Digital Commons Network^™

Serum 25-Hydroxyvitamin D Concentration In Patients With Psoriasis And Rheumatoid Arthritis And Its Association With Disease Activity And Serum Tumor Necrosis Factor-Alpha, Mona A. Atwa, Mona G. Balata, Ashraf M. Hussein, Nashwa I. Abdelrahman, Hazem H. Elminshawy

Saudi Medical Journal

OBJECTIVE: To assess vitamin D status in psoriasis and rheumatoid arthritis (RA) patients and to study whether it was associated with disease activity, inflammatory markers, and serum tumor necrosis factor-alpha (TNF-alpha). METHODS: This cross-sectional study was conducted at Riyadh National Hospital, Riyadh, Saudi Arabia between March and September 2012. It included 43 patients with plaque psoriasis, 55 RA patients and 40 healthy controls matched for age. Blood samples were drawn from all participants for assessment of 25-hydroxyvitamin D [25(OH)D], TNF-alpha, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), parathyroid hormone (PTH), and serum corrected calcium. Disease activity of psoriasis and RA …

Comparative Analysis Of Antiviral Responses In Mouse Embryonic Stem Cells And In Mesenchymal Stem Cells, Jundi Wang

Master's Theses

Embryonic stem cells (ESCs) are cells that have unlimited capacity for selfrenewal and differentiation. These properties make ESCs a great cell source for application in regenerative medicine. When used for cell therapy, ESC-derived cells could be placed in a wounded area that is likely to be exposed to various pathogens. However, it is not well-understood whether ESCs and ESC-derived cells have active antiviral responses against infectious agents from the environment. To answer this important question, I comparatively analyzed the antiviral responses of ESCs and mesenchymal stem cells (MSCs, C3H10Tl/2 cell line) to infectious agents. Using the expression of type I …

Molecular Detection Of Tick-Borne Pathogens Associated With Ixodid Tick Species Infesting Migratory Songbirds And Ruminants, Nabanita Mukherjee

Master's Theses

Ticks are hematophagous arthropods and capable of inoculating various infectious agents to their vertebrate hosts. Ticks attached to birds and ruminants are capable of carrying tick-transmitted microorganisms. In our study, the prevalence of tick-borne pathogens was examined in ticks infesting migratory songbirds and Pakistani ruminants. During spring migration seasons, ticks were removed from northward-migrating songbirds in Louisiana and identified as Amblyomma Jongirostre, Amblyomma nodosum, Amb/yomma ca/caratum, Amblyomma maculatum, and Haemaphysalis species, all are considered as Neotropical ticks. Ticks removed from ruminants were identified as Hya/omma anatolicum, Hyalomma dromedarii, Rhipicephalus microplus, and Rhipicephalus sanguineus. A total of 112 and 72 bacterial …

The Stress Revolution: An Examination Of Acculturative Stress And An Emerging Modern Human Stress Response, Jeffrey Nicklas

Social Sciences

In a world that is so fast pace and always changing, the human biological systems have need to adapt just as swiftly. WIth the dependence on culture that humans all share has led to the building of societies with complex rules, ideals, and accepted roles and ways of life. In these complex societies, great cities and governments have arisen but so too have unnoticed changes to human biology. One of these changes is with environmental stressors and the effects it has on the nervous system. The human body, in these modern times, still responds to perceived stressors with the release …

T-Cell Treatments For Solid And Hematological Tumors, Drew C. Deniger

Dissertations and Theses (Open Access)

Cell-based therapies have demonstrated potency and efficacy as cancer treatment modalities. T cells can be dichotomized by their T cell receptor (TCR) complexes where alpha/beta T cells (95% of T cells) and gamma/delta T cells (+T cells proliferated to clinically significant numbers and ROR1⁺ tumor cells were effectively targeted and killed by both ROR1-specific CAR⁺ T cell populations, although ROR1RCD137 were superior to ROR1RCD28 in clearance of leukemia xenografts in vivo. The second specific aim focused on generating bi-specific CD19-specific CAR⁺ gamma/delta T cells with polyclonal TCRgamma/delta repertoire on CD19⁺ artificial antigen presenting cells (aAPC). …

