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2012

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Dames, Doilies, & Divorce., Tenille Novinger May 2012

Dames, Doilies, & Divorce., Tenille Novinger

Electronic Theses and Dissertations

My work focuses on repurposing historic images and feminine objects to create a contemporary dialogue about the traditions of courtship, marriage and divorce. The use of textiles and feminine objects such as doilies, lace, slips and wallpaper serve as the visual foundation of my work. I am interested in how these objects, often combined with selected texts, create metaphors regarding relationships. Courtship, marriage and divorce are the three potential steps of a relationship. This thesis is arranged into three chapters: materials, themes, and influences found within my studio research and subsequent MA in Studio Arts Exhibition, Dames, Doilies, & Divorce …

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Specific B Alleles Matter In Phytopathogenic Ustilago Maydis., Kavita Burman Aulakh May 2012

Specific B Alleles Matter In Phytopathogenic Ustilago Maydis., Kavita Burman Aulakh

Electronic Theses and Dissertations

The smut fungus, Usti/ago maydis is an obligate parasite on maize plants in order to complete its sexual life cycle. The haploid form is self-sterile but compatible mated cells undergo a dimorphic switch from yeast like to infectious dikaryotic filaments. Mating types are determined by two unlinked loci, the a locus and the b locus. The a locus is involved in self and non-self cell recognition through production and sensing of pheromone. The b locus of compatible mating types encodes a functional transcription factor that is involved in regulation of expression of genes responsible for filamentation, virulence and pathogenicity. Both …

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Bayesian Regression Analysis., Sara Evans May 2012

Bayesian Regression Analysis., Sara Evans

Electronic Theses and Dissertations

Regression analysis is a statistical method used to relate a variable of interest, typically y (the dependent variable), to a set of independent variables, usually, X1, X2,...,Xn . The goal is to build a model that assists statisticians in describing, controlling, and predicting the dependent variable based on the independent variable(s). There are many types of regression analysis: Simple and Multiple Linear Regression, Nonlinear Regression, and Bayesian Regression Analysis to name a few. Here we will explore simple and multiple linear regression and Bayesian linear regression. For years, the most widely used method of regression analysis has been the Frequentist …

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Modeling Small Objects Under Uncertainties : Novel Algorithms And Applications., Amal A. Farag May 2012

Modeling Small Objects Under Uncertainties : Novel Algorithms And Applications., Amal A. Farag

Electronic Theses and Dissertations

Active Shape Models (ASM), Active Appearance Models (AAM) and Active Tensor Models (ATM) are common approaches to model elastic (deformable) objects. These models require an ensemble of shapes and textures, annotated by human experts, in order identify the model order and parameters. A candidate object may be represented by a weighted sum of basis generated by an optimization process. These methods have been very effective for modeling deformable objects in biomedical imaging, biometrics, computer vision and graphics. They have been tried mainly on objects with known features that are amenable to manual (expert) annotation. They have not been examined on …

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"The Best Interest Of The Child" : An Exploration Of The Sociocultural Agendas Associated With The Care Of Orphaned And Vulnerable Children In China., Dennis W. Feaster May 2012

"The Best Interest Of The Child" : An Exploration Of The Sociocultural Agendas Associated With The Care Of Orphaned And Vulnerable Children In China., Dennis W. Feaster

Electronic Theses and Dissertations

The purpose of this study is to explore the set of sociocultural agendas that emerge around the care of orphaned and vulnerable children (OVC) in China. While there is general agreement among stakeholders about the need to work for "the best interests" of OVC, there is significant variance in how these best interests are constructed and defined. An ethnographic scan of attitudes and awareness of OVC and OVC care in Henan Province, China, provide the initial context for exploration. This context is the basis for the subsequent nested case study of a multi-party, intergovernmental cooperative project designed to develop and …

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Development Of Pituitary Tumor-Transforming Gene (Pttg) Transgenic Mice For The Treatment Of Ovarian Cancer., Miranda Y. Fong 1982- May 2012

Development Of Pituitary Tumor-Transforming Gene (Pttg) Transgenic Mice For The Treatment Of Ovarian Cancer., Miranda Y. Fong 1982-

