Digital Commons Network^™

Development Of A Supervisory Control Unit For A Series Plug-In Hybrid Electric Vehicle, Brian Neal Harries

Doctoral Dissertations and Master's Theses

A Series PHEV was chosen, as ERAU's entry into EcoCAR2 through a multidisciplinary architecture selection process. The series architecture was chosen for its mechanical feasibility, consumer acceptability and its performance on energy consumption simulations. The Series PHEV architecture was modeled using Matlab, Simulink, and dSPACE ASM tools, to create a plant model for controller development. A supervisory controller was developed to safely control the interactions between powertrain components. The supervisory control unit was tested using SIL and HIL methodologies. The supervisory controller was developed with an emphasis on fault detection and mitigation for safety critical systems. A power management control …

Hyperspectral Imaging For Non-Contact Analysis Of Forensic Traces, Patrick J. Cullen, G. Edelman, T. Van Leeuwen, M. Aalders, E. Gaston

Articles

Hyperspectral imaging (HSI) integrates conventional imaging and spectroscopy, to obtain both spatial and spectral information from a specimen. This technique enables investigators to analyze the chemical composition of traces and simultaneously visualize their spatial distribution. HSI offers significant potential for the detection, visualization, identification and age estimation of forensic traces. The rapid, non-destructive and non-contact features of HSI mark its suitability as an analytical tool for forensic science. This paper provides an overview of the principles, instrumentation and analytical techniques involved in hyperspectral imaging. We describe recent advances in HSI technology motivating forensic science applications, e.g. the development of portable …

Visual Function After Correction Of Distance Refractive Error With Ready-Made And Custom Spectacles: A Randomized Clinical Trial., Christopher J. Brady, Andrea C Villanti, Monica Gandhi, David S Friedman, Lisa Keay

Wills Eye Hospital Papers

PURPOSE: To evaluate patient-reported outcome measures with the use of ready-made spectacles (RMS) and custom spectacles (CS) in an adult population in India with uncorrected refractive error (URE).

DESIGN: Prospective, double-masked, randomized trial with 1-month follow-up.

PARTICIPANTS: A total of 363 adults aged 18 to 45 years with ≥1 diopter (D) of URE (RMS, n = 183; CS, n = 180).

INTERVENTION: All participants received complete refraction and were randomized to receive CS (full sphero-cylindrical correction) or RMS based on the spherical equivalent for the eye with lower refractive error but limited to the powers in the RMS inventory.

MAIN …

Common Data Set 2012-2013, University Of Minnesota, Morris Office Of Institutional Research

Institutional Effectiveness and Research Reports

No abstract provided.

Gatekeepers And Goalposts: The Need For A New Regulatory Paradigm For Whole Genome Sequence Results, Trevor Woodage

Northwestern Journal of Technology and Intellectual Property

The ability to obtain a person’s whole genome sequence for a cost of one thousand dollars is nearly here. Many clinicians expect that this will usher in an era of personalized medicine by allowing the development of individualized disease-risk profiles, preventive medicine strategies, and treatment options. However, it is not clear that the regulatory strategy that currently controls the approval and availability of more limited genetic tests—typically meant to investigate one or a small number of disease or other traits—provides a satisfactory framework for whole genome sequence testing.

This Perspective takes the position that the generation of whole genome sequence …

Algorithms For Predicting Secondary Structures Of Human Viruses, Hardik Shah

Master's Projects

The mechanism and role of RNA secondary structure elements in the replication and translation of human positive-strand RNA viruses remains poorly understood. These secondary structures are formed when a single RNA strand folds over and base pairs with itself, forming various types of loop structures. RNA strands fold into specific shapes. This unique shape for each nucleic acid chain is the most stable state it can adopt. The lower the energy, i.e., the fold with highest number of base pairs, the higher the stability of the structure. The Dynamic Programming technique, such as the one used in Nussinov- Jacobson algorithm, …

Fact Book 2012, Planning, Research, And Policy Analysis

Fact Book (1988-2019)

