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In Vivo Bone Strain And Finite Element Modeling Of The Mandible Of Alligator Mississippiensis, L. B. Porro, K. A. Metzger, J. Iriarte-Diaz, C. F. Ross

Journal Articles

Forces experienced during feeding are thought to strongly influence the morphology of the vertebrate mandible; in vivo strain data are the most direct evidence for deformation of the mandible induced by these loading regimes. Although many studies have documented bone strains in the mammalian mandible, no information is available on strain magnitudes, orientations or patterns in the sauropsid lower jaw during feeding. Furthermore, strain gage experiments record the mechanical response of bone at a few locations, not across the entire mandible. In this paper, we present bone strain data recorded at various sites on the lower jaw of Alligator mississippiensis …

Two Distinct Categories Of Focal Deletions In Cancer Genomes, M. Rajaram, M. Kato, L. Myeroff, S. D. Markowitz, S. W. Lowe, M. Zhang, A. Krasnitz, R. Lucito, D. Mu, R. S. Powers, +13 Additional Authors

Journal Articles

One of the key questions about genomic alterations in cancer is whether they are functional in the sense of contributing to the selective advantage of tumor cells. The frequency with which an alteration occurs might reflect its ability to increase cancer cell growth, or alternatively, enhanced instability of a locus may increase the frequency with which it is found to be aberrant in tumors, regardless of oncogenic impact. Here we've addressed this on a genome-wide scale for cancer-associated focal deletions, which are known to pinpoint both tumor suppressor genes (tumor suppressors) and unstable loci. Based on DNA copy number analysis …

Absence Of Exposed Bone Following Dental Extraction In Beagle Dogs Treated With 9 Months Of High-Dose Zoledronic Acid Combined With Dexamethasone, M. R. Allen, T. M. G. Chu, S. L. Ruggiero

Journal Articles

Purpose: Factors contributing to osteonecrosis of the jaw with anti-remodeling drug treatment are unclear. Epidemiologic and experimental studies have suggested the combination of bisphosphonates and dexamethasone results in osteonecrosis of the jaw more often than either agent alone. The goal of this study was to assess the combination of these 2 drugs in a large animal model previously shown to be susceptible to exposed bone in the oral cavity when treated with bisphosphonates. Materials and Methods: Skeletally mature beagle dogs were untreated controls or treated with zoledronic acid (ZOL), dexamethasone (DEX), or ZOL plus DEX. ZOL and DEX were given …

Coherent Anti-Stokes Raman Scattering Microscopy By Dispersive Wave Generations In A Polarization Maintaining Photonic Crystal Fiber, Jinhui Yuan, Guiyao Zhou, Hongzhan Liu, Changmin Xia, Xinzhu Sang, Qiang Wu, Chongxiu Yu, Kuiru Wang, Binbin Yan, Ying Han, Gerald Farrell, Lantian Hou

Articles

The polarization maintaining photonic crystal fiber (PM-PCF) with two zero dispersion wavelengths is designed and fabricated by the improved stack-and-draw technology in our laboratory. The broadband blue-shifted and red-shifted dispersive waves (DWs) are efficiently generated from soliton self-frequency shift (SSFS) along the slow axis of PM-PCF. By optimizing the pump parameters and the fiber length, the polarized DWs centered in the normal dispersion region can be used as the pump and Stokes pulses for the high resolution coherent anti-Stokes Raman scattering (CARS) microscopy. Moreover, it is demonstrated that the widely tunable relevant CARS wavelengths can be obtained by adjusting the …

Merepoint Boat Launch Facility Eelgrass Mitigation Measures: 2013 Monitoring Report, Mer Assessment Corporation

Publications

No abstract provided.

Editor And Journal Information

Virginia Journal of Science

Editor and journal information for Virginia Journal of Science, vol. 64, no. 1 & 2, Spring/Summer 2013

Startup Immigration: Stimulating Startup Communities With Immigrant Entrepreneurs, David Vidal

McGeorge Law Review

No abstract provided.