Electronic Theses and Dissertations

This dissertation is a hypothesis-driven research oriented study to determine the role of the pituitary-tumor transforming gene (PTTG) in ovarian cancer, specifically if it is involved in neoplastic transformation leading to tumorigenesis through oncogene activation and the involvement of tumor-suppressor gene, p53. Furthermore, generation of a useful ovarian cancer mouse model provides a platform technology to screen for ovarian cancer diagnosis and treatment options. This dissertation is divided into four chapters covering the etiology of ovarian cancer and a novel treatment strategy for ovarian cancer. The first chapter reviews the related literature encompassing the etiology of ovarian cancer, mouse models …

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Cationic Aminooxy Lipids : Synthesis, Liposome Stabilization And Applications., Xuan Huang May 2012

Cationic Aminooxy Lipids : Synthesis, Liposome Stabilization And Applications., Xuan Huang

Electronic Theses and Dissertations

This dissertation describes research focused on the synthesis, polymerization and applications of cationic aminooxy lipids. An efficient and convenient method was developed to stabilize liposomes using 'click chemistry'. The 'click stabilized liposomes' are fortified via covalent crosslinks generated between aldehyde and aminooxy functionalities in the lipid bilayers. Compared to untreated liposomes (i.e., no lipid-lipid bonding), the 'click' stabilized liposomes are considerably more stable against surfactant-mediated liposome disruption or serum-mediated liposome aggregation. Stabilized liposomes also can react with 'clickable' targeted ligands on the liposome surface for specific organ (e.g. breast cancer cells or liver) targeting. In this thesis, I have explored …

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Identifying Aggregatibacter Actinomycetemcomitans Periodontal Antigens By Immunoscreening., Gerald Bernard Pevow May 2012

Identifying Aggregatibacter Actinomycetemcomitans Periodontal Antigens By Immunoscreening., Gerald Bernard Pevow

Electronic Theses and Dissertations

Periodontitis is a chronic, destructive inflammatory disease of the supporting tissues of the teeth with a high prevalence among adults. While the complete pathogenesis of periodontitis remains unclear, it is initiated and sustained by dental plaque containing pathogens such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Bacteroides forsythus, and Prevotella intermedia. Our hypothesis is that multiple antigens are recognized by human antibodies, and antigens can be identified by use of a genomic expression library. We developed an unbiased global approach to define A. actinomycetemcomitans protein antigens that elicit humoral immune responses and developed a screening method to identify periodontal antigens. We identified …

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Thermally Driven Knudsen Gas Pump Enhanced With A Thermoelectric Material., Kunal Pharas 1979- May 2012

Thermally Driven Knudsen Gas Pump Enhanced With A Thermoelectric Material., Kunal Pharas 1979-

Electronic Theses and Dissertations

The thesis focuses on improving the flowrate of the Knudsen gas pump. The Knudsen pump uses thermal transpiration as the driving mechanism to pump gas. It is a motionless gas pump as the pump does not require any moving actuators for pumping. The thermally driven gas flow is accomplished in the molecular or transitional gas flow regime. The advantage of this pump is that without any moving parts it avoids friction losses and stiction problems which devices in micro scale are prone to suffering due to scaling issues. Thus, this pump is highly robust and reliable. Knudsen pumps in the …

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Emotional Labor In A Gendered Occupation : The Work Of A Female Funeral Director., Allison Scott Pruitt May 2012

Emotional Labor In A Gendered Occupation : The Work Of A Female Funeral Director., Allison Scott Pruitt

Electronic Theses and Dissertations

Hochschild (1983) stated that emotional labor has unique consequences for women. However, most studies of these consequences have been situated in feminized occupations which have wage penalties and little upward mobility (see Sweet and Meiksins, 2004). This poses a problem as it may be difficult to tease apart what stressors are the result of emotional labor and which are a part of the broader issues of feminized work. The present research suggests that the funeral industry is a unique context for the study of women's emotional labor, as it is a numerically male dominated profession (BLS, 2010). Using semi-structured, in-depth …

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Women In Intercollegiate Athletics : An Exploration Of The Career Development Of Female Senior Administrators., Meg C. Hancock May 2012

Women In Intercollegiate Athletics : An Exploration Of The Career Development Of Female Senior Administrators., Meg C. Hancock

