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Articles 5011 - 5040 of 22916
Full-Text Articles in Entire DC Network
Teacher Motivation As An Enhancement To The First Step To Success Early Intervention Program For Children With Tertiary Level Behavioral Challenges., Jon Lee
Electronic Theses and Dissertations
The First Step to Success early intervention program (Walker, 1998) is a secondary prevention intervention that targets primary grade children with moderate or emerging behavior disorders. While the effectiveness of the First Step to Success early intervention program has been documented repeatedly (see Loman, Rodriguez, & Homer, 2010; Walker et aI., 2009), it has also been shown to be less effective with more severely disordered children and has a less dramatic impact on behavior in the home than in the school setting. Efforts to enhance the program's effectiveness with even the most severely behaviorally disordered children have been undertaken, and …
In Vivo And In Vitro Digestibility Of A Complete Pelleted Feed In Horses, Cassandra Renee Sweeney
In Vivo And In Vitro Digestibility Of A Complete Pelleted Feed In Horses, Cassandra Renee Sweeney
Master's Theses
ABSTRACT
COMPLETION OF AN IN VIVO DIGESTIBILITY TRIAL IN HORSES AND IN VITRO DIGESTIBILITY ASSAY DEVELOPMENT
Cassandra Renee Sweeney
In vivo analysis of equine feed digestibility has been the gold standard since the late 1800's, although it can be time consuming, costly, and labor intensive. In vitro digestibility analysis may be more economical and beneficial to both feed manufacturers and consumers. The availability of accurate in vivo data is crucial for critical evaluation and validation of any potential in vitro method (Coles et al., 2005). Ten adult American quarter horse geldings were used in the in vivo digestibility evaluation of …
Mitochondrial Fission Induces Glycolytic Reprogramming In Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, And Early Tumor Growth., Carmela Guido, Diana Whitaker-Menezes, Zhao Lin, Richard G Pestell, Anthony Howell, Teresa A Zimmers, Mathew C Casimiro, Saveria Aquila, Sebastiano Ando', Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti
Mitochondrial Fission Induces Glycolytic Reprogramming In Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, And Early Tumor Growth., Carmela Guido, Diana Whitaker-Menezes, Zhao Lin, Richard G Pestell, Anthony Howell, Teresa A Zimmers, Mathew C Casimiro, Saveria Aquila, Sebastiano Ando', Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti
Department of Stem Cell Biology and Regenerative Medicine Faculty Papers & Presentations
Recent studies have suggested that cancer cells behave as metabolic parasites, by inducing oxidative stress in adjacent normal fibroblasts. More specifically, oncogenic mutations in cancer cells lead to ROS production and the "secretion" of hydrogen peroxide species. Oxidative stress in stromal fibroblasts then induces their metabolic conversion into cancer-associated fibroblasts. Such oxidative stress drives the onset of autophagy, mitophagy, and aerobic glycolysis in fibroblasts, resulting in the local production of high-energy mitochondrial fuels (such as L-lactate, ketone bodies, and glutamine). These recycled nutrients are then transferred to cancer cells, where they are efficiently burned via oxidative mitochondrial metabolism (OXPHOS). We …
Weaponizing Tear Gas: Bahrain’S Unprecedented Use Of Toxic Chemical Agents Against Civilians., Richard Sollom, Holly G. Atkinson
Weaponizing Tear Gas: Bahrain’S Unprecedented Use Of Toxic Chemical Agents Against Civilians., Richard Sollom, Holly G. Atkinson
Publications and Research
The Bahraini government’s response to the early 2011 pro-democracy protests was brutal, systematic, and violent. In addition to birdshot and rubber bullets, government law enforcement attacked unarmed protestors with toxic chemical agents including tear gas. The government’s crackdown on the medical profession was especially harmful, as security forces arrested and detained doctors, raided health facilities, and obstructed patients from receiving necessary care. This report’s findings are based on field research that the authors conducted in Bahrain (April 2012) to investigate excessive use of force by law enforcement officials since June 2011—the end of Bahrain’s state of emergency. The medico-legal team …
Trident - August 2012, Dugoni School Of Dentistry
Trident - August 2012, Dugoni School Of Dentistry
Trident
The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.
