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Understanding Atp-Mediated Vasodilatation In Humans, Anne R. Crecelius, Frank A. Dinenno

Health and Sport Science Faculty Publications

Negative results, cynicism, the piecing together of puzzles and integrating physiology with experimental approaches are all part of the inspiring and meandering journey on the path to understand ATP-mediated vasodilatation. While it is satisfying to be "right" as scientists, we know sometimes the most important progress occurs when data are surprising or contrary to our original hypothesis. The pursuit of explanations for unexpected findings often leads to the best advancements. The story of how our laboratory came to investigate the underlying vasodilatator pathways of adenosine triphosphate (ATP) is an example of such a path to our current understanding.

Epinephrine Regulates Aquaglyceroporin Hc-3 Expression And Subcellular Localization In Cultured Erythrocytes From The Freeze-Tolerant Treefrog, Hyla Chrysoscelis, Connor J. Ratycz

Honors Theses

Cope’s gray treefrog Hyla chrysoscelis, accumulates and distributes glycerol as a cryoprotectant in anticipation of freezing. Transmembrane glycerol and water flux in H. chysoscelis erythrocytes likely occurs through HC-3, an ortholog of mammalian aquaporin 3. HC-3 protein is in higher abundance and is preferentially localized to the plasma membrane in RBCs from cold-acclimated treefrogs as compared to warmacclimated animals. It is hypothesized that neuroendocrine agonists via receptor mediated second messenger pathways integrate signals derived from fasting, dehydration, diurnal, and/or temperature changes during cold-acclimation to regulate HC-3 expression as part of the mechanism of freeze tolerance. In this study, cultured …

Who Knew? Refining The "Knowability" Standard For The Future Of Potentially Hazardous Technologies, Scott P. Kennedy

Washington Journal of Law, Technology & Arts

As consumer technology becomes increasingly complex, so too does the manufacturer’s task in assessing the scope of its duty to warn of potential dangers. A recent decision by the United States Court of Appeals for the Ninth Circuit, Rosa v. Taser International, Inc., offers a prime illustration of this challenge through its analysis of a hazard posed by Taser weaponry. The Rosa court highlights a point of uncertainty in this area of law: courts typically determine which hazards were knowable at the time of manufacture as a matter of law, but they sometimes do so in the absence of …

Abo-Incompatible Organs A Viable And Necessary Source For Transplants, Rachel J. Macpherson

Senior Honors Theses

Despite the astounding technological advancements of modern society, failure to receive a timely organ transplant accounts for the death of approximately 18 U.S. citizens each day. As the population continues to expand, so does the shortage of donor-recipient matching organs. In order to alleviate this deficit, medical researchers have addressed the most common barrier that accounts for donor-recipient denial: blood typing. Within recent years, immunological understanding has progressed leading researchers to believe ABO-incompatible organs may be a viable source for transplantation with unparalleled potential to expand donor availability. It is the intent of this review to increase public awareness of …

From Blue To Green: The Development And Implementation Of A Horticultural Therapy Program For Residents Of A Battered Women’S Shelter, Claire M. Renzetti, Diane R. Follingstad, Diane Fleet

CRVAW Faculty Presentations

No abstract provided.

The Effect Of Shear Stress, Potassium, And Adenosine On Α-1 Adrenergic Vasoconstriction Of Rat Soleus Feed Arteries, Tanner J. Heckle

Seaver College Research And Scholarly Achievement Symposium

During exercise, sympathetic nerve activity increases, augmenting the release of the neurotransmitter norepinephrine (NE) at the arterial wall and into the blood. NE binds to arterial adrenergic receptors to cause vasoconstriction, yet arteries in contracting skeletal muscle dilate during exercise. Previous evidence from Ives et al. suggests that heat and acidosis may partially inhibit constriction resulting from α-1 adrenergic receptors (termed sympatholysis). Our lab has previously demonstrated that rat soleus feed arteries respond to sympathetic signaling solely by α-1 adrenoceptors. We hypothesized that increased levels of arterial wall shear stress, potassium, or adenosine also contribute to sympatholysis, thereby reducing sympathetic …

