Digital Commons Network^™

Unveiling The Biochemical Pathway Responsible For Ankyloglossia (Tongue-Tie) By Tracking Enzymatic Activity Of Apoptosis Pathways, Becca Ringstad

Celebrating Scholarship and Creativity Day (2018-)

Ankyloglossia (Tongue-tie) is a condition that is caused by failed cellular degeneration leading to a short lingual frenulum. This short lingual frenulum tethers the tongue to the bottom palate of the mouth and leads to problems, including breastfeeding for infants, depriving them of important proteins that build the gut microbiome, strengthen the immune system, and fight off antigens. If left untreated, it leads to problems with speech articulation, airway development, and obstructive sleep apnea. Treatment involves a frenectomy, which is the release of the short lingual frenulum using surgical scissors or a laser. Ankyloglossia can occur with conditions such as …

Cancer Gets Extreme: How Extremophiles Can Improve Research And Therapy, Jason Malmgren

Celebrating Scholarship and Creativity Day (2018-)

Extremophiles are organisms that can survive in extreme environmental conditions, and their unique biological adaptations have gained attention for potential applications in cancer research. This paper explores how the molecular characteristics of extremophiles, such as enhanced DNA repair, resistance to oxidative stress, and structural stability, may be useful in improving cancer treatment strategies. A range of studies were examined to understand both direct and indirect roles of extremophile-derived compounds in oncology. Some research shows that compounds from organisms like Deinococcus radiodurans and extremophilic Streptomyces species can inhibit cancer cell growth, increase reactive oxygen species, and trigger apoptosis. Other studies highlight …

Use Of Electroencephalography To Evaluate Neural Correlates Of Attention In The Oddball Paradigm, Folsom J. Berry

Honors Theses

Electroencephalography (EEG) and Event-Related Potentials (ERP) are tools used to study and analyze cognitive processing. EEG measures neuroelectric brain activity from the scalp, while ERPs are time-locked averages that are used to isolate neural responses to stimuli. The P300 (P3) component (positive waveform elicited at 300 milliseconds (ms)) is the primary ERP component. This thesis project had two main objectives. The first objective was to develop conceptual and technical competency in EEG/ERP theory, data acquisition, and processing. The second objective was to implement the visual oddball paradigm through experimental demonstration. This experiment tested the hypothesis that infrequent target stimuli will …

The Impact Of Palm Cooling On The Physiological And Cognitive Function Of Aerobically Trained Individuals, Katherine L. Tibbs

Honors Theses

Background: Cooling strategies have been shown to combat the harmful effects that an increase in body temperature can potentially cause, and palm cooling in particular has been adopted due to its effectiveness in mitigating muscle fatigue during exercise. While there is clear support that this improves muscular strength and endurance, there is a lack of research on the impact palm cooling has on the mental aspect of physical activity. The purpose of this study was to investigate the cognitive and physiological effects of palm cooling on aerobic exercise performance. Methods: Ten aerobically trained participants between the ages of 18-35 were …

Lipid Deposition In Beef Cattle, Kyra L. Elliott

Department of Animal Science: Dissertations, Theses, and Student Research

Both the amount and types of lipid deposition in beef cattle are key determinants of carcass value and meat quality. Amounts of intramuscular, subcutaneous, and visceral fat influence carcass grading outcomes, palatability, and composition traits that are important to beef producers as well as consumers. The objectives of this thesis were to: 1) compare beef grading camera estimates of intramuscular fat to amounts of chemically extractable lipid, 2) characterize the lipidomes of beef intramuscular fat, subcutaneous fat, and lean muscle using shotgun lipidomics, and 3) identify and characterize a novel genetic variant in cattle that may have important implications for …

Characterization Of Activity Changes In Gilts During Estrus Using The NuTrack Livestock Monitoring System, Emily P. Aquino

Department of Animal Science: Dissertations, Theses, and Student Research

Early and accurate detection of estrus in replacement gilts is essential for reproductive success and to ensure efficient production. The objective of this study was to evaluate activity changes occurring relative to first estrus of gilts and subsequent cycles. At ~ 110 days of age, 112 gilts were randomly assigned to 14 pens and placed under continuous video monitoring until the end of the trial at ~ 200 days of age. Daily boar exposure (~ 10 minutes per day) began at ~ 122 days of age. During this period, recorded observations included vulva scores (based on swelling and redness), mounting …