Fact Book 2012 for Illinois State University

Enrollment Report, Fall 2012, Planning, Research, And Policy Analysis

Enrollment Reports (2004-2019)

Enrollment Report for Fall 2012 for Illinois State University

The Free Press Vol 44 Issue 4, 10-01-2012, Kirsten Sylvain

Free Press, The

Concert turnout lower than expected--LePage responds to trustees--Muslim students host Eid reception

An Expeditious Iodine-Catalyzed Synthesis Of 3-Pyrrole-Substituted 2-Azetidinones, Debasish Bandyopadhyay, Jessica Cruz, Ram N. Yadav, Bimal K. Banik

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

2-Azetidinones and pyrroles are two highly important classes of molecules in organic and medicinal chemistry. A green and practical method for the synthesis of 3-pyrrole-substituted 2-azetidinones using catalytic amounts of molecular iodine under microwave irradiation has been developed. Following this method, a series of 3-pyrrole-substituted 2-azetidinones have been synthesized with a variety of substituents at N-1 and at C-4. The procedure is equally effective for mono-as well as polyaromatic groups at the N-1 position of the 2-azetidinone ring. The C-4 substituent has no influence either on the yield or the rate of the reaction. Optically pure 3-pyrrole-substituted 2-azetidinones have also …

Transcending Boundaries: Moroccan Political Thought As A Transnational Platform, And Communities In The Realm Of Activism, Leah Siegel

Independent Study Project (ISP) Collection

My research concerns how individual protestors of the February 20th Movement relate to the rest of the Arab Spring and their own society. I conducted several interviews during November 2012 with participants of the movement currently living in Rabat, each one lasting between 30 minutes to two hours. I initially intended this study to focus on the movement’s relations to the rest of the Arab Spring, but found in my interviews that this question is much more tangential than the question of how participants of the movement relate to their own society. What I discovered was that while the events …

El Dengue En Puerto López La Incidencia Y El Nivel De Conocimiento De La Gente Sobre Las Enfermedades Transmitidas Por Los Mosquitos, Mckenzie Momany

Independent Study Project (ISP) Collection

This study took place in Puerto López, Manabí, Ecuador and focuses primarily on the level of knowledge the townspeople have about dengue and how it is transmitted. It also looks at the incidence of dengue in the town and across neighborhoods. In order to carry out this study, I spent a month living in the coastal town of Puerto López and interviewed 50 townspeople – 10 in each of the five neighborhoods of Jonas Gonzalez, Miraflores, Luís Gencón, San Alejo, and the central neighborhood. Interviewees were questioned about their past history of dengue, as well as their knowledge of the …

Genetically Modified Organisms As A Potential Solution For Decreasing Hunger In Developing Nations: An Ethical Paradox, Rachel Sherman

Independent Study Project (ISP) Collection

I first became aware of and interested in genetically modified organisms (GMOs) in the “Politics of Food in America” course I took spring semester of 2012, my junior year at the University of Texas at Austin. I was intrigued by the fact that such a concept was so unfamiliar to the public, yet genetically engineered products were in our everyday foods. Though I received a basic introduction to GMOs through my course, I was curious to learn more about the regulatory practices of GM crops and the political relationships sustained by GM firms and government agencies in the United States. …

Bent Out Of Shape Embodied Knowledge In The Art Of Copper Repoussé, Tierney Brown

Independent Study Project (ISP) Collection

Over the course of a 1,300 year history the Newar art of moulding copper into fine architectural ornaments and full bodied sacred figures has been passed through family lineages and working apprenticeships. Presently the copper repoussé technique has continued to elude a regulated school format instead favoring individual apprenticeships in the workshops and homes of more experienced artists. In a two week short-apprenticeship and study in Sajan Raj Shakya's workshop in Mangchal Tole, Patan I was instructed in the basics of creating copper forms through repoussé and chasing. This experience is documented both in terms of the delineated process for …

Manifestations Of Tibetan Buddhism In Pudacuo National Park And Its Effectiveness As An Environmental Education Tool, Ellen Martin