Design, Simulation, Prototype, And Testing Of A Notched Blade Energy Generation System, Henry Cabra

USF Tampa Graduate Theses and Dissertations

This dissertation addresses the design, simulation, prototype, and test of a new energy generation system, which transforms rotational motion into electricity by the use of an innovative turbine-generator. The system is divided in two assembled subsystems that interact to finally transform kinetic energy into electricity. The first subsystem is a miniaturized notched impulse turbine system, and the second one is a millimeter permanent magnet generator (PMG) assembled into the turbine.

The conversion of biomechanical energy to electric energy, using clean and free energy produced by a living organism, is being increasingly researched [1]-[11]. These are all viable options, but advantages …

Using Sensor-Based Demand Controlled Ventilation To Realize Energy Savings In Laboratories, Mark B. Chinery

Theses and Dissertations

The building sector in the United States accounted for 41% of domestic and 7% of global energy consumption in 2010, with heating, ventilating, and air-conditioning (HVAC) activities consuming approximately 41.4% of the total facility energy consumption. Within the HVAC system, the parasitic energy accounts for one-third of the total energy consumed while heating and cooling accounts for the balance. The fan energy is approximately 85% of the total parasitic energy in the HVAC system. In a laboratory, energy related to ventilation can account for nearly half of the electrical energy demand. A carbon dioxide (CO2)-based demand controlled ventilation (DCV) strategy …

Physiological Investigation Of Localized Temperature Effects On Vigilance Performance, Justine D. Jeroski

Theses and Dissertations

Despite a long history of vigilance research, the relationship between the vigilance decrement and a broad range of physiology measures has not been fully documented. In an attempt to address this gap, an experiment was designed in which participants detected critical signals displayed at random during a 40-minute simulated air traffic control vigilance task. Three localized temperature condition changes, a positive, negative, or no change, were randomly assigned to participants and administered at the halfway point of the task. In addition to collecting performance data, cerebral oximetry, electrocardiography (ECG), and electrooculography (EOG) were utilized to collect a range of physiological …

Curriculum Minutes 03/06/2014, Curriculum Committee

Curriculum Committee Minutes

Biology Program Review Report, Course Approvals (Divisions of the Humanities and Science and Mathematics), Latin American Area Studies Minor, Online Learning Task Force Update, Writing for the Liberal Arts (WLA) Proposed Changes.

Volume 51, Number 29: March 05, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

Characterizing Phantom Arteries With Multi-Channel Laser Ultrasonics And Photo-Acoustics, Jami L. Johnson, Kasper Van Wijk, Michelle Sabick

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Multi-channel photo-acoustic and laser ultrasonic waves are used to sense the characteristics of proxies for healthy and diseased vessels. The acquisition system is non-contacting and non-invasive with a pulsed laser source and a laser vibrometer detector. As the wave signatures of our targets are typically low in amplitude, we exploit multi-channel acquisition and processing techniques. These are commonly used in seismology to improve the signal-to-noise ratio of data. We identify vessel proxies with a diameter on the order of 1 mm, at a depth of 18 mm. Variations in scattered and photo-acoustic signatures are related to differences in vessel wall …

Selective Anion Sensing By Chiral Macrocyclic Receptors With Multiple Hydrogen-Bonding Sites, Tadashi Ema, Keiichi Okuda, Sagiri Watanabe, Takayuki Yamasaki, Tsuyoshi Minami, Nina A. Esipenko, Pavel Anzenbacher Jr.

Chemistry Faculty Publications

Chiral macrocycles featuring sulfonamide and/or amide groups as anion-binding sites were synthesized. X-ray crystal structures and DFT calculations have shown that they adopt different conformations that may lead to unique binding behavior. Indeed, various anions could be sensed by their colorimetric and/or fluorescence signal output. The chiral macrocycles showed chiral recognition for chiral anions. Furthermore, a multisensor array with two or four chiral receptors discriminated seven phosphate anions (AMP, ADP, ATP, CMP, GMP, Pi, and PPi) with 100% classification accuracy.

