Digital Commons Network^™

Tall Fescue Seed Extraction And Partial Purification Of Ergot Alkaloids, Huihua Ji, Franklin Fannin, J. Klotz, Lowell P. Bush

Kentucky Tobacco Research and Development Center Faculty Publications

Many substances in the tall fescue/endophyte association (Schedonorus arundinaceus/Epichloë coenophiala) have biological activity. Of these compounds only the ergot alkaloids are known to have significant mammalian toxicity and the predominant ergot alkaloids are ergovaline and ergovalinine. Because synthetically produced ergovaline is difficult to obtain, we developed a seed extraction and partial purification protocol for ergovaline/ergovalinine that provided a biologically active product. Tall fescue seed was ground and packed into several different sized columns for liquid extraction. Smaller particle size and increased extraction time increased efficiency of extraction. Our largest column was a 114 × 52 × …

An Evidence-Based Approach To A Replacement Hospital Training Curriculum, Mark D. Beck

Doctor of Nursing Practice (DNP) Projects

Creation of a training and educational curriculum for a new or replacement facility is daunting in its own right, but without a repository of organizational knowledge cataloging the transfer of tacit to explicit knowledge from the organizations previous library of facility openings, the task becomes Herculean, with as many tasks and cast of characters as the original myths. Navigating the shoals, eddies and tides of the various aspects of this project revealed the need for a comprehensive knowledge management solution to training that is coupled with healthcare design principles and initiatives. This purpose of the DNP project is about the …

The Weekly Challenger, December 11, 2014, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The December 11, 2014, issue of The Weekly Challenger.

Palliative Care In Africa: A Global Challenge., Christian R Ntizimira, Jean Luc Nkurikiyimfura, Olive Mukeshimana, Scholastique Ngizwenayo, Diane Mukasahaha, Clare Clancy

Ambulatory and Primary Care Articles

We are often asked what challenges Rwanda has faced in the development of palliative care and its integration into the healthcare system. In the past, patients have been barred from accessing strong analgesics to treat moderate to severe pain, but thanks to health initiatives, this is slowly changing. Rwanda is an example of a country where only a few years ago, access to morphine was almost impossible. Albert Einsten said 'in the middle of difficulty lies opportunity' and this sentiment could not be more relevant to the development of palliative care programmes. Through advocacy, policy, and staunch commitment to compassion, …

New 4-Aminoquinoline Compounds To Reverse Drug Resistance In P. Falciparum Malaria, And A Survey Of Early European Antimalarial Treatments, Katherine May Liebman

Dissertations and Theses

Intermittent fevers caused by Plasmodium parasites have been known for millennia, and have caused untold human suffering. Today, millions of people are afflicted by malaria each year, and hundreds of thousands die. Historically, the most successful synthetic antimalarial drug was chloroquine, as it was safe, inexpensive, and highly efficacious. However, plasmodial resistance to chloroquine now greatly limits its utility. Previously in our laboratories it has been shown that attachment of a "reversal agent moiety" to the side chain of chloroquine can result in the restoration of activity against chloroquine-resistant strains of P. falciparum malaria. In the first part of the …

Daily Eastern News: December 11, 2014, Eastern Illinois University

December

No abstract provided.

Effect Of Hydrogen Peroxide On The Biosynthesis Of Heme And Proteins: Potential Implications For The Partitioning Of Glu-TrnaGlu Between These Pathways, Carolina Farah, Gloria Levicán, Michael Ibba, Omar Orellana

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Glutamyl-tRNA (Glu-tRNA^Glu) is the common substrate for both protein translation and heme biosynthesis via the C5 pathway. Under normal conditions, an adequate supply of this aminoacyl-tRNA is available to both pathways. However, under certain circumstances, Glu-tRNA^Glu can become scarce, resulting in competition between the two pathways for this aminoacyl-tRNA. In Acidithiobacillus ferrooxidans, glutamyl-tRNA synthetase 1 (GluRS1) is the main enzyme that synthesizes Glu-tRNA^Glu. Previous studies have shown that GluRS1 is inactivated in vitro by hydrogen peroxide (H₂O₂). This raises the question as to whether H₂O₂ negatively affects …

Lack Of Medicaid Funding For Occupational Therapy Serving The Autism Spectrum Disorder Population Ages 0-5 Years, Mary O'Donohue

