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First Principles And Ordinances: The Fourth Article Of Faith In Light Of The Temple, Samuel M. Brown

Maxwell Institute Publications

Familiarity can lead to a kind of blindness in life and in religion. The first principles and ordinances of the gospel are particularly at risk for neglectful misunderstanding. Author Samuel M. Brown offers a fresh approach by asking how our relationship with God and others can transform our understanding of the gospel basics of faith, repentance, baptism, and the gift of the Holy Ghost. By weaving a tapestry of personal stories, scripture, and history, Brown shows how the truths taught in the highest Temple ordinances relate to the first principles of the gospel. Get to know the Fourth Article of …

Consensus Report On The Future Of Animal-Free Systemic Toxicity Testing, Marcel Leist, Nina Hasiwa, Costanza Rovida, Mardas Daneshian, David Basketter, Ian Kimber, Harvey Clewell, Tilman Gocht, Alan Goldberg, Francois Busquet, Anna-Maria Rossi, Michael Schwarz, Martin Stephens, Rob Taalman, Thomas B. Knudsen, James Mckim, Georgina Harris, David Pamies, Thomas Hartung

Experimentation Collection

Since March 2013, animal use for cosmetics testing for the European market has been banned. This requires a renewed view on risk assessment in this field. However, in other fields as well, traditional animal experimentation does not always satisfy requirements in safety testing, as the need for human-relevant information is ever increasing. A general strategy for animal-free test approaches was outlined by the US National Research Council’s vision document for Toxicity Testing in the 21st Century in 2007. It is now possible to provide a more defined roadmap on how to implement this vision for the four principal areas of …

Effect Of Shear Stress Direction On Endothelial Function And Enos Phosphorylation In Soleus Feed Arteries, Blanca B. Perez, Jay Brewster, Jeffrey Jasperse

Featured Research

Blood flow feeding tissues and organs is closely regulated in order to meet metabolic and functional needs. Control of blood flow is accomplished by regulating the diameter of the arteries and arterioles feeding different organs. Several neural, hormonal, chemical and mechanical mechanisms contribute to the constriction and dilation of arteries. Shear stress, the frictional force created by streaming blood on the endothelial layer of arteries, is one of these mechanical mechanisms (1). Shear stress causes both acute and long term effects on endothelial cells (1,2,5).

Blood in arteries typically flows away from the heart towards organs (causing antegrade shear stress) …

Introduction To Special Topic Section: Toward A Transpersonal Medicine, Randy Fauver

International Journal of Transpersonal Studies

NA

Exome Sequencing Identifies Nfs1 Deficiency In A Novel Fe-S Cluster Disease, Infantile Mitochondrial Complex Ii/Iii Deficiency, Sali M.K. Farhan, Jian Wang, John F. Robinson, Piya Lahiry, Victoria M. Siu, Chitra Prasad, Jonathan B. Kronick, David A. Ramsay, C. Anthony Rupar, Robert A. Hegele

Paediatrics Publications

Iron-sulfur (Fe-S) clusters are a class of highly conserved and ubiquitous prosthetic groups with unique chemical properties that allow the proteins that contain them, Fe-S proteins, to assist in various key biochemical pathways. Mutations in Fe-S proteins often disrupt Fe-S cluster assembly leading to a spectrum of severe disorders such as Friedreich’s ataxia or iron-sulfur cluster assembly enzyme (ISCU) myopathy. Herein, we describe infantile mitochondrial complex II/III deficiency, a novel autosomal recessive mitochondrial disease characterized by lactic acidemia, hypotonia, respiratory chain complex II and III deficiency, multisystem organ failure and abnormal mitochondria. Through autozygosity mapping, exome sequencing, in silico analyses, …

Development Of A Fatal Noncompressible Truncal Hemorrhage Model With Combined Hepatic And Portal Venous Injury In Normothermic Normovolemic Swine, Ujwal R. Yanala, Jason M. Johanning, Iraklis I. Pipinos, Gustavo F. Larsen, William H. Velander, Mark A. Carlson

Department of Chemical and Biomolecular Engineering: Faculty Publications

Noncompressible truncal hemorrhage and brain injury currently account for most early mortality of warfighters on the battlefield. There is no effective treatment for noncompressible truncal hemorrhage, other than rapid evacuation to a surgical facility. The availability of an effective field treatment for noncompressible truncal hemorrhage could increase the number of warfighters salvaged from this frequently-lethal scenario. Our intent was to develop a porcine model of noncompressible truncal hemorrhage with a ,50% one-hour mortality so that we could develop new treatments for this difficult problem. Normovolemic normothermic domestic swine (barrows, 3 months old, 34–36 kg) underwent one of three injury types …

Using Arduino To Design A Myoelectric Prosthetic, Kathleen Talbot

Honors Theses, 1963-2015

The loss of a limb can be a very traumatic experience for a person. Prosthetics are devices that can help restore some of the functionality to the user. However, without insurance, prosthetics can be very expensive, creating demand for more efficient and cheaper prosthetics. My research uses an Arduino microcontroller to design a myoelectric prosthetic – a prosthetic that reads electrical signals from the residual limb and powers motors for movement.