Alternative Annual Forage Crop Options For Northern Great Plains Cattle Producers: A South Dakota Case Study, Md Parvez, Scott Fausti, Thandiwe Nleya, Patricia Johnson, Kenneth Olsen, John Rickertsen
Alternative Annual Forage Crop Options For Northern Great Plains Cattle Producers: A South Dakota Case Study, Md Parvez, Scott Fausti, Thandiwe Nleya, Patricia Johnson, Kenneth Olsen, John Rickertsen
Economics Staff Paper Series (1969 - 2017)
In the Northern Great Plains region, crop and livestock producers view forage crop production as an important component of their farm management system. During periods of increased environmental risk, alternative annual forage crops may provide producers with a risk reducing alternative to traditional forage crops. An alternative forage crop production study (20 varieties) was conducted by South Dakota State University. Production yield data was analyzed using alternative decision making criteria when outcomes are uncertain. Empirical results provide insight on forage crop planting decisions with respect to the importance of optimal harvest timing, and the ranking of alternative forage crops as …
Investing In An Agricultural Legacy, Leo Paul Goeringer
Investing In An Agricultural Legacy, Leo Paul Goeringer
Graduate Theses and Dissertations
America's agricultural producers continue to age. According to the U.S. Census of Agriculture, the average age of farm operators increased from 55.3 in 2002 to 57.1 in 2007. During the same period, the Census shows a thirty percent decrease in the number of farmers under age 25. Young and beginning producers (YBPs) entering agriculture face high startup costs and a shortage of land to own or rent.
With these concerns in mind, this manuscript details the impact of an innovative proposed loan program for YBPs in Arkansas, which would offer concessionary interest rates and loan fees by participating banks for …
Brief For The National Black Law Students Association As Amicus Curiae In Support Of Respondents, Deborah N. Archer, Aderson Francois, Susan Abraham, New York Law School Racial Justice Project
Brief For The National Black Law Students Association As Amicus Curiae In Support Of Respondents, Deborah N. Archer, Aderson Francois, Susan Abraham, New York Law School Racial Justice Project
Briefs, Court Filings, and Testimonies
August 2012
The National Black Law Students Association (―NBLSA‖) submits this brief as amicus curiae in support of Respondents, urging this Court to affirm the ruling of the United States Court of Appeals for the Fifth Circuit upholding the race-conscious admissions policy of the University of Texas at Austin (―UT Austin‖).1 NBLSA is a membership organization formed in 1968 to promote the educational, professional, political, and social objectives of Black law students. Today, NBLSA is the largest student-run organization in the United States, with nearly 6,000 members, over 200 chapters in our nation‘s law schools, a growing prelaw division, and …
Humboldt Bay And Eel River Estuary Benthic Habitat Project, Susan Schlosser, Annie Eicher
Humboldt Bay And Eel River Estuary Benthic Habitat Project, Susan Schlosser, Annie Eicher
Local Reports and Publications
The Humboldt Bay and Eel River Estuary Benthic Habitat Project (Habitat Project) was intended to support an ecosystem-based management approach to natural resources in the Humboldt Bay ecosystem. The Habitat Project report provides a summary of intertidal and subtidal habitat information, building on previous assessments, plans and profiles.
