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Hslic Annual Report Fy2013-14, Health Sciences Library And Informatics Center

HSLIC Annual Reports

No abstract provided.

Association Between Parity And Rubella Seropositivity Among Older Reproductive-Age Women, Ibtisam Salim Awadh

Master of Medicine in Obstetrics and Gynecology

Background: Rubella virus when it infects a non-pregnant adult or child usually causes a mild febrile rash illness. However, infection in the first 12 weeks of pregnancy causes miscarriages, stillbirths or foetal anomalies known as congenital rubella syndrome (CRS). Factors associated with rubella immunity include age and parity. No studies have been done to isolate the association of parity independent of age. Objectives: To determine the seroprevalence of rubella IgG antibodies among nulliparous and multiparous women of the same age-group attending various clinics in Aga Khan University Hospital, Nairobi, Design: A cross-sectional study of women attending a tertiary hospital, Nairobi, …

Behavior Change Techniques Implemented In Electronic Lifestyle Activity Monitors: A Systematic Content Analysis, Elizabeth J. Lyons, Zakkiyya H. Lewis, Brian G. Mayrsohn, Jennifer L. Rowland

Faculty Bibliography 2010s

Background: Electronic activity monitors (such as those manufactured by Fitbit, Jawbone, and Nike) improve on standard pedometers by providing automated feedback and interactive behavior change tools via mobile device or personal computer. These monitors are commercially popular and show promise for use in public health interventions. However, little is known about the content of their feedback applications and how individual monitors may differ from one another. Objective: The purpose of this study was to describe the behavior change techniques implemented in commercially available electronic activity monitors. Methods: Electronic activity monitors (N=13) were systematically identified and tested by 3 trained coders …

The Potential Impact Of Expanding Target Age Groups For Polio Immunization Campaigns, Radboud J. Duintjer Tebbens, Dominika A. Kalkowska, Steven G. F. Wassilak, Mark A. Pallansch, Stephen L. Cochi, Kimberly M. Thompson

Faculty Bibliography 2010s

Background: Global efforts to eradicate wild polioviruses (WPVs) continue to face challenges due to uninterrupted endemic WPV transmission in three countries and importation-related outbreaks into previously polio-free countries. We explore the potential role of including older children and adults in supplemental immunization activities (SIAs) to more rapidly increase population immunity and prevent or stop transmission. Methods: We use a differential equation-based dynamic poliovirus transmission model to analyze the epidemiological impact and vaccine resource implications of expanding target age groups in SIAs. We explore the use of older age groups in SIAs for three situations: alternative responses to the 2010 outbreak …

Tigecycline For Severe Clostridium Difficile Infection, Ashley Thomas, Farhan Khan, Nizam Uddin, Mark R. Wallace

Faculty Bibliography 2010s

Limited data suggest that tigecycline may be of value in the treatment of Clostridiumdifficile infection. We reviewed our experience using tigecycline to treat severe c. difficile and compared outcomes to similarly ill patients who did not receive tigecycline. We found no difference between the groups. Further study is needed before tigecycline can be recommended for use in severe C. difficile infection.

Migrant Labor, Development, And Hiv In Botswana, William Kearns

HIM 1990-2015

At independence, Botswana was highly underdeveloped and reliant on external capital earned through migrant labor. This presented several challenges to development despite the discovery of diamonds shortly after independence. However, no challenge was greater than the HIV epidemic which came to infect one in four Batswana. This thesis discusses the historical factors which promoted the spread of the virus in the greater context of migrant labor and development within Botswana.

