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Ascension, Mary Beth Spence, Gregory Evans, Sandra Bennett, Charles Patterson, Keely Hopkins, Megan Hopkins, Christian Flathman, Brooks Keel, Jeremy Wilburn

Research & Economic Development

editor: Mary Beth Spence director: Megan Hopkins designer:

Megan Hopkins, Sherry Woods 1: Jeremy Wilburn

Malnutrition In Sickle Cell Anemia: Implications For Infection, Growth And Maturation, Hyacinth I. Hyacinth, Oluwatoyosi A. Adekeye, Christopher S. Yilgwan

Journal of Social, Behavioral, and Health Sciences

Sickle cell anemia (SCA) is a genetic disease that affects mostly individuals of African and/or Hispanic descent, with the majority of cases in sub-Saharan Africa. Individuals with this disease show slowed growth, delayed sexual maturity, and poor immunologic function. These complications could partly be explained by the state of undernutrition associated with the disease. Proposed mechanism of undernutrition include protein hypermetabolism, decreased dietary intake possibly from interleukin-6-related appetite suppression, increased cardiac energy demand/expenditure, and increased red cell turnover. All the above mechanisms manifest as increased resting energy expenditure. Nutritional intervention utilizing single or multiple nutrient supplementation has led to improved …

Molecular And Cellular Signatures Of Phytol Derivatives And The Small Intestinal Submucosa In Shaping Immune Responses To Staphylococcus Aureus, Chowdhury Roshni Roy

All-Inclusive List of Electronic Theses and Dissertations

Vaccines represent the most outstanding success story of modern medicine. In addition to pathogen-derived antigen(s), immune adjuvants are crucial for the development of efficacious new generation vaccines. Most modern vaccines are comprised of purified recombinant proteins, peptides or polysaccharides, which are weakly immunogenic. The incorporation of adjuvants in vaccine formulations not only enhances the immunogenicity of the antigen but also activates various innate and adaptive immune parameters. New-age adjuvants become particularly important in the development of vaccines against some challenging pathogens, such as Staphylococcus aureus, for which vaccines are not yet available or are inadequate. S. aureus has proven exceptionally …

Biochemical Characterization Of Peptidyl-Trna Hydrolase 1 From S. Aureus And B. Cereus, Kasey Taylor Creel

Theses

The critical need for new antibiotics and antibiotic targets is of great urgency to our society in order to combat drug resistance and ward off pathogenic bacteria. One new antibacterial target is the essential bacterial enzyme Peptidyl-tRNA Hydrolase I (Pth1). In the course of protein elongation, ribosomes stall and release peptidyl-tRNA. Peptidyl-tRNA hydrolase 1 releases the tRNA from the peptidyl-tRNA, allowing the tRNA to be recycled in the cell. Without Pthl hydrolysis, peptidyl-tRNAs will accumulate, slowing down and eventually stopping protein synthesis, leading to cell death. The fact that Pthl is an essential gene in E. coli suggests that its …

A Systematic Review Of Educational Interventions To Change Behaviour Of Prescribers In Hospital Settings, With A Particular Emphasis On New Prescribers., Nicola Brennan, Karen Mattick

Peninsula Medical School

AIMS: Prescribing is a complex task and a high risk area of clinical practice. Poor prescribing occurs across staff grades and settings but new prescribers are attributed much of the blame. New prescribers may not be confident or even competent to prescribe and probably have different support and development needs than their more experienced colleagues. Unfortunately, little is known about what interventions are effective in this group. Previous systematic reviews have not distinguished between different grades of staff, have been narrow in scope and are now out of date. Therefore, to inform the design of educational interventions to change prescribing …

The Biology And Taxonomy Of Head And Body Lice— Implications For Louse-Borne Disease Prevention, Denise L. Bonilla, Lance A. Durden, Marina E. Eremeeva, Gregory A. Dasch

Environmental Health Sciences: Faculty Publications

Sucking lice (Phthiraptera: Anoplura) are obligate blood-feeding ectoparasites of placental mammals including humans. Worldwide, more than 550 species have been described and many are specific to a particular host species of mammal [1]. Three taxa uniquely parasitize humans: the head louse, body louse, and crab (pubic) louse. The body louse, in particular, has epidemiological importance because it is a vector of the causative agents of three important human diseases: epidemic typhus, trench fever, and louse-borne relapsing fever. Since the advent of antibiotics and more effective body louse control measures in the 1940s, these diseases have markedly diminished in incidence. However, …

