Digital Commons Network^™

Striped Bass Consumption Of Blueback Herring During Vernal Riverine Migrations: Does Relaxing Harvest Restrictions On A Predator Help Conserve A Prey Species Of Concern?, Justin P. Davis, Eric T. Schultz, Jason C. Vokoun

Open Access Author Fund Awardees' Articles

Anadromous blueback herring Alosa aestivalis are declining throughout much of their range, and fishery closures in some systems have failed to produce population recovery. A potential contributing factor is increased predation pressure from sympatric striped bass Morone saxatilis. We integrated data on the predator–prey interaction between striped bass and blueback herring during vernal migrations into the Connecticut River with data on the in-river striped bass fishery to assess the potential for mitigation of blueback herring mortality via increased striped bass harvest. Striped bass abundance, size structure, diets, and angler catches were assessed within a river segment during spring 2005–2008. …

Murine Gut Microbiota Is Defined By Host Genetics And Modulates Variation Of Metabolic Traits, Autumn M. Mcknite, Maria Elisa Perez-Munoz, Lu Lu, Evan G. Williams, Simon Brewer, Penelope A. Andreux, John W. M. Bastiaansen, Xusheng Wang, Stephen D. Kachman, Johan Auwerx, Robert W. Williams, Andrew K. Benson, Daniel A. Peterson, Daniel C. Ciobanu

Department of Statistics: Faculty Publications

The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by a combination of environmental and host genetic factors and is associated with several polygenic diseases. In this study we combined next-generation sequencing, genetic mapping, and a set of physiological traits of the BXD mouse population to explore genetic factors that explain differences in gut microbiota and its impact on metabolic traits. Molecular profiling of the gut microbiota revealed important quantitative differences in microbial composition among BXD strains. These differences in gut microbial composition are influenced by host-genetics, which …

Ada News - 06/18/2012, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Quantitative Analysis Of Some Important Metals And Metalloids In Tobacco Products By Inductively Coupled Plasma-Mass Spectrometry (Icp-Ms), Syed Ghulam Musharraf, Muhammad Shoaib, Amna Jabbar Siddiqui, Muhammad Najam-Ul-Haq, Aftab Ahmed

Biomedical and Pharmaceutical Sciences Faculty Publications

Background:

Large scale usage of tobacco causes a lot of health troubles in human. Various formulations of tobacco are extensively used by the people particularly in developing world. Besides several toxic tobacco constituents some metals and metalloids are also believed to pose health risks. This paper describes inductively coupled plasma-mass spectrometric (ICP-MS) quantification of some important metals and metalloids in various brands of smoked, sniffed, dipped and chewed tobacco products.

Results:

A microwave-assisted digestion method was used for sample preparation. The method was validated by analyzing a certified reference material. Percentage relative standard deviation (% R.S.D.) between recovered and certified …

Students To Present Findings From Research Trip To Costa Rica, Panama, June 18, 2012, Tom Scherberger

USF St. Petersburg Campus News and Press Releases

No abstract provided.

Lanthorn, Vol. 46, No. 64, June 18, 2012, Grand Valley State University

Volume 46, July 14, 2011 - June 18, 2012

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Warren Family Fund Becomes Endowed Professorship, Alicia Rohan

Browse All News

No abstract provided.

Center For Structural Biology Established, Jim Bakken

Browse All News

No abstract provided.

The Prevalence And Characteristics Of Suicidality In Hiv/Aids As Seen In An African Population In Entebbe District, Uganda, Eugene Kinyanda, Susan Hoskins, Juliet Nakku, Saira Nawaz, Vikram Patel

Dartmouth Scholarship

Suicidality in HIV/AIDS is not only a predictor of future attempted suicide and completed suicide, it is also associated with poor quality of life and poor adherence with antiretroviral therapy. This paper examines the prevalence and correlates of suicidality in HIV/AIDS in the African nation of Uganda.

Analysis Of Periapical Biopsies Submitted For Histopathological Evaluation: A Retrospective Study, Abdullah I. Alqaied

Master's Theses

Apical periodontitis is the most common pathological process in the periapical region. Disciplined clinical and radiographic evaluations and appropriate diagnostic tests can detect lesions related to apical periodontitis. Aside from this, lesions mimicking pulp-related pathology but unrelated to pulpal infection and necrosis are occasionally discovered in the periapical region. The objective of this study was two-fold: (1) to determine the prevalence of diverse periapically located pathological entities, and (2) to apply that information to evaluate the rationale for routine submission of surgically obtained tissue for histological examination and diagnosis. Methods: A 5-year retrospective analysis of pathology reports from the UCONN …

Assessment Of The Oxbow Morphology Of The Caloosahatchee River And Its Evolution Over Time: A Case Study In South Florida, Chloe Delhomme

