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Underrepresentation Of Females In Academia: A Relative Rate Index And System Dynamics Model, Nupur Garg

Yale Medicine Thesis Digital Library

Females continue to be significantly outnumbered by their male counterparts in the academic pipeline at the senior ranks. Confounding the problem is the inadequacy of tools used for measurement and analysis of it. A Relative Rate Index (RRI) is a better tool for measuring gender disparities of academic systems than calculating percentages of females in academia. An RRI determines the junctures and scales at which females fall out of the academic track. The RRIs for academic medicine departments at Yale were created using institutional records. Calculations indicate that the fallout for females in academia occurs from assistant to associate professor …

Analyzing Breast Tumor Response To Neoadjuvant Therapy By Pk Models Of Dynamic-­Contrast Enhanced Mr, Matthew Lidstrom

Yale Medicine Thesis Digital Library

Introduction: Pharmacokinetic modeling of contrast uptake by Dynamic-­‐Contrast Enhanced Magnetic Resonance Imaging studies has shown potential to predict the pathologic response to neoadjuvant therapy in breast cancer patients via several small studies. We will attempt to prospectively validate the performance of several previously published criteria in women undergoing neoadjuvant therapy with bevacizumab or trastuzumab.

Methods: 11 patients underwent dynamic contrast enhanced magnetic resonance imaging both before and after receiving one cycle of trastuzumab or bevacizumab neoadjuvant chemotherapy for a primary breast lesion of greater than two centimeters. By abstracting pharmacokinetic parameters (Ktrans) from each study, predictions for therapeutic response based …

Langerhans Cells Facilitate Mutagenesis And Squamous Cell Carcinoma, Badri Modi

Yale Medicine Thesis Digital Library

LANGERHANS CELLS FACILITATE MUTAGENESIS AND SQUAMOUS CELL CARCINOMA.

Badri G. Modi, Jason Neustadter, Julia Lewis, Renata Filler, Bernice Kwong, Swapna Reddy, Robert Tigelaar, Daniel Kaplan, Adrian Hayday, Michael Girardi. Department of Dermatology, Yale University, School of Medicine, New Haven, CT.

Polyaromatic hydrocarbons (PAHs) are prevalent, potent carcinogens, and 7,12-dimethylbenz[a]anthracene (DMBA) is a model PAH widely used to model epithelial carcinogenesis. To achieve mutagenic effects, DMBA must be activated to DMBA-trans-3,4-diol via cytochrome p450 (CYP) 1B1, and this intermediate is the penultimate carcinogen responsible for inducing the signature mutation in the Hras oncogene. Recently, we observed that mice deficient in Langerhans …

Golgi & Eres Biogenesis In The Malaria-Causing Parasite Plasmodium Falciparum, Michelle Morales

Yale Medicine Thesis Digital Library

GOLGI AND ERES BIOGENESIS IN THE MALARIA-CAUSING PARASITE PLASMODIUM FALCIPARUM. Michelle Morales, Susann Herrmann and Tim-Wolf Gilberger, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Sponsored by Choukri Ben Mamoun, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

Plasmodium falciparum, the parasite causing the most severe form of human malaria, continues to bear a global burden of morbidity and mortality. No vaccine is available and resistance is emerging and expanding to all classes of existing antimalarials. Relatively little is known about the secretory pathway of P. falciparum, which has the ability to export proteins to specialized …

High-Resolution Time-Frequency Analysis Of Neurovascular Responses To Ischemic Challenges, Frederick Romberg

Yale Medicine Thesis Digital Library

The identification and delineation of oscillatory patterns of blood flow associated with cerebral autoregulation mechanisms is the focus of three specific aims. 1) Identify a superior spectral analysis method for the identification of activity due to cholinergic oscillatory control of the microvasculature (COC_micvasc) and compare the effectiveness of the Hilbert-Huang transform (HHT), the smoothed pseudo Wigner-Ville (SPWV) distribution, and the variable-frequency complex demodulation (VFCDM) method to detect such activity. 2) Determine if changes in forehead microcirculation as monitored by noninvasive laser Doppler flowmetry may provide a reliable indication of the adequacy of cerebral blood flow during progressive simulated …

Acute Constipation In Children Receiving Chemotherapy For Cancer, Jonathan Season

Yale Medicine Thesis Digital Library

ACUTE CONSTIPATION IN CHILDREN RECEIVING CHEMOTHERAPY FOR CANCER.

