Digital Commons Network^™

A Business Plan For A Custom Dry Cow Transition Facility And A Calf Ranch, Landon Joseph Fernandes

Dairy Science

In recent economic times the dairy industry has witnessed historic lows in milk price and historic highs in feed prices. As a result many dairies have been forced out of business or have found other ways to diversify in order to offset the accumulated debt from dairying. One possible way a dairy can minimize debt is by sending its transition cows to custom transition cow management facility from dry-off through freshening. This management facility would give optimal care and attention to these cows to ensure metabolic and post calving health issues are minimal and that cows are returned to the …

Differences And Similarities Between Culture-Confirmed Human Granulocytic Anaplasmosis And Early Lyme Disease, Gary P. Wormser, Maria E. Aguero-Rosenfeld, Mary E. Cox, John Nowakowski, Robert B. Nadelman, Diane Holmgren, Donna Mckenna, Susan Bittker, Lois Zentmaier, Denise Cooper, Dionysios Liveris, Ira Schwartz, Harold W. Horowitz

NYMC Faculty Publications

Lyme disease is transmitted by the bite of certain Ixodes ticks, which can also transmit Anaplasma phagocytophilum, the cause of human granulocytic anaplasmosis (HGA). Although culture can be used to identify patients infected with A. phagocytophilum and is the microbiologic gold standard, few studies have evaluated culture-confirmed patients with HGA. We conducted a prospective study in which blood culture was used to detect HGA infection in patients with a compatible clinical illness. Early Lyme disease was defined by the presence of erythema migrans. The epidemiologic, clinical, and laboratory features of 44 patients with culture-confirmed HGA were compared with those of …

Pseudomonas Hopu1 Modulates Plant Immune Receptor Levels By Blocking The Interaction Of Their Mrnas With Grp7, Valerie Nicaise, Anna Joe, Byeong-Ryool Jeong, Christin Korneli, Freddy Boutrot, Isa Westedt, Dorothee Staiger, James R. Alfano, Cyril Zipfel

Center for Plant Science Innovation: Faculty Publications

Pathogens target important components of host immunity to cause disease. The Pseudomonas syringae type III-secreted effector HopU1 is a mono-ADP-ribosyltransferase required for full virulence on Arabidopsis thaliana. HopU1 targets several RNA-binding proteins including GRP7, whose role in immunity is still unclear. Here, we show that GRP7 associates with translational components, as well as with the pattern recognition receptors FLS2 and EFR. Moreover, GRP7 binds specifically FLS2 and EFR transcripts in vivo through its RNA recognition motif. HopU1 does not affect the protein–protein associations between GRP7, FLS2 and translational components. Instead, HopU1 blocks the interaction between GRP7 and FLS2 and …

First Steps Phase I Initiative: Improving Immunizations For Children And Adolescents, Kimberley S. Fox Mpa, Carolyn E. Gray Mph

Population Health & Health Policy

This evalution report, authored by research staff at the USM Muskie School, assesses the change in immunization rates in participating pediatric and family practices that serve a high volume of children insured by MaineCare (Maine's Medicaid system). The authors also summarize lessons learned in implementing changes in practices and challenges in using the immunization measures at the practice-level to inform quality improvement.

Immunological And Reproductive Health Assessment In Herring Gulls And Black-Crowned Night Herons In The Hudson-Raritan Estuary, Keith A. Grasman, Kathy R. Echols, Thomas M. May, Paul H. Peterman

University Faculty Publications and Creative Works

Previous studies have shown inexplicable declines in breeding waterbirds within western New York/New Jersey Harbor between 1996 and 2002 and elevated polychlorinated dibenzo-p-dioxins and polychlorinated biphenyls (PCBs) in double-crested cormorant (Phalacrocorax auritus) eggs. The present study assessed associations between immune function, prefledgling survival, and selected organochlorine compounds and metals in herring gulls (Larus argentatus) and black-crowned night herons (Nycticorax nycticorax) in lower New York Harbor during 2003. In pipping gull embryos, lymphoid cells were counted in the thymus and bursa of Fabricius (sites of T and B lymphocyte maturation, respectively). The phytohemagglutinin (PHA) skin response assessed T cell function in …