Honors Theses

The prevalence of autism in the United States is currently 1 in 68 children (Autism Alliance of Michigan, 2014). This is considered an epidemic. There are a variety of treatments available in the state of Michigan for children with autism, such as occupational therapy, speech therapy, physical therapy, and applied behavior analysis (ABA). Effective April 1^st, 2013, Michigan increased their funding cap for ABA therapy for treating children with autism. However, there is a lack of knowledge within the community and amongst professionals in regards to the critical treatment occupational therapy practitioners provide and as a result, there …

A Critical Analysis Of Infant Mortality In Kalamazoo County, Audrey Jensen

Honors Theses

The following is a review of the state of infant and fetal health in Kalamazoo County in the 21st century. Since infant health is a marker for the effectiveness of health care, this review will analyze the leading causes of infant mortality in Kalamazoo County. Statistical indicators show that Kalamazoo County falls below both state and national IMR averages. The leading causes of infant mortality in Kalamazoo are considered preventable infant deaths. Therefore, this review will make recommendations for the reduction of IMR through the improvement of preventative prenatal healthcare practices.

Identifying Professional Development Opportunities For Remote Healthcare Interpreters On A Shared Network, Suzanne M. Couture

Instructional Design Capstones Collection

Many healthcare organizations are faced with the challenge of complying with an unfunded mandate to provide language services free of charge to individuals with limited English proficiency or those who are deaf or hard of hearing. One method of increasing efficiencies and reducing disparities for these vulnerable populations is to provide access to remote audio/video interpreters on a shared network. The Health Care Interpreter Network (HCIN) is a non-profit organization based in California that comprises more than forty member hospitals and offers service in twenty languages. To support the need for on-going professional development of HCIN’s interpreters, a front-end analysis …

Parenting Stress In Parents Of Young Children With Autism Spectrum Disorders: The Role Of Child Characteristics And Social Support, Lauren D. Haisley

Master's Theses

The current study drew on the Double ABCX model of stress to explore the relationship between parenting stress in parents of children with an autism spectrum disorder (ASD) and factors contributing to heightened levels of stress. Specifically child characteristics, pile-up demands, external resources and parent perception were examined in cross-sectional samples of parents of children 2 (Time 1), 4 (Time 2) and 8 (Time 3) years of age. Additionally a comparison sample of parents of 2 year olds with a developmental delay (DD), and two longitudinal subsamples (2-4 and 4-8) were utilized. Prior to the child’s diagnosis (Time 1), parenting …

Foreign Investments And The Market For Law, Susan Franck

Scholarly Articles in Law Reviews & Journals

In this Article, Professors O'Hara O'Connor and Franck adapt and extend Larry Ribstein's positive framework for analyzing the role of jurisdictional competition in the law market. Specifically, the authors provide an institutional framework focused on interest group representation that can be used to balance the tensions underlying foreign investment law, including the desire to compete to attract investments and countervailing preferences to retain domestic policy-making discretion. The framework has implications for the respective roles of BITs and investment contracts as well as the inclusion and interpretation of various foreign investment provisions.

The Cowl - V.79 - N.13 - Dec 11, 2014

The Cowl

The Cowl - student newspaper of Providence College. Vol 79 - No. 13 - December 11, 2014. 28 pages.

Beneficial Effects Of Simulated Gastro-Intestinal Digests Of Fried Egg And Its Fractions On Blood Pressure, Plasma Lipids And Oxidative Stress In Spontaneously Hypertensive Rats, Forough Jahandideh, Kaustav Majumder, Subhadeep Chakrabarti, Jude S. Morton, Sareh Panahi, Susan Kaufman, Sandra T. Davidge, Jianping Wu

Department of Food Science and Technology: Faculty Publications

Background: We have previously characterized several antihypertensive peptides in simulated digests of cooked eggs and showed blood pressure lowering property of fried whole egg digest. However, the long-term effects of this hydrolysate and its fractions on blood pressure are not known. Therefore, the objectives of the study were to determine the effects of long term administration of fried whole egg hydrolysate and its fractions (i.e. egg white and egg yolk) on regulation of blood pressure and associated factors in cardiovascular disease such as plasma lipid profile and tissue oxidative stress.