The Effect Of Granular Activated Carbon Pretreatment And Sand Pretreatment On Microfiltration Of Greywater, David Christopher
The Effect Of Granular Activated Carbon Pretreatment And Sand Pretreatment On Microfiltration Of Greywater, David Christopher
All Theses
Around the world, water scarcity is driving people to practice water reuse. One form of water reuse is the recycling of greywater, which is household wastewater excluding toilet waste. With adequate treatment, greywater may be recycled onsite for applications that do not require potable water, such as irrigation or toilet flushing. Membrane filtration (including microfiltration (MF)) is one option for greywater treatment. The small footprint, modular nature, and predictable performance of MF make it an attractive option. However, direct MF of greywater can lead to rapid membrane fouling. This thesis investigated two possible pretreatments for reducing membrane fouling and improving …
Effects Of Physiological Dynamic Compression Loading On Gold Nanoparticle Permeation Of Articular Cartilage, Britton Mccaskill
Effects Of Physiological Dynamic Compression Loading On Gold Nanoparticle Permeation Of Articular Cartilage, Britton Mccaskill
All Theses
Articular cartilage is essential part of the human body that aids in support and locomotion. It has unique biochemical and biomechanical properties that allow it to act as a shock absorber to disperse and distribute loading of the joints. However, it has a limited capacity to repair itself because it is not vascularized and must receive its nutrients from the surrounding synovial fluid. Articular cartilage damage can lead to many pathological conditions, including osteoarthritis. Currently, there are many surgical treatment methods that repair some of the damage if it is localized, but for widespread degradation seen in osteoarthritis, there are …
Eco-Theatre And New Media: Devising Toward Transnational Balance, Marnie Jane Glazier
Eco-Theatre And New Media: Devising Toward Transnational Balance, Marnie Jane Glazier
Dissertations
This dissertation seeks to address the pivotal ecological and technological realities of the twenty-first century, currently giving rise to new patterns of existence and new paradigms of human inquiry. This study will ask how technological innovation and environmental urgency have altered the ways in which human beings think, and thus perceive the world around them, changing human behavior, or non-behavior, and calling forth new imperatives for the arts, and namely for the Theatre. Most significantly, the dissertation attempts to traverse the shadow-lands, between our ecologies and our technologies, exploring those essential points of convergence in the borderlands where Eco-Theatre and …
Transgene Delivery Via Microelectromechanical Systems, Aubrey Marie Mueller Wilson
Transgene Delivery Via Microelectromechanical Systems, Aubrey Marie Mueller Wilson
Theses and Dissertations
The invention of pronuclear microinjection initiated the field of transgenic research. Over 30 years later microinjection remains the most straight-forward and most commonly used transgene delivery option. In this work we address the current progress of microelectromechanical systems (MEMS) used as transgenic delivery mechanisms. The nanoinjector is a specially designed MEMS device which uses electrostatic charge to manipulate transgene molecules. The process of nanoinjection was designed as an alternative to microinjection which causes less damage to developing embryos, improves embryo survival, birth rates, and overall efficiency of injections. In vivo testing of nanoinjection demonstrates it is both safe and effective. …
How The Cucumber Tendril Coils And Overwinds, Sharon J. Gerbode, Joshua R. Puzey, Andrew G. Mccormick, L. Mahadevan
How The Cucumber Tendril Coils And Overwinds, Sharon J. Gerbode, Joshua R. Puzey, Andrew G. Mccormick, L. Mahadevan
All HMC Faculty Publications and Research
The helical coiling of plant tendrils has fascinated scientists for centuries, yet the underlying mechanism remains elusive. Moreover, despite Darwin’s widely accepted interpretation of coiled tendrils as soft springs, their mechanical behavior remains unknown. Our experiments on cucumber tendrils demonstrate that tendril coiling occurs via asymmetric contraction of an internal fiber ribbon of specialized cells. Under tension, both extracted fiber ribbons and old tendrils exhibit twistless overwinding rather than unwinding, with an initially soft response followed by strong strain-stiffening at large extensions. We explain this behavior using physical models of prestrained rubber strips, geometric arguments, and mathematical models of elastic …
The Evolution Of Mutualism Between Alpheid Shrimp And Gobiid Fishes: A Balance Between Benefits And Costs, Patrick Lyons
The Evolution Of Mutualism Between Alpheid Shrimp And Gobiid Fishes: A Balance Between Benefits And Costs, Patrick Lyons
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
I describe several assays designed to examine how costs and benefits interact in the development of mutualisms between species. A mutualism occurs between alpheid shrimp and gobiid fishes. These shrimp have poor vision but good burrowing ability. Individual shrimp share their burrows with a goby that, with good vision but no burrowing ability, acts as a watch-out warning shrimp when predators approach. In the Caribbean, a single species, Nes longus, which has been described as a mutualist, follows these behaviors. Others, such as Ctenogobius saepepallens, casually use shrimp burrows, rarely warn shrimp of danger, and are better described as commensalists. …