Simple Objective Detection Of Human Lyme Disease Infection Using Immuno-Pcr And A Single Recombinant Hybrid Antigen, Micah D. Halpern, Claudia R. Molins, Martin Schriefer, Mollie W. Jewett

Faculty Bibliography 2010s

A serology-based tiered approach has, to date, provided the most effective means of laboratory confirmation of clinically suspected cases of Lyme disease, but it lacks sensitivity in the early stages of disease and is often dependent on subjectively scored immunoblots. We recently demonstrated the use of immuno-PCR (iPCR) for detecting Borrelia burgdorferi antibodies in patient serum samples that were positive for Lyme disease. To better understand the performance of the Lyme disease iPCR assay, the repeatability and variability of the background of the assay across samples from a healthy population (n = 36) were analyzed. Both of these parameters were …

Host And Bacterial Determinants Of Staphylococcus Aureus Nasal Colonization In Humans, Gowrishankar Muthukrishnan

Electronic Theses and Dissertations

Staphylococcus aureus (SA), an opportunistic pathogen colonizing the anterior nares in approximately 30% of the human population, causes severe hospital-associated and community-acquired infections. SA nasal carriage plays a critical role in the pathogenesis of staphylococcal infections and SA eradication from the nares has proven to be effective in reducing endogenous infections. To understand SA nasal colonization and its relation with consequent disease, assessment of nasal carriage dynamics among a diverse population and determining factors responsible for SA nasal carriage have become major imperatives. Here, we report on an extensive longitudinal monitoring of SA nasal carriage in 109 healthy individuals over …

Antimicrobial Peptide Resistance And Immunomodulation By Hiv-1 Gp41, Matthew Wood

Electronic Theses and Dissertations

Fusion inhibitors are a class of antiretroviral drugs used to prevent entry of HIV into host cells. Many of the fusion inhibitors being developed, including the drug enfuvirtide (ENF), are peptides designed to mimic, and thereby competitively inhibit, the viral fusion protein gp41. An exception to this is a class of cyclic, cationic, antimicrobial peptides known as θ-defensins, which are produced by many non-human primates and exhibit broad-spectrum antiviral and antibacterial activity. Currently, the θ-defensin analog RC-101 is being developed as a microbicide to prevent sexual transmission of HIV-1. Understanding potential RC-101 resistance, and how resistance to other fusion inhibitors …

Phar 452.01: Therapeutics Ii - Clinical Use Of Antimicrobials, Douglas Allington, Donna G. Beall, Kerry J. Haney, Kendra A. Proacci, Michael P. Rivey

University of Montana Course Syllabi

No abstract provided.

The Hedonic Consequences Of Punishment Revisited, Christopher Wildeman, Kristin Turney, Jason Schnittker

Journal of Criminal Law and Criminology

No abstract provided.

Assessment Of The Capacity Of Ugandan Health Facilities, Personnel, And Resources To Prevent And Control Noncommunicable Diseases, Hilary Eileen Rogers

Public Health Theses

Due to the rapid rise of noncommunicable diseases (NCDs), the Uganda Ministry of Health (MoH) has prioritized NCD prevention, early diagnosis, and management. In partnership with the World Diabetic Foundation, MoH has embarked on a countrywide program to build capacity of the health facilities to address NCDs. A needs assessment was developed and conducted in 13 regional referral hospitals, 27 general hospitals, and 14 health center IVs in Uganda to: (1) assess the capacity of health units to detect and manage noncommunicable diseases; (2) describe provider knowledge, attitudes, resources, and practices, and (3) identify areas of improvement and areas in …

Evidence For Selection Acting On Immune-Related Iron Transport Genes In Wild Rodents, Dylan Adam Duchen

Public Health Theses

Every organism requires certain resources that they cannot endogenously produce; one such dietary component, iron, is essential for many basic cellular functions and the host-immune response. By studying patterns of genetic diversity within the genes involved in immune-related iron transport we can achieve a greater understanding of the evolutionary mechanisms which drive these processes, including those underlying host-pathogen interactions.

