Digital Commons Network^™

Successful Pregnancies After Combined Human Leukocyte Antigen Direct Genotyping And Preimplantation Genetic Diagnosis Utilizing Multiple Displacement Amplification, Ali M. Hellani, Siham M. Akoum, Elias S. Fadel, Hisham M. Yousef, Khaled K. Abu-Amero

Saudi Medical Journal

OBJECTIVE: To devise a new and simple technique to help select normal embryos that are human leukocyte antigen (HLA) matched to their affected siblings for diseases, such as beta-thalassemia or sickle cell anemia, which are common in this part of the world. METHODS: This study was conducted between March 2008 and April 2011 at the preimplantation Genetic Diagnosis Laboratory, Saad Specialist Hospital, Al-Khobar, Kingdom of Saudi Arabia. Embryos were obtained after 7 in vitro fertilization preimplantation genetic diagnosis (IVF-PGD) cycles. Single cells were biopsied, and extracted DNA was amplified by the multiple displacement amplification (MDA) technique. Amplified DNA was then …

Cholecystectomy And The Risk Of Esophageal And Gastric Cancer, Zhenming Ge, Chengjin Zhao, Yamin Wang, Junbo Qian

Saudi Medical Journal

OBJECTIVE: To conduct a meta-analysis of observational studies to explore the relationships between cholecystectomy and the risk of esophageal and gastric cancer (GC). METHODS: The study design was retrospective, and carried out in the First People9s Hospital of Nantong, Jiangsu, China from January 2012 to April 2012. Studies were identified by a literature search of MEDLINE and EMBASE through March 31, 2012, and by manually searching the reference lists of pertinent articles. The summary relative risks (SRRs) with their 95% confidence intervals (CIs) were calculated with a random-effects model. RESULTS: A total of 12 estimates from 6 independent studies (including …

Quality Of Life Of Patients With Chronic Obstructive Pulmonary Disease In The Gulf Cooperation Council Countries, Hani M. Tamim, Sana S. Al-Mutairi, Thamer H. Al-Khouzaie, Bassam H. Mahboub, Suhaila E. Al-Jawder, Omer S. Alamoudi

Saudi Medical Journal

OBJECTIVE: To assess the health-related quality of life (HRQL) of patients with chronic obstructive pulmonary disease (COPD) in 4 Gulf Council Cooperation (GCC) countries. METHODS: We conducted a cross-sectional survey between December 2011 and March 2012 in the following countries: Kingdom of Saudi Arabia (Riyadh, Dammam, and Jeddah), Kuwait, Bahrain, and the United Arab Emirates. The HRQL was measured using the COPD Assessment Test (CAT) and the Chronic Respiratory Disease Questionnaire-Self-Administered Standardized questionnaire (CRQ-SAS). RESULTS: We recruited 120 patients from 6 centers in 4 countries. Their average forced expiratory volume (FEV)1 was 49.3% ( ± 13.4) of predicted, and the …

Pharmaceutical And Biomedical Applications Of Affinity Chromatography: Recent Trends And Developments, David S. Hage, Jeanethe A. Anguizola, Cong Bi, Rong Li, Ryan Matsuda, Efthimia Papastavros, John Vargas-Badilla, Xiwei Zheng

David Hage Publications

Affinity chromatography is a separation technique that has become increasingly important in work with biological samples and pharmaceutical agents. This method is based on the use of a biologically-related agent as a stationary phase to selectively retain analytes or to study biological interactions. This review discusses the basic principles behind affinity chromatography and examines recent developments that have occurred in the use of this method for biomedical and pharmaceutical analysis. Techniques based on traditional affinity supports are discussed, but an emphasis is placed on methods in which affinity columns are used as part of HPLC systems or in combination with …

Modification Of Net Configurations Of The Coda Netlauncher® To Enhance Bird Capture, Amanda M. Prisock, Brian S. Dorr, James C. Cumbee