The Synthesis And Polymerization Behavior Of Polyynes, Racquel Campo Decicco
The Synthesis And Polymerization Behavior Of Polyynes, Racquel Campo Decicco
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Polyynes are 1-dimensional rods composed of sp-hybridized carbon atoms, which have attracted much interest due to their electronic, optical, and physical properties. These carbon oligomers can serve as possible precursors to graphitic ribbons, as subjecting aggregates to heat and/or irradiation can lead to topochemical polymerization. Furthermore, polyynes can serve as models for understanding conjugation, and can be used to predict the properties of carbyne, the linear allotrope of carbon. In this work, the synthesis, characterization, and polymerization behavior of polyynes with various end groups have been thoroughly explored. An iterative synthetic strategy was developed to prepare tetraynes, pentaynes, hexaynes, and …
Investigation Into Pathological Responses Of Two Phenotypes Of The Scleractinian Coral, Montastraea Faveolata, To Putative Marine Vibrio Pathogens, Angela Michele Richards Donì
Investigation Into Pathological Responses Of Two Phenotypes Of The Scleractinian Coral, Montastraea Faveolata, To Putative Marine Vibrio Pathogens, Angela Michele Richards Donì
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Corals of the genus Montastraea in the Caribbean are highly susceptible to disease, although not all neighboring colonies appear to be affected on the same time scales. Stressed corals are unable to function optimally and are less likely to be reproductively successful than those that are not stressed. Montastraea spp. corals, like all corals from the order Scleractinia, are adapted to the narrow ranges in temperature and irradiance found in tropical waters. These environmental factors play an important role in a coral colony's ability to maintain homeostasis and excursions from their normal ranges for extended periods of time can trigger …
Numerical Differential Geometry And Its Applications, Duo Wang
Numerical Differential Geometry And Its Applications, Duo Wang
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
We describe a unified computational framework for polynomial fitting method based on weighted least squares approximations. This framework is first motivated by computing normals and curvatures on discrete surface mesh, then it is extended to construct the continuous global surface and calculate high order surface integration. Finally, the idea of generalized finite difference method is extracted by inverting the Vandermonde matrix from local polynomial fitting, it will be used to solve various geometric geometric partial differential equations and an elastic membrane problem. Different applications require different techniques and impose different challenges including simplicity, accuracy, continuity, robustness and efficiency. Our research …
Gothic Elements And Racial Stereotypes In The Construction Of The Passing Character, Kimberly Divonne Smith
Gothic Elements And Racial Stereotypes In The Construction Of The Passing Character, Kimberly Divonne Smith
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Gothic Elements and Racial Stereotypes In the Construction Of The Passing Character By Kimberly Divonne Smith Doctor of Philosophy In English Stony Brook University 2012 My dissertation analyzes the construction of the passing character in the American literary tradition as s/he is depicted by both black and white authors through their use of gothic elements, in ways that challenged or substantiated racial stereotypes (or sometimes both). Furthermore, this study demonstrates how the passing figure reflects the enduringly haunting racial landscapes of America. Specifically, this comparative study critiques the works of Mark Twain, Charles Chesnutt, Nella Larsen, Danzy Senna, and William …
Using Biomechanics To Study Cell Behavior, Chung-Chueh Chang
Using Biomechanics To Study Cell Behavior, Chung-Chueh Chang
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
To develop stem cells based regenerative therapies, more efficient scaffolds are needed. Here we demonstrate how polymeric elastomer scaffolds can be used to induce differentiation of dental pulp stem cells (DPSCs) through surface interactions in the absence of chemical inducers. We show how these elastomers support DPSC proliferation and adhesion when plated directly on the uncoated polymer surfaces. Instead of physically or chemically crosslinking the polymers, we use the principal of entangled polymer surface confinement (EPSC) to continuously vary the substrate modulus and imprint patterns where only the underlying mechanics are varied while the surface chemistry and topography remains unchanged. …
Substrate Chemistry, Mechanics And Morphology Influence Stem Cell Differentiation And Biomineralization, Aneel K. Bherwani
Substrate Chemistry, Mechanics And Morphology Influence Stem Cell Differentiation And Biomineralization, Aneel K. Bherwani