This thesis describes further evidence of patterns indicative of positive selection within apical regions of the transferrin receptor complex (Tfr1), sites known to be involved in an evolutionary arms race with pathogens, within two rodent species endemic to Europe and Asia, …

The Epidemiology Of Primary Varicella And Herpes Zoster Hospitalizations In The Post-Varicella Vaccine Era: Connecticut, 1996-2012, Elizabeth Humes

Public Health Theses

Background: A vaccine for primary varicella (VZV) was licensed and recommended for use in children as a single dose in 1996, and as two doses in 2006. A vaccine for herpes zoster (HZ) was licensed and recommended for use in adults ≥60 years in 2006. Both vaccines have the potential to modify the epidemiology of VZV and HZ. Rates of hospitalization due to VZV and HZ were examined in the post-vaccine era to characterize the epidemiology of severe disease and to assess the possible impact of vaccination on the incidence of hospitalization.

Methods: Statewide hospital discharge data in Connecticut were …

The Daily Gamecock, Wednesday, October 29, 2014, University Of South Carolina, Office Of Student Media

October

No abstract provided.

Time For T? Immunoinformatics Addresses Vaccine Design For Neglected Tropical And Emerging Infectious Diseases, Frances E. Terry, Leonard Moise, Rebecca F. Martin, Melissa Torres, Nils Pilotte, Steven A. Williams, Anne S. De Groot

Biological Sciences: Faculty Publications

Vaccines have been invaluable for global health, saving lives and reducing healthcare costs, while also raising the quality of human life. However, newly emerging infectious diseases (EID) and more well-established tropical disease pathogens present complex challenges to vaccine developers; in particular, neglected tropical diseases, which are most prevalent among the world's poorest, include many pathogens with large sizes, multistage life cycles and a variety of nonhuman vectors. EID such as MERS-CoV and H7N9 are highly pathogenic for humans. For many of these pathogens, while their genomes are available, immune correlates of protection are currently unknown. These complexities make developing vaccines …

Cabassous Unicinctus (Cingulata: Dasypodidae), Virginia Hayssen

Biological Sciences: Faculty Publications

Cabassous unicinctus (southern naked-tailed armadillo) is a nocturnal, solitary, fossorial myrmecophage that ranges east of the Andes across the central lowlands of South America. It occupies a wide range of habitats including grassland, rain forest, cultivated pastures, flooded grasslands, forest patches, disturbed habitats, and gallery forests. C. unicinctus is listed as "Least Concern" by the International Union for Conservation of Nature and Natural Resources.

A Comparative Content Analysis Of Alcoholism Treatment Programs With A Focus On A Native Treatment Alternative, Mike J. Eshkibok

Theses and Dissertations

A historical account of Native American Indian culture is set forth to provide the antecedent events for understanding problems with and solutions to alcoholism among Native American Indians. Two 12-step alcohol treatment programs are explained, compared, and contrasted: Alcoholics Anonymous (AA) and a Native 12-Step Program.

Qualitative analysis was used to collect information from 13 Native American Indian counselors in alcohol treatment programs and data was analyzed by coding transcripts of taped interviews, then grouping data into categories, determining themes from the categories, and drawing conclusions.

Three conclusions emerged from the qualitative data analyzed from Native American Indian alcohol treatment …

Effects Of Osteocytes On Vibration-Induced Reflex Muscle Activity In Postmenopausal Women, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan, Muharrem Çi̇dem, Suat Hayri̇ Küçük, Hakan Ekmekçi̇, Cengi̇z Bahadir

Turkish Journal of Medical Sciences

To assess whether osteocytes have an effect on reflex myoelectrical activity during whole-body vibration (WBV) in postmenopausal women. Materials and methods: Participants were classified into 2 groups: the low bone mineral density (BMD) group (n = 37) and normal BMD group (n = 43). Hip BMD was measured using dual-energy X-ray absorptiometry. Surface electromyography data recorded from the adductor longus muscle were processed to obtain vibration-induced reflex myoelectrical activity. Changes in plasma sclerostin (SOST) levels with WBV were expressed as a standardized vibration-induced SOST index. Results: The standardized vibration-induced SOST index was 1.03 ± 0.24 in the low BMD group …