Development And Characterization Of An In Vitro Four-Species Anaerobic Dental Biofilm Model, Fernando Andrade

Dissertations and Theses (Open Access)

Dental caries is the most common chronic disease worldwide. It is characterized by the demineralization of tooth enamel caused by acid produced by cariogenic dental bacteria growing on tooth surfaces, termed bacterial biofilms. Cariogenesis is a complex biological process that is influence by multiple factors and is not attributed to a sole causative agent. Instead, caries is associated with multispecies microbial biofilm communities composed of some bacterial species that directly influence the development of a caries lesion and other species that are seemingly benign but must contribute to the community in an uncharacterized way. Clinical analysis of dental caries and …

Fabrication And Characterization Of Radio-Frequency Sensors For Liquid Material Detection, Yuxi He

All Theses

This thesis presents a series of studies on fabrication and characterization of radio-frequency (RF) sensors. In the light of Electromagnetics and Transmission Line Theory, we designed multiple RF sensors with different detection capability emphasis and used them to detect various materials, especially liquid samples and materials in solutions such as dielectric thin films, confined liquids, red blood cells, and malarial pigments (hemozoin). Most sensors were fabricated under clean room environment following the standard process protocols. Proper process developments were also made to achieve special structures and functionalities of our novel sensors. Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM) …

Coccidia Of Gerbils From Mongolia, Ethan Thomas Jensen

School of Biological Sciences: Dissertations, Theses, and Student Research

In this study, gerbils collected in the Mongolia over the summers of 2009-2012 were examined for coccidia. In total, 171 gerbils of three species from 22 localities were examined for coccidia. Coccidian oocysts were identified from 21 gerbils, but those found in 1 of those gerbils were probably pseudoparasites of the host from which they were recovered. From the remaining 20 gerbils, 7 morphotypes of Eimeria and 1 morphotype of Isospora were identified. Four of the 7 morphotypes of Eimeria were attributed to new species which were described in this study. In addition, 10 previously described species of Eimeria were …

Dynamical Behaviors Of Gonorrhea Strain Competition Model, Marisabel Rodriguez

Theses and Dissertations - UTB/UTPA

In the past decades, Gonorrhea, a sexually transmitted bacterial infection caused by Neisseria gonorrhoeae, has become resistant to a wider range of antibiotics. We apply a phenomenological model that takes into account essential ideas such as the effects of different treatment levels, the transformation and conjugation rates of bacteria, and the response of the immune system. Qualitative analysis provides a more integral view of how model parameters affect the emergence of within-host resistance.

Interventions For Common Perinatal Mental Disorders In Women In Low- And Middle-Income Countries: A Systematic Review And Meta-Analysis, Atif Rahman, Jane Fisher, Peter Bower, Stanley Luchters, Thach Tran, M. Taghi Yasamy, Shekhar Saxena, Waquas Waheed

Population Health, East Africa

Objective: To assess the effectiveness of interventions to improve the mental health of women in the perinatal period and to evaluate any effect on the health, growth and development of their offspring, in low- and middle-income (LAMI) countries.

Methods: Seven electronic bibliographic databases were systematically searched for papers published up to May 2012 describing controlled trials of interventions designed to improve mental health outcomes in women who were pregnant or had recently given birth. The main outcomes of interest were rates of common perinatal mental disorders (CPMDs), primarily postpartum depression or anxiety; measures of the quality of the mother-infant relationship; …

The Children Of Amarna: Disease And Famine In The Time Of Akhenaten, Kathleen Kuckens

Graduate Theses and Dissertations

What is now known as Amarna, Egypt there once stood a grand city. Hastily built and quickly abandoned, this once capital city of Egypt was the brainchild of the Pharaoh Akhenaten. In 2002 the final resting place of the inhabitants who populated this ancient city were discovered. Since excavations began at the South Tombs Cemetery an unusual high number of individuals aged 3-25 have been excavated. Out of the 278 individuals excavated thus far, 45% of them fall to the adolescent and sub-adult category. Under normal circumstances this portion of the population tends to be the most robust and resilient, …

Usf Women's Club Yearbook, 2013–2014, Usf Women's Club

USF Women’s Club Collection

Yearbook of the USF Women's Club. Inside is a list of past presidents, officers, committee chairmen, and members for 2013–2014. The booklet also includes a tribute to Grace Allen, interest groups, calendar of events, and a copy of the constitution and by-laws from the handbook.