Independent Study Project (ISP) Collection

Pudacuo National Park in Shangri-la, Yunnan is mainland China’s first national park and comprehensive conservation and eco-tourism attempt. The Nature Conservancy worked with Yunnan provincial government to establish park guidelines and advocate for certain conservation measures. One of the important guidelines that The Nature Conservancy included was local cultural preservation. A primary goal of this experiment in US-modeled national parks is to ensure the longevity of traditional values and beliefs in the parkland area. Pudacuo National Park is not only attempting to conserve the local Tibetan Buddhist tradition but also is attempting to capitalize on the uniqueness of the experience …

A Comparison Of Qualitative And Quantitative Ecological Assessment Methods Of Mangroves In Southwestern Madagascar, Sondra Winders

Independent Study Project (ISP) Collection

Mangroves are unique, tropical, intertidal forests that, among many other important functions, serve as large carbon sinks for the sequestration of atmospheric CO2. This project qualitatively assessed the mangrove forest of Honko Mangrove Conservation and Education (Tulear, Madagascar) in conjunction with Blue Ventures for a proposed Plan Vivo carbon stock project. The qualitative results were then compared with quantitative measurements in order to determine the most effective method of ecological assessment. Sixty-three stands of mangrove forest covering 9.72km2 were identified and mapped. Level of harvest, species composition, density, canopy cover, dominant height, dominant DBH, forest condition and composition were compared …

To Huddle Or Not To Huddle: That Is The Question. A Brief Study Of The Basis For Huddling Behavior In Eulemur Rubriventer, Tessa Behnke

Independent Study Project (ISP) Collection

Common behaviors observed in primates may have important biological and social foundations. This study looks at huddling behavior in several groups of Eulemur rubriventer in Ranomafana National Park, Madagascar, in order to compare the functions of huddling in relation to thermoregulation and social bonding. The proportions of time spent huddling as functions of rainfall and ambient temperature were used to explore the possibility of huddling as a means of thermoregulation. A positive relationship between loose huddling behavior and temperature was deemed significant. Data collected on proximity of individuals to each other (nearest neighbor) was able to establish a significant correlation …

A Comparison Study Of A Bird Population In Lake Alaotra: The Effects Of A Protected Area, Sonya R. Kaufman

Independent Study Project (ISP) Collection

Lake Alaotra, the largest lake in Madagascar, is well known for its diverse plant and animal communities. It is home to three critically endangered endemic species, the Alaotran gentle lemur (Hapelemur griseus alaotrensis), Alaotra Little Grebe (Tachybaptus rufolavatus), and Madagascar pochard (Aythya innotata). Widespread habitat destruction by fire and clear-cutting is destroying the marshland vegetation of the lake, and siltation from erosion runoff and rice field creation is resulting in the ever-decreasing size of the lake. This study looked at the effectiveness of the protected area, Park Bandro, in preserving species diversity, relative abundances, …

Experimental Validation Of Phase Using Nomarski Microscopy With An Extended Fried Algorithm, Scott A. Prahl, Amanda Dayton, Kyle Juedes, Erik J. Sánchez, Rafael Paez López, Donald D. Duncan

Electrical and Computer Engineering Faculty Publications and Presentations

Reconstruction of an image (or shape or wavefront) from measurements of the derivatives of the image in two orthogonal directions is a common problem. We demonstrate how a particular reconstructor, commonly referred to as the Fried algorithm, can be used with megapixel derivative images to recover the original image. Large datasets are handled by breaking the derivative images into smaller tiles, applying the Fried algorithm and stitching the tiles back together. The performance of the algorithm is demonstrated using differential interference contrast microscopy on a known test object.