Attitudes Towards Influenza Vaccination In High Socioeconomic Status Turkish Parents, Suzan Gündüz, Çi̇ğdem Nüket Yüksel, Hale Bozkurt Aktoprak, Meti̇n Canbal, Mehmet Kaya

Turkish Journal of Medical Sciences

To better understand the knowledge, attitudes, and demographic factors that influence the rate of influenza vaccination among high socioeconomic status parents. Materials and methods: questionnaire exploring the attitudes of parents to the influenza vaccine, and their knowledge about influenza and its vaccination, was given to parents of children from 1 through 16 years of age attending the Turgut Özal University Hospital after the 2011/12 influenza season. Results: In the present study, 285 mothers and their children participated and 8.8% (n = 25) of children had the influenza vaccination. Between the vaccinated and nonvaccinated groups, there were statistically significantly differences for …

Insulin-Like Growth Factor 1, Liver Enzymes, And Insulin Resistance In Patients With Pcos And Hirsutism, Evri̇m Çakir, Oya Topaloğlu, Nujen Çolak Bozkurt, Başak Karbek Bayraktar, Aşkin Güngüneş, Müyesser Sayki Arslan, İlknur Öztürk Ünsal, Esra Tutal, Beki̇r Uçan, Tuncay Deli̇başi

Turkish Journal of Medical Sciences

Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PCOS and idiopathic hirsutism (IH). Materials and methods: This was a prospective case-controlled study. The study population consisted of 25 reproductive-age PCOS women, 33 women with IH, and 25 control subjects. Results: Mean IGF-I levels and median ALT levels were higher in patients with IH and …

Hst 5765 : Epidemiology In Public Health, Health Studies

Approved Course Proposals

No abstract provided.

Evaluation Of 48-Week Response Of Treatment-Naive Chronic Hepatitis B Patients To 0.5 Mg/Day Entecavir, Servet Kölgeli̇er, Nazlim Aktuğ Demi̇r, Serap Özçi̇men, Şua Sümer

Turkish Journal of Medical Sciences

The hepatitis B virus (HBV) is an important healthcare problem. Chronic hepatitis B infection may present with a wide range of manifestations from inactive carrier state to cirrhosis and hepatocellular cancer. Therefore, treatment is very important in chronic hepatitis B. In this study, the treatment results of 199 chronic hepatitis B patients taking entecavir 0.5 mg/day for 48 weeks were evaluated. Materials and methods: This study retrospectively evaluated data of 199 treatment-naive chronic hepatitis B patients who were treated with entecavir. Results: Of the 199 treatment-naive chronic hepatitis B patients, 141 (70.9%) were males and 58 (29.1%) were females, and …

Effects Of Whole-Body Vibration On Plasma Sclerostin Level In Healthy Women, Muharrem Çi̇dem, Yunus Karakoç, Hakan Ekmekçi̇, Suat Hayri̇ Küçük, Murat Uludağ, Kerem Gün, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan

Turkish Journal of Medical Sciences

To determine whether plasma sclerostin levels are affected by applying whole-body vibration treatments. Materials and methods: Following a pilot study, the present prospective, randomized, controlled single-blind study was performed on 16 healthy volunteer women (ages 20 to 40 years). Subjects were randomly divided into 2 groups, and whole-body vibration was applied to the treatment group but not to the controls. The plasma sclerostin levels were measured before the treatment and at the 10th minute after whole-body vibration on the 1st, 2nd, and 5th days of application. Results: The plasma sclerostin level measured at 10 min after the whole-body vibration treatment …

Evaluation Of Patients With Zygomycosis, Onur Kaya, Sema Alp Çavuş, Özge Turhan, Meltem Işikgöz Taşbakan, Hüsnü Pullukçu, Mustafa Bülent Ertuğrul, Şebnem Şenol, Çi̇ğdem Banu Çeti̇n, Beti̇l Özhak Baysan, Selda Sayin Kutlu, Di̇lek Yeşi̇m Meti̇n, Meltem Avci, Gülşen Mermut, Vi̇ldan Avkan Oğuz, Nur Yapar

