Digital Commons Network^™

A Study Of Histone Deacetylase Inhibitors: Determination Of The Binding Energetics Of Suberoylanilide Hydroxamic Acid With Zinc And Cobalt And Preliminary Screening Of Nitric Oxide Donors, Erin Gallagher

College of Science and Health Theses and Dissertations

Inhibiting histone deacetylases (HDACs) can suppress tumor cell growth eventually leading to their death, makeing HDACs an important drug target. Therefore, understanding the mechanism behind inhibiting HDACs is imperative. To determine the thermodynamic parameters for the interaction of a known competitive HDAC inhibitor, suberoylanilide hydroxamic acid (SAHA), with zinc(II), the metal ion in the HDAC active site, and cobalt(II), isothermal titration calorimetry (ITC) was used. The results showed that SAHA binds to zinc(II) more strongly than it does to cobalt(II) as the equilibrium binding constants were 4.3 ± 0.5 x 10² M^-1 and 2.0 ± 0.5 x 10 …

A Conservation Plan For Reservoir Canyon Natural Reserve, San Luis Obispo, Ca, Brian M. Provenzale

Master's Theses

My thesis project is to create a conservation plan for the Reservoir Canyon Natural Reserve (RCNR) in San Luis Obispo, California. It is a professional project for the City of San Luis Obispo with the goal of eventual adoption by the City Council. The plan was motivated by City policy, which advises creating conservation plans for open spaces, and by a particular need to address management issues in RCNR that include plant and wildlife conservation, trail access, erosion, electrical utility easements, and other legal matters. The project consists of two main components: the conservation plan and a companion paper. The …

A Kinetic Study Of Anti-Vegf-A Polyclonal Antibodies And Anti-Vegf-A Ssdna Aptamers, Heather A. Hedeen

Master's Theses

A new detection reagent that could possibly augment or replace antibodies research and diagnosis methods are aptamers. Aptamers are ssDNA, RNA or polypeptide constructs that function like active antibodies. Antibodies and aptamers both specifically bind to selected target molecules, and as such they enable the detection or targeting of the presence or absence of a specific antigen.

In order to ensure that ssDNA aptamers perform similarly to antibodies, anti-VEGF-A polyclonal antibody and anti-VEGF-A ssDNA aptamer were evaluated against vascular endothelial growth factor A (VEGF-A) using Surface Plasmon Resonance (SPR). It was hypothesized that the anti-VEGF-A aptamer had the same, if …

Teaching Introductory Programming Concepts: A Comparison Of Scratch And Arduino, Anne Beug

Master's Theses

Computing has become an integral part of modern America. The Bureau of Labor Statistics estimates that between 2008 and 2018, the United States will have 1.4 million job openings in computing fields [1]. Since the early 2000's (just after the "dot com bust"), the number of students enrolled in computing majors (Computer Science, Computer Engineering, etc.) dropped precipitously by over 50%, only starting to rise again in 2009 [2]. One way to rectify to this gap between demand and supply is to start training students in computational thinking during high school. While the Computer Science Advanced Placement AB test has …

Issues Of Concern To Rotumans Abroad: A View From The Rotuma Website, Alan Howard, Jan Rensel

Pacific Studies

This article examines the Rotuman diaspora and its impact on cultural identity, focusing on expatriates’ perceptions of Rotuma as an ancestral home. Despite Rotuma's political affiliation with Fiji for over a century, its people maintain distinct linguistic and cultural ties to Polynesian islands like Tonga, Samoa, and Futuna. Today, most Rotumans live abroad, primarily in Fiji and across various global locations. Drawing on decades of research and online postings from the Rotuma Website, the authors explore how expatriates engage with their heritage, sustain community connections, and navigate identity in the diaspora. Through interviews and long-term fieldwork, the study highlights the …

Vol. 35 No. 1/2 (2012): Pacific Studies Full Issue, The Jonathan Nāpela Center For Hawaiian And Pacific Islands Studies Brigham Young University–HawaiʻI

Pacific Studies

Pacific Studies is published two times a year by The Jonathan Nāpela Center for Hawaiian and Pacific Studies, Brigham Young University Hawai‘i #1979, 55–220 Kulanui Street, Lāʻie, Hawai‘i 96762, but responsibility for opinions expressed in the articles rests with the authors alone. Subscription rate is US$26.00 yearly, payable to The Jonathan Nāpela Center for Hawaiian and Pacific Studies. The Jonathan Nāpela Center for Hawaiian and Pacific Studies (formerly The Pacific Institute) is an organization funded by Brigham Young University Hawai‘i. The Center assists the University in meeting its cultural and educational goals by undertaking a program of teaching, research, and …