Pediatric Pharmacogenomics: A Systematic Assessment Of Ontogeny And Genetic Variation To Guide The Design Of Statin Studies In Children., Jonathan B. Wagner, J Steven Leeder

Manuscripts, Articles, Book Chapters and Other Papers

The dose-exposure-response relationship for drugs may differ in pediatric patients compared with adults. Many clinical studies have established drug dose-exposure relationships across the pediatric age spectrum; however, genetic variation was seldom included. This article applies a systematic approach to determine the relative contribution of development and genetic variation on drug disposition and response using HMG-CoA reductase inhibitors as a model. Application of the approach drives the collection of information relevant to understanding the potential contribution of ontogeny and genetic variation to statin dose-exposure-response in children, and identifies important knowledge deficits to be addressed through the design of future studies.

Molecular Pathway Reconstruction And Analysis Of Disturbed Gene Expression In Depressed Individuals Who Died By Suicide, Vladimir Zhurov, John D. H. Stead, Zul Merali, Miklos Palkovits, Gabor Faludi, Caroline Schild-Poulter, Hymie Anisman, Michael O. Poulter

Brain and Mind Institute

Molecular mechanisms behind the etiology and pathophysiology of major depressive disorder and suicide remain largely unknown. Recent molecular studies of expression of serotonin, GABA and CRH receptors in various brain regions have demonstrated that molecular factors may contribute to the development of depressive disorder and suicide behaviour. Here, we used microarray analysis to examine the expression of genes in brain tissue (frontopolar cortex) of individuals who had been diagnosed with major depressive disorder and died by suicide, and those who had died suddenly without a history of depression. We analyzed the list of differentially expressed genes using pathway analysis, which …

Project Synthesis Of N Acetyl L Histidine Ethyl Amide And Standard Operating Procedure For Fractional Collector, Maneesha Jakkampudi

All Student Theses and Dissertations

Photo oxidation of proteins leads to the formation of cross links of the amino acids in the proteins and leads to induction of cataracts, photo aging of the skin and in the Photodynamic therapy of tumors.

Oxidation of proteins involves significant modification of particular amino acids residues with consequent photodynamic damage. Studies show that tryptophan, tyrosine and histidine side chains gives rise to semi stable peroxides on exposure to singlet oxygen these oxidized structures are studied with low temperature NMR. These peroxides or species derived from them have been postulated as key intermediates in subsequent reactions such as cross linking …

West Nile Virus Seroreversion And The Influence Of Herd Immunity On Disease Risk In A Long-Term Study Of Free-Ranging Birds, Eileen M. Mckee

All Student Theses and Dissertations

The transmission and amplification of West Nile virus (WNV) is driven by the number of susceptible avian hosts. The quantity of susceptible hosts is determined by 1) recruitment of juvenile birds during the breeding season, 2) adult birds previously unexposed to WNV, and 3) adult birds with waning antibody titers. Although rarely tested, avian herd immunity and seroreversion could have a direct impact on Culex infection rate, a proxy for the reproductive number of WNV. In this study, we utilized data from a seven year study investigating WNV transmission ecology in suburban Chicago, Illinois. We tested the hypothesis that herd …

Chemical Proteomics-Based Analysis Of Off-Target Binding Profiles For Rosiglitazone And Pioglitazone: Clues For Assessing Potential For Cardiotoxicity, Brian R. Hoffmann, Mohamed F. El-Mansy, Daniel S. Sem, Andrew S. Greene

Chemistry Faculty Research and Publications

Drugs exert desired and undesired effects based on their binding interactions with protein target(s) and off-target(s), providing evidence for drug efficacy and toxicity. Pioglitazone and rosiglitazone possess a common functional core, glitazone, which is considered a privileged scaffold upon which to build a drug selective for a given target—in this case, PPARγ. Herein, we report a retrospective analysis of two variants of the glitazone scaffold, pioglitazone and rosiglitazone, in an effort to identify off-target binding events in the rat heart to explain recently reported cardiovascular risk associated with these drugs. Our results suggest that glitazone has affinity for dehydrogenases, consistent …

Experimental Documentation Of The Structural Consequences Of Hydrogen-Bonding Interactions To The Proximal Cysteine Of A Cytochrome P450, Piotr J. Mak, Yuting Yang, Sangchoul Im, Lucy A. Waskell, James R. Kincaid

Chemistry Faculty Research and Publications

Resonance Raman spectroscopy is used to document, for the first time, a 6 cm−1 decrease of the Fe-S stretch by introducing an H-bond donor into the proximal pocket of a cytochrome P450, which interacts with the key cysteine thiolate axial ligand. The anticipated trans-effect on bound exogenous ligands is also confirmed and evidence is obtained supporting intimate interaction of the new histidyl-imidazole fragment with the heme periphery.