Immunological And Reproductive Health Assessment In Herring Gulls And Black-Crowned Night Herons In The Hudson-Raritan Estuary, Keith A. Grasman, Kathy R. Echols, Thomas M. May, Paul H. Peterman

University Faculty Publications and Creative Works

Previous studies have shown inexplicable declines in breeding waterbirds within western New York/New Jersey Harbor between 1996 and 2002 and elevated polychlorinated dibenzo-p-dioxins and polychlorinated biphenyls (PCBs) in double-crested cormorant (Phalacrocorax auritus) eggs. The present study assessed associations between immune function, prefledgling survival, and selected organochlorine compounds and metals in herring gulls (Larus argentatus) and black-crowned night herons (Nycticorax nycticorax) in lower New York Harbor during 2003. In pipping gull embryos, lymphoid cells were counted in the thymus and bursa of Fabricius (sites of T and B lymphocyte maturation, respectively). The phytohemagglutinin (PHA) skin response assessed T cell function in …

Vitronectin Inhibits Efferocytosis Through Interactions With Apoptotic Cells As Well As With Macrophages, Hong Beom Bae, Jean Marc Tadie, Shaoning Jiang, Dae Won Park, Celeste P. Bell, Lawrence C. Thompson, Cynthia B. Peterson, Victor J. Thannickal, Edward Abraham, Jaroslaw W. Zmijewski

Faculty Publications

Effective removal of apoptotic cells, particularly apoptotic neutrophils, is essential for the successful resolution of acute inflammatory conditions. In these experiments, we found that whereas interaction between vitronectin and integrins diminished the ability of macrophages to ingest apoptotic cells, interaction between vitronectin with urokinase-type plasminogen activator receptor (uPAR) on the surface of apoptotic cells also had equally important inhibitory effects on efferocytosis. Preincubation of vitronectin with plasminogen activator inhibitor-1 eliminated its ability to inhibit phagocytosis of apoptotic cells. Similarly, incubation of apoptotic cells with soluble uPAR or Abs to uPAR significantly diminished efferocytosis. In the setting of LPSinduced ALI, enhanced …

Community College Fema Citizen Preparedness Training Initiative, John J. Perrone Jr.

DRU Workshop 2013 Presentations – Disaster Resistant University Workshop: Linking Mitigation and Resilience

This 45 Minute presentation will highlight College opportunities through a recent joint Federal Grant Program (Department of Homeland Security- FEMA) entitled: The Community College Citizen Preparedness Program (3CP2). The presentation will be from one of the lead community colleges and include the training material development, expansion of the program via community resources and related homeland security programs and resources available to colleges. The program is now available in an online format and colleges and communities are free to use it via the web link for their students, faculty and the general population. The 3CP2 program is a 2 hour program …

Rectal Transmission Of Transmitted/Founder Hiv-1 Is Efficiently Prevented By Topical 1% Tenofovir In Blt Humanized Mice, Morgan L. Chateau, Paul W. Denton, Michael D. Swanson, Ian Mcgowan, J. Victor Garcia

Biology Faculty Publications

Rectal microbicides are being developed to prevent new HIV infections in both men and women. We focused our in vivo preclinical efficacy study on rectally-applied tenofovir. BLT humanized mice (n = 43) were rectally inoculated with either the primary isolate HIV-1JRCSF or the MSM-derived transmitted/founder (T/F) virus HIV-1THRO within 30 minutes following treatment with topical 1% tenofovir or vehicle. Under our experimental conditions, in the absence of drug treatment we observed 50% and 60% rectal transmission by HIV-1JRCSF and HIV-1THRO, respectively. Topical tenofovir reduced rectal transmission to 8% (1/12; log rank p = 0.03) for HIV-1JRCSF and 0% (0/6; log …

