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2013

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Articles 1531 - 1560 of 2106

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Investigations Of Als1 And Hwp1 Genes In Clinical Isolates Of Candida Albicans, Melek İnci̇, Mustafa Altay Atalay, Burçi̇n Özer, Ömer Evi̇rgen, Ni̇zami̇ Duran, Vi̇cdan Köksaldi Motor, Ayşe Nedret Koç, Yüsüf Önlen, Çeti̇n Kilinç, Süleyman Durmaz Jan 2013

Investigations Of Als1 And Hwp1 Genes In Clinical Isolates Of Candida Albicans, Melek İnci̇, Mustafa Altay Atalay, Burçi̇n Özer, Ömer Evi̇rgen, Ni̇zami̇ Duran, Vi̇cdan Köksaldi Motor, Ayşe Nedret Koç, Yüsüf Önlen, Çeti̇n Kilinç, Süleyman Durmaz

Turkish Journal of Medical Sciences

To explore the presence of ALS1 and HWP1 genes by multiplex polymerase chain reaction (PCR) in Candida albicans strains. Materials and methods: By using the multiplex PCR method, the presence of agglutinin-like sequence 1 (ALS1) and hyphal wall protein 1 (HWP1) genes were investigated in 206 C. albicans strains that were isolated from various clinical samples. Phenotypic identification of slime formation by microplate and tube adherence tests was performed. Results: The presence of the ALS1 gene was detected in 53.9% of all strains, while the HWP1 gene was present in 5.3%. Slime formation was phenotypically detected in the 62.2% of …

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Preliminary Data From A Surveillance Study On Surgical Site Infections And Assessment Of Risk Factors In A University Hospital, Mustafa Namiduru, İlkay Karaoğlan, Riza Çam, Vuslat Boşnak, Ayşe Özlem Mete Jan 2013

Preliminary Data From A Surveillance Study On Surgical Site Infections And Assessment Of Risk Factors In A University Hospital, Mustafa Namiduru, İlkay Karaoğlan, Riza Çam, Vuslat Boşnak, Ayşe Özlem Mete

Turkish Journal of Medical Sciences

Surgical site infections (SSIs) lead to substantial mortality, morbidity, and socioeconomic loss. To explore the rate of infections and risk factors for the development of infection in surgical units. Materials and methods: All patients (n = 1397) who underwent a surgical intervention and were hospitalized for >48 h in surgical units (except the ophthalmology unit) of Gaziantep University Medical Faculty Hospital between 17 March 2008 and 15 July 2008 were included in the study. The Center for Disease Control and Prevention criteria were used for identifying and diagnosing SSIs. Rate of SSI was calculated as the number of SSIs observed …

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The Role Of Vitamin D Deficiency In Parathyroid Hormone Levels, Alpaslan Kiliçarslan, Alma Cenoli̇ Aslan, Gamze Gezgen Jan 2013

The Role Of Vitamin D Deficiency In Parathyroid Hormone Levels, Alpaslan Kiliçarslan, Alma Cenoli̇ Aslan, Gamze Gezgen

Turkish Journal of Medical Sciences

Vitamin D deficiency is an important cause of secondary hyperparathyroidism. We aimed to investigate the effect of vitamin D levels on parathyroid hormone (PTH) levels. Materials and methods: We retrospectively chose 2226 patients who were admitted to our hospital’s general internal medicine department for various reasons and had both PTH and vitamin D tests on the same day. Results: It was found that 22.3% of the patients had high levels of PTH and 92% of them had secondary hyperparathyroidism. The average vitamin D level was 16.4 ng/mL. The vitamin D levels of 64% of the patients were below 20 ng/mL …

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Effect Of The Presence Of Pneumonia On Noninvasive Ventilation Success In Chronic Obstructive Pulmonary Disease Cases With Acute Hypercapnic Respiratory Failure, Serdar Akpinar, Kazim Rollas, Evri̇m Eylem Akpinar, Ali̇ Alagöz, Nazi̇re Uçar, Yusuf Tuğrul Şi̇pi̇t Jan 2013

Effect Of The Presence Of Pneumonia On Noninvasive Ventilation Success In Chronic Obstructive Pulmonary Disease Cases With Acute Hypercapnic Respiratory Failure, Serdar Akpinar, Kazim Rollas, Evri̇m Eylem Akpinar, Ali̇ Alagöz, Nazi̇re Uçar, Yusuf Tuğrul Şi̇pi̇t