Electronic Theses and Dissertations

The roles of assistant and associate athletic director have been identified as positions in the "pipeline" to achieving the position of Athletic Director (Grappendorf, Lough, & Griffin, 2004; Lapchick, 2010). Given the underrepresentation of female Athletic Directors in intercollegiate athletics and the concern that women may experience difficulty accessing such positions, there is a growing need to understand the career experiences and expectations of women in senior-level management positions in intercollegiate athletics. The purpose of this study was to explore the career development of female assistant and associate athletic directors at NCAA Division I institutions. This study investigated participants' (a) …

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Exploration Of The Chemistry Of Alkynes And Selectfluor : Search For Cytotoxic Agents From The Amazonian Rainforest., Zhuang Jin May 2012

Exploration Of The Chemistry Of Alkynes And Selectfluor : Search For Cytotoxic Agents From The Amazonian Rainforest., Zhuang Jin

Electronic Theses and Dissertations

Vicinal dithioethers and alkenyl thioethers were synthesized under environmentally friendly conditions using alkyne and thiol in water. Alkynes were also used to develop a multibond-fonning reaction that fonned cyclic ketones or ketoesters through a goldcatalyzed intramolecular oxygen transfer isomerization of 2-alkynyl-l ,5-diketones or 2- alkyny 1-5 -ketoesters. The investigation of Selectfluor chemistry yielded a highly stereoselective synthesis of fluoroalky (E)-a,ß-unsaturated ketones from allenyl esters, through a gold-catalyzed rearrangement that produced an intennediate dienyl ester. When Selectfluor was combined with copper, it produced two oxidative systems, F-TEDA-BF4 and F-TEDAPF 6, both of which efficiently converted amides into imides at room temperature …

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Theory, Praxis And Transformation : The Dramatic Writing Of Suzan-Lori Parks As Liberatory Critical Pedagogy., Tamika Keene May 2012

Theory, Praxis And Transformation : The Dramatic Writing Of Suzan-Lori Parks As Liberatory Critical Pedagogy., Tamika Keene

Electronic Theses and Dissertations

This research examined how the dramatic writing of Suzan-Lori Parks functioned as a form of critical pedagogy which may serve to elevate the critical consciousness of African American women. It sought to consider the implications of her dramatic writing in relation to the African American female experience. Specifically, this research explored Parks's dramatic work In The Blood by way of a constructed pedagogical model which utilized Henry A. Giroux's perspective on critical pedagogy and Lisa M. Anderson's perspective of a "black feminist aesthetic" (of theatre). This framework also incorporated methods of a literary deconstructive strategy, a black feminist approach and …

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Size- And Shape-Dependent Electrochemistry Of Gold Nanoparticles., Irina V. Khachian May 2012

Size- And Shape-Dependent Electrochemistry Of Gold Nanoparticles., Irina V. Khachian

Electronic Theses and Dissertations

This dissertation describes 1) size-dependent electrochemical oxidation/stripping of chemically synthesized gold nanoparticles (Au NPs), 2) copper underpotential deposition (Cu-VPD) on different sized chemically-synthesized and electrochemically-deposited Au NPs attached to glass/indium-tin-oxide (ITO) electrodes, and 3) electrochemical synthesis of Au nanoplates directly on glass/ITO electrodes. The motivation of this work was to better understand the characteristics and electrochemical properties of metal nanostructures with different sizes and shapes. We synthesized Au nanoparticles with average diameters ranging from 5 to 45 nm by a chemical seed-mediated growth method and electrostatically attached them to amino-functionalized glass/ITO electrodes. Linear sweep voltammograms (LSVs) obtained on electrodes coated …

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Using A Statistical Model To Locate Orthodontic Underserved Areas Capable Of Supporting Practices In Kentucky., Wes Cardall May 2012

Using A Statistical Model To Locate Orthodontic Underserved Areas Capable Of Supporting Practices In Kentucky., Wes Cardall

Electronic Theses and Dissertations

Background: Malocclusion can affect an individual's quality of life. Unfortunately, access to orthodontic treatment is limited for many children. Access is improved when orthodontists select practice locations where their services are most needed. Methods: A statistical model was applied to demographic and dental practice data in Kentucky to determine underserved areas that have the capacity to support additional orthodontic practices. All zip codes and practices were mapped using a geographic information system (GIS). Results: The model identified 30 underserved zip codes with practice-supporting capability, but this number fell to zero after additional verification. Sixteen counties (13.3%) contain areas located more …