Evaluation Of Maternal Bovine Appeasing Substance Administration And Feed Access Time On Finishing Cattle Performance, Behavior, And Carcass Characteristics, Carsten L. Loseke

Department of Animal Science: Dissertations, Theses, and Student Research

Novel products and bunk management techniques may significantly influence economically relevant performance metrics of feedlot cattle. The objective of the first experiment was to evaluate maternal Bovine Appeasing Substance (mBAS) administration on performance, carcass, health, and cortisol outcomes of yearling steers. Steers (n = 1,754, initial BW = 423 kg, SD = 25 kg) were received and assigned to pens for treatment allocation. Steers received either 10 mL of the mBAS or a mineral oil placebo at initial processing and reimplant. Hair samples were collected from a subset (n = 4 steers/pen) on d 0 and d 14. …

Integrating Growth Performance And Pathogen Detection To Investigate Disease Resilience In Commercial Swine, Emmalise Hope Marie Meyer

Department of Animal Science: Dissertations, Theses, and Student Research

Disease resilience is an important trait in commercial swine production, influencing both animal health and growth performance under natural disease challenge. The primary objective of this study was to integrate growth performance data with longitudinal pathogen detection to better understand factors contributing to disease resilience in commercial pigs. A population of 1,014 pigs across four batches was monitored from weaning through the grow-finish phase, with body weights collected to calculate average daily gain (ADG). Genome-wide association analyses were conducted using BayesC and BayesIM approaches to identify genomic regions associated with growth performance. Longitudinal pathogen surveillance was performed using pen-level oral …

Tail Biting In The Nursery: Evaluating Postural, Spatial, And Behavioral Differences Between Tail Biter And Victim Pigs, Storey L. Forster

Department of Animal Science: Dissertations, Theses, and Student Research

This study examined behavioral differences among pigs classified as tail biters, victims, or neutral during the nursery period. A total of 192 undocked nursery pigs were assigned to eight pens and monitored for 30 days using the NUtrack system. Tail biting events were identified from video observations, and pigs contributing to the top 25% of observed tail biting activity were classified as tail biters. Based on weekly tail scoring, pigs assigned a maximum tail injury score ≥ 2 were classified as victims. All other pigs were considered neutral. A total of 700 tail biting events were observed. Thirty-eight pigs …

Application Of High-Pressure Processing To Improve The Color Of Dark Beef, Kara Ann Reynolds

Department of Animal Science: Dissertations, Theses, and Student Research

Deviation of beef from the bright cherry-red color preferred by consumers is often discounted or discarded at retail, resulting in substantial annual economic loss to the beef industry. One such deviation is dark cutting beef, which is characterized by a darker lean appearance that is undesirable to consumers and often rejected. Similarly, beef from mature cattle tends to exhibit a darker surface color, which can also reduce consumer acceptability. High-Pressure processing (HPP) has been investigated as a strategy to improve the color of dark cutting beef. Previous studies have focused on identifying pressure levels and holding times that optimize color …

Population Pharmacokinetics And Dosing Simulations Of Pentobarbital In The Pediatric Population, Victoria Etges Helfer, Lorena Medina-Aymerich, William J. Muller, Marisa Meyer, Amira Al-Uzri, Russell Mcculloh, Chi D. Hornik, Stephen J. Balevic, Rachel G. Greenberg, Daniel K. Benjamin, Sarah G. Anderson, Daniel Gonzalez

Department of Pediatrics Faculty Papers

Pentobarbital is a barbiturate with sedative and anticonvulsant properties, occasionally used in pediatric patients for preoperative sedation, deep sedation during mechanical ventilation, and seizure control. Despite its long-standing clinical use, age-appropriate dosing remains challenging due to variability across studies and limited pediatric pharmacokinetic (PK) data. This study (NCT01431326) aimed to characterize the population pharmacokinetics of pentobarbital in pediatric patients (birth to 21 years) and evaluate dosing strategies using model-based simulations. A two-compartment population PK model, allometrically scaled to total body weight, adequately described pentobarbital plasma concentrations, with no additional covariates identified as significant. Simulations were conducted across four age groups: …