Turkish Journal of Medical Sciences

To investigate the effect of the presence of pneumonia on the success of noninvasive mechanical ventilation (NIMV) in chronic obstructive pulmonary disease (COPD) cases with acute respiratory failure. Materials and methods: Sixty patients admitted to the intensive care unit (ICU) due to COPD exacerbation were included. The patients were divided into 2 groups as those with pneumonia (Group 1) and without pneumonia (Group 2). According to initial pH values, cases were also divided into 3 subgroups based on pH values. C-reactive protein (CRP), APACHE II scores, requirement of endotracheal intubation, mortality, and duration of ICU and hospital stay were also …

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Pcr Detection Of Brucella Abortus In Cow Milk Samples Collected From Erzurum, Turkey, Tüli̇n Arasoğlu, Medi̇ne Güllüce, Hakan Özkan, Ahmet Adigüzel, Fi̇kretti̇n Şahi̇n Jan 2013

Pcr Detection Of Brucella Abortus In Cow Milk Samples Collected From Erzurum, Turkey, Tüli̇n Arasoğlu, Medi̇ne Güllüce, Hakan Özkan, Ahmet Adigüzel, Fi̇kretti̇n Şahi̇n

Turkish Journal of Medical Sciences

In this study, we designed and used 2 different type-specific polymerase chain reaction (PCR) methods for the detection of Brucella abortus. Materials and methods: There were 2 different primer sets (B4/B5 and AF/AR) selected and used for the amplification of 2 different genes that are present in all biovars of Brucella species, including bcsp31, encoding 31-kDa immunogenic cell surface proteins, and omp25, which is known to be one of the virulence factors encoding outer membrane proteins of 26–23 kDa. Results: The results showed that 273 (81.7%) and 317 (94.9%) out of 334 milk samples were positive for brucellosis, as detected …

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Assessment Of Immune Responses To Hepatitis A Vaccination In Children Aged 1 And 2 Years, Solmaz Çelebi̇, Mustafa Kemal Hacimustafaoğlu, Yücehan Albayrak, Ayşe Melda Sinirtaş Jan 2013

Assessment Of Immune Responses To Hepatitis A Vaccination In Children Aged 1 And 2 Years, Solmaz Çelebi̇, Mustafa Kemal Hacimustafaoğlu, Yücehan Albayrak, Ayşe Melda Sinirtaş

Turkish Journal of Medical Sciences

Hepatitis A can be prevented by vaccination. The aim of this study was to determine seropositivity for hepatitis A before vaccination in healthy children 12 and 24 months of age and compare seroconversion rates after vaccination between these 2 groups. Materials and methods: Forty-nine children aged 1 year (Group 1) and 51 children aged 2 years (Group 2) were included in the study. Inactive hepatitis A vaccine (Avaxim, 80 antigenic subtypes, 0.5 mL) were administered to every child in 2 doses, 6 months apart. Anti-hepatitis A virus (HAV) IgG and IgM antibodies were detected by Architect HAVAb-IgG and HAVAb-IgM (Abbott, …

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Immunokinetics Of Theileria Equi Specific Antibodies: A Comparison In Serial And Single Dilution Elisa Antibody End Titres, Yogesh Kumar, Dharam Vir Malhotra, Anil Kumar Nichani, Ashok Kumar, Shruti Dhar, Sanjay Kumar Jan 2013

Immunokinetics Of Theileria Equi Specific Antibodies: A Comparison In Serial And Single Dilution Elisa Antibody End Titres, Yogesh Kumar, Dharam Vir Malhotra, Anil Kumar Nichani, Ashok Kumar, Shruti Dhar, Sanjay Kumar

Turkish Journal of Veterinary & Animal Sciences

Theileria equi, a haemoprotozoan of equids, is responsible for endemic infection/latency in tropical/subtropical parts of the world. The present study investigated the immunokinetics of T. equi infection in experimental animals and the diagnostic applicability of single dilution ELISA vis-à-vis conventional serial dilution ELISA. Sequential serum samples were collected up to 90 days postinfection (PI) from 4 donkeys experimentally infected with T. equi. Immunokinetics of T. equi antibodies end titre were determined by serial and single dilution ELISA. A significant rise in initial ELISA antibody end titre (1:800 in serial dilution ELISA and from 1:600 to 1:650 in single dilution ELISA) …