USF Tampa Graduate Theses and Dissertations

The Caloosahatchee River, located in Southern Florida, was originally a meandering and relatively shallow river. During the 1920s, the Caloosahatchee River was channelized and became the C-43 canal. The channelization has significantly impacted the river ecosystem, particularly the oxbows. The oxbows are the U-shaped water bodies on each side of the river channel, which are the remnant bends of the original river. To understand how anthropogenic influence affects hydrologic systems, the proposed case study was designed to assess the geomorphic changes of the oxbows of the Caloosahatchee River, Florida. Understanding and documenting the evolution of river morphology is becoming increasingly …

Mass Spectrometry-Based Strategies For Protein Biophysics: Effects Of Modification, Structure, And Interactions, Richard Yu-Cheng Huang

All Theses and Dissertations (ETDs)

Two important biophysical characteristics of proteins, their interaction with ligands and their post-translational modifications, modulate various biological processes including signal transduction, chemical synthesis, and cell function. Protein-ligand interactions include the interactions with protein, peptide, DNA, and metal. Characterization of the physical properties of these interactions: binding interfaces, binding affinities, and the protein conformational changes due to the binding) is essential in understanding the mechanism of related diseases and, more importantly, in future drug design.

Mass spectrometry, with its own revolution and improvement, becomes a powerful tool in protein and peptide analysis. In this thesis, we applied two mass spectrometry-based strategies, …

Five Nuclear Loci Resolve The Polyploid History Of Switchgrass (Panicum Virgatum L.) And Relatives, Jimmy Triplett, Yunjing Wang, Jinshun Zhong, Elizabeth Kellogg

Biology Department Faculty Works

Polyploidy poses challenges for phylogenetic reconstruction because of the need to identify and distinguish between homoeologous loci. This can be addressed by use of low copy nuclear markers. Panicum s.s. is a genus of about 100 species in the grass tribe Paniceae, subfamily Panicoideae, and is divided into five sections. Many of the species are known to be polyploids. The most well-known of the Panicum polyploids are switchgrass (Panicum virgatum) and common or Proso millet (P. miliaceum). Switchgrass is in section Virgata, along with P. tricholaenoides, P. amarum, and P. amarulum, whereas P. miliaceum is in sect. Panicum. We have …

International Junior Researcher And Engineer Workshop On Hydraulic Structures Session 5, Mohanad Khodier, Adam Witt, Maria Trujillo, Iordanis Moustakidis, Francois Rulot

International Junior Researcher and Engineer Workshop on Hydraulic Structures

No abstract provided.

Carbon And Nitrogen Assimilation In The Bering Sea Clams Nuculana Radiata And Macoma Moesta, Jared Weems, Katrin Iken, Rolf Gradinger, Matthew Wooller

Marine Biology

We analyzed bulk carbon and nitrogen stable isotope values (delta C-13 and delta N-15) of the benthic clams Nuculana radiata and Macoma moesta from the Bering Sea during controlled feeding experiments (spring of 2009 and 2010) using isotopically labeled sea ice algae. The aim was to determine the ability of these clam species to assimilate carbon and nitrogen from sea ice algae. Specimens were collected in the Bering Sea and placed into jars without sediment (2009, N. radiata only) or into natural sediment cores (2010, both species). The clams were offered isotopically enriched (both C and N) or non-enriched algal …

Eastern Washington University Commencement Program, 2012, Eastern Washington University

Commencement Programs

Program for Eastern Washington University's spring commencement in 2012

Resilience, Insight, And Causation As Moderators Of The Relationships Between Trauma, Perceived Stress, Distress, Depression, Salivary Cortisol, And Dhea Through A Writing Intervention In A Diverse Sample Of Hiv-Positive Individuals, Courtney Biondi Kelsch

Open Access Theses

Background: Adverse psychological factors such as depression and stressful life events have been found to accelerate HIV disease progression, while positive factors such as optimism and spirituality have been found to slow progression to AIDS. The potentially protective role of the positive psychological factor resilience in HIV/AIDS has not been studied extensively. The relationship of resilience to depression, trauma, stress, and stress-related biological markers in HIV remains to be elucidated. In addition, written emotional expression interventions have shown promise in positively influencing HIV disease course, although the mechanisms require further study. Purpose: The aims of this study were to explore …

Investigation Of Inclusion Complexation Between Ferrocene Derivatives And Cucurbiturils, Wei Li

Open Access Dissertations

Cucurbiturils are synthetic macrocyclic molecules prepared by condensation reactions between glycouril and formaldehyde under acidic conditions. They feature a pumpkin-like shape with two identical carbonyl-rimed portals and a hydrophobic cavity.The number of glycouril units ranging from 5 to 8 and 10 leads to varying size of the cavity, and results in their different binding properties to numerous guest molecules. Among all the members of the cucurbituril family, cucurbit[7]uril (CB7) has drawn much attention in host-guest systems due to its high level aqueous solubility (20-30 mM) in neutral H [sub]2 O. Also, it exhibits a good ability to complex a variety …

