Digital Commons Network^™

The Psychiatric Residual Effects From Methamphetamine Use, Janet Ann Larson

Theses and Dissertations

Psychiatric symptoms including psychosis and anxiety-like states have been linked to methamphetamine (MA) use, with severity of psychiatric symptoms has been correlated to duration of use. Prolonged psychiatric residual symptoms have been observed and reported, but there have been no studies that have examined residual effects beyond 12 months of abstinence. There are no studies to date which focus on anger, anxiety, and perception of stress as residual effects following 12 months of abstinence. The purpose of this study was to elucidate whether the critical variables of age, gender, and previous substance use influence the experience of anger, anxiety. and …

Keratin 6 As A Potential Biomarker Of Bladder Cancer Induced By Heavy Metals, Arsenic And Cadmium, Ling Cao

Theses and Dissertations

Arsenic and cadmium (Cd2+) are environmental carcinogens that have been implicated in the development of bladder cancer. However, there are no good in vitro model systems to study the development of bladder cancer caused by these carcinogens. Previous studies from this laboratory have shown that arsenite (As3+) and Cd2+ exposure can cause direct malignant transformation of an immortalized human urothelial cell line, the UROtsa. In the present study the repeatability of the transformation process was examined by isolating and characterizing 6 additional Cd2+- transformed lines and 5 additional As3+- transformed cell lines. All the transformed cell lines formed tumors when …

Leptin Expression And Signaling At The Confluence Of Neurodegenerative Mechanisms In Alzheimer Disease, Gurdeep Singh Atamjit Marwarha

Theses and Dissertations

Alzheimer Disease (AD) is a progressive, debilitating and the most prevalent neurodegenerative disorder affecting 5.5 million people and the sixth leading cause of fatality in the United States. The etiology of AD is not understood and clinically FDA-approved drugs offer only symptomatic relief for a short period of time and in only a subset of AD patients. AD is histopathologically characterized by the presence of extracellular deposits of aggregated Amyloid β (Aβ) peptide as plaques and the intracellular deposition of aggregated hyperphosphorylated tau protein as neurofibrillary tangles (NFT). Leptin, an adipocytokine, has been demonstrated to reduce the genesis of Aβ, …

Post-Translational Regulation Of The Dopamine Transporter, Amy E. Moritz

Theses and Dissertations

The dopamine transporter (DAT) is an integral membrane phosphoprotein found on dopaminergic neurons that mediates the presynaptic reuptake of dopamine and is a site of action for psychostimulants. Numerous DAT functions including efflux, uptake activity, and surface expression are regulated by protein kinase C (PKC) through unknown mechanisms. Basal and PKC stimulated phosphorylation of DAT occurs on multiple serines in the distal N-terminus, but the exact sites modified and the kinases involved are unknown. To address these issues, we examined in vitro phosphorylation of a recombinant DAT N-terminal tail peptide (NDAT). We found that NDAT is phosphorylated at multiple sites …

Synthesis Of Bidentate Ligands Using Cyclopalladated Complexes, Valeria A. Stepanova

Theses and Dissertations

Aminophosphines, diphosphines and related chelating P-containing bidentate ligands, due to their versatile structural features, are considered promising enantioselective catalyst alternatives to symmetric and monodentate phosphine ligands. There are several methods for preparation of such P,N-ligands; however, they are mostly limited to specific cases. In this dissertation, the development of a new general method for synthesis of P-containing bidentate ligands is described. The approach studied is based on using reactions of cyclopalladated complexes (CPCs) with LiPPh2, KPPh2 and HPPh2. This study is the first example of a systematic investigation of reactions of CPCs at a C–Pd bond with phosphorus nucleophiles. A …

Heavy Metal Chemistry Of Sediments In Caves Of The Springfield Plateau, Missouri-Arkansas-Oklahoma: A Link To Subterranean Biodiversity, Travis M. Doughty, Aaron W. Johnson

The Compass: Earth Science Journal of Sigma Gamma Epsilon

We used X-ray fluorescence (XRF) to compare the heavy metal chemistry of sediments in caves in rural and urban areas to the chemistry of sediments from a control cave in a relatively undisturbed watershed in the Springfield (MO) Plateau. Sediment from Smallin Cave near Ozark, MO, the control cave, has the smallest peak sizes for Zn and Mn and a moderately-sized Pb peak. Sediment from the rural cave exhibited larger peaks of Zn and Mn and a smaller Pb peak. Sediment from the urban cave had the largest Zn, Mn and Pb peaks. Interestingly, smaller peak sizes appear to correlate …

Is Geology A Real Science?, Larry E. Davis

The Compass: Earth Science Journal of Sigma Gamma Epsilon

No abstract provided.