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Comparative Evaluation Of Liquid-Phase Blocking Elisa And Solid-Phase Competition Elisa Methods For The Detection Of Antibodies To The Structural Proteins Of Foot-And-Mouth Disease Types O And A Viruses, Murat Şevi̇k, Fahri̇ Ferudun Öztürk Jan 2013

Comparative Evaluation Of Liquid-Phase Blocking Elisa And Solid-Phase Competition Elisa Methods For The Detection Of Antibodies To The Structural Proteins Of Foot-And-Mouth Disease Types O And A Viruses, Murat Şevi̇k, Fahri̇ Ferudun Öztürk

Turkish Journal of Veterinary & Animal Sciences

In this study, we compared 2 methods, liquid-phase blocking ELISA (LPBE) and solid-phase competition ELISA (SPCE), for the detection of antibodies to the structural proteins of foot-and-mouth disease virus (FMDV). These methods were compared using sera collected from cattle (n = 30) without a history of foot-and-mouth disease infection or vaccination, cattle (n = 180) vaccinated with oil-adjuvanted bivalent vaccine, and international reference sera (positive, weak positive, and negative) for FMDV serotypes O and A. The results showed that SPCE had a better specificity (96.67% for serotype O and 100% for serotype A) than LPBE (90% for serotype O and …

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Helical Computed Tomography Application In Rabbit Liver Anatomy: Comparison With Frozen Cross-Sectional Cuts, Kamelia Stamatova Yovcheva, Rosen Dimitrov, Yuliana Toneva, Penka Yonkova, Dimitar Kostov, Anton Rusenov, Krassimira Uzunova, Violeta Yordanova Jan 2013

Helical Computed Tomography Application In Rabbit Liver Anatomy: Comparison With Frozen Cross-Sectional Cuts, Kamelia Stamatova Yovcheva, Rosen Dimitrov, Yuliana Toneva, Penka Yonkova, Dimitar Kostov, Anton Rusenov, Krassimira Uzunova, Violeta Yordanova

Turkish Journal of Veterinary & Animal Sciences

Our focus has been to study and compare the anatomical helical computed tomography (CT) features of the normal rabbit liver with its native cross-sectional anatomy. Helical CT was used for scanning the cranial part of the abdominal cavity. The slice thickness was 5 mm. Frozen transversal anatomic cross-sections with a thickness of 10 mm were obtained from the cranial abdominal part of 4 animals following euthanasia. They were compared with the corresponding helical CT scans. At Th9 (thoracic vertebra), the helical CT images showed in the whole aspect a normal liver. It was a massive, heterogeneous, soft tissue, with normal …

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Microbiological And Parasitological Quality Of Honey Produced In İstanbul, Emek Dümen, Hayretti̇n Akkaya, Gülay Merve Öz, Funda Hati̇ce Sezgi̇n Jan 2013

Microbiological And Parasitological Quality Of Honey Produced In İstanbul, Emek Dümen, Hayretti̇n Akkaya, Gülay Merve Öz, Funda Hati̇ce Sezgi̇n

Turkish Journal of Veterinary & Animal Sciences

In this study, 500 honey samples (with combs) were collected directly from the hives in various parts of İstanbul. The presence and the interactions of different microbiological and parasitological parameters (coliforms, Escherichia coli, Staphylococcus aureus, Ascosphaera apis, Aspergillus flavus, Aspergillus fumigatus, Paenibacillus larvae, Melissococcus pluton, and Nosema spp.) were investigated. According to the results, 80 samples (16%) tested positive for coliforms, 18 samples (3.6%) for E. coli, 67 samples (13.4%) for S. aureus, 51 samples (10.2%) for A. apis, 22 samples (4.4%) for A. flavus, 32 samples (6.4%) for A. fumigatus, 16 samples (3.2%) for P. larvae, 29 samples (5.8%) …

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Levamisole Enhances Global And Differential Leukocyte Numbers In Peripheral Blood Of Dogs With Ehrlichiosis, Dhagma Renata Denis Souza, Andreia Lima Tome Melo, Livia Saab Muraro, Daniel Moura Aguiar, Deijanira Albuquerque Jan 2013

