Digital Commons Network^™

Hepatitis E Antibodies In Laboratory Rabbits From 2 Us Vendors, Leslie Birke, Stephania A. Cormier, Dahui You, Rhett W. Stout, Christian Clement, Merlin Johnson, Hilary Thompson

Faculty Publications

We tested laboratory rabbits from 2 US vendors for antibodies against hepatitis E virus (HEV); Seroprevalences were 40% and 50%. Retrospective analysis of an ocular herpes simplex 1 experiment demonstrated that HEV seropositivity had no effect on experiment outcome. HEV probably is widespread in research rabbits, but effects on research remain unknown.

Developing Ethread Pipeline Using Saga-Pilot Abstraction For Large-Scale Structural Bioinformatics, Anjani Ragothaman, Sairam Chowdary Boddu, Nayong Kim, Wei Feinstein, Michal Brylinski, Shantenu Jha, Joohyun Kim

Faculty Publications

While most of computational annotation approaches are sequence-based, threading methods are becoming increasingly attractive because of predicted structural information that could uncover the underlying function. However, threading tools are generally compute-intensive and the number of protein sequences from even small genomes such as prokaryotes is large typically containing many thousands, prohibiting their application as a genome-wide structural systems biology tool. To leverage its utility, we have developed a pipeline for eThread - a meta-threading protein structure modeling tool, that can use computational resources efficiently and effectively. We employ a pilot-based approach that supports seamless data and task-level parallelism and manages …

Vitamin D Levels Are Low In Adult Patients With Sickle Cell Disease In Jamaica And West Africa, Bamidele O. Tayo, Titilola S. Akingbola, Babatunde L. Salako, Colin A. Mckenzie, Marvin Reid, Jennifer Layden, Ifeyinwa Osunkwo, Jacob Plange-Rhule, Amy Luke, Ramon Durazo-Arvizu, Richard S. Cooper

Faculty Publications

Background: Patients with sickle cell disease in the USA have been noted to have lower levels of vitamin D – measured as 25-hydroxyvitamin D (25(OH)D) – compared to controls. Average serum 25(OH)D levels are also substantially lower in African Americans than whites, while population distributions of 25(OH)D among Jamaicans of African descent and West Africans are the same as among USA whites. The purpose of this study was to examine whether adult patients with sickle cell disease living in tropical regions had reduced 25(OH)D relative to the general population. Methods: We analyzed serum 25(OH)D in stored samples collected from studies …

Comparison Of Patients From Nigeria And The Usa Highlights Modifiable Risk Factors For Sickle Cell Anemia Complications, Titilola S. Akingbola, Bamidele O. Tayo, Babatunde Salako, Jennifer E. Layden, Lewis L. Hsu, Richard S. Cooper, Victor R. Gordeuk, Santosh L. Saraf

Faculty Publications

To identify factors that affect manifestations of sickle cell anemia we compared patients 11-30 years of age from University of Ibadan, Ibadan, Oyo, Nigeria (n = 214) and University of Illinois at Chicago, Chicago, IL, USA (n = 209). Paralleling findings in the general populations of the two countries, the Chicago patients were more often overweight or obese as defined by the Centers for Disease Control and Prevention (Atlanta, GA, USA) guidelines, and more often had elevated blood pressure (BP) as defined by the National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD, USA guidelines. The Ibadan patients did not …

Research Capacity. Enabling The Genomic Revolution In Africa, Charles Rotimi, Akin Abayomi, Alash'le Abimiku, Victoria May Adabayeri, Clement Adebamowo, Ezekiel Adebiyi, Adebowale D. Ademola, Adebowale Adeyemo, Dwomoa Adu, Dissou Affolabi, Godfred Agongo, Samuel Ajayi, Sally Akarolo-Anthony, Rufus Akinyemi, Albert Akpalu, Marianne Alberts, Orlando Alonso Betancourt, Ahmed Mansour Alzohairy, Gobena Ameni, Olukemi Amodu, Gabriel Anabwani, Kristian G. Andersen, Fatiu Arogundade, Oyedunni Arulogun, Danny A. Asogun, Rasheed Bakare, Naby Balde, Mary Lynn Baniecki, Christine Beiswanger, Alia Benkahla, Lara Bethke, Micheal Boehnke, Vincent Boima

Faculty Publications

No abstract provided.