United States Department of Agriculture Wildlife Services: Staff Publications

We modified and evaluated capture nets fi red from the Coda Netlauncher^® as a tool for capturing various avian species. We modified the netlauncher by using customized nets to maximize the area of the capture zone. We captured 137 birds, comprising 12 species, in 23 attempts between July 2008 and October 2009 using this method. Capture success rates varied from 25 to 69% were comparable to success rates reported for other capture methods for these species. However, individual capture success for different net configurations varied greatly from 3 to 65%. Minimal injuries and 2 bird fatalities were reported. The …

Prion Remains Infectious After Passage Through Digestive System Of American Crows (Corvus Brachyrhynchos), Kurt C. Vercauteren, John L. Pilon, Paul B. Nash, Gregory E. Phillips, Justin W. Fischer

United States Department of Agriculture Wildlife Services: Staff Publications

Avian scavengers, such as American crows (Corvus brachyrhynchos), have potential to translocate infectious agents (prions) of transmissible spongiform encephalopathy (TSE) diseases including chronic wasting disease, scrapie, and bovine spongiform encephalopathy. We inoculated mice with fecal extracts obtained from 20 American crows that were force-fed material infected with RML-strain scrapie prions. These mice all evinced severe neurological dysfunction 196–231 d postinoculation (x̅ = 198; 95% CI: 210–216) and tested positive for prion disease. Our results suggest a large proportion of crows that consume prion-positive tissue are capable of passing infectious prions in their feces (p = 1.0; …

Homelessness: Causes, Culture And Community Development As A Solution, Kaitlin Philipps

Pell Scholars and Senior Theses

This thesis seeks to explain the reasons that homelessness occurs, and how it is currently being dealt with in public policy. Triggers and predictors of homelessness are explored and it is shown that triggers are almost always compounded, indicating a multitude of factors that lead to homelessness. The culture and community surrounding the homeless lifestyle is seen as playing a significant role in how the individual copes with their homelessness. The norms and values of their culture are investigated and its role in rehabilitation is explored. Current institutions for helping the homeless are analyzed for different success rates. Additionally, initiatives …

The Alternative Crosstalk Between Rage And Nitrative Thioredoxin Inactivation During Diabetic Myocardial Ischemia-Reperfusion Injury., Yi Liu, Yan Qu, Rutao Wang, Yanzhuo Ma, Chenhai Xia, Chao Gao, Jingyi Liu, Kun Lian, Aibing Xu, Xiaoyan Lu, Lu Sun, Lu Yang, Wayne B. Lau, Erhe Gao, Walter Koch, Haichang Wang, Ling Tao

Department of Emergency Medicine Faculty Papers

The receptor for advanced glycation end products (RAGE) and thioredoxin (Trx) play opposing roles in diabetic myocardial ischemia-reperfusion (MI/R) injury. We recently demonstrated nitrative modification of Trx leads to its inactivation and loss of cardioprotection. The present study is to determine the relationship between augmented RAGE expression and diminished Trx activity pertaining to exacerbated MI/R injury in the diabetic heart. The diabetic state was induced in mice by multiple intraperitoneal low-dose streptozotocin injections. RAGE small-interfering RNA (siRNA) or soluble RAGE (sRAGE, a RAGE decoy) was via intramyocardial and intraperitoneal injection before MI/R, respectively. Mice were subjected to 30 min of …

Verify, Then Trust: How To Legalize Off-Label Drug Marketing, Fazal Khan, Justin Holloway

Scholarly Works

This article will discuss the current state of off-label medicine, relevant legislation in the area, and a proposal designed to capture the benefits of off-label medicine while limiting its dangers when practiced perniciously. Part II will discuss the regulations in place governing off-label promotion and will detail the practice of ghostwriting and its associated concerns. Part III will analyze the costs and benefits of off-label marketing and practice of medicine, and will utilize a case study to demonstrate the predicament of drug manufacturers. Part IV will set forth a proposal to use the newly created Patient-Centered Outcomes Research Institute to …