The Development Of General Anesthesia, Andrew Williams

Theses & ETDs

This thesis was structured into two distinct parts. The first part is a brief history of the development of both the field of anesthesia and anesthetic agents, while the second part is focused on the last 100 years and is less about the history of anesthesia and more about the pharmacological properties of the anesthetics and their effects on human physiology. Regarding the history section, I chose to highlight those people and events that I felt most important to the development of the field of anesthesia. The latter section is meant to delve more into the chemistry and biology associated …

Gonzaga University Factbook 2014-15, Institutional Research, Gonzaga University

Institutional Research

The Gonzaga University Factbook contains information on student enrollments, demographic profiles, admissions statistics, majors, retention and graduation rates, degree completions, faculty information, and more. It is updated annually with the most current and commonly-needed information about Gonzaga University.

Did Androgen-Binding Protein Paralogs Undergo Neo- And/Or Subfunctionalization As The Abp Gene Region Expanded In The Mouse Genome?, Robert C. Karn, Amanda G. Chung, Christina M. Laukaitis

Scholarship and Professional Work - LAS

The Androgen-binding protein (Abp) region of the mouse genome contains 30 Abpa genes encoding alpha subunits and 34 Abpbg genes encoding betagamma subunits, their products forming dimers composed of an alpha and a betagamma subunit. We endeavored to determine how many Abp genes are expressed as proteins in tears and saliva, and as transcripts in the exocrine glands producing them. Using standard PCR, we amplified Abp transcripts from cDNA libraries of C57BL/6 mice and found fifteen Abp gene transcripts in the lacrimal gland and five in the submandibular gland. Proteomic analyses identified proteins corresponding to eleven of the …

Disclosing Big Data, Michael Mattioli

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

3d Reconstruction Of Ryr1 And Structural Validation Under Different Levels Of Noise, Joshua J. Lobo

Theses and Dissertations

Ryanodine receptors (RyR) are intracellular channels that are intricately involved in Ca2+ release. These channels large membrane proteins~2.26MDa in size. In this multi-goal project firstly we successfully studied the gating mechanics of the RyR1 in the presence of Mg2+. We used single particle reconstruction and image processing techniques to obtain the 3D structure of the RyR1 with Mg2+. The 3D structure in the presence of Mg2+ and an ATP analog is the closest representation of human physiological conditions. The open and closed state structures of RyR1 are known. However, the physiologically closed state has not been studied before. Understanding this …

Novel Technologies For The Detection And Mitigation Of Drowsy Driving, Samuel Lawoyin

Theses and Dissertations

In the human control of motor vehicles, there are situations regularly encountered wherein the vehicle operator becomes drowsy and fatigued due to the influence of long work days, long driving hours, or low amounts of sleep. Although various methods are currently proposed to detect drowsiness in the operator, they are either obtrusive, expensive, or otherwise impractical. The method of drowsy driving detection through the collection of Steering Wheel Movement (SWM) signals has become an important measure as it lends itself to accurate, effective, and cost-effective drowsiness detection. In this dissertation, novel technologies for drowsiness detection using Inertial Measurement Units (IMUs) …

Marijuana Consumption And The Perception Of Harm, David Ruggeri

Theses and Dissertations

Drug use is a public health issue with one-third of the United States population having reported consuming marijuana at some point in their lifetime. This paper examines how the perception of risk (both health and criminal sanctions) affects consumption behavior. This study examined marijuana consumption for the age ranges of 12-17, 18-25, and 26 and older during the years of 1999-2007.

