAT currently supports a wide range of 12 different expressive modeling languages with many application domains and has attracted thousands of registered users from hundreds of organizations. In this invited talk, we will present the PAT system and its vision on “Event Analytics” (EA) which is beyond “Data Analytics”. The EA research is based on applying model checking to event planning, scheduling, prediction, strategy analysis and decision …

Clones Of Streptococcus Zooepidemicus From Outbreaks Of Hemorrhagic Canine Pneumonia And Associated Immune Responses, Sridhar Velineni, John F. Timoney, Kim Russell, Heidi J. Hamlen, Patricia Pesavento, William D. Fortney, P. Cynda Crawford

Maxwell H. Gluck Equine Research Center Faculty Publications

Acute hemorrhagic pneumonia caused by Streptococcus zooepidemicus has emerged as a major disease of shelter dogs and greyhounds. S. zooepidemicus strains differing in multilocus sequence typing (MLST), protective protein (SzP), and M-like protein (SzM) sequences were identified from 9 outbreaks in Texas, Kansas, Florida, Nevada, New Mexico, and Pennsylvania. Clonality based on 2 or more isolates was evident for 7 of these outbreaks. The Pennsylvania and Nevada outbreaks also involved cats. Goat antisera against acutely infected lung tissue as well as convalescent-phase sera reacted with a mucinase (Sz115), hyaluronidase (HylC), InlA domain-containing cell surface-anchored protein (INLA), membrane-anchored protein (MAP), SzP, …

Why Primate Models Matter, Kimberley A. Phillips, K. L. Bales, J. P. Capitanio, A. Conley, P. W. Czoty, B. A. 'T Hart, William D. Hopkins, S.L. Hu, L. A. Miller, M. A. Nader, P. W. Nathanielsz, J. Rogers, C. A. Shively, M.L. Voytko

Psychology Faculty Research

Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their similarity to humans in physiology, neuroanatomy, reproduction, development, cognition, and social complexity – yet it is these very similarities that make the use of NHPs in biomedical research a considered decision. As primate researchers, we feel an obligation and responsibility to present the facts concerning why primates are used in various areas of biomedical research. Recent decisions in the United States, including the phasing out of chimpanzees in research by the National …

Delayed Switch Of Antiretroviral Therapy After Virologic Failure Associated With Elevated Mortality Among Hiv-Infected Adults In Africa, Maya L. Petersen, Linh Tran, Elvin H. Geng, Steven J. Reynolds, Andrew Kambugu, Robin Wood, David Bangsberg, Constantin T. Yiannoutsos, Steven G. Deeks, Jeffrey N. Martin

OHSU-PSU School of Public Health Faculty Publications and Presentations

Objective—Routine monitoring of plasma HIV RNA among HIV-infected patients on antiretroviral therapy (ART) is unavailable in many resource-limited settings. Alternative monitoring approaches correlate poorly with virologic failure and can substantially delay switch to second-line therapy. We evaluated the impact of delayed switch on mortality among patients with virologic failure in Africa.

Design—A cohort.

Methods—We examined patients with confirmed virologic failure on first-line non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens from four cohorts with serial HIV RNA monitoring in Uganda and South Africa. Marginal structural models aimed to estimate the effect of delayed switch on mortality in a hypothetical trial in which …

Persistent Hiv-Related Stigma In Rural Uganda During A Period Of Increasing Hiv Incidence Despite Treatment Expansion, Brian T. Chan, Sheri D. Weiser, Yap Boum Ii, Mark J. Siedner, Rain Mocello, Jessica E. Haberer, Peter Hunt, Jeffrey N. Martin, Kenneth H. Mayer, David Bangsberg, Alexander C. Tsai

OHSU-PSU School of Public Health Faculty Publications and Presentations

Objective—Program implementers have argued that the increasing availability of anti-retroviral therapy (ART) will reduce the stigma of HIV. We analyzed data from Uganda to assess how HIV-related stigma has changed during a period of ART expansion.

Design—Serial cross-sectional surveys.

Methods—We analyzed data from the Uganda AIDS Rural Treatment Outcomes (UARTO) study during 2007-2012 to estimate trends in internalized stigma among people living with HIV (PLHIV) at the time of treatment initiation. We analyzed data from the Uganda Demographic and Health Surveys (DHS) from 2006 and 2011 to estimate trends in stigmatizing attitudes and anticipated stigma in the general population. We …

Retention And Risk Factors For Attrition Among Adults In Antiretroviral Treatment Programmes In Tanzania, Uganda And Zambia, Olivier Koole

OHSU-PSU School of Public Health Faculty Publications and Presentations

OBJECTIVES—We assessed retention and predictors of attrition (recorded death or loss to follow-up) in antiretroviral treatment (ART) clinics in Tanzania, Uganda and Zambia.