Rat Brain Pro-Oxidant Effects Of Peripherally Administered 5 Nm Ceria 30 Days After Exposure, Sarita S. Hardas, Rukhsana Sultana, Govind Warrier, Mo Dan, Rebecca L. Florence, Peng Wu, Eric A. Grulke, Michael T. Tseng, Jason M. Unrine, Uschi M. Graham, Robert A. Yokel, D. Allan Butterfield

Chemistry Faculty Publications

The objective of this study was to determine the residual pro-or anti-oxidant effects in rat brain 30 days after systemic administration of a 5 nm citrate-stabilized ceria dispersion. A ∼4% aqueous ceria dispersion was iv-infused (0 or 85 mg/kg) into rats which were terminated 30 days later. Ceria concentration, localization, and chemical speciation in the brain was assessed by inductively coupled plasma mass spectrometry (ICP-MS), light and electron microscopy (EM), and electron energy loss spectroscopy (EELS), respectively. Pro- or anti-oxidant effects were evaluated by measuring levels of protein carbonyls (PC), 3-nitrotyrosine (3NT), and protein-bound-4-hydroxy-2-trans-nonenal (HNE) in the hippocampus, cortex, and …

An Investigation Of The Self-Efficacy Beliefs Of Black And Hispanic Students That Have Experienced Success Or Failure In Mathematics, Dayton Fennimore Hibbs

Seton Hall University Dissertations and Theses (ETDs)

No abstract provided.

Exploring The Experiences Of Racial Identity And Stereotype Threat In African American Male Medical Doctors, Christopher G. Beaumont

Seton Hall University Dissertations and Theses (ETDs)

No abstract provided.

Unlv Magazine, Tony Allen, Afsha Bawany, Shane Bevell, Holly Ivy Devore, Megan Downs, Brian Sodoma, Ched Whitney

UNLV Magazine

No abstract provided.

Hrc Enews -- Fall 2012, Megan M. Iudice

Publications (HRC)

HRC eNews is an electronic newsletter to keep individuals informed about developments at the Harry Reid Center for Environmental Studies, located on the campus of the University of Nevada, Las Vegas.

Food Fortification Improves The Intake Of All Fortified Nutrients, But Fails To Meet The Estimated Dietary Requirements For Vitamins A And B6, In Lactating South African Women, Peggy C. Papathakis, Kerry E. Pearson

Food Science and Nutrition

Objective To investigate the impact of fortification by comparing food records and selected biochemical indicators of nutritional status pre- and post-fortification.

Design Mean intake from 24 h recalls (n 142) was compared with the Estimated Average Requirement (EAR) to determine the proportion with inadequate intake. In a subsample (n 34), diet and serum retinol, folate, ferritin and Zn were compared pre- and post-fortification for fortified nutrients vitamin A, thiamin, riboflavin, niacin, folic acid, Fe and Zn.

Setting South Africa.

Subjects Breast-feeding women (ninety-four HIV-infected, forty eight HIV-uninfected) measured at ∼6, 14, 24 weeks, and 9 and 12 months …

The Long Term Effect Of Parental Involvement In A Child's Education: A Ten-Step Approach, Eraina Ross-Aseme

Doctoral Dissertations and Projects

Parental Involvement in a child's education is very important to the child becoming a productive citizen. Some parents find themselves getting in at the start of their child entering elementary school; parental involvement should begin before the school age years. Research has demonstrated the effectiveness of establishments such as schools, churches and businesses partnering in a child's education. The goal of this project is to empower parents to build stronger support systems with schools, neighborhoods, churches and communities. Its aim is to show parents, school systems and businesses that collaboration in the education arena can be strengthened to achieve a …

Single-Sex Education Versus Coeducation In North Georgia Public Middle Schools, Catherine Blake

Doctoral Dissertations and Projects

The U.S. Department of Education is giving more liberties to school districts to offer single-sex schools in order to adequately serve the needs of students. The purpose of this quantitative causal-comparative study was to test the theory of students' performances based on their educational environment by comparing students who received instruction in a single gender classroom in a public middle school compared to students who received instruction in a mixed gender classroom in a public middle school. The achievement test, Georgia Criterion Referenced Competency Test, was used with each site school. There were two years of data collected with the …