Sequence Analysis Of Ancylostoma Secreted Protein 2 Of Necator Americanus From Thai Isolates, C Ungcharoensuk, U Pattanawong, T Tia, C Putaporntip, S. Jongwutiwes

Chulalongkorn Medical Journal

Problem/background : Hookworm infection is one of the major neglected tropical infectious diseases causing both overt and cryptic morbidity among ~600 million people living in tropical areas. As conventional hookworm control measures by improving sanitation and mass anthelminthic drug administration are not sustainable, development of hookworm vaccines is mandatory. One of the major vaccine candidates is Ancylostoma secreted protein-2 of Necator americanus (Na-ASP-2). To date, only one Na-ASP-2 sequence is available; therefore, it remains unknown whether the effectiveness of a vaccine derived from this molecule may be compromised by antigenic diversity in hookworm population. Objectives : To determine the Na-ASP-2 …

Effect Of Individualized Homoeopathic Treatment In Influenza Like Illness: A Multicenter, Single Blind, Randomized, Placebo Controlled Study, P Chakraborty, C Lamba, D Nayak, M John, D Sarkar, Amitava Poddar, J Arya, K Raju, Kumar Vivekanand

Indian Journal of Research in Homoeopathy

Background: In the past decade the upsurge of influenza throughout the globe was significant and in recent years this has resurfaced showing failures of all the preventive and therapeutic measures against it. Thus, this study was undertaken to evaluate the effect of homoeopathic medicines in the treatment of Influenza like illness (primary objective) and to compare the complication rate among patients receiving homoeopathic medication as compared to the patients receiving placebo and also to compare the efficacy of LM potency vis-ΰ-vis Centesimal potency (secondary objective). Material and Methods: This was a multicenter, prospective, randomized, triple arm placebo controlled trial conducted …

Antioxidant Treatment Regulates The Humoral Immune Response During Acute Viral Infection, Katie E. Crump, P. Kent Langston, Sujana Rajkarnikar, Jason M. Grayson

Biology Faculty Articles

Generation of reactive oxygen intermediates (ROI) following antigen receptor ligation is critical to promote cellular responses. However, the effect of antioxidant treatment on humoral immunity during a viral infection was unknown. Mice were infected with lymphocytic choriomeningitis virus (LCMV) and treated with Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP), a superoxide dismutase mimetic, from days 0 to 8 postinfection. On day 8, at the peak of the splenic response in vehicle-treated mice, virus-specific IgM and IgG antibody-secreting cells (ASC) were decreased 22- and 457-fold in MnTBAP-treated animals. By day 38, LCMV-specific IgG ASC were decreased 5-fold in the bone marrow of drug-treated mice, …

Daily Contact With A Patient And Poor Housing Affordability As Determinants Of Pulmonary Tuberculosis In Urban Pakistan, Batool A. Haider, Saeed Akhtar, Juanita Hatcher

Community Health Sciences

Objective: This study aimed to evaluate the factors associated with pulmonary tuberculosis (TB) among individuals aged 15years or more in urban Karachi, Pakistan.DESIGN AND SETTING: A case-control design was implemented in three major tertiary-care hospitals to select cases (n=342) with active pulmonary TB (i.e. two sputum smears positive for Mycobacterium tuberculosis with clinical and radiographic evidence of current pulmonary TB and diagnosed between August 2002 and October 2003. Selected controls (n=342) were surgery patients from the same hospitals at time of recruitment of the cases, without clinical and radiographic evidence of pulmonary TB.Results: Multivariable logistic regression model showed that daily …

Prevalence Of Colistin And Tigecycline Resistance In Acinetobacter Baumannii Clinical Isolates From 2 Hospitals In Riyadh Region Over A 2-Year Period, Abeer M. Baadani, Sahar I. Thawadi, Noura A. El-Khizzi, Ali S. Omrani