Sampling Locality Is More Detectable Than Taxonomy Or Ecology In The Gut Microbiota Of The Brood-Parasitic Brown-Headed Cowbird (Molothrus Ater), Sarah M. Hird, Bryan C. Carstens, Steven W. Cardiff, Donna L. Dittmann, Robb T. Brumfield

Faculty Publications

Brown-headed Cowbirds (Molothrus ater) are the most widespread avian brood parasite in North America, laying their eggs in the nests of approximately 250 host species that raise the cowbird nestlings as their own. It is currently unknown how these heterospecific hosts influence the cowbird gut microbiota relative to other factors, such as the local environment and genetics. We test a Nature Hypothesis (positing the importance of cowbird genetics) and a Nurture Hypothesis (where the host parents are most influential to cowbird gut microbiota) using the V6 region of 16S rRNA as a microbial fingerprint of the gut from 32 cowbird …

Aga Khan University, Report 2014, Aga Khan University

The Aga Khan University Reports Archives

• The Greatest Challenge of Our Time
• Transforming the University
• AKU Overview
• Going Where the Need is Greatest
• Our People
• Research with Impact
• Notable Developments
• World-Class Graduate Professional Education
• Investing in Excellence with Your Support
• AKU by the Numbers
• University Governance
• Financial Highlights

2014 Accountability Report Usf System, Usf

USF Accountability Reports

No abstract provided.

2014 Accountability Report Usf Tampa, Usf

USF Accountability Reports

No abstract provided.

25 Years After Vi Typhoid Vaccine Efficacy Study, Typhoid Affects Significant Number Of Population In Nepal, Deepak Bajracharya, M. Imran Khan, Alfred Pach Iii, Parisha Shrestha, Nilesh Joshi, Shyam R. Upreti, Thomas Wierzba, Mahesh Puri, Sushant Sahastrabuddhe, R. Leon Ochiai

Centre of Excellence in Women and Child Health

Salmonella Typhi, first isolated in 1884, results in infection of the intestines and can end in death and disability. Due to serious adverse events post vaccination, whole cell killed vaccines have been replaced with new generation vaccines. The efficacy of Vi polysaccharide (ViPS) vaccine, a new generation, single-dose intramuscular typhoid vaccine was assessed in Nepal in 1987. However, despite the availability of ViPS vaccine for more than 25 years, Nepal has one of the highest incidence of typhoid fever. Therefore we collected information from hospitals in the Kathmandu Valley from over the past five years. There were 9901 enteric fever …

Characterization Of Bacteriophages From Environmental Water Samples And The Potential Of Bacteriophages Tailspike Proteins (Tsp) In Bacteria Detection, Gayathri Upeksha Gunathilaka

Wayne State University Theses

ABSTRACT

CHARACTERIZATION OF BACTERIOPHAGES FROM ENVIRONMENTAL WATER SAMPLES AND THE POTENTIAL OF BACTERIOPHAGES TAILSPIKE PROTEINS (TSP) IN BACTERIA DETECTION

by

GAYATHRI UPEKSHA GUNATHILAKA

May 2014

Advisor: Dr. Yifan Zhang

Major: Nutrition and Food Science

Degree: Master of Science

The high abundance of phage in the environment and their specificity with the bacteria host make them an excellent tool for bacteria detection. To characterize phage specific to Salmonella and E. coli from water samples in the Southeastern Michigan and to develop a novel bacterial detection method using phage, environmental water samples were collected from rivers and waste water treatment plant (WWTP) …

Lost In Translation: Statistical Inference In Court, Erica Beecher-Monas

Law Faculty Research Publications

No abstract provided.