Turkish Journal of Medical Sciences

Zygomycosis is a severe angioinvasive infection caused by Zygomycetes. We retrospectively investigated 16 cases of zygomycosis. Materials and methods: The data of patients, who had been followed between 2004 and 2010 in 8 tertiary-care teaching hospitals, were reviewed. Demographic characteristics, underlying diseases, and clinical signs and symptoms of the patients, as well as diagnostic methods, data obtained by radiological imaging methods, and the therapies, were recorded. Therapeutic approaches, antifungal agents and duration of use, and the characteristics of the cases were identified. Results: The study included 11 female and 5 male subjects. The most common symptoms and clinical signs were …

Treatment Of Infectious Mastitis, Elizabeth Sandberg,

Theses and Dissertations

Mastitis is a complication of breast feeding encountered often by primary care providers. The goal of treating mastitis is not only resolution of the infection, but also the continuation of lactation so that both mother and child may continue to enjoy the innumerable health benefits of breastfeeding. The patient discussed in this case study is a first time mother who is exclusively breastfeeding, but whose planned change in feeding schedules places her at risk for developing mastitis as a result of engorgement or plugged milk ducts. This case report examines current recommendations and evidence for treatment of infectious mastitis. Attention …

The Price Of Failure Of Informed Consent Law: Coercive Sterilizations Of Hiv-Positive Women In South Africa, Lindsay Carniak Mclaughlin

Minnesota Journal of Law & Inequality

No abstract provided.

A Kinetic Analysis Of The Inhibition Of Fox-4 Β-Lactamase, A Plasmid-Mediated Ampc Cephalosporinase, By Monocyclic Β-Lactams And Carbapenems, Krisztina M. Papp-Wallace, Susana Mallo, Christopher R. Bethel, Magdalena A. Taracila, Andrea M. Hujer, Ana Fernandez, Julian A. Gatta, Kerri M. Smith, Yan Xu, Malcolm G.P. Page, Eric Desarbre, German Bou, Robert A. Bonomo

Chemistry Faculty Publications

Abstract: Objectives: Class C β-lactamases are prevalent among Enterobacteriaceae; however, these enzymes are resistant to inactivation by commercially available β-lactamase inhibitors. In order to find novel scaffolds to inhibit class C β-lactamases, the comparative efficacy of monocyclic β-lactam antibiotics (aztreonam and the siderophore monosulfactam BAL30072), the bridged monobactam β-lactamase inhibitor BAL29880, and carbapenems (imipenem, meropenem, doripenem and ertapenem) were tested in kinetic assays against FOX-4, a plasmid-mediated class C β-lactamase (pmAmpC). Methods: The FOX-4 β-lactamase was purified. Steady-state kinetics, electrospray ionization mass spectrometry (ESI-MS) and ultraviolet difference (UVD) spectroscopy were conducted using the β-lactam scaffolds described. Results: The Ki values …

Hiding The Statute In Plain View: University Of Texas Southwestern Medical Center V. Nassar, Michael J. Zimmer

Faculty Publications & Other Works

No abstract provided.

Influence Of Marianismo On Colorectal Cancer Screening Behavior Among Hispanic Women In The United States, Robin Thompson

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer death in the United States (U.S).1 Although early detection and treatment can reduce CRC-related morbidity and mortality, almost twothirds of patients are diagnosed with advanced stage disease indicating non-adherence to recommended screening guidelines.1 Indeed, less than half of individuals over 50 years of age get screened at recommended intervals.2 More specifically, lower rates of CRC screening exist among these groups: those identifying as being of Hispanic origin, the uninsured, disabled individuals, and women.3 In a 2011 report from the National Center on Health …