Role Of Human Metapneumovirus, Influenza A Virus And Respiratory Syncytial Virus In Causing Who-Defined Severe Pneumonia In Children In A Developing Country, Asad Ali, Asif Raza Khowaja, Maaman Zahoor Bashir, Fatima Aziz, Sultan Mustafa, Anita Zaidi

Department of Paediatrics and Child Health

Objective: The role of respiratory viruses in causing severe, life threatening pneumonia in children in developing countries is not well established. Our study aims to determine the role of human metapneumovirus (HMPV), influenza A virus and respiratory syncytial virus (RSV) in children, aged 6 weeks to 2 years, hospitalized with WHO defined severe pneumonia (tachypnea plus any general danger sign or chest in-drawing) at a public sector hospital in Karachi, Pakistan.
Methods: This study was conducted from November 2010 to September 2011 at Abbassi Shaheed Hospital, a large public tertiary care hospital in Karachi, Pakistan. Children admitted with WHO-defined severe …

Setting Research Priorities For Preconception Care In Low- And Middle-Income Countries: Aiming To Reduce Maternal And Child Mortality And Morbidity, Sohni Dean, Igor Rudan, Fernando Althabe, Aimee Webb Girard, Christopher Howson, Ana Langer, Joy Lawn, Mary-Elizabeth Reeve, Katherine C. Teela, Mireille Toledano

Department of Paediatrics and Child Health

No abstract provided.

Global Epidemiology Of Invasive Meningococcal Disease, Rabab Z. Jafri, Syed Asad Ali, Nancy E. Messonnier, Carol Tevi-Benissan, David Durrheim, Juhani Eskola, Florence Fermon, Keith P. Klugman, Mary Ramsay, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Neisseria meningitidis is one of the leading causes of bacterial meningitis globally and can also cause sepsis, pneumonia, and other manifestations. In countries with high endemic rates, the disease burden places an immense strain on the public health system. The worldwide epidemiology of invasive meningococcal disease (IMD) varies markedly by region and over time. This review summarizes the burden of IMD in different countries and identifies the highest-incidence countries where routine preventive programs against Neisseria meningitidis would be most beneficial in providing protection. Available epidemiological data from the past 20years in World Health Organization and European Centre for Disease Prevention …

An Innovative Approach To Action Research In Family Violence Prevention, Linnaya M. Graf, Nancy K. Rea, William M. Barkley

Journal of Sustainable Social Impact

Violence prevention remains a priority in the current public health agenda because of continuing high rates and debilitating effects of violence that exist across the globe (U.S. Department of Health and Human Services, Administration on Children, Youth and Families [USDHHS-ACF], 2009; World Health Organization [WHO], 2013). This article presents the use of an innovative qualitative study developed from community action research methods in the area of family violence. By applying the combined framework of force field analysis (Lewin, 1958) and the public health model (Centers for Disease Control, 2002; Knox & Aspy, 2011), the current study identified factors that positively …

Topological And Historical Considerations For Infectious Disease Transmission Among Injecting Drug Users In Bushwick, Brooklyn (Usa), Kirk Dombrowski, Richard Curtis, Samuel Friedman, Bilal Khan

Department of Sociology: Faculty Publications

Recent interest by physicists in social networks and disease transmission factors has prompted debate over the topology of degree distributions in sexual networks. Social network researchers have been critical of “scale-free” Barabasi-Albert approaches, and largely rejected the preferential attachment, “rich-get-richer” assumptions that underlie that model. Instead, research on sexual networks has pointed to the importance of homophily and local sexual norms in dictating degree distributions, and thus disease transmission thresholds. Injecting Drug User (IDU) network topologies may differ from the emerging models of sexual networks, however. Degree distribution analysis of a Brooklyn, NY, IDU network indicates a different topology than …

Engaging Teenagers With Science Through Comics, Amy N. Spiegel, Julia Mcquillan, Peter Halpin, Camillia Matuk, Judy Diamond

Department of Sociology: Faculty Publications

It is increasingly important for all citizens, and especially youth, to understand how viruses impact our health, communities and environment. Particularly for youth less interested in traditional science learning materials, comics may provide a way to engage teenagers with scientific information about viruses. We compared the impacts of different formats of educational materials on teenagers’ knowledge of, attitudes toward, and engagement with information about viruses. High school students (N = 873) were randomly assigned to read either a high quality comic or essay about viruses. Latent class analysis grouped youth into one of four categories that captured a range from …

Bridging The Gap Between Health And Justice, Lior Gideon

Publications and Research

No abstract provided.