The Composition And Stability Of The Vaginal Microbiota Of Normal Pregnant Women Is Different From That Of Non-Pregnant Women, Roberto Romero, Sonia S. Hassan, Pawel Gajer, Adi L. Tarca, Douglas W. Fadrosh, Lorraine Nikita, Marisa Galuppi, Ronald F. Lamont, Piya Chaemsaithong, Jezid Miranda, Tinnakorn Chaiworapongsa, Jacques Ravel

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

This study was undertaken to characterize the vaginal microbiota throughout normal human pregnancy using sequence-based techniques. We compared the vaginal microbial composition of non-pregnant patients with a group of pregnant women who delivered at term.

Results

A retrospective case–control longitudinal study was designed and included non-pregnant women (n = 32) and pregnant women who delivered at term (38 to 42 weeks) without complications (n = 22). Serial samples of vaginal fluid were collected from both non-pregnant and pregnant patients. A 16S rRNA gene sequence-based survey was conducted using pyrosequencing to characterize the structure and stability of the vaginal …

Rnao's 70 Per Cent Full-Time Employment For Nurses Survey: Hospital And Long-Term Care Sectors, Registered Nurses' Association Of Ontario, 70% Full-Time Nursing Employment Working Group Joint Provincial Nursing Committee

General Submissions: Nursing as Profession

The 70 per cent Full-Time Employment for Nurses Survey was initiated by the 70% Full-Time Nursing Employment Working Group (FTNEWG), a working group of the Joint Provincial Nursing Committee (JPNC). RNAO led the project, which was implemented in July 2012 and targeted all employers of nurses in the hospital and long-term care (LTC) sectors. The findings of the report are relevant to nursing human resource (HR policy), and are targeted at government, employers, nursing associations and the College of Nurses of Ontario.

Visionary Leadership: Charting A Course For The Health System And Nursing In Ontario, Registered Nurses' Association Of Ontario

General Submissions: Nursing as Profession

The Registered Nurses' Association of Ontario (RNAO) believes it's important to look down the road, today, and begin planning the future of our health system. By doing so, we can reach our destination with a clear sense of what we want, and how we get there. The work of registered nurses (RN) and nurse practitioners (NP) is central to our health system. The role they play is critical to creating a system that is person-centred, timely, effective, and efficient. That's why Ontario's nurses have developed a vision - a bold vision - to ensure Ontarians are served by a system …

Using An Epidemiological Approach To Critically Analyze A Population Health Problem - Al Hamsa Prison, Libya, Anthony Gomez

General Submissions: Community and Population-based Materials

Population health as defined by Nash, Reifsnyder, Fabius & Pracilio (2011) is the "distribution of health outcomes within a population, the health determinants that influence distribution, and the policies and interventions that impact the determinants" (p. xxxv). Studying a health problem that affects the population would always lead to a better healthcare delivery system, promoting health services that are accessible, affordable, available, and acceptable.

Characterisation Of The Vaginal Microflora Of Human Immunodeficiency Virus (Hiv) Positive And Negative Women In A Sub-Urban Population Of Kenya, Teresa N. Kiama, Rita Verhelst, Paul M. Mbugua, Mario Vaneechoutte, Hans Verstraelen, Benson Estambale, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Lactobacilli predominate normal vaginal microflora and are important in maintenance of vaginal health. The current study set out to identify and compare culture isolates of vaginal microflora of human immunodeficiency virus (HIV) positive (HIV+ ) and HIV negative (HIV- ) women at different phases during menstrual cycle from a sub-urban population of Kenya. Seventy four (74) women, 41 HIV+ and 33 HIV- , followed up two consecutive menstrual cycles, had high vaginal swabs taken to prepare Gram stains for six visits and anaerobic cultures for four. All 751 isolates identified by t-DNA polymerase chain reaction (PCR) belong to 51 species. …

Identifying Factors Associated With The Uptake Of Prevention Of Mother To Child Hiv Transmission Programme In Tigray Region, Ethiopia: A Multilevel Modeling Approach, Wondwossen Lerebo, Steven Callens, Debra Jackson, Christina Zarowsky, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Prevention of mother to child HIV transmission (PMTCT) remains a challenge in low and middle-income countries. Determinants of utilization occur – and often interact - at both individual and community levels, but most studies do not address how determinants interact across levels. Multilevel models allow for the importance of both groups and individuals in understanding health outcomes and provide one way to link the traditionally distinct ecological- and individual-level studies. This study examined individual and community level determinants of mother and child receiving PMTCT services in Tigray region, Ethiopia.