Neurosteroid-Mediated Regulation Of Brain Innate Immunity In Hiv/Aids: Dhea-S Suppresses Neurovirulence, Amber Paul, Ferdinand G. Maingat, Maria J. Polyak, Pornpun Vivithanaporn, Farshid Noorbakhsh, Samir Ahboucha, Glen B. Baker, Keir Pearson, Christopher Power

Publications

Neurosteroids are cholesterol-derived molecules synthesized within the brain, which exert trophic and protective actions. Infection by human and feline immunodeficiency viruses (HIV and FIV, respectively) causes neuroinflammation and neurodegeneration, leading to neurological deficits. Secretion of neuroinflammatory host and viral factors by glia and infiltrating leukocytes mediates the principal neuropathogenic mechanisms during, although the effect of neurosteroids on these processes is unknown. We investigated the interactions between neurosteroid mediated effects and lentivirus infection outcomes. Analyses of HIV-infected uninfected human brains disclosed a reduction in neurosteroid synthesis enzyme expression. Human neurons exposed to supernatants from HIV macrophages exhibited suppressed enzyme expression without …

Verify, Then Trust: How To Legalize Off-Label Drug Marketing, Fazal Khan, Justin Holloway

Penn State Law Review (2003 - Present)

No abstract provided.

2012 Fall Vol. 29 No. 2, Alumni Affairs School Of Medicine

Medicinews

No abstract provided.

Pawnshops, Behavioral Economics, And Self Regulation, Paige Marta Skiba, Susan Payne Carter

Vanderbilt Law School Faculty Publications

Pawnbroking is the oldest source of credit. There is growing public interest in day-to-day pawnbroking operations, as evidenced by the popularity of reality shows such as “Pawn Stars” and “Hardcore Pawn.” Television viewers’ curiosity about an old credit institution may be due to the fact that 7% of all U.S. households have used pawn credit. Although pawnshops predate biblical times, researchers know surprisingly little about this ancient form of banking and its customers. We fill this gap by documenting detailed information on pawnshop loan repayment and default, and by discussing how pawnshop borrowers’ behavior is consistent with various behavioral economics …

Rice Consumption And Urinary Arsenic Concentrations In U.S. Children, Matthew A. Davis, Todd A. Mackenzie, Kathryn L. Cottingham, Diane Gilbert-Diamond, Tracy Punshon, Margaret R. Karagas

Dartmouth Scholarship

Background: In adult populations, emerging evidence indicates that humans are exposed to arsenic by ingestion of contaminated foods such as rice, grains, and juice; yet little is known about arsenic exposure among children.

Objectives: Our goal was to determine whether rice consumption contributes to arsenic exposure in U.S. children.

Methods: We used data from the nationally representative National Health and Nutrition Examination Survey (NHANES) to examine the relationship between rice consumption (measured in 0.25 cups of cooked rice per day) over a 24-hr period and subsequent urinary arsenic concentration among the 2,323 children (6–17 years of age) who participated in …

Confronting Supreme Court Fact Finding, Allison Orr Larsen

Faculty Publications

No abstract provided.

Nutrition And Diabetic Management In Urban Kenya, Madeline Jackson

Independent Study Project (ISP) Collection

This Independent Study project sought to identify the changes in nutrition from the traditional Luo culture to the new urban setting and explore the management, perceptions and prevalence of Type II diabetes in an increasingly urban area. The focus was on Type II diabetes since the majority of disease burden stems from this acquired form of the diabetes. Through speaking with elderly community members and shadowing the first line diabetic treatment centers in Kisumu, an assessment of the relationship between changing nutrition and diabetic management showed numerous gaps in the system that will continue to increase unless something is done. …

Development Of A Procedure To Measure The Effectiveness Of N95 Respirator Filters Against Nanoparticles, Fariborz Haghighat, Ali Bahloul, Jaime Lara, Reza Mostofi, Alireza Mahdavi