Dorothy Crandall Bliss

Virginia Journal of Science

Obituary for Dorothy Crandall Bliss

Ethnicity As A Moderator Of Motivational Interviewing For Incarcerated Adolescents After Release, Mary Clair, L.A.R. Stein, Shayna Soenksen, Rosemarie A. Martin, Rebecca Lebeau, Charles Golembeske

Psychology Faculty Publications

Motivational interviewing (MI) has been found to be an effective treatment for substance using populations, including incarcerated adolescents. Although some studies suggest MI is more successful with individuals from minority backgrounds, the research remains mixed. The current study investigated the impact of ethnicity on treatment in reducing alcohol and marijuana use among incarcerated adolescents. Adolescents (14–19 years of age) were recruited from a state juvenile correctional facility and randomly assigned to receive MI or relaxation therapy (RT) (N = 147; 48 White, 51 Hispanic, and 48 African American; 126 male; 21 female). Interviews were conducted at admission to the …

Abcc3 As A Marker For Multidrug Resistance In Non-Small Cell Lung Cancer, Yanbin Zhao, Hailing Lu, An Yan, Yanmei Yang, Qingwei Meng, Lichun Sun, Hui Pang, Chunhong Li, Xiaoqun Dong, Li Cai

Biomedical and Pharmaceutical Sciences Faculty Publications

Multidrug resistance (MDR) contributes to the failure of chemotherapy and high mortality in non-small cell lung cancer (NSCLC). We aim to identify MDR genes that predict tumor response to chemotherapy. 199 NSCLC fresh tissue samples were tested for chemosensitivity by MTT assay. cDNA microarray was done with 5 samples with highest resistance and 6 samples with highest sensitivity. Expression of ABCC3 mRNA and protein was detected by real-time PCR and immunohistochemisty, respectively. The association between gene expression and overall survival (OS) was examined using Cox proportional hazard regression. 44 genes were upregulated and 168 downregulated in the chemotherapy-resistant group. ABCC3 …

Insights Into The Conformation Of Aminofluorene-Deoxyguanine Adduct In A Dna Polymerase Active Site, Vaidyanathan G. Vaidyanathan, Fengting Liang, William A. Beard, David D. Shock, Samuel H. Wilson, Bongsup P. Cho

Biomedical and Pharmaceutical Sciences Faculty Publications

The active site conformation of the mutagenic fluoroaminofluorene-deoxyguanine adduct (dG-FAF, N-(2′-deoxyguanosin-8-yl)-7-fluoro-2-aminofluorene) has been investigated in the presence of Klenow fragment of Escherichia coli DNA polymerase I (Kfexo⁻) and DNA polymerase β (pol β) using ¹⁹F NMR, insertion assay, and surface plasmon resonance. In a single nucleotide gap, the dG-FAF adduct adopts both a major-groove- oriented and base-displaced stacked conformation, and this heterogeneity is retained upon binding pol β. The addition of a non-hydrolysable 2′-deoxycytosine-5′-[(α,β)-methyleno]triphosphate (dCMPcPP) nucleotide analog to the binary complex results in an increase of the major groove conformation of the adduct at the expense …

Synthesis And Antiproliferative Activities Of Quebecol And Its Analogs, Kasiviswanadharaju Pericherla, Amir Nasrolahi Shirazi, V. Kameshwara Rao, Rakesh K. Tiwari, Nicholas Dasilva, Kellen T. Mccaffrey, Yousef A. Beni, Antonion González-Sarrías, Navindra P. Seeram, Keykavous Parang, Anil Kumar

Biomedical and Pharmaceutical Sciences Faculty Publications

Simple and efficient synthesis of quebecol and a number of its analogs was accomplished in five steps. The synthesized compounds were evaluated for antiproliferative activities against human cervix adenocarcinoma (HeLa), human ovarian carcinoma (SK-OV-3), human colon carcinoma (HT-29), and human breast adenocarcinoma (MCF-7) cancer cell lines. Among all the compounds, 7c, 7d, 7f, and 8f exhibited antiproliferative activities against four tested cell lines with inhibition over 80% at 75 μM after 72 h, whereas, compound 7b and 7g were more selective towards MCF-7 cell line. The IC₅₀ values for compounds 7c, 7d, and 7f …

A Comparative Study Of Hollow Copper Sulfide Nanoparticles And Hollow Gold Nanospheres On Degradability And Toxicity, Laingran Guo, Irene Panderi, Daisy D. Yan, Kevin Szulak, Yajuan Li, Yi-Tzai Chen, Hang Ma, Daniel B. Niesen, Navindra P. Seeram, Aftab Ahmed, Bingfang Yan, Dionysios Pantazatos, Wei Lu

Biomedical and Pharmaceutical Sciences Faculty Publications

Gold and copper nanoparticles have been widely investigated for photothermal therapy of cancer. However, degradability and toxicity of these nanoparticles remain concerns. Here, we compare hollow CuS nanoparticles (HCuSNPs) with hollow gold nanospheres (HAuNS) in similar particle sizes and morphology following intravenous administration to mice. The injected pegylated HCuSNPs (PEG-HCuSNPs) are eliminated through both hepatobiliary (67 percentage of injected dose, %ID) and renal (23 %ID) excretion within one month postinjection. By contrast, 3.98 %ID of Au is excreted from liver and kidney within one month after iv injection of pegylated HAuNS (PEG-HAuNS). Comparatively, PEG-HAuNS are almost nonmetabolizable, while PEG-HCuSNPs are …