Role Of Phosphoinositide-Based Signaling In Virulence In Entamoeba Histolytica, Amrita Koushik

All Dissertations

Entamoeba histolytica is an intestinal protozoan parasite and is the causative agent of amoebiasis. Upon entering the human host, cellular processes such as adhesion, phagocytosis, motility and secretion play a vital role in its propagation and pathogenicity. In other systems, each of these cellular processes is preceded by activation of signal transduction pathways, which often involve membrane phosphoinositides such as phosphatidylinositol 4,5-bisphosphate (PI(4,5)P₂). Little is known about phosphoinositide signaling in E. histolytica pathogenicity. In this study, we demonstrated that PI(4,5)P₂ is localized to cholesterol-rich microdomains, lipid rafts, of the E. histolytica membrane and to the trailing edge …

Antibacterial Effects Of Proteases On Different Strains Of Escherichia Coli And Listeria Monocytogenes, Hanan Eshamah

All Dissertations

Escherichia coli O157:H7 and Listeria monocytogenes are pathogens that have received special attention by federal agencies, food safety researchers and food industries due to their economic and human health impact. To reduce the presence of these pathogens, alternative interventions have been studied. However, increasing consumer's demand for natural ingredients has made the investigations of effectiveness of natural antimicrobials necessary. In this study, in vitro antimicrobial activity of bromelain and papain against E. coli JM109 and L. monocytogenes was investigated. Furthermore, actinidin and papain were evaluated to reduce populations of L. monocytogenes strain and three mixed strains of E. coli O157:H7 …

A Comparative Analysis Of Emergency Management Decision-Making Skills Of School Officials: The Impact Of Training On Perspectives And Performance, Matthew Miraglia

Education Doctoral

School officials are responsible for preparing schools to meet students’ needs while facing the complex security challenges of the 21st century. In the event of a disaster, school officials, despite not being emergency management professionals, must make appropriate decisions and lead effectively in order to maintain safety and ensure educational continuity at their schools. The actions of school officials before, during, and after a disaster will likely play a key role in the safe and effective delivery of education in the future. This study was a comparative analysis of school officials in the New York City Metropolitan Region. The study …

Cues And Deterrents To Smoking: A Comparison Of Different Types Of Smokers, Monica Page Daniel

Graduate Theses and Dissertations

Objective. It was the purpose of this study to determine if different types of smokers, as defined by their smoking frequency and behavior in the presence of others or alone, indicate different cues and deterrents to cigarette smoking. Smoker types included daily smokers and occasional smokers, with who subgroups of occasional smokers including Social smokers and chipper smokers. Methodology. A sample of 824 college students completed a cross-sectional survey regarding their smoking behaviors in the past 30 days, beliefs regarding health consequences and bystander intervention, and reasons and locations where they smoked and or refrained from smoking in the past …

Hybrid Nanostructured Textile Bioelectrode For Unobtrusive Health Monitoring, Pratyush Rai

Graduate Theses and Dissertations

Coronary heart disease, cardiovascular diseases and strokes are the leading causes of mortality in United States of America. Timely point-of-care health diagnostics and therapeutics for person suffering from these diseases can save thousands of lives. However, lack of accessible minimally intrusive health monitoring systems makes timely diagnosis difficult and sometimes impossible. To remedy this problem, a textile based nano-bio-sensor was developed and evaluated in this research. The sensor was made of novel array of vertically standing nanostructures that are conductive nano-fibers projecting from a conductive fabric. These sensor electrodes were tested for the quality of electrical contact that they made …

The Interactive Effects Of Multiple Stressors On Lithobates Catesbeianus And Anaxyrus Americanus, Matthew Kyle Holden

Graduate Theses and Dissertations

Amphibian populations worldwide have experienced dramatic declines, and many species have already become locally, regionally, or globally extirpated with thousands more being threatened with extinction. These declines have occurred more rapidly in amphibians than any other group of vertebrates, which is especially concerning to scientists because amphibians serve as indicator species of overall environmental health. Major causes for amphibian declines are discussed in Chapter 1 and include: habitat modification and destruction, commercial over-exploitation, introduced species, environmental contaminants, global climate change, and infectious diseases.