Saudi Medical Journal

OBJECTIVE: To describe the rates and patterns of colistin and tigecycline resistance among Acinetobacter baumannii (A. baumannii) isolates from clinical specimens from 2 major hospitals in Riyadh Region over a 2-year period. METHODS: This is a retrospective review of records of all clinical isolates of A. baumannii from the departments of microbiology at King Faisal Specialist Hospital and Research Center (KFSHRC) and Prince Sultan Military Medical City (PSMMC), Riyadh, Kingdom of Saudi Arabia for the period from January 2010 to December 2011. RESULTS: Records for 1307 Acinetobacter species isolates were identified. The overall tigecycline resistance rates were 9.7% and colistin …

Mt Scorp: Behavioral Risk Factor Surveillance System: Outdoor Recreation And Resident Health, Alex L. Metcalf, Elizabeth Covelli Metcalf, Norma P. Nickerson

Institute for Tourism and Recreation Research Publications

The Behavioral Risk Factor Surveillance System (BRFSS) provides state-based data on health and risk behaviors among adults. Several supplemental outdoor recreation related questions were included in the 2011 questionnaire to assist with the State Comprehensive Outdoor Recreation Plan process and are analyzed in this report.

Bioequivalence Of Azithromycin For Oral Suspension After A Single Dose 600 Mg Oral Administration, P Banharnsupawath, W Thanindratarn, U. Suvanakoot

Chulalongkorn Medical Journal

Background : Azithromycin is a broad spectrum azalide antibiotic which was suggested to be first-line treatment in children for some respiratory tract infections, urethritis and mycobacterium avium complex infection with AIDs complications. The drug is well absorbed and has long half-life which supports a short time administration at higher dose regimens. Pharmacokinetic and bioequivalence of azithromycin have been extensively studied in many oral dosage forms at the standard dose of 500 mg; however, there is no bioequivalence study at higher dose carried out in an oral suspension dosage form. Objective : To investigate bioequivalence of azithromycin powder for oral suspension …

Additional Routes To Staphylococcus Aureus Daptomycin Resistance As Revealed By Comparative Genome Sequencing, Transcriptional Profiling, And Phenotypic Studies, Yang Song, Aileen Rubio, Radheshyam K. Jayaswal, Jared A. Silverman, Brian J. Wilkinson

Faculty Publications – Biological Sciences

Daptomycin is an extensively used anti-staphylococcal agent due to the rise in methicillin-resistant Staphylococcus aureus, but the mechanism(s) of resistance is poorly understood. Comparative genome sequencing, transcriptomics, ultrastructure, and cell envelope studies were carried out on two relatively higher level (4 and 8 mu g/ml(-1)) laboratory-derived daptomycin-resistant strains (strains CB1541 and CB1540 respectively) compared to their parent strain (CB1118; MW2). Several mutations were found in the strains. Both strains had the same mutations in the two-component system genes waIK and agrA. In strain CB1540 mutations were also detected in the ribose phosphate pyrophosphokinase (prs) and polyribonucleotide nucleotidyltransferase genes (pnpA), a …

Current Topics In Medical, Urban, And Veterinary Entomology: 4th Annual Roundtable Discussion, K. T. Edwards

Midsouth Entomologist

No abstract provided.

Lps And Pan-Induced Podocyte Injury In An In Vitro Model Of Minimal Change Disease: Changes In Tlr Profile., Tarak Srivastava, Mukut Sharma, Kok-Hooi Yew, Ram Sharma, R Scott Duncan, Moin A. Saleem, Ellen T. Mccarthy, Alexander Kats, Patricia A. Cudmore, Uri S. Alon, Christopher J. Harrison

