Digital Commons Network^™

Dual Use Research Policy Implementation, Carole R. Baskin, Todd J. Richardson

Saint Louis University Journal of Health Law & Policy

No abstract provided.

Life Sciences Dual Use Research Of Concern, Public Health And Safety, And The Doctrine Of Unconstitutional Conditions, Vickie J. Williams

Saint Louis University Journal of Health Law & Policy

No abstract provided.

Biodiplomacy: A Better Approach To Dual Use Concerns, Victoria Sutton

Saint Louis University Journal of Health Law & Policy

No abstract provided.

Regulating Dual Use Research To Promote Public Trust: A Reply To Dr. Franz, Robert Gatter

Saint Louis University Journal of Health Law & Policy

No abstract provided.

Cpg And Interleukin-15 Synergize To Enhance Ifn-Gamma Production By Activated Cd8(+) T Cells, Dustin Cobb, Sigi Guo, Ronald B. Smeltz

Bioelectrics Publications

Interleukin-15 (IL-15) regulates the development and maintenance of memory CD8(+) T cells. Paradoxically, we previously reported that IL-15 could enhance CD8(+) T-cell responses to IL-12, a proinflammatory cytokine required for optimal priming of effector CD8(+) T cells. To expand the physiological relevance of these findings, we tested IL-15 for its ability to enhance T-cell responses to bacterial CpG. Expectedly, CpG enhanced the production of IFN-gamma by CD8(+) T cells polyclonally activated with anti-CD3. However, addition of IL-15 to CpG-stimulated cultures led to a striking increase in IFN-gamma production. The effect of CpG and IL-15 was also evident with CD8(+) T …

The Genetic Basis Of Fitness: Detecting Inbreeding Depression And Selective Sweeps In Bighorn Sheep, Martin Dennis Kardos

Graduate Student Theses, Dissertations, & Professional Papers

Understanding the fitness effects of inbreeding is a crucial and long standing goal in conservation and evolutionary biology. Many studies measure individual inbreeding (F, the proportion of genome that is identical by descent) and its fitness effects using either pedigrees or molecular markers. Knowing which genes most strongly affect fitness can help to explain why some individuals outperform others, and elucidate the mechanisms of inbreeding depression and adaptation. However, identifying adaptive genes is difficult in most species because of limited genomic resources.

I used simulations to evaluate the performance of marker- and pedigree-based measures of F and inbreeding depression. I …

Modeling Dengue Virus Infection Patients For Each Severity Of Dengue Disease In Thailand, Montip Tiensuwan, Timothy O'Brien

Mathematics and Statistics: Faculty Publications and Other Works

Dengue is an infectious mosquito-borne viral disease. Dengue or dengue-like epidemics ranks highly among new and newly emerging infectious diseases in public health significance and may affect persons of all ages in dengue endemic area. Dengue virus infections may lead to dengue fever (DF), dengue haemorrhagic fever (DHF) and may lead to hypovolaemic shock (dengue shock syndrome, DSS) then we separate dengue data by severity of dengue disease, i.e., DF, DHF and DSS. The objective of this study is to find factors which affect the dengue virus infection patients for each severity of dengue disease in Thailand by using multiple …

Novel Insights Into The Function And Regulation Of Group X Secretory Phospholipase A2, Joseph D. Layne Jr

Theses and Dissertations--Nutritional Sciences

Group X secretory phospholipase A₂ (GX sPLA₂) hydrolyzes membrane phospholipids producing free fatty acids and lysophospholipids. Previous studies from our lab suggest that mice with targeted deletion of GX sPLA₂ (GX KO) have increased age-related weight gain due to an increase in overall adiposity. Paradoxically, this increased adiposity is associated with improved age-related glucose intolerance. GX KO mice also demonstrate a reduced inflammatory response to lipopolysaccharide injection. In vitro studies indicate this phenotype may be attributable to blunted macrophage mediated inflammatory responses. Given the role of macrophages in promoting adipose tissue (AT) inflammation and metabolic dysfunction …

Physiological Effects Of Tourism And Associated Food Provisioning In An Endangered Iguana, Charles R. Knapp, Kirsten N. Hines, Trevor T. Zachariah, Caro Perez-Heydrich, John B. Iverson, Sandra D. Buckner, Shelley C. Halach, Christine R. Lattin, L. Michael Romero

Faculty Publications

© The Author 2013. Deliberately feeding wildlife is an increasingly popular tourism-related activity despite a limited understanding of long-term impacts on the species being fed. As a result, tourist behaviours that may have adverse impacts on imperiled species have often been encouraged without the necessary evaluation or oversight. Here, we report the responses of Northern Bahamian Rock Iguanas (Cyclura cychlura) to human-visitation pressure and associated food provisioning. We compared a variety of blood chemistry parameters of iguanas subjected to supplemental feeding at popular tourist destinations with iguanas occurring on islands where supplemental feeding does not take place. We demonstrate that …