Distributions Of Industry Payments To Massachusetts Physicians, Aaron S. Kesselheim, Christopher Robertson, Kent Siri, Puneet Batra, Jessica M. Franklin

Faculty Scholarship

Some states have mandated systematic public disclosure of payments made by drug- and device-makers to health care practitioners. We used Massachusetts data to characterize the distribution of payment types and the variation among medical specialties.

The 30 months’ of data included 32,227 reported payments to 11,734 Massachusetts physicians, for a total of $76.7 million. The most common form of payment was food. Compensation for bona fide services was the payment type with the highest value.

We found that 25% of currently licensed Massachusetts physicians received at least one payment during the study period. Prevalence ranged by specialties from pediatricians (12%) …

Preventing Violent Extremism Through Value Complexity: Being Muslim Being British, Jose Liht, Sara Savage

Journal of Strategic Security

This article reports on an intervention designed to prevent violent extremism in young UK Muslims, and provides an empirical assessment of its effectiveness. The course was designed to expose participants to the multiplicity of value priorities that influential Muslims embody, and to structure group activities that allow participants to explore all value positions on issues central to radical Islamist discourse, free from criticism or social pressure. The intervention, a 16 contact hour course using films and group activities that enables participants to problem solve according to a broad array of their own values, was pre and post tested with 81 …

Austrian Syndrome: Triad Of The Past Or Harbinger Of The Future?, Mira Mitry Md, Suzanne J. Templer Do, Stacey Smith Md, Facp, Eugene P. York Md, Facp

Department of Medicine

No abstract provided.

Mothers Who Formula Feed: Their Practices, Support Needs And Factors Influencing Their Infant Feeding Decision., Roslyn Tarrant, Margaret Sheridan-Pereira, Roberta A. Mccarthy, Katherine M. Younger, John M. Kearney

Articles

The majority of mothers in Ireland provide formula milk to their infants during the initial weeks postpartum; however, data are lacking on their formula feeding practices and support needs. This prospective Dublin-based observational study, which included 450 eligible mother-term infant pairs recruited and followed up to 6 months postpartum, aimed to advance our understanding of maternal formula feeding practices, their reasons for deciding to formula feed, sources of feeding information and perceived support needs; insights into infant formula milk consumption patterns in relation to current feeding guidelines are also provided. In summary, the vast majority of infants at 6 weeks …

Fluidic Sensor Devices Utilizing Dry Film Resist As Main Structural Materials, Sijia Gong

Masters Theses

"In this thesis, two types of fluidic sensor devices are demonstrated. The first device utilizes a dry film resist (DFR) as the main structural material of fluidic device utilizing the photolithography process. The second one involves a simple, low-cost sensor platform composed of ubiquitous materials such as polymer tubing and metal wires. Both devices are prepared to measure the dissolved oxygen content, as a model target analyte, based on the oxygen quenching reaction of a ruthenium complex fluorophore as the reporting agent. Characterization of sensors is conducted based on the fluorescence lifetime measurement. The first type of sensor is constructed …

I Wasn’T Strong Like This When I Started Out: True Stories Of Becoming A Nurse, Lee Gutkind, Karen Wolk Feinstein

Books

This collection of true narratives reflects the dynamism and diversity of nurses, who provide the first vital line of patient care. Here, nurses remember their first “sticks,” first births, and first deaths, and reflect on what gets them through long, demanding shifts, and keeps them in the profession.