Dinosaur Tracks And Trackways In The Escalante Member Of The Entrada Formation (Middle Jurassic), Twentymile Wash, Grand Staircase-Escalante National Monument, Utah, Robert L. Eves, Gayle L. Pollock, Larry E. Davis

The Compass: Earth Science Journal of Sigma Gamma Epsilon

No abstract provided.

Using Macroinvertebrate Community Composition To Distinguish Between Natural And Anthropogenic Sedimentation, Amanda E. Schutt

Theses and Dissertations

Excess fine sediment from human activity is a major pollutant to streams across the U.S.; however, distinguishing human-induced sedimentation from natural fine sediment is complex. The U.S. Environmental Protection Agency recently implemented a protocol for the quantitative field assessment of human-induced sedimentation using measurements of stream geomorphology. Macroinvertebrate community composition, streambed sediment stability, and sediment composition were studied at 49 sites in the James River watershed in central Virginia. Sediment composition was found to be a stronger driver of community composition than sediment stability. Although I was not able to show that macroinvertebrate metrics were related to sediment stability independently …

Human Cytomegalovirus Induces Tlr4 Signaling Components In Monocytes Altering Tirap, Tram And Downstream Interferon-Beta And Tnf-Alpha Expression., Kok-Hooi Yew, Cory Carpenter, R Scott Duncan, Christopher J. Harrison

Manuscripts, Articles, Book Chapters and Other Papers

Using TLR pathways, primary human cytomegalovirus (HCMV) induces innate responses including the production of inflammatory cytokines. Mounting evidence suggests that LPS recognition by TLR4/MD2/CD14 results in differential utilization of TIRAP-TRAF6 and TRAM-TRIF signaling, thereby leading to transcriptional activation of various cytokine genes. However, relative roles of the TLR4/MD2/CD14 complex and its adaptor proteins TIRAP and TRAM involved in regulating monocyte responses to HCMV are incomplete. Here, we provided evidence supporting the notion that the TLR4/MD2/CD14 complex contributes notably to HCMV-induced signaling and subsequent cytokine production in monocytes. In particular, induction of both IL-6 and IL-8 is associated with elevated TIRAP …

Human Cytomegalovirus Induces Tlr4 Signaling Components In Monocytes Altering Tirap, Tram And Downstream Interferon-Beta And Tnf-Alpha Expression, Kok-Hooi Yew, Cory Carpenter, R. Scott Duncan, Christopher J. Harrison

Student Publications

Using TLR pathways, primary human cytomegalovirus (HCMV) induces innate responses including the production of inflammatory cytokines. Mounting evidence suggests that LPS recognition by TLR4/MD2/CD14 results in differential utilization of TIRAP-TRAF6 and TRAM-TRIF signaling, thereby leading to transcriptional activation of various cytokine genes. However, relative roles of the TLR4/MD2/CD14 complex and its adaptor proteins TIRAP and TRAM involved in regulating monocyte responses to HCMV are incomplete. Here, we provided evidence supporting the notion that the TLR4/MD2/CD14 complex contributes notably to HCMV-induced signaling and subsequent cytokine production in monocytes. In particular, induction of both IL-6 and IL-8 is associated with elevated TIRAP …

Montana Kaimin, September 7, 2012, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Gsu View, 2012-09-06, Office Of Marketing And Communications

GSU View

Newsletter published by Governors State University 2007-current.

Western News, Sept. 6, 2012, Western Michigan University

Western News (1972-2018)

Story highlights: Recognition set for Sangren Hall, Lee Honors College; WMU named among nation's best; Summer 2012 news; On Campus with Joseph Fee.

September 6, 2012, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Commonwealth Times 2012-09-06

Commonwealth Times, 1969-

No abstract provided.

2012-09-06, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

Landscape Of Transcription In Human Cells, Jainab Khatun

Biology Faculty Publications and Presentations

Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell’s regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, …

Educational Policies Committee Agenda, September 6, 2012, Utah State University

Educational Policies Committee

• Subcommittee Reports
• Curriculum Subcommittee
• Course Approvals
• Academic Standards Subcommittee
• General Education Subcommittee

Curriculum Subcommittee Minutes, September 6, 2012, Utah State University

Educational Policies Committee

Department of Agricultural Systems Technology and Education

• Title Change, Credit Hour Change, Course Description Change

Department of Landscape Architecture and Environmental Planning

• New Course
• Title Change, Course Description Change
• Title Change
• Credit Hour Change
• Title Change, Credit Hour Change, Course Description Change

Department of Art and Design

• University Studies Request

Department of Management

• Prerequisite Change

School of Teacher Education and Leadership

• Course Description Change

Department of Communicative Disorders and Deaf Education

• Title Change, Credit Hour Change, Course Description Change
• Title Change, Course Description Change

Department of Psychology

• Course Description Change

Department of Electrical and Computer Engineering

• Prerequisite Change, Course Description …

Uab Alum, World-Renowned Sustainability Expert To Speak Sept. 20, Jim Bakken

Browse All News

No abstract provided.