Intracellular Glucocorticoid Receptors Inspleen, But Not Skin, Vary Seasonally Inwild House Sparrows (Passer Domesticus), Christine R. Lattin, K. Waldron-Francis, L. Michael Romero

Faculty Publications

Over the short-term and at physiological doses, acute increases in corticosterone (CORT) titres can enhance immune function. There are predictable seasonal patterns in both circulating CORT and immune function across many animal species, but whether CORT receptor density in immune tissues varies seasonally is currently unknown. Using radioligand binding assays, we examined changes in concentrations of glucocorticoid receptors (GR) and mineralocorticoid receptors (MR) in spleen and skin in wild-caught house sparrows in Massachusetts during six different life-history stages: moult, early winter, late winter, pre-egg-laying, breeding and late breeding. Splenic GR and MR binding were highest during the pre-laying period. This …

Particulate Matter Containing Environmentally Persistent Free Radicals And Adverse Infant Respiratory Health Effects: A Review, Jordy Saravia, Greg I. Lee, Slawo Lomnicki, Barry Dellinger, Stephania A. Cormier

Faculty Publications

The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are also at significant risk for exposure. Infants are affected differently than adults due to drastic immaturities, both physiologically and immunologically, and it is becoming apparent that they represent a critically understudied population. Highlighting our work funded by the ONES award, in this review we argue the understated importance of utilizing infant models to truly understand …

Parasites Of Invasive Carp And Native Fish In The Wabash River, Justin Wilcox

Masters Theses

Although the majority of introduced non-native species fail to establish, proliferate and spread to the point of causing observable damage, there are a significant minority that achieve biological successes far beyond what they do in their native ranges. Parasites and pathogens are theorized to play an important role in determining the outcome of invasions by non-native species, both as potential mediators of the population growth of invasive species and as invasive species themselves. This study examines and compares the abundance and species richness of digestive tract helminths in native and non-native fish of the lower Wabash River, a single waterpool …

Experiences Of Kenyan Healthcare Workers Providing Services To Men Who Have Sex With Men: Qualitative Findings From A Sensitivity Training Programme, Elise M. Van Der Elst, Evans Gichuru, Anisa Omar, Jennifer Kanungi, Zoe Duby, Miriam Midoun, Sylvia Shangani, Susan M. Graham, Adrian D. Smith, Eduard J. Sanders, Don Operario

Community & Environmental Health Faculty Publications

Introduction

Men who have sex with men (MSM) in Kenya are at high risk for HIV and may experience prejudiced treatment in health settings due to stigma. An on-line computer-facilitated MSM sensitivity programme was conducted to educate healthcare workers (HCWs) about the health issues and needs of MSM patients.

Methods

Seventy-four HCWs from 49 ART-providing health facilities in the Kenyan Coast were recruited through purposive sampling to undergo a two-day MSM sensitivity training. We conducted eight focus group discussions (FGDs) with programme participants prior to and three months after completing the training programme. Discussions aimed to characterize HCWs’ challenges in …

Undergraduate And Graduate Course Descriptions, 2013 Spring, Wright State University

Course Descriptions

Wright State University undergraduate and graduate course descriptions from Spring 2013.

Assessment Of H1n1 Vaccine Effectiveness In Preventing Hospitalization In Children, Felicity Lenes-Voit

Yale Medicine Thesis Digital Library

Assessment of H1N1 vaccine effectiveness in preventing hospitalization in children

Felicity Lenes-Voit, Alexandra P. Grizas, Novagrami George, Nancy Holabird, Rebekah Stein and Marietta Vázquez. Department of Pediatrics. Yale School of Medicine. New Haven, CT.

2013

In 2009, the first influenza epidemic of the new millennium emerged. H1N1 disproportionately infected, hospitalized and killed pediatric patients, but the bulk of research on effective prevention was centered on the adult population. In order to address this gap, we conducted a matched case-control study to investigate the effectiveness of H1N1 vaccination in preventing hospitalization due to influenza-related illness in children and adolescents aged 6 …

Identification Of Factors Associated With Acute Pyelonephritis Complicated By Ureteral Stones, Warren Perry

Yale Medicine Thesis Digital Library

In theory, the evaluation of acute pyelonephritis (APN) does not require imaging, but in practice computed tomography (CT) may be ordered because of fear of an obstructing ureteral calculus that may present with similar symptoms. Childbearing age women are susceptible to the radiation exposure of CT imaging and have the highest incidence for APN. It is unknown what combination of clinical signs and point-of-care tests may help identify which patients with APN may require (or be able to avoid) advanced imaging.