Teaching Culture With A Modern Valuable: Lessons About Money For And From Tongan Youth In New Zealand, Ping-Ann Addo

Pacific Studies

This article explores how diaspora, monetary wealth, and kinship intersect in transnational Tongan families, framing diaspora as both a cultural phenomenon and a means of engaging with modernity. While remittances are often emphasized, the study examines nonremittance money practices among Tongans in New Zealand, showing how shifting uses of money redefine kinship and obligation. Traditional forms of wealth, like koloa and ngāue, remain significant, but money now plays a vital role in expressing family values and sustaining social bonds. The article highlights tensions between tradition and modernity, obligation and autonomy, and material and relational value, offering insights into how …

Discourses On Chuukese Customary Adoption, Migration, And The Laws Of State(S), Manuel Rauchholz

Pacific Studies

This article concerns Chuukese adoption, child exchange, and fosterage practices and how they are continued or discontinued when Chuukese migrate to Guam, Hawai‘i, or the continental United States.1 By focusing on one cultural practice and the system of values attached to it, I hope to pinpoint some of the major changes that take place when key identity- shaping factors diversify and are no longer shared by an ethnic group, let alone families within that ethnic group. We will see how, for Chuukese today, “cultural citizenship” is a “dual process of self-making and being made within the webs of power linked …

Return Migration To American Samoa, Fepulea‘I Micah Van Der Ryn

Pacific Studies

This article examines the rising phenomenon of return migration to American Samoa, driven by economic, social, and familial factors. With a growing percentage of residents consisting of "returnees" from the U.S.-based Samoan diaspora, this migration reflects deep connections to land, kinship, and cultural identity. Using case studies and interviews, the study analyzes how returnees reintegrate into traditional Samoan structures, navigating values such as tautua (service), alofa (compassion), and fa‘aāloalo (respect). Differences in governance between American Samoa and independent Samoa shape migration patterns, influencing land tenure and chiefly authority. Socioeconomic and environmental factors also impact migration decisions, revealing a complex interplay …

A Survey Of Non-Classical Polyandry, Kathrine E. Starkweather, Raymond Hames

Department of Anthropology: Faculty Publications

We have identified a sample of 53 societies outside of the classical Himalayan and Marquesean area that permit polyandrous unions. Our goal is to broadly describe the demographic, social, marital, and economic characteristics of these societies and to evaluate some hypotheses of the causes of polyandry. We demonstrate that although polyandry is rare it is not as rare as commonly believed, is found worldwide, and is most common in egalitarian societies. We also argue that polyandry likely existed during early human history and should be examined from an evolutionary perspective. Our analysis reveals that it may be a predictable response …

Lesbian/Queer/Same-Gender-Loving Women Graduate Students In Mental Health Related Fields: A Grounded Theory Of Attitudes Toward Transgender Individuals, Bonnie M. Benson

Dissertations

Transgender (trans) issues are an emerging area of research within counseling psychology. As such, little is known about how individuals form their attitudes toward trans people. Despite evidence that lesbian women are one group that has held biased views of the trans population, the literature has not addressed the perceptions that lesbian women have of trans individuals. Furthermore, the campus climate literature has attended to how LGBT students experience campus discrimination, but this literature has not addressed within-group differences, that is, attitudes and interactions among LGBT members of a university community, such as those between lesbians and trans people. The …

I'M The Same Me: Communication And Renegotiation Of Identity In The Weight-Loss Surgery Experiences Of Women, Heather D. Schild

Masters Theses

Adult obesity rates are on the rise in the United States according to the Centers for Disease Control (2009) which has led to an increase in obesity-related illnesses such as diabetes and heart disease. Weight-loss surgery (WLS) has become accepted as a "cure" for obesity by the medical community. There has been a dramatic increase in the number of obese individuals electing to undergo WLS every year; 82% of these individuals are women (AHRQ, 2007). More women may be electing to undergo these procedures than men due to the pressures women face in American culture to achieve social standards of …

Complexity Theory And Political Change: Talcott Parsons Occupies Wall Street, Martin Zwick