Chapter 2 discusses the major research aspects of the thesis by examining the interactive effects of multiple …

Evaluation Of Water Sanitation Options For Poultry Production, Pramir Maharjan

Graduate Theses and Dissertations

An evaluation of poultry farm water supplies was conducted to determine the value and impact of water system sanitation practices in commercial broiler houses on microbial levels. Water line cleaning between flocks using concentrated disinfectant solution before placing chicks reduced biofilms retained in the lines to a safe level. Occasional microbial surges were noticed during different points of flock grow-out period even when daily water sanitation was present indicating water is highly susceptible to microbial contamination. However, the daily water sanitation practice controlled the occasional microbial surges in water from sustaining and kept drinking water to a microbiologically acceptable level. …

Comparison Of Potential Salmonella Portals Of Entry And Tissue Distribution Following Challenge Of Poultry, Gopala Krishna Kallapura Sheshagiri

Graduate Theses and Dissertations

The following studies evaluated our hypothesis that transmission by the fecal-respiratory route may be a viable portal of entry for Salmonella and could explain some clinical impressions of relatively low-dose infectivity under field conditions in relation to the requisite high oral challenge dose that is typically required for infection of poultry through the oral route in laboratory studies. Initial field reports indicating tracheal sampling to be a sensitive tool for monitoring Salmonella infection in commercial flocks, suggested that tracheal contamination could be a good indicator of Salmonella infection under commercial conditions. Further, a usual assumption regarding airborne Salmonella reaching the …

Decoding Literary Aids: A Study On Issues Of The Body, Masculinity, And Self Identity In U.S. Aids Literature From 1984-2011, Alexander Shimon Abrams

Graduate Theses and Dissertations

Rather than waiting decades to respond, novelists of nearly every literary genre began conceptualizing the AIDS epidemic shortly after the first documented case of the virus in the United States in 1981. Writers, feeling a sense of urgency, wasted little time constructing didactic texts that differ from much historical fiction in that they were written as the tragedy they are commenting on occurred. However, AIDS literature has changed as the disease has spread well beyond the gay communities of San Francisco and New York, causing people to reexamine their longstanding beliefs on masculinity, sexuality, and body politics.

My Master's thesis …

Parameter Learning For Latent Network Diffusion, Xiaojian Wu, Akshat Kumar, Daniel Sheldon, Shlomo Zilberstein

Research Collection School Of Computing and Information Systems

Diffusion processes in networks are increasingly used to model dynamic phenomena such as the spread of information, wildlife, or social influence. Our work addresses the problem of learning the underlying parameters that govern such a diffusion process by observing the time at which nodes become active. A key advantage of our approach is that, unlike previous work, it can tolerate missing observations for some nodes in the diffusion process. Having incomplete observations is characteristic of offline networks used to model the spread of wildlife. We develop an EM algorithm to address parameter learning in such settings. Since both the E …

Disease Ecology Of A Microsporidian Parasite And Its Effects On Mottled Sculpin, Jared Joseph Homola

Masters Theses

Infectious disease can influence organisms at all levels of ecological organization, from individuals to ecosystems. Likewise, the ecosystems where pathogens exist directly influence their success. Recent theoretical studies have tied disease prevalence to biotic factors such as genetic diversity, biodiversity, and host behavior, and abiotic factors that include temperature and increased nutrient concentrations. Parasites included in the phylum Microspora are increasingly recognized for being ubiquitous in nature, although their ecological roles are generally unknown. This study examined several environmental, community, and host-related metrics to compare the biotic and abiotic aspects of 16 small streams; 6 with mottled sculpin (Cottus …

Summer Indiana Bat Ecology In The Southern Appalachians: An Investigation Of Thermoregulation Strategies And Landscape Scale Roost Selection, Kristina Hammond