Enhanced Near-Surface Soil Labile Carbon And Microbial Indicators Under Cover Crops And Crop Diversification In Long-Term No-Till Systems, Sainfort Vital, Sutie Xu, Namrata Ghmire, Peter Sexton, Jixiang Wu, Christopher Graham, Lan Xu, Mengistu Geza

Natural Resource Management Faculty Publications

No-till systems improve soil functions and are widely adopted in South Dakota cropping systems. However, these cropping systems have become increasingly simplified due to reduced small grain adoption, potentially reducing carbon inputs and microbial diversity. Therefore, this study aimed to (i) quantify the effects of crop rotations and cover cropping on soil organic carbon (SOC), total nitrogen (TN), and their labile fractions across the 0–80 cm soil profile, and (ii) assess how these management practices affect microbial properties in the topsoil (0–7.5 cm), using a long-term no-till (>30 years) field experiment in South Dakota. Main treatments included a corn …

Preclinical Animal Modeling To Investigate Redox-Mediated Molecular Dysfunction In Traumatic Brain Injury, Brandon Z. Mcdonald

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Impacts associated with traumatic brain injury (TBI) induce a multitude of neurological morbidities mediated by a spread of biochemical dysfunction. Redox stress is a significant contributor to TBI pathophysiology and several redox stress markers have substantial evidence to support their role in diagnosing preclinical and clinical TBI. However, there is a critical need to verify their translational utility through correlations with behavioral, imaging, and molecular modalities. In chapter two, we examined the therapeutic efficacy of an antioxidant treatment (NPC3) using a controlled cortical impact (CCI) mouse model of TBI. NPC3 alleviated glial expression and reactivity while influencing the expression of …

Factors Affecting The Efficacy Of Free Choice Vitamin & Mineral Supplementation Programs, Tanner K. Wansing

Department of Animal Science: Dissertations, Theses, and Student Research

While free choice vitamin and mineral supplements are widely used within the cow/calf sector, large knowledge gaps exist around the proper management of those supplements. This thesis discusses two factors affecting the efficacy of supplementation. The first interest was the stability of vitamin A when stored with a common free choice mineral supplement. This research addressed a critical data gap by generating information on vitamin A stability within the beef industry, as current data are predominantly based in the swine industry. Vitamin A was discovered to be stable until 4 months of storage regardless of storage conditions, whereas after 4 …

Cytoplasmic Shift Of Interferon Regulatory Factors Co‐Evolved With Jawed Vertebrate Innate Immunity, Vanessa M. Hubing

Honors Program: Senior Projects (Public)

The emergence of jaws in early vertebrates introduced a novel feeding apparatus and powerful oral defenses, but it also increased the risk of physical injury and pathogen exposure. Interferon regulatory factors (IRFs) play critical roles in orches-trating innate immunity and inflammation in response to invading microbes and tissue damage, with their subcellular local-ization being essential to some IRFs' function. Our results indicate that IRF members underwent independent expansion and diversification in two distinct vertebrate lineages: jawed and jawless vertebrates. The jawed vertebrate-specific factor, IRF5, has maintained conserved nuclear export sequences throughout evolution, while newly diversified IRF members in jawed verte-brates …

Lewis Carroll’S Curious Creatures: Examining Carroll’S Use Of Animal Characters Within The Context Of His Life And Victorian Era England, Nima M. Faunce

Honors Program: Senior Projects (Public)

Lewis Carroll’s Alice’s Adventures in Wonderland (1865) has maintained a wide readership since its publication, but many aspects of Carroll’s original intentions and inspirations are lost on modern readers. By examining his animal characters through the lens of his personal life and Victorian England, a deeper understanding of his novel is uncovered. Some of his characters directly reflect individuals from his real life, such as the Liddell family, while other characters provide a window into Victorian beliefs and practices. This paper investigates each of Carroll’s animal characters in order of appearance and determines possible points of inspiration from his personal …

The Consumptive Female Ideal: The Case Study Of “Snow White”, Nayla G. Torres Ruiz

Honors Program: Senior Projects (Public)

Tuberculosis (TB), also known as “consumption” or “phthisis,” was one of the most pervasive and culturally significant diseases of the eighteenth and nineteenth centuries. Despite its high mortality rate—claiming more lives than cholera and smallpox combined—TB was widely romanticized in art, literature, and popular culture, particularly as a feminine disease associated with beauty, purity, fragility, and moral virtue. The physical traits of consumption—pale skin, rosy cheeks, red lips, glassy eyes, and a slender, delicate frame—became an ideal of female beauty, one that many women sought to emulate through restrictive diets, toxic cosmetics, and evolving fashion trends, such as increasingly tight …