Complex Systems Faculty Publications and Presentations

Complexity theory can assist our understanding of social systems and social phenomena. This paper illustrates this assertion by linking Talcott Parsons' model of societal structure to the Occupy Wall Street movement. Parsons' model is used to organize ideas about the underlying causes of the recession that currently afflicts the US. While being too abstract to depict the immediate factors that precipitated this crisis, the model is employed to articulate the argument that vulnerability to this type of event results from flaws in societal structure. This implies that such crises can be avoided only if, in Parsons' terms, structural change occurs …

Complexity Theory And Political Change: Talcott Parsons Occupies Wall Street [Presentation], Martin Zwick

Complex Systems Faculty Publications and Presentations

Complexity theory can assist our understanding of social systems and social phenomena. This paper illustrates this assertion by linking Talcott Parsons' model of societal structure to the Occupy Wall Street movement. Parsons' model is used to organize ideas about the underlying causes of the recession that currently afflicts the US. While being too abstract to depict the immediate factors that precipitated this crisis, the model is employed to articulate the argument that vulnerability to this type of event results from flaws in societal structure. This implies that such crises can be avoided only if, in Parsons' terms, structural change occurs …

Gsp And Development: Increasing The Effectiveness Of Nonreciprocal Preferences, Matthew G. Snyder

Michigan Journal of International Law

The intellectual foundations of nonreciprocal preferences were first laid out in the 1960s, as several scholars noted developing countries' increasing reliance on highly volatile, low-value-added exports like agricultural and mineral commodities. The Generalized System of Preferences (GSP), which became the mechanism for implementing nonreciprocal preferential market access, was developed in this context. GSP was envisioned as part of a larger development strategy that included import-substitution policies, infant industry protection, and preferential access to developed countries' markets. As GSP granted preferential access over World Trade Organization (WTO) most favored nation (MFN) rates, development economists anticipated that it would provide developing countries' …

Mathematics And Religion: Our Languages Of Sign And Symbol (Book Review), Calvin Jongsma

Faculty Work Comprehensive List

Reviewed Title: Mathematics and Religion: Our Languages of Sign and Symbol by Javier Leach. West Conshohocken, PA: Templeton Press, 2010, 188 pages. ISBN 9781599471495.

Energy Aware Algorithms For Managing Wireless Sensor Networks, Abhishek Karpate

Student Work

While the majority of the current Wireless Sensor Networks (WSNs) research has prioritized either the coverage of the monitored area or the energy efficiency of the network, it is clear that their relationship must be further studied in order to find optimal solutions that balance the two factors. Higher degrees of redundancy can be attained by increasing the number of active sensors monitoring a given area which results in better performance. However, this in turn increases the energy being consumed. In our research, we focus on attaining a solution that considers several optimization parameters such as the percentage of coverage, …

Identifying Core Components In Software Systems, Phillip Meyer

Student Work

As large software systems are highly complex, they can be difficult for a developer to understand. If a core subset of a software system could be extracted which contains the most important classes and connections of the larger system, studying this core would be useful for efficiently understanding the overall system. In this research we examine research into core/periphery structures in networks, primarily focusing on the use of k-core decomposition. The extracted dependencies of three open source Java software systems provide the inputs, with forty different versions of these systems analyzed in total. We derive inter-class dependencies from these releases …

Novel Platform Development Using An Assembly Of Carbon Nanotube, Nanogold And Immobilized Rna Capture Element Towards Rapid, Selective Sensing Of Bacteria, Elizabeth I. Maurer, Kristen K. Comfort, Saber M. Hussain, John J. Schlager, Sharmila M. Mukhopadhyay

Chemical and Materials Engineering Faculty Publications

This study examines the creation of a nano-featured biosensor platform designed for the rapid and selective detection of the bacterium Escherichia coli. The foundation of this sensor is carbon nanotubes decorated with gold nanoparticles that are modified with a specific, surface adherent ribonucleic acid (RNA) sequence element. The multi-step sensor assembly was accomplished by growing carbon nanotubes on a graphite substrate, the direct synthesis of gold nanoparticles on the nanotube surface, and the attachment of thiolated RNA to the bound nanoparticles.