Methods: A multistage probability sampling method was used for this …

Herbal And Microbial Products For The Management Of Obesity, Maha Salama, Soheir El Zalabani, Essam Abdel Sattar

Pharmacy

Obesity is a global epidemic and one of the major health burdens of modern times. The prevalence of obesity is increasing worldwide; it constitutes a serious problem in developed as well as developing countries. Beside adults, the number of obese teenagers and children in particular has dramatically increased. Obesity is characterized by accumulation of excess fat in adipose tissues in an extent to produce adverse effects on health, leading to a reduction in life expectancy and/or a raise in health hazards. People are classified as overweight (pre-obese) and obese on the basis of the Body Mass Index (BMI), crude measure …

Genome-Wide Tissue-Specific Gene Expression, Co-Expression And Regulation Of Co-Expressed Genes In Adult Nematode Ascaris Suum, Bruce A. Rosa, Douglas P. Jasmer, Makedonka Mitreva

Open Access Publications

No abstract provided.

Isoprenoid Biosynthesis In Plasmodium Falciparum, Ann M. Guggisberg, Rachel E. Amthor, Audrey R. Odom

Open Access Publications

No abstract provided.

Filarial Antigenemia And Loa Loa Night Blood Microfilaremia In An Area Without Bancroftian Filariasis In The Democratic Republic Of Congo, Didier K. Bakajika, Maurice M. Nigo, Jean Pierre Lotsima, Germain A. Masikini, Kerstin Fischer, Melanie M. Lloyd, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.

An Outbreak Of Acute Febrile Illness Caused By Sandfly Fever Sicilian Virus In The Afar Region Of Ethiopia, 2011, David Wang

Open Access Publications

No abstract provided.

Engineering Recombinant Orsay Virus Directly In The Metazoan Host Caenorhabditis Elegans, Hongbing Jiang, Carl J. Franz, David Wang

Open Access Publications

No abstract provided.

Novel Approach Identifies Snps In Slc2a10 And Kcnk9 With Evidence For Parent-Of-Origin Effect On Body Mass Index, Felicia Gomez, Ingrid B. Borecki, Et Al

Open Access Publications

No abstract provided.

Effectiveness Of Screening Hospital Admissions To Detect Asymptomatic Carriers Of Clostridium Difficile: A Modeling Evaluation, Cristina Lanzas, Erik R. Dubberke

Open Access Publications

No abstract provided.

Strategies To Prevent Central Line-Associated Bloodstream Infections In Acute Care Hospitals: 2014 Update, Jonas Marschall, Leonard A. Mermel, Mohamed Fakih, Lynn Hadaway, Alexander Kallen, Naomi P. O'Grady, Ann Marie Pettis, Mark E. Rupp, Thomas Sandora, Lisa L. Maragakis, Deborah S. Yokoe

Open Access Publications

No abstract provided.

Rho1 Regulates Adherens Junction Remodeling By Promoting Recycling Endosome Formation Through Activation Of Myosin Ii, Hanako Yashiro, Andrew J. Loza, James B. Skeath, Gregory D. Longmore

Open Access Publications

No abstract provided.

Curricular Priorities For Business Ethics In Medical Practice And Research: Recommendations From Delphi Consensus Panels, James M. Dubois, Elena M. Kraus, Kamal Gursahani, Anthony Mikulec, Erin Bakanas

Open Access Publications

No abstract provided.

Detection Of A Divergent Parainfluenza 4 Virus In An Adult Patient With Influenza Like Illness Using Next-Generation Sequencing, Seweryn Bialasiewicz, Jodie Mcvernon, Terry Nolan, Stephen B. Lambert, Guoyan Zhao, David Wang, Michael D. Nissen, Theo P. Sloots

Open Access Publications

No abstract provided.