Synthesis And Characterization Of Chain-End Functionalization Of Glycosaminoglycans, Nikola Paulic, Jacob J. Weingart

Undergraduate Research Posters 2012

This presentation reports the CSU Summer Undergraduate Research project, which is the synthesis and characterization of chain-end functionalized CS derivatives, which will be used to investigate various bio-orthogonal conjugation reactions in attempt to create a novel CS-rTM conjugate.

Investigating Axonal Biology Using Microfluidic Devices, James Deyling, Brittany Kastan

Undergraduate Research Posters 2012

During nervous system development, various diffusing biomolecules play a critical role in neurite outgrowth and guidance, resulting in the formation of a complex circuitry. However, the precise mechanism by which these molecules are spatio-temporally delivered to the growing tip of the neurites is unclear. Overall, the results suggest to the utility of this device for studying neurobiology, tissue engineering and cell migration.

Derivatization Of Free Glycans For Glycan Sensor And Glyco-Functionalization Applications, Rhonda D. Jones

Undergraduate Research Posters 2012

Glycans, especially, cell surface glycans acting as receptors, are involved in a wide range of biological processes. Analysis of the cell surface glycans provides a basis for understanding the molecular mechanism of glycan-mediated biological process. The present method can be applied in derivatizing sugars from natural sources for glycan sensor and glyco-functionalization applications.

Curriculum Subcommittee Agenda, September 6, 2012, Utah State University

Educational Policies Committee

Department of Agricultural Systems Technology and Education

• Title Change, Credit Hour Change, Course Description Change

Department of Landscape Architecture and Environmental Planning

• New Course
• Title Change, Course Description Change
• Title Change
• Credit Hour Change
• Title Change, Credit Hour Change, Course Description Change

Department of Art and Design

• University Studies Request

Department of Management

• Prerequisite Change

School of Teacher Education and Leadership

• Course Description Change

Department of Communicative Disorders and Deaf Education

• Title Change, Credit Hour Change, Course Description Change
• Title Change, Course Description Change

Department of Psychology

• Course Description Change

Department of Electrical and Computer Engineering

• Prerequisite Change, Course Description …

Biological Evaluation Of Cyclooxygenase-2 Inhibitor Nimesulide Derivatives As Anti-Agents, Amandeep Singh, Snigdha Chennamaneni

Undergraduate Research Posters 2012

Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. A series of new nimesulide analogs were evaluated with cell proliferation assay based on a non-small lung cancer cell line H292. The results showed that several derivatives were very active to against H292 cell growth with IC50s of sub nano mole. These results suggest the possibility of using these nimesulide derivatives as chemo preventive agents.

Analysis Of Crossover Interference In Yeast, Hanna Morris

Undergraduate Research Posters 2012

Meiosis is one type of cell division that produces germ cells. In Meiosis I, the DNA in a diploid cell is doubled and homologous chromosomes separate. In Meiosis II, each pair of sister chromatids are separated, resulting in four haploid daughter cells. The nine intervals were analyzed under several conditions and the number, timing, and distribution of crossovers was determined. Results and their compatibility with current models of synaptonemal complex functions will be discussed.

Structure-Function Of U11 Snrna In The Minor Splicing Pathway, Mark P. Biro, Jagjit Singh

Undergraduate Research Posters 2012

In human, the majority of protein coding genes are interrupted by dispensable intervening sequences (introns). These introns are removed by nuclear precursor (pre) mRNA splicing process to produce a mature mRNA needed for productive protein production in the cell. We are studying the splicing of minor class or U12-type introns which are spliced by U11, U12, U4atac, U5 and U6atac snRNAs. U11 snRNA binds to the 5’ end or splice site of the intron by RNA-RNA base-pairing to initiate the splicing process. Our results show the functionality of the genetic mutation suppressor assay in establishing the role of U11 snRNA …

Status Of The State-Endangered Mussel, Ligumia Nasuta, In The Upper Cuyahoga River, Rachel E. Andrikanich, Stephanie A. Sredniawa

Undergraduate Research Posters 2012

The primary objective of our research was to assess population size and range of Ligumia nasuta, the Eastern Pond mussel in the Cuyahoga River watershed. We conclude that the Eastern Pond mussel may be all but gone from the East Branch and West Branch Cuyahoga Rivers, but may persist in better numbers in Portage County. Further studies are required before the sustainability of this species can be fully assessed.

Size And Shape Characterization Of Salt Dependent Thermoreversible Micelles Synthesized From Elastin-Like Polypeptides, Kaitlin W. Vandemark

Undergraduate Research Posters 2012

Environmentally responsive nanoparticles synthesized from Elastin-Like Polypeptides (ELP) present a promising system for applications such as biosensors, drug delivery vehicles, and viscosity modifiers.