The application of the compounded nanomaterials for sensor development has the distinct advantage of retaining the electrical behavior …

Phosphorylation Of Vasodilator-Stimulated Phosphoprotein Ser239 Suppresses Filopodia And Invadopodia In Colon Cancer., David S Zuzga, Joshua Pelta-Heller, Peng Li, Alessandro Bombonati, Scott A Waldman, Giovanni Mario Pitari

Department of Pharmacology and Experimental Therapeutics Faculty Papers

In colorectal cancer, the antitumorigenic guanylyl cyclase C (GCC) signalome is defective reflecting ligand deprivation from downregulation of endogenous hormone expression. Although the proximal intracellular mediators of that signal transduction system, including cyclic guanosine monophosphate (cGMP) and cGMP-dependent protein kinase (PKG), are well characterized, the functional significance of its distal effectors remain vague. Dysregulation of ligand-dependent GCC signaling through vasodilator-stimulated phosphoprotein (VASP), an actin-binding protein implicated in membrane protrusion dynamics, drastically reduced cGMP-dependent VASP phosphorylation levels in colorectal tumors from patients. Restoration of cGMP-dependent VASP phosphorylation by GCC agonists suppressed the number and length of locomotory (filopodia) and invasive (invadopodia) …

Exact Solutions Of The Generalized Benjamin Equation And (3 + 1)- Dimensional Gkp Equation By The Extended Tanh Method, N. Taghizadeh, M. Mirzazadeh, S. R. Moosavi Noori

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, the extended tanh method is used to construct exact solutions of the generalized Benjamin and (3 + 1)-dimensional gKP equation. This method is shown to be an efficient method for obtaining exact solutions of nonlinear partial differential equations. It can be applied to nonintegrable equations as well as to integrable ones.

A Postulate For Tiger Recovery: The Case Of The Caspian Tiger, Carlos A. Driscoll, I. Chestin, H. Jungius, O. Pereladova, Y. Darman, E, Dinerstein, J. Seidensticker, J. Sanderson, S. Christie, Shu-Jin Luo, S. Shrestha, Y. Zhuravlev, Olga Uphyrkina, Y. V. Jhala, S. P. Yadav, D. G. Pikunov, Nobuyuki Yamaguchi, David E. Wildt, J. L. D. Smith, L. Marker, P. J. Nyhus, R. Tilson, David W. Macdonald, Stephen J. O'Brien

Biology Faculty Articles

Recent genetic analysis has shown that the extinct Caspian Tiger (P. t. virgata) and the living Amur Tigers (P. t. altaica) of the Russian Far East are actually taxonomically synonymous and that Caspian and Amur groups historically formed a single population, only becoming separated within the last 200 years by human agency. A major conservation implication of this finding is that tigers of Amur stock might be reintroduced, not only back into the Koreas and China as is now proposed, but also through vast areas of Central Asia where the Caspian tiger once lived. However, under the current tiger conservation …

A Method For Rearing Large Quantities Of The Damselfly, Ischnura Ramburii (Odonata: Coenagrionidae), In The Laboratory, Jason L. Locklin, Joshua S. Huckabee, Eben Gering

Biology Faculty Articles

Laboratory based experimental designs typically require large sample sizes of genetically related organisms at the same developmental stage. Several described methods for rearing damselflies have been published, but these methods require laborious techniques when rearing large quantities of damselflies simultaneously. We have developed a relatively easy and inexpensive method for rearing large quantities of a coenagrionid damselfly that streamlines previously published methods and employs new techniques that increase efficiency and yield. Culturing large numbers of damselflies in the laboratory is manageable and opens diverse research avenues.

Evaluating The Effectiveness Of The Yasp Intervention: Adolescent Substance Use Outcomes, Whitney Nicole Brown

Loma Linda University Electronic Theses, Dissertations & Projects

Issues of alcohol and drug use are more pronounced during adolescence than at any other period of the life span. There is currently a need for research focusing on evaluating developmentally appropriate interventions for adolescents at risk for substance use issues. The present study seeks to evaluate the effectiveness of YASP (Youth Alternative Solutions Program), a hospital-based intervention program at Loma Linda University Medical Center. It is hypothesized that participation in YASP will decrease levels of substance use, change substance use outcome expectancies, decrease negative consequences resulting from substance use and increase participants sense of self-efficacy. A sample 27 adolescents …

Role Of The Pituitary-Adrenal Axis In G-Csf Therapy After Neonatal Hypoxia-Ischemia, Melissa Stephanie Charles