The Effect Of Perturbation On Interface And Intramuscular Temperatures During An Ice Water Immersion, Andrew Dean Jedlicka

Dissertations and Theses @ UNI

Context: It seems that clinicians build ice water immersions differently, with one protocol factor, perturbation, being different. Perturbation may affect cooling efficacy of the immersion. Objective: Compare the cooling efficacy of 3 different ice water perturbation protocols on interface and muscle temperatures during Tx. Design: Crossover trial. Setting: Laboratory. Patients or Other Participants: Sixteen active volunteers in accordance with university IRB. Interventions: During 2 sessions separated by 48 hours both legs were immersed independently in 38 L cylinder coolers filled to the fibular head. Independent variables will be perturbation [Immersion with no perturbation (ImmNP), Immersion with perturbation every 3 min. …

The Association Of Psychosocial Factors On Hiv/Aids Disease Progression, Melissa Margolis

Scripps Senior Theses

Despite a rise in the number of studies looking at the relationship of psychosocial factors (coping style, personality type, and social support) on HIV/AIDS severity, there remains a lack of conclusive answers about the specific association between these factors. This study used a meta-analytic method of analysis to address these issues in the post anti-retroviral treatment modality world. A systematic search of major psychology and medical computerized databases led to 110 studies used in the meta-analysis. Social support was found to have the strongest relationship with HIV progression. Structural social support had greater protective effect on HIV progression than functional …

Novel Polyomaviruses Of Nonhuman Primates: Genetic And Serological Predictors For The Existence Of Multiple Unknown Polyomaviruses Within The Human Population, Nelly Scuda, Nadege Freda Madinda, Chantal Akoua-Koffi, Edgard Valerie Adjogoua, Diana Wevers, Jörg Hofmann, Kenneth N. Cameron, Saj Leendertz, Emmanuel Couacy-Hymann, Martha Robbins, Christophe Boesch, Michael A. Jarvis, Ugo Moens, Lawrence Mugisha, Sébastien Calvignac-Spencer, Fh Leendertz, Bernhard Ehlers

School of Biomedical Sciences

No abstract provided.

A Fimh Inhibitor Prevents Acute Bladder Infection And Treats Chronic Cystitis Caused By Multidrug-Resistant Uropathogenic Escherichia Coli St131., Makrina Totsika, Maria Kostakioti, Thomas J. Hannan, Mathew Upton, Scott A. Beatson, James W. Janetka, Scott J. Hultgren, Mark A. Schembri

School of Biomedical Sciences

BACKGROUND: Escherichia coli O25b:H4-ST131 represents a predominant clone of multidrug-resistant uropathogens currently circulating worldwide in hospitals and the community. Urinary tract infections (UTIs) caused by E. coli ST131 are typically associated with limited treatment options and are often recurrent. METHODS: Using established mouse models of acute and chronic UTI, we mapped the pathogenic trajectory of the reference E. coli ST131 UTI isolate, strain EC958. RESULTS: We demonstrated that E. coli EC958 can invade bladder epithelial cells and form intracellular bacterial communities early during acute UTI. Moreover, E. coli EC958 persisted in the bladder and established chronic UTI. Prophylactic antibiotic administration …

Quasi-Experimental Evaluation Of Undergraduate Learning In A Multidimensional Wellness Course, Kristi Leonard

Dissertations and Theses @ UNI

Introductory wellness courses are common among American institutions of higher education. These courses are typically of a unidimensional approach, focusing on just the physical component of wellness. Some wellness educators would argue that a multidimensional approach is a richer and more valuable learning experience. Furthermore, technology has played a larger role in wellness education, as it is being created, developed, and implemented into the field. Therefore, college wellness educators and curriculum designers need to determine the implications for both online and face-to-face instructional methods in their execution of teaching the holistic concept of wellness to their students.

The purpose of …

A Study Of The Effect Of Organizational Communication Cultures On Interorganizational Collaboration Of Crisis Response, Laura Pechta

Wayne State University Dissertations

Recent history has indicated that crises are becoming more frequent rather than exceptional events. Dozens of organizations, often with very different missions, methods, technologies and cultures, are called upon to coordinate activities in order to mitigate the crisis and assist in recovery efforts. Although several interorganizational coordination perspectives and strategies have been proposed, they have neglected to examine how different organizational communication cultures of crisis response organizations involved in an Emergency Operations Center (EOC) may affect crisis collaboration efforts. Previous studies have also disregarded the important distinction between crisis coordination and crisis collaboration and the challenges and benefits of each …

Tetab(46), A Predicted Heterodimeric Abc Transporter Conferring Tetracycline Resistance In Streptococcus Australis Isolated From The Oral Cavity, Philip J. Warburton, Lena Ciric, Avigdor Lerner, Lorna A. Seville, Adam P. Roberts, Peter Mullany, Elaine Allan

School of Biomedical Sciences

No abstract provided.