Levamisole Enhances Global And Differential Leukocyte Numbers In Peripheral Blood Of Dogs With Ehrlichiosis, Dhagma Renata Denis Souza, Andreia Lima Tome Melo, Livia Saab Muraro, Daniel Moura Aguiar, Deijanira Albuquerque

Turkish Journal of Veterinary & Animal Sciences

Ehrlichiosis is a disease caused by Ehrlichia, a genus of obligatory intracellular bacteria that parasitize leukocytes and provoke several hematological alterations. In this work, we investigated the effect of levamisole associated with doxycycline on peripheral leukocytes in dogs PCR-positive for ehrlichial DNA. Twenty-one Ehrlichia-infected dogs were randomly distributed in 2 groups: a control group (n = 10) and a levamisole-treated group (n = 11). Blood samples were collected from each animal for hematological and DNA analysis both before initiating the experiment and 5 days later. All dogs were treated with doxycycline (10 mg/kg body weight), cimetidine (5 mg/kg of body …

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A Clinical Case: Vitamin C-Responsive Dermatosis In A Holstein Native Cross Bull Calf, Amin Anoushepour, Mehdi Sakha, Pejman Mortazavi Jan 2013

A Clinical Case: Vitamin C-Responsive Dermatosis In A Holstein Native Cross Bull Calf, Amin Anoushepour, Mehdi Sakha, Pejman Mortazavi

Turkish Journal of Veterinary & Animal Sciences

A male pony foal aged 2 days, reportedly not passing urine since birth and showing moderate signs of colic, was presented for treatment. The clinical examination revealed moderate tachycardia, tachypnea, and mild abdominal distension. Uroperitoneum was confirmed by peritoneocentesis and abdominal fluid-to-serum creatinine ratio (>2:1). After stabilization of the patient, tube cystotomy was performed using infusion set tubing to bypass the urine, allowing the tear on the caudodorsal wall of the bladder to heal itself without suturing. The foal resumed normal urination on day 6 and the catheter was removed 3 days later. Complications were not detected during the …

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Assessment Of Amiodarone Effects On Intact Cats' Electrocardiograms, Farzad Gouya, Ali Shabestari Asl Jan 2013

Assessment Of Amiodarone Effects On Intact Cats' Electrocardiograms, Farzad Gouya, Ali Shabestari Asl

Turkish Journal of Veterinary & Animal Sciences

Amiodarone can be used for treatment of ventricular and supraventricular arrhythmias in canine medicine, but its exact role in feline electrocardiography and its side effects have not been proven. The aim of this study was the evaluation of amiodarone and its different dosages' effects on intact feline heart electrocardiograms. Eight healthy stray cats were selected and control electrocardiogram was obtained. Amiodarone tablets were prescribed twice daily at 10 mg/kg for 7 days. The same protocol was repeated with doses of 15 and 25 mg/kg. Hexagonal electrocardiograms were obtained at the end of each stage. Electrocardiograms were evaluated for P amplitude …

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Scrapie Cases In The Northern Cyprus, Aydin Gürel, Ahmet Gülçubuk, Nuri̇ Turan, Christopher Richard Helps, Hüseyi̇n Yilmaz Jan 2013

Scrapie Cases In The Northern Cyprus, Aydin Gürel, Ahmet Gülçubuk, Nuri̇ Turan, Christopher Richard Helps, Hüseyi̇n Yilmaz

Turkish Journal of Veterinary & Animal Sciences

Scrapie is a fatal neurodegenerative disease affecting small ruminants that causes economic losses in many countries. It is categorized together with other fatal neurodegenerative diseases as a transmissible spongiform encephalopathy. The aim of this study was to investigate clinical cases and the cause of death in a flock of sheep from Northern Cyprus (Turkish Republic of Northern Cyprus) suspected of having scrapie. Brains from 4 sheep showing clinical signs of classical scrapie, out of a flock of 200 animals, were analyzed by histopathological examination and infective prion enzyme-linked immunosorbent assay (ELISA). The 4 affected sheep were 2-3 years of age …

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Modeling Social Transmission Dynamics Of Unhealthy Behaviors For Evaluating Prevention And Treatment Interventions On Childhood Obesity, Leah M. Frerichs, Ozgur M. Araz, Terry T.-K. Huang Jan 2013