Loma Linda University Electronic Theses, Dissertations & Projects

Several reports indicate that the activity of the hypothalamic-pituitary-adrenal axis (HPA) as measured by the increased level of adrenocorticotropic hormone (ACTH), and corticosterone is increased after a brain insult. These hormones are the effectors secreted respectively by the pituitary and adrenal glands. It has been shown that the down-regulation of corticosterone levels can improve detrimental outcomes associated with ischemic brain injuries. Neonatal hypoxia-ischemia (HI) is a devastating perinatal event with a grim prognosis and limited therapeutic strategies. In recent studies, granulocyte-colony stimulating factor (G-CSF) has shown promise in neonatal HI investigations by improving neuromotor function and reducing apoptosis in the …

Brief Heterogeneous Inpatient Groups: A Process-Oriented Psychoeducational Model, Wesley Cook

Loma Linda University Electronic Theses, Dissertations & Projects

In the U.S., we currently have an increase in admissions to psychiatric hospitals and a lack of research exploring inpatient group psychotherapy. Diagnostically homogeneous therapy groups outperform therapy groups with mixed symptoms, however, due to managed health care, psychiatric hospitals typically run brief duration, diagnostically heterogeneous groups. A review of the research literature was conducted in order to locate empirical studies that could offer treatment recommendations regarding how to facilitate brief duration, diagnostically heterogeneous inpatient psychotherapy groups. Although this review revealed little information about this specific type of group, common factors from inpatient studies were extracted. Based on a synthesis …

Mechanism Of Lmx1b-Regulated Limb Dorsalization, Jennifer Feenstra

Loma Linda University Electronic Theses, Dissertations & Projects

Lmx1b, a LIM homeodomain transcription factor is necessary for limb, kidney, eye, and central nervous system development. Lmx1b knockout (KO) mice display; abnormal limb dorsalization with distal ventral-ventral limbs, nephropathy, ocular malformations, loss of dopaminergic/serotonergic neurons, and reduced cerebellum and tectum formation. The developmental mechanisms utilized by Lmx1b remain largely unknown; to investigate downstream targets, we have used the limb as a model because of its accessibility and striking Lmx1b KO phenotype. To identify candidate genes, we compared gene arrays from Lmx1b KO and wildtype mouse limbs during limb dorsalization, i.e., 11.5, 12.5, and 13.5 days post coitum. We identified …

Second Generation Korean-American Parents: Social Context Influence On Parenting, Lana H. Kim

Loma Linda University Electronic Theses, Dissertations & Projects

Korean-American families are an underrepresented group within the family therapy literature. In particular, the realities and lived experiences of American born second generation Korean-American parenting couples is limited. Therefore, this qualitative grounded theory dissertation used a social constructionist lens to understand how American born second generation Korean-Americans, raised amidst contrasting Korean and western cultural ideologies, conceptualize parenting and position themselves in relation to their children within parent-child relationships. Semi-structured interviews were conducted with 20 parenting couples of children between 0-10 years of age to illuminate ways in which multiple cultural discourses, bicultural socialization, and racialized experiences influence the parenting process. …

Analysis Of Minocycline As A Radioprotectant, Shalini Mehrotra

Loma Linda University Electronic Theses, Dissertations & Projects

Exposure to radiation is increasing in a variety of settings including space exploration, diagnostic medical procedures and radiotherapy. Cells of the hematopoietic system, such as white blood cells (WBC), are especially sensitive to radiation and their decline can result in Acute Radiation Syndrome (ARS). Radiotherapy is often used for cancers of the central nervous system (CNS), but includes the risk for normal tissue damage, often leading to cognitive impairment. The literature suggests that tetracyclines can be radioprotectors of the hematopoietic system with potential utility in radiation emergencies and anticancer radiotherapy. Minocycline, a semisynthetic tetracycline derivative, has anti-inflammatory, free radical scavenging, …

Successful Again Through A Family Resilience Lens, A'Verria Sirkin Martin

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined successful aging through a family resilience lens by developing a psychometrically tested assessment that can be used to measure family and individual resilience in a population of older adults and by then applying these latent structures to predict successful aging across four domains; self-rated successful aging, psychosocial health, cognitive decline, and physical health. Data from 1,006 older adults were analyzed in three steps. The first identified the underlying latent structure through principle component (exploratory) factor analysis (EFA). The second included the use of confirmatory factor analysis to validate the structure from the first step. The third utilized …