We aimed to identify factors associated with ureteral stones in APN patients with the future goal of designing a …

Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

The Hygiene Hypothesis, Monique Lutz

Theses & ETDs

Since the 1950s there has been an unprecedented rise in the prevalence of allergies and autoimmune diseases in developed countries. The 'hygiene hypothesis' is one of several explanations as to why this may be occurring. It hypothesizes that excessive sanitation and antibiotic use has drastically changed the microbial environment and our susceptibility to them. The hypothesis attributes the lack of immune system interactions with helminths and microbes to poor immune health and development. Research in this field has evolved from epidemiologic observations to the discovery of immune regulation mechanisms. Treatments that utilize parasitic worms and microbes have shown promising results …

The Criminalization Of Pregnant Substance Abusers And The Implications For Reproductive Rights, Brittani Mclemore

Theses & ETDs

This thesis will explore the criminalization of pregnant substance abuse and the effects on perceptions of motherhood. Specifically, it employs Foucault's theory of biopower to understand how legislation, the prison-industrial complex, and the medicalization of pregnancy allow the state to define and assume responsibility for "unfit mothers." Such occurrences are portrayed as operating for the benefit of the fetus. However, I posit that these initiatives are better understood as responses to economic and social anxieties. I then assess the implications of criminalizing pregnant substance abuse for reproductive rights.

A Genotyping Analysis Of The Major Histocompatibility Complex In Two Polar Species: Genetic Diversity In The Arctic Fox And Southern Elephant Seal, Krystaal Mcclain

Theses & ETDs

The major histocompatibility complex (MHC) is part of the immune system in all vertebrates, potentially providing protection from a wide range of pathogens, and thus increasing individual fitness. The insight into species ability for long-term survival is key for conservation as populations with high diversity in the immune system may have increased survival to novel pathogens and changing environments. Conversely, when diversity is lost, the ability of a species to cope with new diseases and parasites could be reduced resulting in lower survival rates and increased infection. Historically, extreme cold temperatures in polar environments have prevented an influx of pathogens, …

The Real Issue Behind Stanford V. Roche: Faulty Conceptions Of University Assignment Policies Stemming From The 1947 Biddle Report, Sean O'Connor

Faculty Scholarship

No abstract provided.

Evaluating Genetic Status And Management Tradeoffs For Conservation Of Cutthroat Trout (Oncorhynchus Clarkii), Kellie Jahan Carim

Graduate Student Theses, Dissertations, & Professional Papers

Habitat fragmentation and invasive species are two of the primary threats to global biodiversity, yet biologists have tested few guidelines for protecting species under these conditions. These threats are particularly relevant to conservation of freshwater species like the Cutthroat Trout (Oncorhynchus clarkii). Hybridization with introduced Rainbow Trout (O. mykiss) has already caused extinction of one subspecies and threatens extant populations. Additionally, Cutthroat populations have lost genetic diversity across their range due to habitat destruction and fragmentation. These threats create a catch-22 for managers, wherein treating one problem (connecting populations) may lead to the other (interactions with invasive species). Furthermore, little …

"Conspicuous Consumption:" Germs And Climate Cures In Denver, 1882-1915, Sydney Rene Gwinn

Graduate Student Theses, Dissertations, & Professional Papers

This thesis argues that the health-seeker’s quest for climatic cures persisted after the germ theory of disease began to alter medical approaches to tuberculosis after its announcement in 1882. Buoyed by anti-modern sentiments and a lack of effective medicinal interventions, physicians continued to recommend that tuberculosis patients travel to Denver to seek recovery in a healthier climate. In turn, Denver’s polity and public health approaches were shaped by the influences of the migration of tuberculosis patients to the city. After 1882, new approaches focused on sanitation and isolation began to take hold among physicians and public health reformers who worked …

Lifeline Newsletter Annual Issue 2013, Department Of Emergency Medicine

Department of Emergency Medicine Archives

WHO Collaborating Centre for Emergency Medicine and Trauma Care, Overview of Emergency Medicine Residency Program, Meet Our People, Greetings From The Editorial Board, Message From The Chair, Recognition, Academic Achievement, Academic Travelogue, Code Orange In AKU, City Vibes, VIP Seminar Series, Golden Words, Country Call, Research Notes, Social Events, Quality Initiatives In the Department, Guess The Picture, Academic Initiatives, Around the world, Life In ED, Continuting Education, DEM Chronicles, Reflections from Department of Emergency Medicine, Meet Our People, Congratulations!, Additions to The DEM Family, LOL Creative Corner, Tribute, Answer Of Guess The Picture, Picture Gallery