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Abstract 1:DPSC were obtained from pulp tissues of extracted wisdom teeth under protocols approved by the Stony Brook University Internal Review Board. Primary cells were isolated by enzymatic digestion and used from 3rd-5th passage. For experiments on differentiation, cultures were grown in alpha-MEM supplemented with 10% fetal bovine serum, 0.2 mM L-ascorbic acid 2- phosphate, 2 mm glutamine, 10 mM beta-glycerol phosphate either with or without 10 nM dexamethasone. After 21-days samples were examined using confocal microscopy of cells stained with Alexafluor 488-linked phalloidin and propidium iodide, and by scanning electron microscopy (SEM) and Energy dispersive X-ray Analysis (EDAX). Using …
Aerobic And Anaerobic Ammonia Oxidizers In The Cariaco Basin: Identification, Quantification And Community Structure, Sara Cernadas Martin
Aerobic And Anaerobic Ammonia Oxidizers In The Cariaco Basin: Identification, Quantification And Community Structure, Sara Cernadas Martin
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
Fluorescence in situ hybridization (FISH) and quantitative PCR (q-PCR) analyses were performed to characterize the populations mediating ammonium oxidation processes in the oxic, suboxic and anoxic layers of the Cariaco Basin (Venezuela). To examine possible metabolic connections between nutrients and functional groups, distributions were compared to nutrient availability. Anaerobic ammonia-oxidizing bacteria (anammox), aerobic ammonia-oxidizing bacteria (AOB), and ammonia-oxidizing Archaea (AOA) were quantified within the water column. Two peaks in abundance of anammox bacteria were consistently observed during the three cruises that took place on December 8, 2010; May 6, 2011 and November 9, 2011 (C-175, C-180 and C-186). One peak …
Two P53 Mutants Display Differential Gain-Of-Function Effects On Tumorigenesis In Vivo, Walter George Hanel
Two P53 Mutants Display Differential Gain-Of-Function Effects On Tumorigenesis In Vivo, Walter George Hanel
Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)
p53 is a transcription factor which promotes cell cycle arrest, DNA damage repair, and apoptosis in the presence of DNA damage or oncogenic signaling. It is mutated in more than half of all human cancers demonstrating its clinical significance. Most studies have shown mutation of p53 to be associated with a poor clinical outcome for a broad variety of tumors. Unlike most other tumor suppressors which undergo genomic loss or silencing during tumor progression, p53 undergoes missense mutation within its coding region with retention of expression of the mutated protein in tumors. More importantly, mutant p53 proteins undergo drastic stabilization …
Hormonal Induction Of Polo-Like Kinases (Plks) And Impact Of Plk2 On Cell Cycle Progression In The Rat Ovary, Feixue Li, Misung Jo, Thomas E. Curry, Jing Liu
Hormonal Induction Of Polo-Like Kinases (Plks) And Impact Of Plk2 On Cell Cycle Progression In The Rat Ovary, Feixue Li, Misung Jo, Thomas E. Curry, Jing Liu
Obstetrics and Gynecology Faculty Publications
The highly conserved polo-like kinases (Plks) are potent regulators of multiple functions in the cell cycle before and during mitotic cell division. We investigated the expression pattern of Plk genes and their potential role(s) in the rat ovary during the periovulatory period. Plk2 and Plk3 were highly induced both in intact ovaries and granulosa cells in vivo after treatment with the luteinizing hormone (LH) agonist, human chorionic gonadotropin (hCG). In vitro, hCG stimulated the expression of Plk2 in granulosa cells, but not Plk3. This induction of Plk2 expression was mimicked by both forskolin and phorbol 12 myristate 13-acetate (PMA). Moreover, …
Sediment Mixing In The Tropical Pacific And Radiolarian Stratigraphy, Ted C. Moore Jr, Larry A. Mayer, Mitchell Lyle
Sediment Mixing In The Tropical Pacific And Radiolarian Stratigraphy, Ted C. Moore Jr, Larry A. Mayer, Mitchell Lyle
Center for Coastal and Ocean Mapping
The reworking of older radiolarian microfossils into near-surface sediments of the tropical Pacific has long been the source of confusion for the development of radiolarian stratigraphy and of puzzlement over the mechanism(s) that could effect such pervasive reworking. Widespread dissolution “pits” in the sediments of the tropical Pacific are believed to be associated with hydrothermal circulation cells in the older oceanic crust and are here linked to processes which expose older sections and inject older non-carbonate material into near-bottom waters. Discharging waters of these circulation cells tend to dissolve carbonate in near-surface sediments; thus, only the non-carbonate material (including radiolarians) …
Production And Degradation Of 4-Ethylphenol In Lactobacillus Sp. Pep8 Cultures And In Blended Swine Lagoon Enrichments, Clinton W. Copp
Production And Degradation Of 4-Ethylphenol In Lactobacillus Sp. Pep8 Cultures And In Blended Swine Lagoon Enrichments, Clinton W. Copp
Masters Theses & Specialist Projects
4-Ethylphenol (4-EP) is a malodorant of swine waste and is derived from a component of lignin called p-coumaric acid (p-CA). The production of 4-EP from lignin in swine waste is untested. Additionally, the effect of Fe (III) on 4-EP levels is unknown. Four experiments were performed to determine if Lactobacillus sp. pep8 cultures, as well as enriched swine lagoon slurries, could liberate p-CA from lignin and convert p-CA to 4-EP. Furthermore, it was tested if the addition of Fe (III) influences the conversion of p- CA to 4-EP.