Rapports de recherche scientifique

Les risques pour la santé et la sécurité des travailleurs exposés à l’inhalation de nanoparticules (NP) soulèvent de plus en plus d’inquiétudes. Parmi les sources d’émission de nanoparticules en milieu de travail figurent les effluents et les émanations de divers procédés, tels l’ablation et le fraisage laser. Les nanoparticules ont des propriétés potentiellement toxiques, à savoir une surface totale, une concentration en nombre et une réactivité surfacique élevées. Il a été démontré que l’inhalation – la voie d’exposition la plus courante aux nanoparticules – a des effets nocifs sur les fonctions pulmonaires, et que les particules déposées dans les poumons …

The Determinants Of Helminth Infection In Baboons, Rita Monfort

Publications and Research

THE DETERMINANTS OF HELMINTH INFECTION IN BABOONS

Summary Paragraph:

Intestinal parasitic helminths are common in wild primate populations [1, 2] and can impose a significant burden on their host’s fitness. Numerous factors can affect the prevalence and diversity of intestinal parasites in natural populations including environmental factors [3, 4], the host’s behavior and genetics [5, 6]. How these different factors interact in natural populations remains unclear. This is in all probability due to the fact that previous studies have seldom looked at the prevalence and diversity of parasitic helminths in the same species but in different habitats over periods longer …

Making Sex The Same: Ending The Unfair Treatment Of Males In Family Law, Myrisha S. Lewis

Faculty Publications

No abstract provided.

Jefferson Alumni Bulletin – Volume 61, Number 4, Fall 2012

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

Features:

• Melanoma: Personalized Medicine's Latest Poster Child
• Getting a Head Start on Treating Migraines

Departments:

• Dean's Column
• Findings: Breast Cancer Tumors Lacking RB Protein Function Respond Better to Neoadjuvant Chemotherapy
• Faculty Profile: Aaron Dumont: Unraveling the Mysteries of Neuroscience
• On Campus
• Alumni Weekend 2012
• Alumnus Profile: Joseph M. Giordano, MD '67: Revolutionizing Trauma Care - and Saving an American President
• Class Notes and In Memoriam (login to view)
• Alumni Giving

Phase Ii Evaluation Of Dasatinib In The Treatment Of Recurrent Or Persistent Epithelial Ovarian Or Primary Peritoneal Carcinoma: A Gynecologic Oncology Group Study., Russell J Schilder, William E Brady, Heather A Lankes, James V Fiorica, Mark S Shahin, Xun C Zhou, Robert S Mannel, Harsh B Pathak, Wei Hu, R Katherine Alpaugh, Anil K Sood, Andrew K Godwin

Department of Medical Oncology Faculty Papers

OBJECTIVES: Preclinical data suggest an important role for the sarcoma proto-oncogene tyrosine kinase (SRC) in the oncogenesis of epithelial ovarian cancer (EOC) or primary peritoneal carcinoma (PPC). The Gynecologic Oncology Group (GOG) conducted a Phase II trial to evaluate the efficacy and safety of dasatinib, an oral SRC-family inhibitor in EOC/PPC, and explored biomarkers for possible association with clinical outcome.

METHODS: Eligible women had measurable, recurrent or persistent EOC/PPC and had received one or two prior regimens which must have contained a platinum and a taxane. Patients were treated with 100mg orally daily of dasatinib continuously until progression of disease …

Level Of Agreement In The Mental Models Of Human Factors Practitioners And Systems Engineers Working In Collaborative Teams, Jerry A. Gordon

Doctoral Dissertations and Master's Theses

Emerging research in complexity science recognizes traditional techniques for engineering systems do not always work for complex systems. Designing complex systems requires individuals to have knowledge of engineering as well as human performance. To this end, design efforts rely often on multi-disciplinary teams. While any two members of a design team may view the system design problem in vastly different manners, this study sought to identify a possible systemic effect on approach by the differing education and experience obtained by social practitioners, represented by human factors, and technical practitioners, represented by systems engineers. It further examined the impact of the …