Passive Biaxial Mechanical Properties And In Vivo Axial Pre-Stretch Of The Diseased Human Femoropopliteal And Tibial Arteries, Alexey Kamenskiy, Iraklis I. Pipinos, Yuris A. Dzenis, Clay Lomneth, Syed A. Jaffar Kazmi, Nicholas Y. Phillips, Jason N. Mactaggart

Department of Mechanical and Materials Engineering: Faculty Publications

Surgical and interventional therapies for atherosclerotic lesions of the infrainguinal arteries are notorious for high rates of failure. Frequently, this leads to expensive reinterventions, return of disabling symptoms, or limb loss. Interaction between the artery and repair material likely plays an important role in reconstruction failure, but data describing the mechanical properties and functional characteristics of human femoropopliteal and tibial arteries are currently not available. Diseased superficial femoral (SFA, n=10), popliteal (PA, n=8), and tibial arteries (TA, n=3) from 10 patients with critical limb ischemia were tested to determine passive mechanical properties using planar biaxial extension. All …

A Study Of Biliverdin, Serum Albumin And Hemoglobin In The Scincid Lizard, Prasinohaema, Oliver Sinquefield

Honors Capstones

No abstract provided.

Bjc Today

BJC Today

No abstract provided.

Volume 51, Number 27: February 19, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

Curricular Affairs Committee Report #511 Appendix C, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

Redox Pioneer: Professor Joe M. Mccord, David M. Schnell, Daret K. St Clair

Graduate Center for Nutritional Sciences Faculty Publications

Dr. Joe McCord (Ph.D. 1970) is recognized here as a Redox Pioneer because he has published at least three articles on antioxidant/redox biology as first/last author that have been cited over 1000 times and has published at least 37 articles each cited over 100 times. Dr. McCord is known for the monumental discovery of the antioxidant superoxide dismutase (SOD) while a graduate student under fellow redox pioneer Irwin Fridovich and demonstrating its necessity to aerobic life. Beyond this, McCord's career is distinguished for bridging the gap from basic science to clinical relevance by showing the application of SOD and superoxide …

Sjsu Erfa News, Fall 2014, San Jose State University, Emeritus And Retired Faculty Association

Emeritus and Retired Faculty Association (ERFA) Newsletter

Volume 28, Number 2

Leaders Eat Last, Jacl Editors

Journal of Applied Christian Leadership

No abstract provided.

A Systems Biology Approach To Iron Metabolism, Reinhard C. Laubenbacher, Suzy V. Torti

UCHC Articles - Research

Iron is critical to the survival of almost all living organisms. However, inappropriately low or high levels of iron are detrimental and contribute to a wide range of diseases. Recent advances in the study of iron metabolism have revealed multiple intricate pathways that are essential to the maintenance of iron homeostasis. Further, iron regulation involves processes at several scales, ranging from the subcellular to the organismal. This complexity makes a systems biology approach crucial, with its enabling technology of computational models based on a mathematical description of regulatory systems. Systems biology may represent a new strategy for understanding imbalances in …

Iso-66, A Novel Inhibitor Of Macrophage Migration Inhibitory Factor, Shows Efficacy In Melanoma And Colon Cancer Models, K. Ioannou, K. F. Cheng, G. V. Crichlow, A. I. Birmpilis, E. J. Lolis, O. E. Tsitsilonis, Y. Al-Abed

Journal Articles

Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory cytokine, which possesses a contributing role in cancer progression and metastasis and, thus, is now considered a promising anticancer drug target. Many MIF-inactivating strategies have proven successful in delaying cancer growth. Here, we report on the synthesis of ISO-66, a novel, highly stable, small-molecule MIF inhibitor, an analog of ISO-1 with improved characteristics. The MIF:ISO-66 co-crystal structure demonstrated that ISO-66 ligates the tautomerase active site of MIF, which has previously been shown to play an important role in its biological functions. In vitro, ISO-66 enhanced specific and non-specific anticancer immune responses, …