Experiment 1 tested Lactobacillus sp. pep8 cultures to determine if the addition …
Extending Story Listening As A Practice Of Communal Formation At The Lake Orion Church Of Christ, Eric R. Magnusson
Extending Story Listening As A Practice Of Communal Formation At The Lake Orion Church Of Christ, Eric R. Magnusson
Doctor of Ministry Theses and Dissertations
This doctor of ministry thesis presents the results of a project that explores the potential for extending a practice of story listening as a way of forming community across social circles at the Lake Orion Church of Christ in Lake Orion, Michigan. The intervention involved guiding a group of six participant-researchers, each of whom had previous experience in story listening, through six sessions in the fall of 2011. Each phase of the project was informed by a participatory social Trinitarian theology. The first three sessions were designed to empower participant-researcher pairs to facilitate story listening groups of four to five …
2012 Tsu Undergraduate Research Program, David Owerbach
2012 Tsu Undergraduate Research Program, David Owerbach
Office of Research Institutional Research and Scholarship
No abstract provided.
Influence Of Solvent On The Chiral Resolution Of Organic Molecules On Au(111): Ec-Stm Study Of Biphenyl Dicarboxylic Acid On Au(111) In An Aqueous Environment, Byung I. Kim, Joey Hanson, Matthew Turner, Lauren Reeder
Influence Of Solvent On The Chiral Resolution Of Organic Molecules On Au(111): Ec-Stm Study Of Biphenyl Dicarboxylic Acid On Au(111) In An Aqueous Environment, Byung I. Kim, Joey Hanson, Matthew Turner, Lauren Reeder
Physics Faculty Publications and Presentations
Adsorption-induced chiral resolution of organic molecules is important due to its potential applications in stereo-selective catalysis. We studied the adsorption-induced chiral resolution using a model achiral molecule of 4,4′ biphenyl dicarboxylic acid (BPDA) on Au(111) in 0.1 M perchloric acid (HClO4) by electrochemical scanning tunneling microscopy (EC-STM). Our experimental data showed that the BPDA molecules formed island structures with distinctive preferred orientations at the length scale of the molecular size. The molecules did not show any orientational ordering above the length scale, indicating that chiral resolution was absent in the aqueous environment. Previously, the molecules were found to …
Low Gene Expression Of Bone Morphogenetic Protein 7 In Brainstem Astrocytes In Major Depression, Gregory A. Ordway, Attila Szebeni, Michelle J. Chandley, Craig A. Stockmeier, Lianbin Xiang, Samuel S. Newton, Gustavo Turecki, Michelle M. Duffourc, Meng Yang Zhu, Hobart Zhu, Katalin Szebeni
Low Gene Expression Of Bone Morphogenetic Protein 7 In Brainstem Astrocytes In Major Depression, Gregory A. Ordway, Attila Szebeni, Michelle J. Chandley, Craig A. Stockmeier, Lianbin Xiang, Samuel S. Newton, Gustavo Turecki, Michelle M. Duffourc, Meng Yang Zhu, Hobart Zhu, Katalin Szebeni
ETSU Faculty Works
The noradrenergic locus coeruleus (LC) is the principal source of brain norepinephrine, a neurotransmitter thought to play a major role in the pathology of major depressive disorder (MDD) and in the therapeutic action of many antidepressant drugs. The goal of this study was to identify potential mediators of brain noradrenergic dysfunction in MDD. Bone morphogenetic protein 7 (BMP7), a member of the transforming growth factor-β superfamily, is a critical mediator of noradrenergic neuron differentiation during development and has neurotrophic and neuroprotective effects on mature catecholaminergic neurons. Real-time PCR of reversed transcribed RNA isolated from homogenates of LC tissue from 12 …