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Depression In Reproductive-Age Women : Assessment Of Infectious, Endocrinological, And Immunological Correlates From An Evolutionary Perspective., Amber N. Carrier May 2012

Depression In Reproductive-Age Women : Assessment Of Infectious, Endocrinological, And Immunological Correlates From An Evolutionary Perspective., Amber N. Carrier

Electronic Theses and Dissertations

Depression is one of the most frequent causes of disability worldwide. It can affect the psychological, social, and physical wellbeing of those that suffer from it, the majority of which are women. Depression has been linked to immune activation as well as serotonin depletion through a reduction in its precursor, tryptophan. Chlamydia trachomatis infection and estrogen can influence both the immune system and tryptophan levels, thereby biochemically inducing a depressive state. If this is the case, the use of exogenous estrogen through oral contraceptive pills (OCPs) could increase depressive symptoms, while the use of antibiotics to treat C. trachomatis infection …

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Sulfur Oxygenation Of Ruthenium-Dithiolate Nitrile Hydratase Mimic Enhances Ligand Lability And Hydrolysis Activity., Cesar Antonio Masitas Castillo May 2012

Sulfur Oxygenation Of Ruthenium-Dithiolate Nitrile Hydratase Mimic Enhances Ligand Lability And Hydrolysis Activity., Cesar Antonio Masitas Castillo

Electronic Theses and Dissertations

Nitrile hydratase (NHase) is a metalloenzyme that contains a non-heme iron (III) or non-corin cobalt (III) in a non-redox active role. NHase is used as biocatalyst in the industry for the hydrolysis of nitriles to arnides. The trivalent metal ions are six coordinate with the ligand sphere made up of three cysteines, two amide nitro gens, and a waterlhydroxide or nitrile substrate. Interestingly, the N2S3 active site contains two post-translationally modified cysteine residues, resulting in an unusual thiolato (RS-), sulfenate (RS(O)-), sulfinate (RS(Oh-) donor set. Synthetic work to mimic the unusual donor set by direct oxygenation of a metallodithiolate precursor …

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Building A Dynamic Model Linking Potential Mercury Regulations To Risk To Susceptible Populations., Caroline Biagi Chan May 2012

Building A Dynamic Model Linking Potential Mercury Regulations To Risk To Susceptible Populations., Caroline Biagi Chan

Electronic Theses and Dissertations

Human exposure to mercury has been shown to cause a number of adverse health outcomes, predominantly neurological effects. The developing fetus is most susceptible, and even low levels of exposure have been shown to produce nervous system deficits. A systems approach was used to address the problem of human exposure to mercury from the consumption of contaminated fish from local waterways. Two models were developed in order to link environmental levels of mercury with human exposure. The human exposure model characterizes the disposition of mercury in the human body and fetus. The bioaccumulation model tracks the movement of mercury from …

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3d Visualization Of In-Flight Recorded Data., Gyuchoon Cho 1975- May 2012

3d Visualization Of In-Flight Recorded Data., Gyuchoon Cho 1975-

Electronic Theses and Dissertations

Human being can easily acquire information by showing the object than reading the description of it. Our brain stores images that the eyes are seeing and by the brain mapping, people can analyze information by imagination in the brain. This is the reason why visualization is important and powerful. It helps people remember the scene later. Visualization transforms the symbolic into the geometric, enabling researchers to observe their simulations and computations (Flurchick, 2001). As a consequence, many computer scientists and programmers take their time to build better visualization of the data for users. For the flight data from an aircraft, …

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Mad At Miles : A Black Woman's Guide To Truth : Theatre Building Using Myths, Motifs, And Archetypes., Triza Triza Cox May 2012

Mad At Miles : A Black Woman's Guide To Truth : Theatre Building Using Myths, Motifs, And Archetypes., Triza Triza Cox