Perceptions of health risk of marijuana vary from by age groups (12-17, 18-25, and 26 years of age and up). Persons age 26 and older perceive the health risks to be the greatest for occasional marijuana consumption, trailed by …

Effects Of Acute Stress And Gender On Decision-Making, Stephanie Elaine Wemm

Legacy Theses & Dissertations (2009 - 2024)

The current study examined the effects of a social stressor on subsequent performance on the Iowa Gambling Task (IGT), and the role of sex on this relationship. Fifty-six participants (24 men and 32 women) were assigned randomly to a social stressor (Trier Social Stress Test) or a control condition while their subjective emotional reactions and their physiological arousal (skin conductance and heart rate) were measured. Findings showed that participants in the stress condition responded with higher skin-conductance levels and heart rate during the social stressor, in addition to reporting greater negative affect directly following the social stressor. They also made …

Working It Out At Haddington Townhouses, Rachael Oyewole, Aliya Shaikh

Bridging the Gaps Posters 2014

No abstract provided.

Determinants Of Bite Force In Four Species Of Sharks From The Gulf Of Mexico With An Emphasis On The Atlantic Sharpnose Shark, Rhizoprionodon Terraenovae, Kyle Walter Rice

Electronic Theses and Dissertations

Bite force can provide valuable information regarding the physiological ecology of an organism. However, there have been few studies wherein bite force in sharks has been considered. Herein I report on a study of the bite force of four species of sharks with particular emphasis on that of the atlantic sharpnose shark, rhizoprionodon terraenovae. Among the four species examined, blacktip shark, carcharhinus limbatus bite force was significantly higher than that of sharpnose, rhizoprionodon terraenovae. There was no significant difference between the bite force of those species compared with the same for finetooth shark, c. Isodon and spinner shark, c. Brevipinna. …

Trauma-Focused Equine Assisted Psychotherapy : A Quantitative Study Of Intervention Effectiveness, Nakita Dziegielewski

Theses, Dissertations, and Projects

This study uses a quantitative lens to examine if Natural Lifemanship's ® Trauma- Focused Equine Assisted Psychotherapy ™ (TF-EAP) model is effective in reducing the psychological, emotional, and/or behavioral problems in youth with a trauma history. Secondary data was collected on behalf of Spirit Reins, the organization that implements Natural Lifemanship's ® TF-EAP ™ model, and used to determine the effectiveness of their traumainformed treatment intervention. Through a pre and post-test research design, data analysis was conducted on 40 youths' Child and Adolescent Functional Assessment Scale (CAFAS) total scores to determine intervention effectiveness. Findings suggest that Natural Lifemanship's ® TF-EAP …

Investigating The Effect Of Insurance Fraud On Mouse Usage In Human-Computer Interactions, Martin Hibbeln, Jeffrey L. Jenkins, Christoph Schneider, Joseph S. Valacich, Markus Weinmann

Faculty Publications

The completion of online forms is the catalyst for many business and governmental processes. However, providing fraudulent information in such forms is pervasive, resulting in costly consequences for organizations and society. Furthermore, detecting fraudulent responses in online forms is often very difficult, time consuming, and expensive. This research proposes that analyzing users’ mouse movements may reveal when a person is being fraudulent. Namely, based on neuroscience and deception theory, the paper explains how deception may influence hand movements captured via the computer mouse. In an insurance fraud context, a study is conducted to explore these proposed relationships. The results suggest …

Occurrence And Effects Of Repeated Trauma Exposure In Emergency Medical Personnel, Casie Ann Probst

Electronic Theses and Dissertations

This study focuses on the prevalence and severity of post-traumatic stress symptoms in Emergency Medical Services (EMS) personnel. Summative PTSD Checklist (PCL-C) scores were collected and analyzed from 102 active, adult EMS professionals working in Pennsylvania. Data analysis shows EMS professionals are experiencing severe post-traumatic stress symptoms at a higher rate than the general public. The severity and prevalence of EMS post-traumatic stress symptoms are comparable to those of American veterans returning from active combat zones in Iraq. Based on the results, several suggestions are proposed regarding how to effectively minimize the experience of post-traumatic stress symptoms in EMS professionals.

Cochlear Development And Auditory Function In The Absence Of Thyroid Hormone Transporters Mct8 And Oatp1c1, Richard Sinn

All Graduate Theses, Dissertations, and Other Capstone Projects

Thyroid hormone (TH) is essential for the development and maturation of the nervous system. The thyroid gland secretes an active form of TH, triiodothyronine, and a prohormone, thyroxine, into the blood. TH is charged, which prevents it from passively diffusing across cell membranes and thus requires cell membrane transporters to facilitate its movement into and out of cells. However, whether TH transporters are required for TH-mediated developmental events, including the auditory system, is largely unknown.