Ampk And Akt Differentially Regulate The Upr In Acute Lymphoblastic Leukemia: Therapeutic Implications., Jeffim N. Kuznetsov

Open Access Dissertations

Acute Lymphoblastic Leukemia (ALL) is the most common hematological malignancy and the main cause of cancer-related death in children. Current chemotherapy treatments based mainly on antifolate regimens have lead to high cure rates (≈80%), however event-free survival (EFS) for children and adults diagnosed with chemotherapy resistant phenotypes of ALL or after the relapse, continues to be dismal (EFS ∼10-20%). High-risk chemotherapy treatment based on intensification strategies and/or the use of stem cell transplantation have led to marginal improvements with limited impact on cure rates of resistant/refractory or relapsed ALL phenotypes. Our studies attempted to discover highly effective treatment strategies for …

The Effects Of Harvesting On Ecological Communities, Douglas Robert Scheib

Open Access Dissertations

In this paper, we derive and study a model for three species interacting via intraguild predation. We assume logistic growth for both the resource and consumer species, and functional responses with saturation, interspecific interference, and intraspecific interference for the predator-prey interactions. This leads to Beddington-DeAngelis-type functional responses. We consider local and global properties of the resource-consumer subsystem, and give conditions for permanence. We then consider permanence in the full system, along with the effects varying some of the parameters has on the invasibility and exclusion of each species. We also look at the effects that harvesting each species in the …

Computational Analysis Of Calcium Signaling And Membrane Electrophysiology In Cerebellar Purkinje Neurons Associated With Ataxia, Leslie M. Loew, Sherry-Ann Brown

UCHC Articles - Research

Background

Mutations in the smooth endoplasmic reticulum (sER) calcium channel Inositol Trisphosphate Receptor type 1 (IP3R1) in humans with the motor function coordination disorders Spinocerebellar Ataxia Types 15 and 16 (SCA15/16) and in a corresponding mouse model, the IP3R1delta18/delta18 mice, lead to reduced IP3R1 levels. We posit that increasing IP3R1 sensitivity to IP3 in ataxias with reduced IP3R1 could restore normal calcium response. On the other hand, in mouse models of the human polyglutamine (polyQ) ataxias, SCA2, and SCA3, the primary finding appears to be hyperactive IP3R1-mediated calcium release. It has been suggested that the polyQ SCA1 mice may also …

Digital Community Voices Committee Programming Inventory For July 2012 Meeting, Dana Neugent, Joseph A. Santiago

Digital Community Voices Committee

Digital Community Voices Committee Programming Inventory for the July 2012 meeting. This will be used by the committee to decide what to show on PBS and RI Interstate in order to showcase past and future diversity programing here at URI.

Eng 2009g-051: Literature And Human Values: Race, Age, Gender, Chris Wixson

Summer 2012

No abstract provided.

Autophagy And Senescence In Cancer-Associated Fibroblasts Metabolically Supports Tumor Growth And Metastasis Via Glycolysis And Ketone Production., Claudia Capparelli, Carmela Guido, Diana Whitaker-Menezes, Phd, Gloria Bonuccelli, Renee Balliet, Timothy G Pestell, Allison F Goldberg, Richard Pestell, Anthony Howell, Sharon Sneddon, Ruth Birbe, Aristotelis Tsirigos, Ubaldo E. Martinez-Outshoorn, Federica Sotgia, Michael P. Lisanti

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Senescent fibroblasts are known to promote tumor growth. However, the exact mechanism remains largely unknown. An important clue comes from recent studies linking autophagy with the onset of senescence. Thus, autophagy and senescence may be part of the same physiological process, known as the autophagy-senescence transition (AST). To test this hypothesis, human fibroblasts immortalized with telomerase (hTERT-BJ1) were stably transfected with autophagy genes (BNIP3, CTSB or ATG16L1). Their overexpression was sufficient to induce a constitutive autophagic phenotype, with features of mitophagy, mitochondrial dysfunction and a shift toward aerobic glycolysis, resulting in L-lactate and ketone body production. Autophagic fibroblasts also showed …

Ctgf Drives Autophagy, Glycolysis And Senescence In Cancer-Associated Fibroblasts Via Hif1 Activation, Metabolically Promoting Tumor Growth., Claudia Capparelli, Diana Whitaker-Menezes, Carmela Guido, Renee Balliet, Timothy G Pestell, Anthony Howell, Sharon Sneddon, Richard Pestell, Ubaldo E. Martinez-Outshoorn, Michael P. Lisanti, Federica Sotgia

Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations

Previous studies have demonstrated that loss of caveolin-1 (Cav-1) in stromal cells drives the activation of the TGF-β signaling, with increased transcription of TGF-β target genes, such as connective tissue growth factor (CTGF). In addition, loss of stromal Cav-1 results in the metabolic reprogramming of cancer-associated fibroblasts, with the induction of autophagy and glycolysis. However, it remains unknown if activation of the TGF-β / CTGF pathway regulates the metabolism of cancer-associated fibroblasts. Therefore, we investigated whether CTGF modulates metabolism in the tumor microenvironment. For this purpose, CTGF was overexpressed in normal human fibroblasts or MDA-MB-231 breast cancer cells. Overexpression of …

Millipeds From The Eastern Dakotas And Western Minnesota, Usa, With An Account Of Pseudopolydesmus Serratus (Say, 1821) (Polydesmida: Polydesmidae); First Published Records From Six States And The District Of Columbia, Rowland M. Shelley, Bruce A. Snyder

Insecta Mundi

The diplopod orders Callipodida and Polydesmida, and their respective families Abacionidae and Xystodesmidae, are initially recorded from South Dakota as is Polydesmidae from North Dakota. Other new records of indigenous taxa include Abacion Rafinesque, 1820/A. texense (Loomis, 1937) and Pleuroloma/P. flavipes, both by Rafinesque, 1820, from South Dakota, and Pseudopolydesmus Attems, 1898/P. serratus (Say, 1821) from Alabama, Connecticut, Delaware, New Hampshire, North Dakota, South Carolina, and the District of Columbia. New records of Aniulus garius Chamberlin, 1912, A. (Hakiulus) d. diversifrons (Wood, 1867), and Oriulus venustus (Wood, 1864) (Julida: Parajulidae) are provided for western Minnesota and/or eastern …

Two New Genera Of Hispines (Coleoptera: Chrysomelidae: Cassidinae) From Ecuador, C. L. Staines, Laura Zamorano

Insecta Mundi

Bicristispa gracilis, new genus and new species, and Orbispa confluens, new genus and new species (Coleoptera: Chrysomelidae: Cassidinae), both from canopy fogging material from Ecuador are described and illustrated. Comparative notes distinguishing them from similar genera are provided.

Snoqualmia, A New Polydesmid Milliped Genus From The Northwestern United States, With A Description Of Two New Species (Diplopoda, Polydesmida, Polydesmidae), William A. Shear

Insecta Mundi

Snoqualmia, new genus, is described for two species of polydesmid millipeds from the northwestern United States: Snoqualmia snoqualmie, new species, from Washington State, and S. idaho, new species, from Idaho. Males of S. idaho possess unusually complex gonopods, perhaps the most complex to be found in the Order Polydesmida. Snoqualmia is placed in context with other polydesmid genera known from North America. The polydesmid fauna of North America is discussed, as well as characters of the gonopods of the family.

Tropidosteptes Forestierae (Hemiptera: Heteroptera: Miridae: Mirinae): A New Species Of Plant Bug Injuring Ornamental Florida Swampprivet, Forestiera Segregata (Oleaceae), In South Florida, Thomas J. Henry, Doug L. Caldwell, Susan E. Halbert

Insecta Mundi

The mirine plant bug Tropidosteptes forestierae, new species (Hemiptera: Miridae) is described from Collier County, Florida, where it was found causing serious injury to an extensive ornamental hedge of Florida swampprivet, Forestiera segregata (Jacq.) Krug and Urb. (Oleaceae). Adult male and female, fifth instar, and egg are described. Color images of the adults, nymph, egg, and injury; scanning photomicrographs of selected adult structures; and illustrations of male genitalia are provided. A key to help distinguish the 16 species of Tropidosteptes known to occur in the southeastern United States is given.

Single-Molecule Tools Elucidate H2a.Z Nucleosome Composition, Jiji Chen, Andrew Miller, Ann L. Kirchmaier, Joseph M.K. Irudayaraj

Birck and NCN Publications

Although distinct epigenetic marks correlate with different chromatin states, how they are integrated within single nucleosomes to generate combinatorial signals remains largely unknown. We report the successful implementation of single molecule tools constituting fluorescence correlation spectroscopy (FCS), pulse interleave excitation-based Forster resonance energy transfer (PIE-FRET) and fluorescence lifetime imaging-based FRET (FLIM-FRET) to elucidate the composition of single nucleosomes containing histone variant H2A.Z (Htz1p in yeast) in vitro and in vivo. We demonstrate that yeast nucleosomes containing Htz1p are primarily composed of H4 K12ac and H3 K4me3 but not H3 K36me3 and that these patterns are conserved in mammalian cells. Quantification …