Manuscripts, Articles, Book Chapters and Other Papers

Minimal change disease (MCD), the most common idiopathic nephrotic syndrome in children, is characterized by proteinuria and loss of glomerular visceral epithelial cell (podocyte) ultrastructure. Lipopolysaccharide (LPS) and puromycin aminonucleoside (PAN) are used to study podocyte injury in models of MCD in vivo and in vitro. We hypothesized that LPS and PAN influence components of the innate immune system in podocytes such as the Toll-Like Receptor (TLRs), TLR adapter molecules, and associated cytokines. Our results show that cultured human podocytes constitutively express TLRs 1-6 and TLR-10, but not TLRs 7-9. LPS (25 μg/ml) or PAN (60 μg/ml) caused comparable derangement …

Elevated Chemerin Levels In Pakistani Men: An Interrelation With Metabolic Syndrome Phenotypes, Syeda Sadia Fatima, Kiymet Bozaoglu, Rehana Rehman, Faiza Alam, Abdul Shakoor Memon

Department of Biological & Biomedical Sciences

Chemerin is a novel protein linked to adipocyte differentiation and the development of metabolic imbalances. We sought to examine the relationship of chemerin with metabolic syndrome disturbances including body fat percentage, serum lipid, glucose, insulin levels and body fat percentage in lean and obese volunteers. A cross-sectional study of 90 randomly selected healthy males from Pakistan were divided into three groups as per Body Mass Index (BMI) criteria for South Asian Population. Anthropometric measurements were taken for BMI, waist circumference, hip circumference and body fat percentage, while serum analyses were performed for fasting blood glucose, fasting insulin, fasting lipid profile …

A Prevelance Of Drug- Resistance In Previously Treated Tuberculous Patients In Baghdad, Muhammed.W. Al-Obaidy

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Multi drug resistant tuberculosis (MDR-TB) is a majorpublic health problem because treatment is complicated;cure -rates are below those for drug-susceptible T.B., and patients may remain infectious for months or years despite receiving the best available therapy. The phenomenon of resistance was detected soon after the introduction of streptomycin for treatment of T.B. OBJECTIVE: To identify prevalence of MDR- TB patients in Baghdad. PATIENT AND METHOD : Across-sectional study, over a period of 1 YEAR (from January to December2012) had been carried out in Baghdad in order to identify the prevalence of drug-resistant tuberculosis in previously treated patients. 168 …

Mechanisms Of Protective Activity Of West Nile Virus Anti-Envelope Antibodies In Vitro And In Vivo, Matthew Raymond Vogt

All Theses and Dissertations (ETDs)

West Nile virus: WNV) is a neurotropic flavivirus capable of causing severe disease and death in humans. Studies in mice have demonstrated that the humoral immune response against WNV limits primary infection and protects against a secondary challenge. Accordingly, passive transfer of immune serum or monoclonal antibodies: MAb) against the envelope: E) protein either prior to WNV infection or shortly thereafter is sufficient to protect mice from disease. The E protein is an immunodominant antigen in the antibody response to WNV infection, and the most potent neutralizing MAbs recognize an epitope on the lateral ridge of domain III: DIII-LR) of …

Extracorporeal Shock Wave Therapy For Chronic Planter Fasciitis Associated With Enthesophytosis, Nizar Abdul Lateef, Sami Salman, Ahmad Fahim

Iraqi Postgraduate Medical Journal

ABSTRACT: BACKGROUND: Painful heel is a common syndrome characterized by severe pain in the inferior or posterior aspect of the heel, which is aggravated by weight bearing, becoming progressively worse and often incapacitating, with evidence of a spur in about 50% of cases. OBJECTIVE: To evaluate the efficacy of extracorporeal shock wave treatment (ESWT) in calcaneal enthesophytosis (heel spur). PATIENT AND METHODS: Ninety four patients (66 women, 28 men) were examined who had heel pain associated with heel spur. A double blind randomised study was performed in which 52 patients underwent a standardized treatment (group 1) and 42 patients had …

Towards The Development Of Tropolone Natural Product Derivatives As Novel, Potent Anticancer Therapeutics That Selectively Target Histone Deacetylase (Hdac) Enzymes, Sophia Nnenna Ononye