J. Hale Season, Farzana D. Pashankar, Joseph McNamara, and Dinesh S. Pashankar. Sections of Pediatric Gastroenterology and Pediatric Hematology-Oncology, Department of Pediatrics, Yale University, School of Medicine, New Haven, CT.

We hypothesized that the prevalence of constipation amongst children on chemotherapy would be high, and that certain pharmacologic interventions commonly used in this population (especially vinca alkaloids, narcotic analgesics, and ondansetron) would be associated with constipation. We also hypothesized that constipation would be perceived as an important problem with a significant impact on lifestyle. We prospectively studied 61 children receiving chemotherapy for …

Cellular Response To Prosthetic Wear Debris Differs In Rheumatoid Versus Non-Rheumatoid Arthritis, Anant Vasudevan

Yale Medicine Thesis Digital Library

Anant Vasudevan, Edward F. DiCarlo, Timothy Wright, Dan Chen, Mark. P Figgie, Steven R. Goldring, Lisa A. Mandl. Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY. (Sponsored by Carrie Swigart, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine).

In the setting of inflammatory arthritis, the histopathologic reaction to foreign body wear debris generated from a failing arthroplasty has not been definitively characterized. This study examined whether patients with rheumatoid arthritis (RA) demonstrate different patterns of prosthetic wear or cellular responses to implant wear debris compared to patients without inflammatory joint disease. Thirty-eight …

Foretelling The Future Of Prognostication: A Historically Inspired Domain-Based Approach For The Elderly, John Thomas

Yale Medicine Thesis Digital Library

FORETELLING THE FUTURE OF PROGNOSTICATION: A HISTORICALLY INSPIRED DOMAIN-BASED APPROACH FOR THE ELDERLY

John M. Thomas and Terri R. Fried. Section of Geriatrics, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

Hypothesis: 1) Physicians' decisions to discuss hospice as an option for terminally ill patients are based on a limited approach to prognostication that excludes many patients who may benefit from discussions. 2) Identifying broader domains of health most important for prognostication, as an alternative to calculating life expectancy or mortality risk, might encourage prognostication and improve physician-patient communication.

Aims: 1) To examine the association between …

An Incompletely Penetrant Col7a1 Mutation Causes Dystrophic Epidermolysis Bullosa And Epidermolysis Bullosa Pruriginosa, Catherine Yang

Yale Medicine Thesis Digital Library

Epidermolysis bullosa pruriginosa (EBP) is a rare subtype of dystrophic epidermolysis bullosa (DEB) characterized by intense pruritus, nodular or lichenoid lesions, and violaceous linear scarring most prominent on the extensor extremities. Remarkably, identical mutations in COL7A1, which encodes an anchoring fibril protein present at the dermal-epidermal junction, can cause both DEB and EBP with either autosomal dominant or recessive inheritance. We present one family with both dystrophic and pruriginosa phenotypes of epidermolysis bullosa. The proband is a 19-year-old Caucasian female who initially presented in childhood with lichenoid papules affecting her extensor limbs and intense pruritus consistent with EBP. Her maternal …

Sew It Seams: Wearing The Symbols Of Distant Neighbors, Tamar Reva Einstein

Expressive Therapies Dissertations

This art-based expressive therapy study investigated opinions and feelings about cultures in the city of Jerusalem and the country of Israel at large. A coat, designed and sewn by the researcher, was covered with symbols that were identified with peoples who have been victims of violence, discrimination, dehumanization, and conflict within and across cultural groups in Jerusalem. The symbols of the cultures in Jerusalem were placed on the coat so that they touched each other at the seams. Following Phase 1 of the study, which included 24 participants, Phase 2 of the study included 4 additional participants who were selected …