Communication Disorders And Indigenous Australians : A Synthesis And Critique Of The Available Literature, Jasmyn Hall

Theses : Honours

Purpose: To synthesise and critique the available diverse literature related to communication disorders experienced by Indigenous Australians. This is in order to provide health professionals with a resource guide for evidence based decision making. The review has a specific focus on prevalence, assessment and effective treatment of communication disorders and explores these across the lifespan.

Method: A three phase systematic search process was adopted. A number of key databases, speech pathology journals and grey literature sources were searched to obtain articles relevant to the research aims. Two researchers independently rated articles for inclusion as well as methodological quality using the …

Alcohol Consumption And Its Correlates Among Residents Of Mining Town, Kitwe, Zambia: 2011 Population Based Survey, Cosmas Zyaambo, Olesegun Babaniyi, Peter Songolo, Adamson S. Muula, Emmanuel Rudatsikira, Seter Siziya

Faculty Publications

Alcohol consumption is a risk factor for non-communicable diseases such as cardiovascular diseases, liver cirrhosis and cancers. It has also been associated with risky sexual behaviors, hence, attributed as a factor in the increase of HIV incidence and prevalence. A cross sectional study was conducted using a modified World Health Organizations Global Non Communicable Diseases (NCD) Surveillance Initiative NCD-STEPs 1and 2. Multivariate logistic regression was used to examine the determinants of alcohol consumption. A total of 1627 individuals participated in the survey, of which 42.3% were males. Some 22.3% (36.2% of male and 12.1% of female; p<0.001) participants reported to have consumed alcohol during the 30 days preceding the survey. The factors considered to be associated with alcohol consumption were age, sex and smoking. Compared to respondents age 25-34 years, respondents of age 35-44 years were 38% (AOR = 1.38, 95%CI [1.11, 1.70]) more likely to report having consumed alcohol and those aged 45 years or older were 26% (AOR = 0.74, 95%CI [0.60, 0.93]) less likely to report having consumed alcohol. Female respondents were 47% (AOR = 0.53, 95%CI [0.46, 0.60]) less likely to report consuming alcohol compared to male respondents. Compared to respondents who reported smoking cigarettes, those who did not smoke cigarettes were 51% (AOR = 0.49, 95%CI [0.40, 0.59]) less likely to consume alcohol. The rate of alcohol consumption is high in this mining town. Factors identified in this study as associated with alcohol consumption, i.e., male sex, age, cigarette smoking, should be considered in designing interventions to curtail the level of alcohol consumption.

An Exploratory Examination Of The Factors Influencing Indonesian Sme's Sustainability Practices In The Textile And Chemical Industries, Bulan Prabawani

Theses: Doctorates and Masters

All firms have an impact on the environment in which they operate, for example in the exploration and processing of environmental resources to make a profit. Manufacturing firms, in particular have the potential to pollute the environment with dangerous liquid and solid wastes. Small and medium sized enterprises (SMEs) make a significant contribution to the global economy in both developing and developed countries. Individually, SMEs appear to have little environmental impact, but accumulatively, they have a considerable impact, not only economically but also environmentally. However, managing environment impact is not usually core business for SMEs.

SMEs often suffer from a …

Biomarkers Of Disease : Concentrations In The Serum Of Women During Natural And Stimulated Ovarian Cycles And During Early Pregnancy, Melissa Stemp

Theses: Doctorates and Masters

Molecular biomarkers are chemical signatures that all cell types possess. They are used in medicine to evaluate both normal biological events and pathogenic processes. A series of biomarkers associated with cancer of the breast, ovaries and other parts of the female reproductive tract and the monitoring of pregnancy were measured in disease‐free women. The biomarkers measured were prostate specific antigen (PSA), CA125, CA15‐3, CA72‐4, and pregnancy associated plasma protein‐a (PAPP‐A). The patterns of change during natural and stimulated ovarian cycles and early pregnancy were investigated to determine if these biomarkers could reflect normal events relating to ovulation and implantation/placentation. In …