Doctoral Dissertations

Cancer is the second leading cause of death in the United States. Inhibitors that target key enzymes involved in epigenetic alterations, particularly histone deacetylases (HDACs), are garnering interest in cancer research because of their unique ability to reversibly induce terminal differentiation of transformed cells by influencing chromatin structure. Through an in-house collaborative effort, derivatives of hinokitiol, a troplone-related non-benzenoid aromatic compound, are being synthesized and characterized by the Wright and Anderson laboratories as HDAC inhibitors (HDACi). Given the novelty of these tropolones as antineoplastic agents, a number of biochemical and functional studies were conducted in order to develop tropolones as …

Alumni @ Large

Colby Magazine

Alumni notes

Newsmakers

Milestones

Vacationland Vietnam: Jim Sullivan '87

Old Meets New: Joshua Eldred '96

Young Minds Awakened: Natalie Ginsburg '07

Obituaries

Development, Testing, And Deployment Of An Air Sampling Manifold For Spiking Elemental And Oxidized Mercury During The Reno Atmospheric Mercury Intercomparison Experiment (Ramix), B. D. Finley, D. A. Jaffe, K. Call, Seth Lyman, M. Sexauer Gustin, C. Peterson, M. Miller, T. Lyman

USU Uintah Basin Faculty Publications

The Reno Atmospheric Mercury Intercomparison Experiment (RAMIX) was in Reno, NV from August 22, 2011 to September 16, 2011. The goals of the experiment were to compare existing and new methods for measurements of ambient elemental and oxidized Hg, and to test these with quantitative spikes of Hg0, HgBr2, O3 and water vapor. In this paper we describe the design, testing, and deployment of a high flow manifold system designed to deliver ambient air and spiked compounds to multiple instruments simultaneously. The manifold was constructed of 1” OD PFA tubing and heated to 115 °C for the entire active zone. …

Kondisi Sanitasi Lingkungan Perumahan Dan Kontaminasi Escherichia Coli Pada Penyajian Makanan Pendamping Air Susu Ibu Lokal, Aria Kusuma, Haryoto Kusnoputranto, I Made Djaja, Rizal Syarief

Kesmas

Bayi sangat rentan terhadap penyakit yang disebabkan oleh Makanan Pendamping Air Susu Ibu lokal (MP-ASI lokal). Sampai saat ini belum diketahui keamanan penyajiannya dari kontaminasi mikrobiologi. Penelitian ini bertujuan mengetahui kontaminasi Escherichia coli (E. coli) pada penyajian MP-ASI lokal dan mengamati hubungan antara kondisi sanitasi rumah, seperti Sarana Air Bersih (SAB), tempat mencuci peralatan makan bayi, kondisi Saluran Pembuangan Air Limbah (S PAL), kondisi tempat sampah dan keberadaan hewan berkeliaran di dalam rumah terhadap kontaminasi E. coli pada penyajian. Desain penelitian ini adalah potong lintang yang mengamati penyajian MP-ASI lokal bagi bayi usia 6-12 bulan pada 138 rumah. Lokasi penelitian …

Targeted Estimation Of Variable Importance Measures With Interval-Censored Outcomes, Stephanie Sapp, Mark J. Van Der Laan, Kimberly Page

U.C. Berkeley Division of Biostatistics Working Paper Series

In most experimental and observational studies, participants are not followed in continuous time. Instead, data is collected about participants only at certain monitoring times. These monitoring times are random, and often participant specific. As a result, outcomes are only known up to random time intervals, resulting in interval-censored data. In contrast, when estimating variable importance measures on interval-censored outcomes, practitioners often ignore the presence of interval-censoring, and instead treat the data as continuous or right-censored, applying ad-hoc approaches to mask the true interval-censoring. In this paper, we describe Targeted Minimum Loss-based Estimation methods tailored for estimation of variable importance measures …

New Opportunities Arise For Research Travel To Africa, Greg Williams

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No abstract provided.

New Opportunities Arise For Uab Research Travel To Africa, Jim Bakken

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No abstract provided.