Geospatial Science And The Changing Environment: Applied Methods For Sustainable Agriculture And Landscape Management, Harrison Wakefield Smith

Graduate Theses and Dissertations

Rapid environmental change is disrupting agricultural productivity, ecological function, and the long-term resilience of managed landscapes. At the same time, the rapid growth of geospatial data science has improved our understanding of environmental change and increasingly is being used to improve sustainability in agricultural and environmental management. However, critical gaps remain that limit the applicability of data-driven insights in landscape management. This dissertation investigates the potential of geospatial analytics for sustainable agriculture and landscape management, with a focus on applied methods that operate across spatial and temporal scales. Using field, landscape, regional, and national datasets, it explores the capabilities and …

Association Between Cholinesterase Inhibitor-Overactive Bladder Antimuscarinic Prescribing Cascade And Risk Of Delirium And Falls Among Individuals Living With Dementia, Sarah Beth Tucker, Bryan L. Love Pharm D., Chijoke M. Okeke, Erin D. Zwick, Chengwen Teng Pharm.D., Ph.D., Jingkai Wei, Ibraheem M. Karaye, Saud Alsahali, Krithika Rajagopalan, Ismaeel Yunusa Ph.D.

Faculty Publications

Background

Prescribing cascades occur when cholinesterase inhibitor (ChEI)-induced urinary incontinence is misinterpreted as a new condition, leading to overactive bladder (OAB) antimuscarinic initiation. We evaluated whether the ChEI-OAB antimuscarinic prescribing cascade was associated with delirium or falls compared with mirabegron in older adults living with dementia.

Methods

We conducted a retrospective cohort study using the Anlitiks All-Payor Claims database (2015–2020). Participants were adults aged ≥ 65 years with dementia newly prescribed a ChEI with no prior ChEI or OAB therapy (180 days). A 60-day window identified OAB treatment initiation after ChEI therapy. Exposures were OAB antimuscarinics or mirabegron. Outcomes were …

Genome-Wide Phenotypic Characterization Of Mycobacteriophage Mercurio, Tyler Downs

Departmental Honors & Graduate Capstone Projects

Bacteriophages, or phages, are being piloted as a supplemental or alternative therapeutic to antibiotics against drug-resistant Mycobacterium pathogens, such as M. tuberculosis, which pose a global public health crisis.  Characterizing bacteriophage genomes can provide insights into efficacy in phage therapy before implementation or elucidate new targets to manipulate bacterial growth.  Overexpression of individual phage genes is useful to study a gene product’s function independent of others.  Here, the results of phage Mercurio plasmid library overexpression in plate-based assays are described.  Mercurio infects nonpathogenic Mycobacterium smegmatis and is genetically related to bacteriophages infecting pathogenic Mycobacterium species.  Eleven gene products of …

Multi-Task Growing Interpretable Neural Network For Multi-Target Symbolic Regression, Hussein Rajabu

All Theses

Over the past decade, deep learning has achieved remarkable success across domains such as computer vision and natural language processing. Despite their strong predictive capabilities, these models often function as black boxes, limiting transparency and making them difficult to trust in high-stakes applications such as healthcare and business decision-making. While explainable artificial intelligence (XAI) methods improve interpretability, most approaches remain post-hoc, focusing on statistical associations rather than uncovering the underlying functional mechanisms governing predictions.

Symbolic regression (SR) has emerged as a promising direction within XAI by directly discovering explicit mathematical expressions that describe relationships between inputs and outputs. Unlike traditional …

Bindley Bioscience Center Technical Overview, Natasha Nikolaidis

University General Facility Boilerplate Descriptions

No abstract provided.

The Effect Of Two Desensitizing Agents In Treatment Of Dentin Hypersensitivity In Cervical Lesions (A Randomized Clinical Trial), Hend Sayed Ahmed, Mohamed Fouad Haridy, Hoda Fouda, Sara Katarya, Youssef M. Haridy

Dentistry

No abstract provided.