Modeling Social Transmission Dynamics Of Unhealthy Behaviors For Evaluating Prevention And Treatment Interventions On Childhood Obesity, Leah M. Frerichs, Ozgur M. Araz, Terry T.-K. Huang

Department of Supply Chain Management and Analytics: Faculty Publications

Research evidence indicates that obesity has spread through social networks, but lever points for interventions based on overlapping networks are not well studied. The objective of our research was to construct and parameterize a system dynamics model of the social transmission of behaviors through adult and youth influence in order to explore hypotheses and identify plausible lever points for future childhood obesity intervention research. Our objectives were: (1) to assess the sensitivity of childhood overweight and obesity prevalence to peer and adult social transmission rates, and (2) to test the effect of combinations of prevention and treatment interventions on the …

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Multilocus Sequence Typing For Characterization Of Staphylococcus Pseudintermedius, S. M. Solyman, C. C. Black, B. Duim, V. Perreten, E. Van Duijkeren, J. A. Wagenaar, L. C. Eberlein, L. N. Sadeghi, R. Videla, D. A. Bemis, S. A. Kania Jan 2013

Multilocus Sequence Typing For Characterization Of Staphylococcus Pseudintermedius, S. M. Solyman, C. C. Black, B. Duim, V. Perreten, E. Van Duijkeren, J. A. Wagenaar, L. C. Eberlein, L. N. Sadeghi, R. Videla, D. A. Bemis, S. A. Kania

United States Army: Publications

Staphylococcus pseudintermedius is an opportunistic pathogen in dogs. Four housekeeping genes with allelic polymorphisms were identified and used to develop an expanded multilocus sequence typing (MLST) scheme. The new seven-locus technique shows S. pseudintermedius to have greater genetic diversity than previous methods and discriminates more isolates based upon host origin.

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Unique Structural Modifications Are Present In The Lipopolysaccharide From Colistin-Resistant Strains Of Acinetobacter Baumannii, Mark R. Pelletier, Leila G. Casella, Jace W. Jones, Mark D. Adams, Daniel V. Zurawski, Karsten R. O. Hazlett, Yohei Doi, Robert K. Ernst Jan 2013

Unique Structural Modifications Are Present In The Lipopolysaccharide From Colistin-Resistant Strains Of Acinetobacter Baumannii, Mark R. Pelletier, Leila G. Casella, Jace W. Jones, Mark D. Adams, Daniel V. Zurawski, Karsten R. O. Hazlett, Yohei Doi, Robert K. Ernst

United States Army: Publications

Acinetobacter baumannii is a nosocomial opportunistic pathogen that can cause severe infections, including hospital-acquired pneumonia, wound infections, and sepsis. Multidrug-resistant (MDR) strains are prevalent, further complicating patient treatment. Due to the increase in MDR strains, the cationic antimicrobial peptide colistin has been used to treat A. baumannii infections. Colistin-resistant strains of A. baumannii with alterations to the lipid A component of lipopolysaccharide (LPS) have been reported; specifically, the lipid A structure was shown to be hepta-acylated with a phosphoethanolamine (pEtN) modification present on one of the terminal phosphate residues. Using a tandem mass spectrometry platform, we provide definitive evidence that …

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Fluid Balance And Cardiac Function In Septic Shock As Predictors Of Hospital Mortality, Scott T. Micek, Colleen Mcevoy, Matthew Mckenzie, Nicholas Hampton, Joshua A. Doherty, Marin H. Kollef Jan 2013

Fluid Balance And Cardiac Function In Septic Shock As Predictors Of Hospital Mortality, Scott T. Micek, Colleen Mcevoy, Matthew Mckenzie, Nicholas Hampton, Joshua A. Doherty, Marin H. Kollef

Open Access Publications

No abstract provided.

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A Review Of Factors That Influence Individual Compliance With Mass Drug Administration For Elimination Of Lymphatic Filariasis, Alison Krentel, Peter U. Fischer, Gary J. Weil Jan 2013

A Review Of Factors That Influence Individual Compliance With Mass Drug Administration For Elimination Of Lymphatic Filariasis, Alison Krentel, Peter U. Fischer, Gary J. Weil

Open Access Publications

No abstract provided.