Caloric Restriction-Mediated Induction Of Lipid Metabolism Gene Expression In Liver Is Enhanced By Keap1-Knockdown, Supriya R. Kullkarni, Laura E. Armstrong, Angela L. Slitt

Biomedical and Pharmaceutical Sciences Faculty Publications

Purpose: CR increases fatty acid oxidation to decrease tissue lipid content. The Nuclear factor E2-related factor 2 (Nrf2)-Kelch like ECH associated Protein 1 (Keap1) pathway is an antioxidant gene regulatory pathway that has been previously investigated in weight gain. However, limited interaction of Nrf2/Keap1 and CR exists. The purpose of this study was to determine how Keap1 knockdown (Keap1-KD), which is known to increase Nrf2 activity, affects the CR response, such as weight loss, hepatic lipid decrease, and induction of fatty acid oxidation gene expression.

Methods: C57BL/6 and Keap1-KD mice were maintained on 40% CR or fed ad libitum for …

Book Review, David R. Boyd, The Environmental Rights Revolution: A Global Study Of Constitutions, Human Rights, And The Environment, Bradford Mank, Suzanne Smith

Faculty Articles and Other Publications

David R. Boyd’s book entitled, The Environmental Rights Revolution: A Global Study of Constitutions, Human Rights, and the Environment, provides a comprehensive overview of nations that have incorporated the right to a healthy environment in their constitutions. Throughout his research, Boyd analyzes the effectiveness of environmental protection provisions in national constitutions and seeks to determine whether constitutional provisions guaranteeing the right to a healthy environment have measurable, positive effects on the environment. His wide-ranging compilation and analysis of environmental rights provisions in numerous countries is an important contribution to international human rights literature. Although Boyd explains that treating the right …

Ethnicity And Gender Comparisons Of Health Consequences In Adults With Alcohol Dependence, Karen G. Chartier, Michie N. Hesselbrock, Victor M. Hesselbrock

Social Work Publications

The moderating effects of ethnicity and gender on factors associated with physical health consequences in adults with alcohol dependence was examined using data from the 2001–2002 U.S. National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Black and White respondents with a lifetime diagnosis of DSM-IV alcohol dependence were selected for the study (n = 3,852). A multiple-group structural equation model tested ethnicity, gender, and intervening variables as predictors of physical health status in alcohol dependent men and women. Study findings offer implications for clinical practice with alcohol dependent individuals by identifying likely target groups and problems for intervention.

Genotype-Based Ancestral Background Consistently Predicts Efficacy And Side Effects Across Treatments In Catie And Star*D, Daniel E. Adkins, Renan P. Souza, Karolina A. Aberg, Shaunna L. Clark, Joseph L. Mcclay, Patrick F. Sullivan, Edwin J. C. G. Van Den Oord

Biomarker Research and Personalized Medicine Publications

Only a subset of patients will typically respond to any given prescribed drug. The time it takes clinicians to declare a treatment ineffective leaves the patient in an impaired state and at unnecessary risk for adverse drug effects. Thus, diagnostic tests robustly predicting the most effective and safe medication for each patient prior to starting pharmacotherapy would have tremendous clinical value. In this article, we evaluated the use of genetic markers to estimate ancestry as a predictive component of such diagnostic tests. We first estimated each patient’s unique mosaic of ancestral backgrounds using genome-wide SNP data collected in the Clinical …

Virginia Commonwealth University Graduate And Professional Programs Bulletin Courses [2013], Virginia Commonwealth University

VCU Bulletins

Listing of professional and graduate courses for 2013-2014.

Virginia Commonwealth University Undergraduate Bulletin [2013], Virginia Commonwealth University

VCU Bulletins

Undergraduate bulletin for Virginia Commonwealth University for the academic year 2013-2014. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for undergraduate programs.

Critical Analysis Of Contemporary Public Health Genomics And Needs Assessment For Public Health Genomics Course Curriculum, Kim London

Master of Public Health Program Student Publications

Objective: To analyze the need for increased content on genomics in Public Health (PH) academic curriculum.

Methods: A literature synthesis was performed of various genetic science studies. Results were assessed with regard to the number and type of genomic studies published, cost to perform genetic analyses, health care provider and the public’s use and understanding of genetic testing capabilities. A search was conducted and assessment performed of public health genomics curriculum at accredited public health educational programs.