Methods and Results: We used spontaneously hypertensive rats (SHR), an …

Structure-Based Drug Design And Synthesis Of Anti-Infective And Anticancer Agents, Narendran Gummudipundi Dayanandan

Doctoral Dissertations

Resistance to antibiotics is on the rise at an alarming pace. The problem is exacerbated by the lack of new class of therapeutic agents and targets. Modes of resistance include alteration of drug target, modification of ligand, and reduction of the intracellular concentration of drug. Dihydrofolate reductase (DHFR) is a validated drug target for the treatment of infectious diseases and cancer. The binding of ligands to DHFR inhibits the downstream folate pathway that is vital for purine and thymidylate synthesis. Trimethoprim (TMP), a clinically used antifolate exhibits resistance in both gram-positive and gram-negative bacteria. In this thesis, methods have been …

The Eastern Echo, December 11, 2014, Section A, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Safe Use Of Biological Degreasing Stations, Denis Bégin, Michel Gérin, Jacques Lavoie

Fiches

No abstract provided.

Developmental And Cultural Perspectives On Children’S Postoperative Pain Management At Home, Brooke N. Jenkins, Michelle A. Fortier

Psychology Faculty Articles and Research

Outpatient surgery is extremely common in children, and approximately 4 million children experience significant pain after surgery in the USA each year. Management of children's postoperative pain in the home setting is suboptimal and is impacted by characteristics of children and parents, as well as the larger family and cultural context. In particular, developmental status of the child, parental beliefs regarding pain expression and analgesic use in children, cultural values and language barriers can affect management of children's postoperative pain. Targeting the myriad barriers to children's pain management by capitalizing upon the use of tailored interventions may help bridge the …

Otter Realm, December 11, 2014, California State University, Monterey Bay

The Otter Realm

International Students Protest: Their Fight For Fair Housing And Treatment -- World In Transition -- Fall 2014 Capstone Festival -- Excessive Restraint: CSUMB Officer Disciplined For Not Using Taser On Suicidal Student -- In Loving Memory: Remembering Edwin Galicia -- International Student Protest: Protests Result In Town Hall Meeting For Fair Housing -- Behind The Scenes: Capstone Tales And Advice From A Senior And Faculty -- A Holiday Back In Time: Christmas In The Adobes: Locals Light Up Downtown Monterey In A Historic Christmas Tradition -- Ringing In The New Year: New Year's Eve Sights And Sounds -- No Justice, …

A Study On The Relationships Of Professional Development, Teacher Working Conditions And Job Satisfaction While Controlling For Years Of Teaching Experience And Grade Level Taught, Daniel W. Silvia

Seton Hall University Dissertations and Theses (ETDs)

“Over the next ten years, 1.6 million teachers will retire, and 1.6 million new teachers will be needed to take their place. This poses both an enormous challenge and an extraordinary opportunity for our education system: “if we succeed in recruiting, preparing, and retaining great teaching talent, we can transform public education in this country and finally begin to deliver an excellent education for every child” (Duncan, 2011, pg. 1). Indeed, teacher preparation and professional development is an extremely important issue facing our educational system today. There is a great deal of research that supports the idea that the most …

Kenyon Collegian - December 11, 2014

The Kenyon Collegian

No abstract provided.

Onsite Integrative Clinics: Acupuncture, Positive Patient Outcomes, And Frequency Of Provider Office Visits, Sherry Shoemaker Phd

Dissertations

Purpose and Aims. There is limited information about outcomes of care, resource utilization, and associated costs for patients who receive acupuncture in integrative health settings. The purpose of this study was to address this gap through the following aims: To examine: (1) changes in patient pain levels pre/post acupuncture treatments; (2) relationships between receiving acupuncture treatments (number of treatments, length of time, select demographic factors, (age, gender), pain level pre and post acupuncture treatments; (3) relationships between number of treatments, length of time, age, gender, pain level (pre/post acupuncture treatments) and provider visits (pre/post acupuncture treatments); and (4) relationship between …

Lack Of Medicaid Funding For Occupational Therapy Serving The Autism Spectrum Disorder Population Ages 0-5 Years, Nadia Yala

Honors Theses

The prevalence of autism in the United States is currently 1 in 68 children (Autism Alliance of Michigan, 2014). This is considered an epidemic. There are a variety of treatments available in the state of Michigan for children with autism, such as occupational therapy, speech therapy, physical therapy, and applied behavior analysis (ABA). Effective April 1^st, 2013, Michigan increased their funding cap for ABA therapy for treating children with autism. However, there is a lack of knowledge within the community and amongst professionals in regards to the critical treatment occupational therapy practitioners provide and as a result, there …