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Serological Diagnosis Of North American Paragonimiasis By Western Blot Using Paragonimus Kellicotti Adult Worm Antigen, Peter U. Fischer, Kurt C. Curtis, Scott M. Folk, Patricia P. Wilkins, Luis A. Marcos, Gary J. Weil Jan 2013

Serological Diagnosis Of North American Paragonimiasis By Western Blot Using Paragonimus Kellicotti Adult Worm Antigen, Peter U. Fischer, Kurt C. Curtis, Scott M. Folk, Patricia P. Wilkins, Luis A. Marcos, Gary J. Weil

Open Access Publications

No abstract provided.

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Mupirocin And Chlorhexidine Resistance In Staphylococcus Aureus In Patients With Community-Onset Skin And Soft Tissue Infections, Stephanie A. Fritz, Patrick G. Hogan, Bernard C. Camins, Ali J. Ainsworth, Carol Patrick, Madeline S. Martin, Melissa J. Krauss, Marcela Rodriguez, Carey-Ann D. Burnham Jan 2013

Mupirocin And Chlorhexidine Resistance In Staphylococcus Aureus In Patients With Community-Onset Skin And Soft Tissue Infections, Stephanie A. Fritz, Patrick G. Hogan, Bernard C. Camins, Ali J. Ainsworth, Carol Patrick, Madeline S. Martin, Melissa J. Krauss, Marcela Rodriguez, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.

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Hospital Flood Preparedness And Flood-Related Psychological Consequences In 15 Provinces In Central Thailand After Implementation Of A National Guideline, Anucha Apisarnthanarak, Thana Khawcharoenporn, Keith F. Woeltje, David K. Warren Jan 2013

Hospital Flood Preparedness And Flood-Related Psychological Consequences In 15 Provinces In Central Thailand After Implementation Of A National Guideline, Anucha Apisarnthanarak, Thana Khawcharoenporn, Keith F. Woeltje, David K. Warren

Open Access Publications

No abstract provided.

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Comparison Of Pcr And Quantitative Real-Time Pcr Methods For The Characterization Of Ruminant And Cattle Fecal Pollution Sources, Meredith R. Raith, Catherine A. Kelty, John F. Griffith, Alexander Schriewer, Stefan Wuertz, Sophie Mieszkin, Michele Gourmelon, Georg H. Reischer, Andreas H. Farnleitner, Jared S. Ervin, Patricia A. Holden, Darcy L. Ebentier, Jennifer A. Jay, Dan Wang, Alexandria B. Boehm, Tiong Gim Aw, Joan B. Rose, E. Balleste, W.G. Meijer, Mano Sivaganesan, Orin C. Shanks Jan 2013

Comparison Of Pcr And Quantitative Real-Time Pcr Methods For The Characterization Of Ruminant And Cattle Fecal Pollution Sources, Meredith R. Raith, Catherine A. Kelty, John F. Griffith, Alexander Schriewer, Stefan Wuertz, Sophie Mieszkin, Michele Gourmelon, Georg H. Reischer, Andreas H. Farnleitner, Jared S. Ervin, Patricia A. Holden, Darcy L. Ebentier, Jennifer A. Jay, Dan Wang, Alexandria B. Boehm, Tiong Gim Aw, Joan B. Rose, E. Balleste, W.G. Meijer, Mano Sivaganesan, Orin C. Shanks

United States Environmental Protection Agency: Publications

The State of California has mandated the preparation of a guidance document on the application of fecal source identification methods for recreational water quality management. California contains the fifth highest population of cattle in the United States, making the inclusion of cow-associated methods a logical choice. Because the performance of these methods has been shown to change based on geography and/or local animal feeding practices, laboratory comparisons are needed to determine which assays are best suited for implementation. We describe the performance characterization of two end-point PCR assays (CF128 and CF193) and five real-time quantitative PCR (qPCR) assays (Rum2Bac, BacR, …

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Impacts Of Migratory Sandhill Cranes (Grus Canadensis) On Microbial Water Quality In The Central Platte River, Nebraska, Usa, Jason R. Vogel, Dale W. Griffin, Hon S. Ip, Nicholas J. Ashbolt, Matthew T. Moser, Jingrang Lu, Mary K. Beitz, Hodon Ryu, Jorge W. Santo Domingo Jan 2013