METHODS—We conducted a retrospective cohort study among adults (≥18 years) starting ART during 2003–2010. We purposefully selected six health facilities per country and randomly selected 250 patients from each facility. Patients who visited clinics at least once during the 90 days before data abstraction were defined as retained. Data on individual and programme level risk factors for attrition were obtained through chart review and clinic manager interviews. Kaplan–Meier curves for retention across sites were created. Predictors of …

High Medication Adherence During Periconception Periods Among Hiv-1–Uninfected Women Participating In A Clinical Trial Of Antiretroviral Pre-Exposure Prophylaxis, Lynn T. Matthews, Renee Heffron, Nelly R. Mugo, Craig R. Cohen, Craig W. Hendrix, Connie Celum, David Bangsberg, Jared M. Baten

OHSU-PSU School of Public Health Faculty Publications and Presentations

Introduction: Pre-exposure prophylaxis (PrEP) may be an important safer conception strategy for HIV-1–uninfected women with HIV-1–infected partners. Understanding medication adherence in this population may inform whether PrEP is a feasible safer conception strategy.

Methods: We evaluated predictors of pregnancy and adherence to study medication among HIV-1–uninfected women enrolled in a randomized placebo-controlled trial of PrEP among African HIV-1– serodiscordant couples. Participants were counseled on HIV-1 risk reduction, contraception, and adherence and tested for pregnancy at monthly study visits. Pill counts of dispensed drug were performed and, at a subset of visits, plasma was collected to measure active drug concentration.

Results: …

Discovery And Characterization Of Novel Polyomaviruses In Humans, Erica Anne Siebrasse

All Theses and Dissertations (ETDs)

The family Polyomaviridae is comprised of small, double-stranded DNA viruses of approximately 5,000 base pairs. Two polyomaviruses are well-established human pathogens and cause significant morbidity and mortality in immunocompromised patients. These viruses were discovered in the 1970s, but the last seven years have seen an explosion of novel human polyomavirus discoveries. The work described here seeks to address two questions: "Are there additional, novel polyomaviruses infecting humans?" and "Do these polyomaviruses cause disease in their human hosts?" The discovery of an additional novel polyomavirus, MW polyomavirus (MWPyV), is described. MWPyV was discovered in the stool of a healthy child from …

Asset Holdings And Undernutrition Of Young Children: Evidence From China Health And Nutrition Survey, Minchao Jin

All Theses and Dissertations (ETDs)

Undernutrition is an underlying determinant of 45% of all childhood deaths annually, resulting in 3.1 million deaths to children less than five years globally (Black et al., 2013). The adverse effects of undernutrition, especially chronic undernutrition, could cause impaired physical growth, mental development retardation, low productivity and poverty during adulthood, and undernutrition of next generation. Worldwide, over 200 million children are undernourished (Black et al., 2013). Thus, there is an imperative to identify effective preventive actions or interventions for child undernutrition. Studies have documented links between undernutrition and low income, but few has tackling the causation from assets to child …

In Vivo Functions Of Inhibitory Immunoreceptors During Viral Infection, Aaron Rapaport

All Theses and Dissertations (ETDs)

CD8+ T cells and NK cells are two effector cells of the mammalian immune system that rely on activating and inhibitory immunoreceptors to determine the outcome of an interaction with a target cell. An infected or transformed target cell can upregulate a variety of ligands that bind to activating receptors. Activating signals within an effector cell can then elicit responses that kill the target directly by lysing it or indirectly by secreting cytokines and chemokines that attract and activate other immune cells. In contrast, a healthy target cell can maintain expression of ligands for inhibitory receptors that restrain effector cell …

Host-Microbial Interactions That Modulate Luminal Iga, Clara Moon

All Theses and Dissertations (ETDs)

IgA is the most abundant immunoglobulin produced in the body, most of which can be found at mucosal sites such as the intestine where it plays an important role at a critical intersection between the host immune system and the microbiota. In the work detailed here, I sought to investigate IgA delivery and stability using in vitro and in vivo methods. First, I developed a primary intestinal epithelial monolayer system, and utilized this system to evaluate factors that modulate IgA transcytosis. In vivo, I interrogated baseline levels of fecal IgA in WT mice and surprisingly observed a binary phenotype in …