Sensing Development Of A Soybean Canopy Under P Or K Nutritional Stress, Martin M. Navarro

Theses and Dissertations--Plant and Soil Sciences

The normalized difference vegetative index (NDVI) has been correlated with physiological plant parameters and used to evaluate plant growth. There is little information about the use of this technique to detect soybean nutrient deficiencies. The objective of this work was to determine the ability of the NDVI sensor to detect P and K deficiencies, and grain yield reduction, in soybean. During 2010 and 2011, NDVI measurements were made on a soybean field trial site known to exhibit yield responses to both P and K nutrition. Four replicates of 8 levels each of P and K nutrition were evaluated. The NDVI …

Invasive Ecology Of Exotic Old World Bluestem Grasses And Insights For Coastal Prairie Restoration In South Texas, Marvin E. Ruffner

Theses and Dissertations--Plant and Soil Sciences

Despite the agronomic benefits of exotic grass plantings for pasture and rangeland forage, exotic grass invasions are capable of having dramatic and widespread impacts on native communities and ecosystems. Exotic Old World bluestem grasses (OWBG; Bothriochloa and Dichanthium spp.) have become increasingly invasive throughout the central and southern U.S. Little is known regarding the impacts of OWBG invasion on native grassland and savannah ecology and how to successfully control OWBG invasions in natural areas. Accordingly, this dissertation research had several objectives: 1) Evaluate the efficacy of herbicide and/or disking to control OWBG; 2) Assess the relative competitive ability of the …

The Role Of Auxin Resistant 1 (Axr1) In Arabidopsis Cytokinin Signaling, Yan Li

Theses and Dissertations--Plant and Soil Sciences

The plant hormone cytokinin plays essential roles in many aspects of growth and development. The cytokinin signal is transmitted by a multistep phosphorelay to the members of two functionally antagonistic classes of Arabidopsis response regulators (ARRs): the type-B ARRs (response activators) and type-A ARRs (negative-feedback regulators). Previous studies have shown that mutations in AXR1, encoding a subunit of the E1 enzyme in the related to ubiquitin (RUB) modification pathway, leads to decreased cytokinin sensitivity. This research shows that the cytokinin resistance of axr1 seedlings is suppressed by loss-of-function of type-A ARRs and that the cytokinin resistance caused by …

Venezuelan Tepuis: Their Caves And Biota, R. Aubrecht, C. L. Barrio-Amorós, Abraham Breure

KIP Monographs

From the Preface: "The world at the top of the tepuis of Venezuela is amazing. Ever since Sir Arthur Conan Doyle wrote "The Lost World", the enigma of the South American steep and isolated table-mountains have attracted many people. Everyone in our research team dreamt about exploring these "blank spaces on the map". However, despite this great attraction, scientific literature concerning tepuis has remained rather scarce. We are therefore proud to present this scientific monograph on tepuis, which is considered to be only the second issue of its kind, following the work of Huber (1992). This volume summarizes the main …

Homeostatic Imbalance In Epithelial Ducts And Its Role In Carcinogenesis, Katarzyna A. Rejniak

Oncologic Sciences Faculty Publications

An epithelial duct is a well-defined multicellular structure composed of tightly packed cells separating and protecting body compartments that are used for enzyme secretion and its transport across the internal. The structural and functional integrity (homeostasis) of such ducts is vital in carrying many life functions (breathing, lactation, production of hormones). However, the processes involved in maintaining the homeostatic balance are not yet fully understood. On the other hand, the loss of epithelial tissue architecture, such as filled lumens or ductal disorganization, are among the first symptoms of the emerging epithelial tumors (carcinomas). Using the previously developed biomechanical model of …

3,3-Dimethyl-1,2,3,4-Tetra­Hydro­Cyclo­Penta­[B]Indole-1,2-Dione (Bruceolline E), Jason A. Jordon, Jeanese C. Badenock, Gordon W. Gribble, Jerry P. Jasinski, James A. Golen

Dartmouth Scholarship

The title compound, C13H11NO2, crystallizes with two mol­ecules in the asymmetric unit. The crystal packing is stabilized by N—H⋯O hydrogen bonds, which link the mol­ecules into chains along [10], and weak C—H⋯O inter­actions.