Impacts Of Migratory Sandhill Cranes (Grus Canadensis) On Microbial Water Quality In The Central Platte River, Nebraska, Usa, Jason R. Vogel, Dale W. Griffin, Hon S. Ip, Nicholas J. Ashbolt, Matthew T. Moser, Jingrang Lu, Mary K. Beitz, Hodon Ryu, Jorge W. Santo Domingo

United States Geological Survey: Staff Publications

Wild birds have been shown to be significant sources of numerous types of pathogens that are relevant to humans and agriculture. The presence of large numbers of migratory birds in such a sensitive and important ecosystem as the Platte River in central Nebraska, USA, could potentially serve a significant source of birdderived pathogens in the water/sediment and riverine environment. In 2009 and 2010, a study was completed to investigate the potential water-quality impacts of Sandhill Cranes and Snow Geese on the microbial water quality of the central Platte River during their spring migration period. Fecal material, river-bottom sediment, and water …

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Scrub Typhus With Sepsis And Acute Respiratory Distress Syndrome, Asok Kurup, Aneesh Issac, Jin Phang Loh, Too Bou Lee, Robert Chua, Pradeep Bist, Chien-Chung Chao, Michael Lewis, Duane J. Gubler, Wei Mei Ching, Eng Eong Ooi, Bindu Sukumaran Jan 2013

Scrub Typhus With Sepsis And Acute Respiratory Distress Syndrome, Asok Kurup, Aneesh Issac, Jin Phang Loh, Too Bou Lee, Robert Chua, Pradeep Bist, Chien-Chung Chao, Michael Lewis, Duane J. Gubler, Wei Mei Ching, Eng Eong Ooi, Bindu Sukumaran

United States Navy: Publications

Scrub typhus is a major infectious threat in the Asia-Pacific region. We report an unusual case of scrub typhus in a patient in Singapore who presented with sepsis and acute respiratory distress syndrome but lacked the pathognomonic eschar. The patient recovered after appropriate diagnosis and doxycycline treatment. Rickettsial diseases should be included in the differential diagnosis of febrile illnesses in regions where the diseases are endemic, and absence of eschar should not be the criterion used to rule out scrub typhus.

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Identification Of BlaOxa-51-Like, BlaOxa-58, BlaDim-1, And BlaVim Carbapenemase Genes In Hospital Enterobacteriaceae Isolates From Sierra Leone, Tomasz A. Leski, Umaru Bangura, David H. Jimmy, Rashid Ansumana, Stephen E. Lizewski, Robert W. Li, David A. Stenger, Chris R. Taitt, Gary J. Vora Jan 2013

Identification Of BlaOxa-51-Like, BlaOxa-58, BlaDim-1, And BlaVim Carbapenemase Genes In Hospital Enterobacteriaceae Isolates From Sierra Leone, Tomasz A. Leski, Umaru Bangura, David H. Jimmy, Rashid Ansumana, Stephen E. Lizewski, Robert W. Li, David A. Stenger, Chris R. Taitt, Gary J. Vora

United States Navy: Publications

We describe the results of a molecular epidemiological survey of 15 carbapenemase-encoding genes from a recent collection of clinical isolates from Mercy Hospital in Bo, Sierra Leone. The most salient findings revealed that (i) 60% of the isolates harbored multiple carbapenemase genes; (ii) the blaDIM-1 gene, which has previously only been reported in The Netherlands, is also circulating in this environment; and (iii) blaOXA-51-like and blaOXA-58 genes, which were thought to reside exclusively in Acinetobacter species, can also be found in members of the Enterobacteriaceae.

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Rhodotorula Minuta Fungemia In A Ewe Lamb, C. G. Chitko-Mckown, K. A. Leymaster, M. P. Heaton, D. D. Griffin, J. K. Veatch, S. A. Jones, M. L. Clawson Jan 2013

Rhodotorula Minuta Fungemia In A Ewe Lamb, C. G. Chitko-Mckown, K. A. Leymaster, M. P. Heaton, D. D. Griffin, J. K. Veatch, S. A. Jones, M. L. Clawson