Prosecuting The Undead: Federal Criminal Law In A World Of Zombies, Michael L. Smith

Faculty Articles

Adam Chodorow's recent essay, Death and Taxes and Zombies, has alerted the legal world to the dangers posed by the looming zombie apocalypse. Chodorow successfully demonstrates that existing tax laws are woefully inadequate in a world where the undead outnumber the taxpaying living. In this Essay, I argue that while tax law may be ill suited to address the zombie apocalypse, federal criminal law offers an alternative approach to solving the problems that Chodorow identifies. In fact, the only plausible explanation for the existence of seemingly pointless features of federal criminal law is that these features are precautions for this …

Development Of A Subunit Vaccine Against Bovine Diarrhea Caused By K99 Enterotoxigenic Escherichia Coli And Bovine Viral Diarrhea Virus, Emad Hashish

Electronic Theses and Dissertations

Bovine diarrhea is economically one of the most important problems in cattle industry. Enterotoxigenic Escherichia coli (ETEC), particularly strains expressing K99 (F5) fimbriae and heat-stable type I (STa) enterotoxin is the predominant bacterial cause of diarrhea in calves; whereas bovine viral diarrhea virus (BVDV) causes diarrhea and other illness to cattle at all ages. A vaccine that prevents against both K99 fimbrial ETEC and BVDV could benefit greatly to cattle producers worldwide. We hypothesized that a novel multivalent vaccine composed of K99, STa and BVDV E2 antigens could induce immunity for broad protection against bovine diarrhea. In this study we …

A Small Outbreak Of Tularemia In A Rural Area, İbak Gönen

Turkish Journal of Medical Sciences

To assess clinically and epidemiologically an outbreak of tularemia detected in a small village in Tokat Province in Turkey. Materials and methods: Recorded clinical and laboratory data of 15 serologically confirmed patients, who either presented to hospital or were diagnosed during family medicine visits to the village during the outbreak, were assessed. Forms including a questionnaire about the symptomatology and previously given treatments were filled out by the patients. In addition, the entire village was investigated to establish the origin of the outbreak. Results: Ages of the 15 individuals (9 females) ranged between 10 and 75, and the mean was …

Orthophenylphenol In Healthcare Environments: A Trial Related To A New Administration Method And A Review Of The Literature, Ali̇cem Teki̇n, Tuba Dal, Caferi̇ Tayyar Selçuk, Özcan Deveci̇, Recep Teki̇n, Mahmut Mete, Sai̇m Dayan, Sali̇h Hoşoğlu

Turkish Journal of Medical Sciences

To investigate antibacterial and antifungal effectiveness of orthophenylphenol (Fumispore, LCB, La Salle, France) with a new administration method in healthcare environments. Materials and methods: This study was performed in 3 units of the Dicle University Hospital. Surface swab and ambient air samples were collected just before the application of Fumispore and 6 h later. All samples were inoculated onto plate count agar and Sabouraud dextrose agar. The total aerobic colony count (ACC) was determined by using the standard method based on quantitative bacterial measurement. Results: In total, 30 surface swabs and 6 ambient air samples were collected. The mean values …

Impulsivity As A Correlate Of Waterpipe Tobacco Smoking, Dinah Ayna

Wayne State University Theses

Waterpipe tobacco smoking has become increasingly popular in the past decade, yet no studies examined personality predictors of its use. This study is the first to assess impulsivity as a potential correlate for waterpipe tobacco smoking use and frequency. 43.2% reported ever using the waterpipe, with 64% of those reporting use less than once a month. Arab students were 3-5 times more likely to have used a waterpipe. Arab ethnicity moderated the relationship between waterpipe smoking and impulsivity such that self-reported (but not laboratory) impulsivity predicted lifetime waterpipe smoking for non-Arabs, but not for Arabs. Waterpipe users were also more …

Development Of Peptide Inhibitors Targeting Clostridium Difficile Toxins A/B And Characterizing The Regulatory Role Of A Putative Negative Regulator Tcdc In Clostridium Difficile Toxin Gene Expression, Sanofar Jainul Abdeen

Wayne State University Dissertations

Clostridium difficile infections cause one of the most common and vital hospitalacquired

diseases often associated with broad-spectrum antibiotic usage. TcdA and TcdB

are the key virulence factors involved in major patho-physiology. While standard

antibiotics provide some respite, due to the high relapse rates and the emergence of more

severe disease presentations, antibiotics alone have often proven to be suboptimal.

Therefore there is a desperate need to develop an effective non-antimicrobial

therapeutics. Part of this work focuses on identification and further characterization of

peptide therapeutic that target the major virulence factor TcdA/TcdB. Towards

development of mechanistic-based anti-toxin agent, phage display was …