Seg1 Controls Eisosome Assembly And Shape, Karen E. Moreira, Sebastian Schuck, Bianca Schrul, Florian Fröhlich, James B. Moseley

Dartmouth Scholarship

Eisosomes are stable domains at the plasma membrane of the budding yeast Saccharomyces cerevisiae and have been proposed to function in endocytosis. Eisosomes are composed of two main cytoplasmic proteins, Pil1 and Lsp1, that form a scaffold around furrow-like plasma membrane invaginations. We show here that the poorly characterized eisosome protein Seg1/Ymr086w is important for eisosome biogenesis and architecture. Seg1 was required for efficient incorporation of Pil1 into eisosomes and the generation of normal plasma membrane furrows. Seg1 preceded Pil1 during eisosome formation and established a platform for the assembly of other eisosome components. This platform was further shaped and …

2012-2013 Southern Illinois University Bulletin Carbondale Campus (Graduate Catalog), Southern Illinois University Carbondale

SIU Bulletins and Course Catalogs Archives

No abstract provided.

2012-2013 Southern Illinois University Bulletin Carbondale Campus (Undergraduate Catalog), Southern Illinois University Carbondale

SIU Bulletins and Course Catalogs Archives

No abstract provided.

Negotiating The Ideological Boundaries Of "The Four Freedoms": An Analysis Of African American Rhetoric From World War Ii, Jansen Blake Werner

All Graduate Theses, Dissertations, and Other Capstone Projects

This project explores how African Americans continued the quest for civil rights during WWII. In order to do so, however, one must acknowledge that black spokespersons responded to competing discourses--particularly, the discourses of U.S. officials such as President Franklin D. Roosevelt. In an era where propaganda pervaded the public sphere, the sheer force of the white majority in the U.S. was politically and socially overwhelming. Thus, non-dominant groups, such as African Americans, were forced to react from a restricted discursive space. In this regard, my analysis cuts two-fold. First, I examine how President Roosevelt galvanized support for his "Four Freedoms" …

Organizational Wellness Programs: Who Participates And Does It Help?, Justin Michael Dumond

All Graduate Theses, Dissertations, and Other Capstone Projects

Several research questions exist concerning the effectiveness of employee wellness programs. Do Theory of Reasoned action components such as health attitudes and intentions lead to wellness program involvement? Does wellness program involvement moderate the relationships between occupational stress, turnover, and job performance, such that wellness involvement mitigates the negative impact of occupational stress? Additionally, does wellness involvement moderate the relationships between work/life imbalance, turnover, and job performance, such that wellness involvement mitigates the negative impact of work/life imbalance? Data from 10,430 employees of an organization with an optional wellness program was analyzed. Hypotheses relating to TRA and the work/life imbalance-job …

State Of Utah V. David W. Ward : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2007– 2019)

Appeal from a conviction for aggravated assault, a third degree felony, in the Fourth Judicial District, Wasatch County, the Honorable Derek P. Pullan presiding.

Toward The History Of Study Of Symbiogenesis: On The English Translation Of B. M. Kozo-Polyansky’S A New Principle Of Biology (1924), Victor Fet

Biological Sciences Faculty Research

We reproduce the text by Victor Fet, which was read on 6 October 2011 at the Moscow Society of Naturalists during the presentation of new book translation (B.M. Kozo- Polyansky. Symbiogenesis: A New Principle of Evolution / transl. by Victor Fet; ed. by Victor Fet & Lynn Margulis. Cambridge, Mass.: Harvard University Press, 2010. 138 p.) This half- forgotten book by Boris M. Kozo-Polyansky was known only by name to Western biologists. Victor Fet gives a brief history of this new translation, enthusiastically initiated and supported by Lynn Margulis (1938–2011), a famous naturalist who was always eager to gave credit …

A Response To Appleton And Pollak, I. Glenn Cohen, Daniel L. Chen

Minnesota Law Review Headnotes, Vols. 94-106 (2009-2022)

No abstract provided.