Graduate Teaching Assistants: Responding To The Challenges Of Internationalisation, Jennie Winter, Rebecca Turner, Sharon Gedye, Patricia Nash, Vivien Grant

Plymouth Institute of Education

The last decade has seen intensification in moves to professionalise the practice of university teaching, including graduate teaching assistants (GTAs). It has also seen significant growth in terms of the internationalisation of the postgraduate student body and changing expectations around doctoral training. These transformations have implications for the construction, delivery, and management of educational training for this group, yet little contemporary research exists investigating the adaptability of academic development and institutions to such change. This paper reports empirical research exploring these issues using a UK-based case study. The research investigated the international doctoral students’ experience of a teaching course and …

Meta-Analysis Of Close Relationships And Goal Attainment, Amanda Brady, Jennifer Wilson, Nichole Davis

University Presentation Showcase Event

Everyone has goals that they desire to achieve in their lives. These goals span across many areas: relationships, education, career, health, etc. There are many factors that motivate people to achieve those goals. We were specifically interested in examining how goal attainment was different if people were personally motivated or if they were motivated by a significant other in their lives. Our research question was: "Do close relationships have an effect on goal attainment?" We located studies that compared personally-autonomous reasons (PAR) in children and adults to relationally-autonomous reasons (RAR) in children and adults. We compared 18 studies that analyzed …

Quality Internships For Part-Time Graduate Students: An Exploratory Study Of A University/Agency Partnership, Irene S. Mcclatchey, Alan Kirk

PRISM: A Journal of Regional Engagement

The university student population is changing and more students choose to complete graduate programs while working full-time and going to school part-time. Part-time graduate students, who are working towards a professional degree in the human services domain often struggle finding quality internship placements that are available during non-regular office hours. At the same time, non-profit organizations, especially those who are small and lesser known, struggle to recruit, train, and retain high quality volunteers. This is especially problematic since the number of non-profits is increasing and the number of volunteers decreasing. To look for answers both university part-time programs and non-profits …

“We Are Jamaicans. We Are Brothers”: History, Brotherhood, And Independence In Kerry Young’S Pao, Tzarina T. Prater

Anthurium: A Caribbean Studies Journal

Kerry Young’s first Novel, Pao, is written in the “voice” of a Chinese Jamaican, a voice that exhibits little if no syntactical or grammatical difference from those with whom he works and lives in the underworld of Chinatown in Kingston, Jamaica. Pao, our central protagonist, arrives to Jamaica in 1938, a time of tremendous social upheaval. The novel charts Pao’s growing political consciousness through his romantic relationships with: the “improper” black prostitute and madam, Gloria Campbell, who is the site of romantic love, and the “proper” Fay Wong, daughter of a grocery store chain owner and link to respectability. …

The Pleasures Of Excerpts: George Lamming, New World Quarterly, And The Novel, Kathleen Deguzman

Anthurium: A Caribbean Studies Journal

This essay examines an understudied moment in George Lamming’s career: his guest editorship of New World Quarterly’s Barbados independence issue in 1966. With a reputation for writing difficult, dense fiction, Lamming has faced criticism from both fellow authors and literary scholars for the incompatibility of esoteric literature with working-class Caribbean readers. But in the Barbados independence issue of New World Quarterly, Lamming includes excerpts from two of his novels, In the Castle of My Skin and Of Age and Innocence. I examine these excerpts, as well as the special Barbados issue more generally, alongside Lamming’s fiction to …

Ko Ko Gyi [Myanmar, Activist], Ko Ko Gyi

Digital Narratives of Asia

Myanmar democracy activist Ko Ko Gyi spent a total of 17 years in prison for his political beliefs. First detained for his involvement in student protests in 1989, he was eventually released in 2012, along with 600 others, when the military-led government began implementing reforms. Mr Ko Ko Gyi now champions democracy and human rights issues as General Secretary of the 88 Generation Peace and Open Society. He was also a member of the government's Rakhine Investigation Commission to investigate the sectarian violence in Rakhine state. He speaks to DNA about the darkest days of his time in the infamous …

We Are...Marshall, December 10, 2014, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.