School of Veterinary and Biomedical Sciences: Faculty Publications

An 8-month-old crossbred ewe, normal upon physical examination, was humanely euthanized for tissue collection. After approximately 3 weeks in tissue culture, fungi began budding out of cells obtained from the choroid plexus. After an additional 3 weeks, budding was observed in kidney cell cultures and eventually in monocyte cultures as well. Serum from the lamb was submitted to the Veterinary Diagnostic Laboratory at Colorado State University for fungal diagnosis and was found negative for Aspergillus, Blastomyces, Coccidioidomycosis and Histoplasmosis. DNA was isolated from fungi collected from tissue culture supernatants and used in a set of pan-fungal PCR assays with …

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Interferon Inducible Protein Ifi35 Negatively Regulates Rig-I Antiviral Signaling And Supports Vesicular Stomatitis Virus Replication, Anshuman Das, Phat X. Dinh, Debasis Panda, Asit K. Pattnaik Jan 2013

Interferon Inducible Protein Ifi35 Negatively Regulates Rig-I Antiviral Signaling And Supports Vesicular Stomatitis Virus Replication, Anshuman Das, Phat X. Dinh, Debasis Panda, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

In a genome-wide siRNA screen, we recently identified the interferon (IFN) inducible protein 35 (IFI35, also known as IFP35) as a factor required for VSV infection. Studies reported here were conducted to further understand the role and requirement of IFI35 in VSV infection. Consistent with the siRNA screening data, we found that depletion of IFI35 led to reduced VSV replication at the level of viral gene expression. Although no direct interaction of IFI35 with the viral replication machinery was observed, we found that IFI35 negatively regulated the host innate immune response and rescued poly(I:C)-induced inhibition of VSV replication. Promoter-driven reporter …

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Sequence-Optimized And Targeted Double-Stranded Rna As A Therapeutic Antiviral Treatment Against Infectious Myonecrosis Virus In Litopenaeus Vannamei, J. Dustin Loy, Duan S. Loy, Mark A. Mogler, Bruce Janke, Kurt Kamrud, D. L. Hank Harris, Lyric C. Bartholomay Jan 2013

Sequence-Optimized And Targeted Double-Stranded Rna As A Therapeutic Antiviral Treatment Against Infectious Myonecrosis Virus In Litopenaeus Vannamei, J. Dustin Loy, Duan S. Loy, Mark A. Mogler, Bruce Janke, Kurt Kamrud, D. L. Hank Harris, Lyric C. Bartholomay

School of Veterinary and Biomedical Sciences: Faculty Publications

Infectious myonecrosis virus (IMNV) is a significant and emerging pathogen that has a tremendous impact on the culture of the Pacific white shrimp Litopenaeus vannamei. IMNV first emerged in Brazil in 2002 and subsequently spread to Indonesia, causing large economic losses in both countries. No existing therapeutic treatments or effective interventions currently exist for IMNV. RNA interference (RNAi) is an effective technique for preventing viral disease in shrimp. Here, we describe the efficacy of a double-stranded RNA (dsRNA) applied as an antiviral therapeutic following virus challenge. The antiviral molecule is an optimized dsRNA construct that targets an IMNV sequence …

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Bovine Herpes Virus 1 (Bhv-1) And Herpes Simplex Virus Type 1 (Hsv-1) Promote Survival Of Latently Infected Sensory Neurons, In Part By Inhibiting Apoptosis, Clinton Jones Jan 2013

Bovine Herpes Virus 1 (Bhv-1) And Herpes Simplex Virus Type 1 (Hsv-1) Promote Survival Of Latently Infected Sensory Neurons, In Part By Inhibiting Apoptosis, Clinton Jones

School of Veterinary and Biomedical Sciences: Faculty Publications

α-Herpesvirinae subfamily members, including herpes simplex virus type 1 (HSV-1) and bovine herpes virus 1 (BHV-1), initiate infection in mucosal surfaces. BHV-1 and HSV-1 enter sensory neurons by cell-cell spread where a burst of viral gene expression occurs. When compared to non-neuronal cells, viral gene expression is quickly extinguished in sensory neurons resulting in neuronal survival and latency. The HSV-1 latency associated transcript (LAT), which is abundantly expressed in latently infected neurons, inhibits apoptosis, viral transcription, and productive infection, and directly or indirectly enhances reactivation from latency in small animal models. Three anti-apoptosis genes can be substituted for LAT, which …

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