Results: The cost to sequence a single genome declined from $10 million in 2007 to under $10 thousand in 2012. This cost reduction …

Cyanine 5.5 Conjugated Nanobubbles As A Tumor Selective Contrast Agent For Dual Ultrasound-Fluorescence Imaging In A Mouse Model, Liyi Mai, Anna Yao, Jing Li, Qiong Wei, Ming Yuchi, Xiaoling He, Mingyue Ding, Qibing Zhou

Medicinal Chemistry Publications

Nanobubbles and microbubbles are non-invasive ultrasound imaging contrast agents that may potentially enhance diagnosis of tumors. However, to date, both nanobubbles and microbubbles display poor in vivo tumor-selectivity over non-targeted organs such as liver. We report here cyanine 5.5 conjugated nanobubbles (cy5.5-nanobubbles) of a biocompatible chitosan–vitamin C lipid system as a dual ultrasound-fluorescence contrast agent that achieved tumor-selective imaging in a mouse tumor model. Cy5.5-nanobubble suspension contained single bubble spheres and clusters of bubble spheres with the size ranging between 400–800 nm. In the in vivo mouse study, enhancement of ultrasound signals at tumor site was found to persist over …

Cultivate Fall/Winter 2013, Utah State University

Cultivate Magazine

No abstract provided.

Criminal Securities Fraud And The Lower Materiality Standard, Wendy Gerwick Couture

Articles

No abstract provided.

Could The American Psychiatric Association Cause You Headaches? The Dangersous Interaction Between The Dsm-5 And Employment Law, Douglas A. Hass

Loyola University Chicago Law Journal

No abstract provided.

Blended Courses In Law School: The Best Of Online And Face-To-Face Learning?, Gerald F. Hess

McGeorge Law Review

No abstract provided.

The Canary In The Coal Mine: What The University Can Learn From Legal Education, Richard A. Matasar

McGeorge Law Review

No abstract provided.

Until Men Bear Children, Women Must Not Bear The Costs Of Reproductive Capacity: Accommodating Pregnancy In The Workplace To Achieve Equal Employment Opportunities, Maryn Oyoung

McGeorge Law Review

No abstract provided.

Stereotactic Body Radiotherapy For Localized Prostate Cancer: Disease Control And Quality Of Life At 6 Years, A. J. Katz, M. Santoro, F. Diblasio, R. Ashley

Journal Articles

Background: Stereotactic body radiotherapy (SBRT) may yield disease control for prostate cancer in a brief, hypofractionated treatment regimen without increasing treatment toxicity. Our report presents a 6-year update from 304 low- (n = 211), intermediate- (n = 81), and high-risk (n = 12) prostate cancer patients who received CyberKnife SBRT. Methods: The median PSA at presentation was 5.8 ng/ml. Fifty-seven patients received neoadjuvant hormonal therapy for up to one year. The first 50 patients received a total dose of 35 Gy in 5 fractions of 7 Gy. The subsequent 254 patients received a total dose of 36.25 Gy in 5 …

Circulating Microparticles: Square The Circle, N. S. Barteneva, E. Fasler-Kan, M. Bernimoulin, J. N. Stern, E. D. Ponomarev, L. Duckett, I. A. Vorobjev

Journal Articles

BACKGROUND: The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. RESULTS: MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50 and 1000 nm. MPs are capable of transferring peptides, proteins, lipid components, microRNA, mRNA, and DNA from one cell to another without direct cell-to-cell contact. Growing evidence suggests that MPs present in peripheral blood and body fluids contribute to the development and progression of cancer, and are of pathophysiological relevance for autoimmune, inflammatory, infectious, cardiovascular, …

The Immune Cell Infiltrate Populating Meningiomas Is Composed Of Mature, Antigen-Experienced T And B Cells, L. Fang, D. E. Lowther, M. L. Meizlish, R. C. Anderson, J. N. Bruce, J. N. Stern, G. Yaari, L. Lovato, K. M. Cronk, K. C. O'Connor, +4 Additional Authors

Journal Articles

BACKGROUND: Meningiomas often harbor an immune cell infiltrate that can include substantial numbers of T and B cells. However, their phenotype and characteristics remain undefined. To gain a deeper understanding of the T and B cell repertoire in this tumor, we characterized the immune infiltrate of 28 resected meningiomas representing all grades. METHODS: Immunohistochemistry was used to grossly characterize and enumerate infiltrating lymphocytes. A molecular analysis of the immunoglobulin variable region of tumor-infiltrating B cells was used to characterize their antigen experience. Flow cytometry of fresh tissue homogenate and paired peripheral blood lymphocytes was used to identify T cell phenotypes …