Probiotics: Achieving A Better Regulatory Fit, Diane E. Hoffmann, Claire M. Fraser, Francis Palumbo, Jacques Ravel, Virginia Rowthorn, Jack Schwartz

Faculty Scholarship

In 2007, the National Institutes of Health (NIH) launched the Human Microbiome Project (HMP), a $150 million initiative to characterize the microbial communities found at several different sites on the human body and to analyze the role of these microbes in human health and disease. Many lines of research have demonstrated the significant role of the microbiota in human physiology. The microbiota is involved, for example, in the healthy development of the immune system, prevention of infection from pathogenic or opportunistic microbes, and maintenance of intestinal barrier function. The HMP findings are helping us understand the role and variation of …

Physician Assistant Fort Lauderdale 2014, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

A Test Of Spielberger’S State-Trait Theory Of Anger With Adolescents: Five Hypotheses, Colleen Quinn, David Rollock, Scott R. Vrana

Psychology Publications

Spielberger’s state-trait theory of anger was investigated in adolescents (n = 201, ages 10-18, 53% African American, 47% European American, 48% female) using Deffenbacher’s five hypotheses formulated to test the theory in adults. Self-reported experience, heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) responses to anger provoking imagery scripts found strong support for the application of this theory to adolescents. Compared to the low trait anger (LTA) group, adolescents with high trait anger (HTA) produced increased HR, SBP and DBP, and greater self-report of anger to anger imagery (intensity hypothesis) but not greater self-report or cardiovascular …

Perceptions From Graduates Of Professional Athletic Training Programs Involved In Peer-Assisted Learning, Dana K. Bates

Faculty Publications - Department of Kinesiology

Context: Research has not explored how peer-assisted learning (PAL) impacts graduates once they are practicing as athletic trainers. Peer-assisted learning has been used in a variety of health education settings but there is a lack of data on its effects on the performance of graduates.

Objective: To investigate professional graduates’ perceptions of PAL pedagogy in their athletic training education and the impact of that experience on their first job.

Design: Qualitative study using a phenomenological approach.

Setting: One-on-one phone interviews with athletic training graduates.

Patients or Other Participants: Participants were from 8 accredited athletic training programs that varied in terms …

Integrating Philosophy, Cognitive Science, And Computational Methods At A Polytechnic Institution: Experiences Of Interdisciplinary Course Designs For Critical Thinking, Mehmet Vurkaç

Electrical & Computer Engineering Faculty Scholarship

No abstract provided.

Adolescence And Human Sexuality, Donald E. Greydanus, Hatim A. Omar

Pediatrics Faculty Publications

Human sexuality is a complex phenomenon involving the interaction of biology, sex, core gender identity, and gender role behavior. Successful completion of normal stages of sexuality development is important for children and adolescents to allow for optimal life as an adult. Controversies arise for clinicians as they work with their pediatric patients regarding health care sexuality issues. It is important that clinicians help these patients in an unbiased and neutral manner. As adults, these children and adolescents will function in a number of sexuality roles, whether heterosexual, homosexual, or bisexual. This chapter reviews many of these complex and critical issues …

Measuring The Effects Of An American Physiological Society's Phun Week Activity On 2Nd Grade Students, James Edelman

All-Inclusive List of Electronic Theses and Dissertations

In the last few years the United States has been on the decline in the fields of science and technology. The American Physiological Society (APS) has developed a program to engage young minds with scientists. Physiology Understanding Week (PhUn) is the APS initiative to use interactive experiments to engage school-age children with science and physiology. Even though PhUn Week has been going on since 2005, systematic assessment of the activities effects is rare. Here, we sought to assess if an APS PhUn Week activity enhances physiology understanding and interest in science in second grade children form a rural area. The …