Electronic Theses and Dissertations

This thesis chronicles my journey within the framework of a hero's journey, as a theatre artist in the Master of Fine Arts program at the University of Louisville's Theatre Arts Department. This thesis is divided into six chapters that explore the importance of using and understanding myths, motifs, and archetypes for character development in general and specifically for building the ensemble production from Pearl Cleage's collection of essays: Mad at Miles: A Black Woman's Guide to Truth. The Introduction explores the origins of the drive for humans to create art. Chapter One investigates my attraction to theatre through my personal …

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Computational Modelling Of Cobalamin-Dependent Enzymatic Reactions : Activation Of Co-C Bond In Adenosylcobalamin-Dependent Mutases And Cob(Ii)Alamin/Cob(I)Alamin Redox Process In Methyltransferases., Manoj Kumar May 2012

Computational Modelling Of Cobalamin-Dependent Enzymatic Reactions : Activation Of Co-C Bond In Adenosylcobalamin-Dependent Mutases And Cob(Ii)Alamin/Cob(I)Alamin Redox Process In Methyltransferases., Manoj Kumar

Electronic Theses and Dissertations

The role of the active site tyrosine residue in the Co-C5' bond activation in the context of adenosylcobalamin-dependent mutases has been computationally investigated. The density functional, complete active space self-consistent field and quantum mechanics/molecular mechanics calculations have predicted that the deprotonated tyrosine can serve as a redox center potentially causing the one-electron reduction of B12 cofactor. As a result, the reduced form of adenosylcobalamin has been suggested to participate in B12 catalysis and an alternate mechanism for explaining the origin of catalysis in adenosylcobalamin-dependent mutases has been proposed. The implications of the involvement of the reduced B12 cofactor in the …

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Genetic Ablation Of Cav1 Differentially Affects Melanoma Tumor Growth And Metastasis In Mice: Role Of Cav1 In Shh Heterotypic Signaling And Transendothelial Migration., Franco Capozza, Casey Trimmer, Remedios Castello-Cros, Sanjay Katiyar, Diana Whitaker-Menezes, Antonia Follenzi, Marco Crosariol, Gemma Llaverias, Federica Sotgia, Richard G Pestell, Michael P Lisanti May 2012

Genetic Ablation Of Cav1 Differentially Affects Melanoma Tumor Growth And Metastasis In Mice: Role Of Cav1 In Shh Heterotypic Signaling And Transendothelial Migration., Franco Capozza, Casey Trimmer, Remedios Castello-Cros, Sanjay Katiyar, Diana Whitaker-Menezes, Antonia Follenzi, Marco Crosariol, Gemma Llaverias, Federica Sotgia, Richard G Pestell, Michael P Lisanti

Department of Cancer Biology Faculty Papers

Both cell-autonomous and non-cell-autonomous factors contribute to tumor growth and metastasis of melanoma. The function of caveolin-1 (Cav1), a multifunctional scaffold protein known to modulate several biologic processes in both normal tissue and cancer, has been recently investigated in melanoma cancer cells, but its role in the melanoma microenvironment remains largely unexplored. Here, we show that orthotopic implantation of B16F10 melanoma cells in the skin of Cav1KO mice increases tumor growth, and co-injection of Cav1-deficient dermal fibroblasts with melanoma cells is sufficient to recapitulate the tumor phenotype observed in Cav1KO mice. Using indirect coculture experiments with fibroblasts and melanoma cells …

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Student Honors And Awards Program 2012, University Relations May 2012

Student Honors And Awards Program 2012, University Relations

UMM Honors and Awards Ceremony

In recognition of students who demonstrate academic excellence and enrich campus life.

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Hidden Voices Of Hermaphrodites, Zohra Asif Jetha, Nasreen Sulaiman Lalani, Gulnar Akber Ali May 2012

Hidden Voices Of Hermaphrodites, Zohra Asif Jetha, Nasreen Sulaiman Lalani, Gulnar Akber Ali

School of Nursing & Midwifery

Gender is a psychological component which is given by the society to a person, while sex is a biological component which is awarded by the God. However, there are certain conditions in which the biological aspects are put to challenge with the social and psychological aspects of gender. Hermaphrodites are a third gender role, who is neither male or female man nor woman but contains the element of both. One may question that if they are neither male nor female then who they are and whether they are equally treated in our society. Looking at the challenges faced by hermaphrodites, …