Colby College Catalogue 2012 - 2013, Colby College

Colby Catalogues

Colby College Catalogue: September 2012 - August 2013

Health Care Providers' Intention To Provide Culturally Competent Health Care To Somali Based Upon The Indirect Measures Of The Integrated Behavioral Model, Amanda Kaye Ciesinski

All Graduate Theses, Dissertations, and Other Capstone Projects

The purpose of this cross-sectional study was to assess health care providers' intention to provide culturally competent health care to Somali based upon the constructs of the Integrated Behavioral Model by indirect measures. Using ZoomerangTM data collection systems, data were collected on a non-random and purposive sample. Every physician, nurse practitioner, and physician assistant in a non-administrative role at a rural primary care clinic located in Minnesota was recruited by email. A sample of thirty-one health care providers was used in this study. The survey was divided into four main scales based on the constructs of the Integrated Behavioral Model. …

Groundwater: A Comparative Analysis Of The Regulation Of Groundwater Encountered In Surface Mining, Jason Aamodt, Krystina Phillips, Rene Annesley

Oklahoma Law Review

No abstract provided.

Is A Substantive, Non-Positivist United States Environmental Law Possible?, Dan Tarlock

Michigan Journal of Environmental & Administrative Law

U.S. environmental law is almost exclusively positive and procedural. The foundation is the pollution control and biodiversity conservation statutes enacted primarily between 1969–1980 and judicial decisions interpreting them. This law has created detailed processes for making decisions but has produced few substantive constraints on private and public decisions which impair the environment. Several substantive candidates have been proposed, such as the common law, a constitutional right to a healthy environment, the public trust, and the extension of rights to fauna and flora. However, these candidates have not produced the hoped for substantive law. Many argue that a substantive U.S. environmental …

Gaba Is Excitatory In Adult Vasopressinergic Neuroendocrine Cells, Juhee Haam, Ion R. Popescu, Linda A. Morton, Katalin C. Halmos, Ryoichi Teruyama, Yoichi Ueta, Jeffrey G. Tasker

Faculty Publications

Neuronal excitability in the adult brain is controlled by a balance between synaptic excitation and inhibition mediated by glutamate and GABA, respectively. While generally inhibitory in the adult brain, GABAA receptor activation is excitatory under certain conditions in which the GABA reversal potential is shifted positive due to intracellular Cl-accumulation, such as during early postnatal development and brain injury. However, the conditions under which GABA is excitatory are generally either transitory or pathological. Here, we reveal GABAergic synaptic inputs to be uniformly excitatory in vasopressin (VP)-secreting magnocellular neurons in the adult hypothalamus under normal conditions. The GABA reversal potential (EGABA) …

Identification Of An Oxygenic Reaction Center Psbadc Operon In The Cyanobacterium Gloeobacter Violaceus Pcc 7421, Tuan A. Nguyen, Jasmina Brescic, David J. Vinyard, Thenappan Chandrasekar, G. Charles Dismukes

Faculty Publications

Gloeobacter violaceus, the earliest diverging oxyphotobacterium (cyanobacterium) on the 16S ribosomal RNA tree, has five copies of the photosystem II psbA gene encoding the D1 reaction center protein subunit. These copies are widely distributed throughout the 4.6 Mbp genome with only one copy colocalizing with other PSII subunits, in marked contrast to all other psbA genes in all publicly available sequenced genomes. A clustering of two other psb genes around psbA3 (glr2322) is unique to Gloeobacter. We provide experimental proof for the transcription of a psbA3DC operon, encoding three of the five reaction center core subunits (D1, D2, and CP43). …