Modeling Martian Planetary Entry Descent And Landing Using Monte Carlo Driven Response Surface Methodology, Narcrisha S. Norman

Mechanical & Aerospace Engineering Theses & Dissertations

Response surface methodology (RSM) is a statistical method that explores the relationships between several descriptive variables and one or more response variables. For over sixty years, among other areas, it has been utilized in quality engineering, process engineering, aircraft engineering, economics, chemical engineering, automotive engineering and design/technique optimization. In this dissertation, RSM is utilized to produce regression models that represent the planetary entry, descent and landing (EDL) process. A complete understanding of EDL process is an essential component of any planetary exploration. Research in this area is ongoing and confidence in the ability to explore known celestial bodies is growing. …

Thresholds Of Change In Decomposition Rate Along A Dune/Swale Transect On A Virginia Barrier Island, Dominic J. Graziani

Biological Sciences Theses & Dissertations

Aboveground and belowground decomposition rates were determined along a barrier island dune/swale transect located on the Virginia Coast Reserve-Long Term Ecological Research Site using litterbags and wooden dowels. The objective was to determine the influence of fine scale changes in the environment on decomposition to identify any potential thresholds affecting decomposition rate. Wax myrtle (Morella cerifera L. Small) leaves and dowels of southern yellow pine wood were used as standard substrates to evaluate environmental influences on decay. Aboveground (F=6.494, p < 0.0001) and belowground (F=5.705, p < 0.0001) decay rates (yr^-1) showed significant variation among litterbag/dowel locations. Aboveground decay rates (yr^-1) ranged from 0.339 (Upper Dune station) …

Configuration Studies Of Electrostatic And Magnetostatic Active Space Radiation Shielding, Trac K. Nguyen

Electrical & Computer Engineering Theses & Dissertations

Developing successful and optimal solutions for mitigating the hazards of radiation in deep space is critical for the success of deep-space long duration explorations, including mission to the Moon, Mars and beyond. A recent report (Tripathi et al., 2008) had explored the feasibility of using electrostatic shielding in conjunction with state-of-the-art materials shielding technologies.

In this thesis research, we study the active electrostatic shielding strategy and examine a hybrid configuration that utilizes both electrostatic and magnetostatic fields. The main advantages of this system are shown to be: (i) much lower magnetic fields that could be below the thresholds set for …

Subnanosecond Exposure Systems For Biological Studies, Jongbong Nah

Electrical & Computer Engineering Theses & Dissertations

The research of bioelectrics has expanded to subnanosecond pulse region and entered a new domain of biophysics of cell interaction with ultra-short and intense electric fields. As subnanosecond pulses may be delivered by antennas to the human body and is very attractive to the medical community, the study of subnanosecond pulse effects calls for exposure systems for both cells and tissues. Two systems were designed in the scope of this thesis, used for cells and tissues respectively. The exposure system designed for cell exposure is a cuvette consisting of two parallel aluminum gaps. This cuvette is placed in a coaxial …

Nonthermal Plasma Jet Efficacy On Candida Kefyr, Amber Marie Mattson Jackson

Electrical & Computer Engineering Theses & Dissertations

The inactivation abilities of a nonthermal plasma jet were investigated with the yeast C. kefyr, a pathogen with increasing importance in healthcare. The plasma is generated using a microhollow cathode discharge (MHCD) geometry operated with a DC voltage of 2 kV and a current of 30 mA using air as the operating gas at an airflow rate of 8 SLM. The plasma discharge approaches room temperature at a few mm away from the plasma jet allowing for the use on heat sensitive surfaces. Dry air and humid air were used as the operating gas to see if humidity plays …