The purpose of the present study was to investigate two specific TH transporters, monocarboxylate transporter 8 (Mct8) and organic anion transporting polypeptide 1c1 (Oatp1c1), and …

The Relationship Between Stress And Dementia: An Investigation Of Physiological And Psychological Connections Across The Lifespan, Andrew Kuck

Honors Projects

While many studies have examined the relationship between stress and dementia, there is no general consensus on what the relationship is, or even whether such a relationship exists at all (Fountoulakis, 2011; Wang, 2012). This literature review consequently considers a broad range of hypotheses on the topic. The central focus of this review was to identify what aspects of stress – throughout life – increase the likelihood of dementia in the elderly. The available research indicates that there is indeed a relationship between stress and dementia, and that stress interacts with dementia risk in multiple ways. There is, first of …

Understanding Melatonin Receptor Pharmacology: Latest Insights From Mouse Models, And Their Relevance To Human Disease, Gianluca Tosini, Sharon Owino, Jean Luc Guillaume, Ralf Jockers

Neuroscience: Faculty Publications

Melatonin, the neuro-hormone synthesized during the night, has recently seen an unexpected extension of its functional implications toward type 2 diabetes development, visual functions, sleep disturbances, and depression. Transgenic mouse models were instrumental for the establishment of the link between melatonin and these major human diseases. Most of the actions of melatonin are mediated by two types of G protein-coupled receptors, named MT1 and MT2, which are expressed in many different organs and tissues. Understanding the pharmacology and function of mouse MT1 and MT2 receptors, including MT1/MT2 heteromers, will be of crucial importance to evaluate the relevance of these mouse …

The Effect Of Moderate Altitude On High Intensity Running Performance During A Game With Collegiate Female Soccer Players, Jonathan Bohner

Electronic Theses and Dissertations

Competition often requires teams that reside at sea level to compete against opponents whose residence is at a moderate altitude. This may pose a potential competitive disadvantage considering that moderate altitude may cause decrements in VO2max, distance covered, and time to exhaustion in endurance athletes. The purpose of this study was to examine the effect of altitude on game performance measures. Six NCAA Division I female soccer players (20.33 ± 1.21 y; 168 ± 6.45 cm; 62.5 ± 6.03 kg) were retrospectively examined. Comparisons were made between two competitions that were played at sea level (SL) within two weeks of …

Psyx 391.01: Special Topics - Health Psychology, Craig P. Mcfarland

University of Montana Course Syllabi

No abstract provided.

Bulletin Of Yale University School Of Nursing 2014-2015, Yale School Of Nursing

Yale School of Nursing Bulletins and Catalogues

Series 110, Number 15

September 5, 2014

Bio 2210 : Anatomy And Physiology I, Biological Sciences

Approved Course Proposals

No abstract provided.

Human Cardiovascular Responses To Artificial Gravity Variables: Ground-Based Experimentation For Spaceflight Implementation, Mark Howarth

Theses and Dissertations--Biomedical Engineering

One countermeasure to cardiovascular spaceflight deconditioning being tested is the application of intermittent artificial gravity provided by centripetal acceleration of a human via centrifuge. However, artificial gravity protocols have not been optimized for the cardiovascular system, or any other physiological system for that matter. Before artificial gravity protocols can be optimized for the cardiovascular system, cardiovascular responses to the variables of artificial gravity need to be quantified.

The research presented in this document is intended to determine how the artificial gravity variables, radius (gravity gradient) and lower limb exercise, affect cardiovascular responses during centrifugation. Net fluid (blood) shifts between body …

Persimals, Steven Luper

Philosophy Faculty Research

What sort of thing, fundamentally, are you and I? For convenience, I use the term persimal to refer to the kind of thing we are, whatever that kind turns out to be. Accordingly, the question is, what are persimals? One possible answer is that persimalhood consists in being a human animal, but many theorists, including Derek Parfit and Jeff McMahan, not to mention John Locke, reject this idea in favor of a radically different view, according to which persimalhood consists in having certain sorts of mental or psychological features. In this essay, I try to show that the animalist approach …

Creating Domestic Dependents: Indian Removal, Cherokee Sovereignty And Women’S Rights, Jesslyn R. Collins-Frohlich

Theses and Dissertations--English

What, this project asks, are the impacts of the alliance between women and Native Americans in the nineteenth century debate over Indian Removal? How might groups similarly excluded from patriarchal systems of government by race and gender turn exclusion into arguments for inclusion? In what ways might this alliance change interpretations of the women’s right and Native American rights movements? While arguments made by women and Native Americans during Indian Removal receive considerable scholarly attention, most studies-especially those concerned with women’s involvement- subordinate Indian Removal to abolition or create significant omissions in the narratives of both movements by adopting a …