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Surface Characterization Of Nephila Clavipes Dragline Silk, Benoit Faugas May 2012

Surface Characterization Of Nephila Clavipes Dragline Silk, Benoit Faugas

All Theses

To design synthetic fibers for extreme applications, many research groups are trying to identify how the structure of natural fibers (such as spider silk) leads to desirable properties such as high tensile strength.
Spider silk is a biological fiber having mechanical properties that exceed those of the best man made fibers in terms of high tensile strength and large extensibility, this combination providing the silk with a large work of rupture. While the bulk structure, composition and properties have been intensively studied elsewhere, this study focuses on elucidating the Nephila clavipes spider dragline silk surface structure and composition, as well …

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Cost Effective Malaria Risk Control Using Remote Sensing And Environmental Data, Md Zahidur Rahman, Leonid Roytman, Abdel Hamid Kadik May 2012

Cost Effective Malaria Risk Control Using Remote Sensing And Environmental Data, Md Zahidur Rahman, Leonid Roytman, Abdel Hamid Kadik

Publications and Research

Malaria transmission in many part of the world specifically in Bangladesh and southern African countries is unstable and epidemic. An estimate of over a million cases is reported annually. Malaria is heterogeneous, potentially due to variations in ecological settings, socio-economic status, land cover, and agricultural practices. Malaria control only relies on treatment and supply of bed networks. Drug resistance to these diseases is widespread. Vector control is minimal. Malaria control in those countries faces many formidable challenges such as inadequate accessibility to effective treatment, lack of trained manpower, inaccessibility of endemic areas, poverty, lack of education, poor health infrastructure and …

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Humboldt Bay Region Sea Level Rise Data Synthesis: Appendix, Whelan Gilkerson May 2012

Humboldt Bay Region Sea Level Rise Data Synthesis: Appendix, Whelan Gilkerson

Local Reports and Publications

This excel spreadsheet characterizes data sources as well as other online resources relevant to sea level rise planning and adaptation. This appendix represents the bulk of the effort involved in this synthesis project.

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Mossville Environmental Action Now V. United States: Is A Solution To Environmental Injustice Unfolding?, Jeannine Cahill-Jackson May 2012

Mossville Environmental Action Now V. United States: Is A Solution To Environmental Injustice Unfolding?, Jeannine Cahill-Jackson

Pace International Law Review Online Companion

This article chronicles and analyzes the Inter-American Commission on Human Rights (IACHR) case resulting from the petition: Mossville Environmental Action Now v. United States. Part I illuminates the harms faced by the residents of Mossville and the little that has been done to remedy their situation. It provides an in-depth look at the data that has been collected by the U.S. government and analyzed by the members of Mossville Environmental Action Now, which shows levels of dioxin contamination in both the people and the environment of Mossville and their significance. Part I also discusses environmental racism and environmental justice …

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The Application Of Food Landscape In Johns De La Howe School, Shuowei Qin May 2012

The Application Of Food Landscape In Johns De La Howe School, Shuowei Qin

All Theses

Recently, food landscape has been put forward under ecological urbanism. Most of our food in the plate comes from miles away and transporting them consumes large amount non-renewable energy in earth. At the same time, our existing landscape suffers from the land degrading because of old ecological paradigm. Food landscape encourages combining edible plants in our landscape and works under new ecological paradigm which could best address those two main problems. Food landscape is a newly coined word and does not have a specific definition. From intensive literature review, the origin, the rationale, and the benefits of food landscape will …

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To Live, To Love, To Labor: Challenging The Rigidity Of The Public And Private Spheres, Mallory Neil May 2012

To Live, To Love, To Labor: Challenging The Rigidity Of The Public And Private Spheres, Mallory Neil

All Theses

JŸrgen Habermas's bourgeois public sphere theory led many historians to adopt new categories of social divisions. More specifically, gender historians utilized the theory in order to explain the exclusion of women from the political realm. Imparting male and female classifications onto the public and private spheres, in turn, led to the claim of complete social immobility for women. In the 1990s and 2000s, however, gender historians began to question the rigidity of the gendered spheres. This study adopts this line of argument by looking at the lives of Madame de Sta‘l, George Sand, and Lucie Aubrac. These women present three …

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