Influence Of Asd On Morality, Spencer Brown

Harriet L Wilkes Honors College Theses

Autism is known as a developmental disorder that incurs a social skills deficit on those that have it. This social skills deficit has been proposed to affect further aspects of autistic people’s psychology such as empathy and morality. Studies using the moral stages theory of development have found that those with autism are deficient in these proposed social skills. However, further research into how morality and empathy, as well as the results of experiments looking into morality in autistic populations, have brought the accuracy of moral reasoning into doubt. In the present paper, we review the literature on how empathy, …

Aggregation And Collation Of Texas Crayfish Museum Specimens To Determine Their Current Conservation Statuses, Adrian Alvarez

Biology Theses

Crayfish account for over half of the macroinvertebrate biomass in many ecosystems and serve as crucial bioindicators because of their behavioral and physiological adaptability to environmental changes. Despite being home to approximately 52 native crayfish species, Texas currently lacks protective regulations. This gap is primarily because of insufficient information regarding their distribution and occurrences within the state, including their statuses as Species of Greatest Conservation Need (SGCN). This study focuses on compiling and comparing crayfish museum records with current iNaturalist field survey data across Texas to address these knowledge gaps and recommend updates to SGCN statuses. Five species not currently …

Cis-Variant Gene-Expression Association Analysis: A Targeted Approach To Identify Functional Cis-Regulatory Variation, Sofiya Arora

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Phenotypic diversity in plants is largely driven by changes in gene function arising from mutations in both the coding and regulatory regions. Regulatory variation is particularly pervasive because it can fine-tune gene expression without disrupting protein function and is therefore less likely to be strongly selected against in natural populations. As a result, it has played a central role in evolution and domestication. In our previous genome-wide eQTL mapping study in maize, nearly two-thirds of the expressed genes were found to harbor detectable cis-expression quantitative trait loci (cis-eQTLs) with strong local effects on gene expression. Though these cis-variants are widespread, …

Quantitative Genetics, Genomics, And Phenomics In Maize And Sorghum, Nikee Shrestha

Complex Biosystems Program: Dissertations and Student Research

Generating the best crop varieties and hybrids requires identifying genes associated with the phenotype of interest and screening thousands of varieties across multiple locations. Quantitative genetics, along with comparative genomics, phenomics, and machine learning approaches, can help us identify target genes associated with the phenotype of interest to develop the right genotypes. Satellite platforms offer logistical and technical advantages in scalability and accessibility and could facilitate plot-level predictions, especially with steadily improving spatial resolution, thereby empowering the large-scale screening of thousands of genotypes across diverse locations. In the first chapter, I evaluated over 20,000 plot-level images of over 80 hybrid …

Immigrants And The Battle For Our Nation In The Courts, Raquel E. Aldana

University of the Pacific Law Review

No abstract provided.

Fisheries Management Paper No. 313: Western Australian Statewide Small Pelagic Scalefish Resource Harvest Strategy, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Management Papers

Harvest strategies for Western Australia’s (WA) aquatic resources are formal documents developed by the Department of Primary Industries and Regional Development (DPIRD, the Department) to support decision-making processes that ensure the outcomes are consistent with the principles of Ecologically Sustainable Development (ESD; Fletcher 2002a) and Ecosystem Based Fisheries Management (EBFM; Fletcher et al. 2012).

Harvest strategies are a key component of all contemporary fishery management systems and a requirement for certification under the Marine Stewardship Council (MSC; Marine Stewardship Council 2018). The objectives of ESD are reflected in the objects of the Fish Resources Management Act 1994 (FRMA).

This Statewide …

Engineering Silicone Magnetic Fluids For Localized Radiation Attenuation During Ocular Melanoma Brachytherapy, Zachary L. Caprow

All Dissertations

Ocular melanoma is commonly treated using plaque brachytherapy; however, radiation-induced damage to healthy ocular tissues frequently results in partial or complete vision loss. This work investigates the development of an injectable, magnetically responsive silicone magnetic fluid designed to localize adjacent to the tumor and attenuate low-energy gamma radiation during treatment.

The material system consists of iron oxide nanoparticles surface-functionalized with a siloxane polymer, in which the nanoparticles provide magnetic responsiveness and radiation attenuation, while the polymer coating ensures colloidal stability, injectability, and biocompatibility. A one-pot synthetic approach was developed wherein a functionalized siloxane polymer containing iron-affinitive groups was reacted with …