All-Inclusive List of Electronic Theses and Dissertations

In the southern Appalachians there are few data on the roost ecology of the federally endangered Indiana bat (Myotis sodalis). During 2008-2012, we investigated roosting ecology of the Indiana bat in ~280,000 ha in the Great Smoky Mountains National Park, Cherokee National Forest, and Nantahala National Forest in the southern Appalachians Mountains of Tennessee and North Carolina. We investigated 2 aspects of the Indiana bat’s roosting ecology: thermoregulation and the extrinsic factors that influence body temperature, and landscape-scale roost selection. To investigate thermoregulation of bats at roost, we used data gathered in 2012 from 6 female Indiana bats (5 adults …

An Sir Approach To Modeling Business Interactions In A Marketplace, Jessica R. Beiter

Theses

As interest in online coupons from distributors like Groupon and Living Social have grown, eBay has proposed and built a marketplace. This marketplace is called eBay Local. It is a place where local merchants can post coupons that distributors can bid on the right to publish. Based on some initial data, we have built a model to t and predict the growth of this marketplace. The influence of salesmen and organic growth convert potential merchants into active members of the marketplace posting their goods and services. We have modeled the recruitment and retention of businesses within the marketplace, based on …

Population Genetics And Drug Resistance Markers: An Essential For Malaria Surveillance In Pakistan, Afsheen Raza, Mohammad Asim Beg

Department of Pathology and Laboratory Medicine

Plasmodium (P.) vivax is the prevalent malarial species accounting for 70% of malaria cases in Pakistan. However, baseline epidemiological data on P. vivax population structure and drug resistance are lacking from Pakistan. For population structure studies, molecular genetic markers, circumsporozoite protein (csp) and merozoite surface protein-1 (msp-1) are considered useful as these play an important role in P. vivax survival under immune and environmental pressure. Furthermore, these genes have also been identified as suitable candidates for vaccine development. While efforts for effective vaccine are underway, anti-malarial agents remain the mainstay for control. Evidence of resistance against commonly used anti-malarial agents, …

Avian Influenza Biosecurity: Filling The Gaps With Non-Traditional Education, Jennifer Madsen, Nathaniel Tablante

Journal of Extension

Outbreaks of highly pathogenic avian influenza have become endemic, crippling trade and livelihood for many, and in rare cases, resulting in human fatalities. It is imperative that up-to-date education and training in accessible and interactive formats be available to key target audiences like poultry producers, backyard flock owners, and emergency responders. Online tools such as Moodle™, Second Life™, and Facebook are excellent resources for Extension educators and have been implemented in the arsenal of the avian influenza biosecurity program. However, each online tool has its pros and cons, and Extension educators must use the best tool for each target audience.

Volume 50, Number 50: July 31, 2013, University Of North Dakota

University Letter Archive

No abstract provided.

Antimycobacterial And Cytotoxicity Evaluation Of The Constituents Of Monodora Carolinae, Nyangi Magori, Stephen S Nyandoro, Joan Je Munissi, Matthias Heydenreich

Tanzania Journal of Science

Phytochemical investigation of the stem bark of the recently described species Monodora carolinae (Annonaceae) afforded prenylindole derivatives (E)-4-(1H-indol-6-yl)-but-3-en-2-one (1), 5-formylindole (2), fatty acid (Z)-hexade-7-enoic acid (3) and the lignanamide cannabisin B (4). The structures of the isolated compounds were established using NMR and MS analyses. The antimycobacterial activities of the extracts and isolated compounds were evaluated against Mycobacterium madagascariense (MM) and M. indicus pranii (MIP) using the two-fold microtitre dilution method. While the extracts exhibited minimum inhibitory concentration (MIC) ranging from 500 – 1000 µg/mL, the isolated compounds were 125 – 250 µg/mL, indicating very low activity. Cytotoxic effects were …

Creating A New Kind Of Hero At Wellstar Health System, Donald H. Campbell

Journal of Executive Education

When Dr. Marcus Welby practiced medicine things were different. A diagnosis was not always simple but a cure was never far out of sight. More importantly the roles of physician, patient, nurse and family were clear. The doctor was in charge. His actions were never questioned. Operating on an infectious disease model of medical care where every illness had a cause, an effect, and a cure, he was revered as the holder of the key to the cure. He held most, if not all of the information. Communication was typically one way. No one ever questioned the information, its source, …