Pattern Of Household Drug Storage, Retno Gitawati

Kesmas

Household storage of pharmaceutical is world-widely practice, including in Indonesia. The purpose of this study was to obtain the pattern of medicine storage, the sources and reasons of medicine kept in households. Acrosssectional survey was conducted on October 2011, involving 250 adult household respondents, randomly selected from three subdistricts in North Jakarta, and have approved the written consents, and interviewed with structured questionnaire. Data were performed in univariate and bivariate analysis with chi square test. The majority of household (82%) stored drugs at home; analgesic-antipyretic nonsteroidal anti-inflammatory was the type of drugs kept by mostly (76.1%) of household. Out of …

Asupan Vitamin D Rendah Dan Keparahan Demam Berdarah Dengue Pada Anak Usia 1-14 Tahun, Nur Siyam, Siswanto Agus Wilopo, Mohammad Hakimi

Kesmas

Demam berdarah dengue (DBD) menimbulkan syok dan kematian. Penderita DBD di Yogyakarta sebagian besar usia 1 - 12 tahun dengan DBD parah. Asupan vitamin D rendah diasumsikan penyebab DBD parah. Asumsi ini perlu dibuktikan dengan menganalisis pengaruh asupan Vitamin D dan keparahan DBD. Rancangan penelitian adalah studi kasus kontrol. Penelitian di bangsal rawat inap anak dan instalasi catatan medik RS Jogja dan RSUP Dr. Sardjito. Kasus adalah anak usia 1 - 14 tahun dengan DBD grade III & IV, kontrolnya DBD grade I & II. Data asupan vitamin D diambil dengan food frequency questionnaire (FFQ). Variabel luar adalah indeks massa …

Investigating Propargyl-Linked Antifolates In Inhibiting Bacterial And Fungal Dihydrofolate Reductase, Joshua Andrade

Honors Scholar Theses

Antimicrobial agents have been invaluable in reducing illness and death associated with bacterial infection. However, over time, bacteria have evolved resistance to all major drug classes as a result of selective pressure. The advancement of new drug compounds is therefore vital. The Anderson-Wright Lab has focused on developing potent and selective inhibitors of dihydrofolate reductase (DHFR), an enzyme key in cell proliferation and survival, in several pathogenic species. The lab has found that a set of compounds, known as propargyl-linked antifolates, are DHFR inhibitors that are both biologically effective and have strong pharmacokinetic properties.

The efficacy of novel propargyl-linked antifolates …

Diagnosis Dini Tuberkulosis Pada Kontak Serumah Dengan Penderita Tuberkulosis Paru Melalui Deteksi Kadar Ifn-Γ, Sri Andarini Indreswari, Suharyo Suharyo

Kesmas

Tuberkulosis paru masih merupakan masalah dunia. Indonesia menempati peringkat ke tiga di dunia pada tahun 2012. Target nasional Case Detection Rate tahun 2012 adalah 70%, sedangkan pencapaian Jawa Tengah sebesar 58,48%. Penelitian ini bertujuan untuk memperoleh batas kadar interferon (IFN) γ pada orang kontak serumah dengan penderita tuberkulosis paru sebagai dasar diagnosis dini penyakit tuberkulosis. Penelitian dilakukan secara kohort selama dua tahun (2011 - 2013) di Balai Kesehatan Masyarakat Paru Semarang. Pada akhir penelitian, terdapat 12 responden kontak dan 13 tidak kontak serumah. Uji Wilcoxon menunjukkan perbedaan bermakna rerata kadar IFN-γ antara kelompok kontak dengan kelompok tidak kontak serumah (nilai …

Identification Of Srnas Expressed By The Human Pathogen Neisseria Gonorrhoeae Under Disparate Growth Conditions, Ryan Mcclure, Brian Tjaden, Caroline Genco

Faculty Research and Scholarship

In the last several years, bacterial gene regulation via small RNAs (sRNAs) has been recognized as an important mechanism controlling expression of essential proteins that are critical to bacterial growth and metabolism. Technologies such as RNA-seq are rapidly expanding the field of sRNAs and are enabling a global view of the “sRNAome” of several bacterial species. While numerous sRNAs have been identified in a variety of both Gram-negative and Gram-positive bacteria, only a very small number have been fully characterized in the human pathogen Neisseria gonorrhoeae, the etiological agent of the STD gonorrhea. Here we present the first analysis …