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2012

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Bioconversionof Biomass Residuefrom Thecultivation Of Pea Sprouts On Spent Pleurotussajor-Cajucompost Employing Lumbricus Rubellus, Azizi Abu Bakar, Noor Zalina Mahmood, Noorlidah Abdullah, Rosna Mat Taha Jan 2012

Bioconversionof Biomass Residuefrom Thecultivation Of Pea Sprouts On Spent Pleurotussajor-Cajucompost Employing Lumbricus Rubellus, Azizi Abu Bakar, Noor Zalina Mahmood, Noorlidah Abdullah, Rosna Mat Taha

Research Publications (2011 to 2015)

Vermicomposting is a green technology for the purpose of nutrient enrichment from a variety of organic waste products. In this study, saw dust-based spent mushroom compost (SMC), an organic waste and biomass residue, was used as a medium for the cultivation of pea sprouts. After harvesting the pea sprouts, the growth medium was reused to culture earthworms, Lumbricus rubellus. The culturing activity was conducted for 50 days without any pre-composting or thermocomposting. Thus duration of vermicomposting process was shortened as opposed to previous work on vermicomposting of saw dust-based SMC (no amendment) for 70 days. The culturing treatments were conducted …

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Boesenbergia Rotunda: From Ethnomedicine To Drug Discovery, T. Eng-Chong, L. Yean-Kee, C. Chin-Fei, H. Choon-Han, W. Sher-Ming, C.T. Li-Ping, F. Gen-Teck, Norzulaani Khalid, N. Abd Rahman, S.A. Karsani, S. Othman, R. Othman, R. Yusof Jan 2012

Boesenbergia Rotunda: From Ethnomedicine To Drug Discovery, T. Eng-Chong, L. Yean-Kee, C. Chin-Fei, H. Choon-Han, W. Sher-Ming, C.T. Li-Ping, F. Gen-Teck, Norzulaani Khalid, N. Abd Rahman, S.A. Karsani, S. Othman, R. Othman, R. Yusof

Research Publications (2011 to 2015)

Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientists worldwide to further investigate its medicinal properties. Advancement in drug design and discovery research has led to the development of synthetic drugs from B. rotunda metabolites via bioinformatics and medicinal chemistry studies. Furthermore, with the advent of genomics, transcriptomics, proteomics, and metabolomics, new insights on the biosynthetic pathways of B. rotunda metabolites can be …

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Characterization Of Quorum Sensing And Quorum Quenching Soil Bacteria Isolated From Malaysian Tropical Montane Forest, T.M. Chong, C.L. Koh, C.K. Sam, Y.M. Choo, W.F. Yin, Kok Gan Chan Jan 2012

Characterization Of Quorum Sensing And Quorum Quenching Soil Bacteria Isolated From Malaysian Tropical Montane Forest, T.M. Chong, C.L. Koh, C.K. Sam, Y.M. Choo, W.F. Yin, Kok Gan Chan

Research Publications (2011 to 2015)

We report the production and degradation of quorum sensing N-acyl-homoserine lactones by bacteria isolated from Malaysian montane forest soil. Phylogenetic analysis indicated that these isolates clustered closely to the genera of Arthrobacter, Bacillus and Pseudomonas. Quorum quenching activity was detected in six isolates of these three genera by using a series of bioassays and rapid resolution liquid chromatography analysis. Biosensor screening and high resolution liquid chromatography-mass spectrometry analysis revealed the production of N-dodecanoyl-L-homoserine lactone (C12-HSL) by Pseudomonas frederiksbergensis (isolate BT9). In addition to degradation of a wide range of N-acyl-homoserine lactones, Arthrobacter and Pseudomonas spp. also degraded p-coumaroyl-homoserine lactone. To …

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Characterization Of Shigella Sonnei In Malaysia, An Increasingly Prevalent Etiologic Agent Of Local Shigellosis Cases, X.P. Koh, C.S. Chiou, N. Ajam, H. Watanabe, N. Ahmad, Kwai Lin Thong Jan 2012

Characterization Of Shigella Sonnei In Malaysia, An Increasingly Prevalent Etiologic Agent Of Local Shigellosis Cases, X.P. Koh, C.S. Chiou, N. Ajam, H. Watanabe, N. Ahmad, Kwai Lin Thong

Research Publications (2011 to 2015)

Background: Shigellosis is a major public health concern worldwide, especially in developing countries. It is an acute intestinal infection caused by bacteria of the genus Shigella, with a minimum infective dose as low as 10-100 bacterial cells. Increasing prevalence of Shigella sonnei as the etiologic agent of shigellosis in Malaysia has been reported. As there is limited information on the genetic background of S. sonnei in Malaysia, this study aimed to characterize Malaysian S. sonnei and to evaluate the prospect of using multilocus variable-number tandem-repeat (VNTR) analysis (MLVA) for subtyping of local S. sonnei. Methods: Forty non-repeat clinical strains of …

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Comparative Genetic Analysis Of Vp4, Vp1 And 3d Gene Regions Of Enterovirus 71 And Coxsackievirus A16 Circulating In Malaysia Between 1997-2008, Y.F. Chan, K.L. Wee, C.W. Chiam, C.S. Khor, S.Y. Chan, W.M.Z.W.N. Amalina, I.C. Sam Jan 2012

Comparative Genetic Analysis Of Vp4, Vp1 And 3d Gene Regions Of Enterovirus 71 And Coxsackievirus A16 Circulating In Malaysia Between 1997-2008, Y.F. Chan, K.L. Wee, C.W. Chiam, C.S. Khor, S.Y. Chan, W.M.Z.W.N. Amalina, I.C. Sam

Research Publications (2011 to 2015)

Three genomic regions, VP4 capsid, VP1 capsid and 3D RNA polymerase of human enterovirus 71 (EV-71) and coxsackievirus A16 (CV-A16) were sequenced to understand the evolution of these viruses in Malaysia. A total of 42 EV-71 and 36 CV-A16 isolates from 1997-2008 were sequenced. Despite the presence of many EV-71 subgenotypes worldwide, only subgenotypes B3, B4, B5, C1 and C2 were present in Malaysia. Importation of other subgenotypes such as C3, C4/D and C5 from other countries was infrequent. For CV-A16, the earlier subgenotype B1 was replaced by subgenotypes B2a and the recent B2c. Subgenotype B2a was present throughout the …

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Comparison Of Methicillin-Resistant And Methicillin-Sensitive Staphylococcus Aureus Strains Isolated From A Tertiary Hospital In Terengganu, Malaysia, King Ting Lim, Chew Chieng Yeo, Zarizal Suhaili, Kwai Lin Thong Jan 2012

Comparison Of Methicillin-Resistant And Methicillin-Sensitive Staphylococcus Aureus Strains Isolated From A Tertiary Hospital In Terengganu, Malaysia, King Ting Lim, Chew Chieng Yeo, Zarizal Suhaili, Kwai Lin Thong

Research Publications (2011 to 2015)

Staphylococcus aureus is a persistent human pathogen responsible for a variety of infections ranging from soft-tissue infections to bacteremia. The objective of this study was to determine genetic relatedness between methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) strains. We isolated 35 MRSA and 21 MSSA strains from sporadic cases at the main tertiary hospital in Terengganu, Malaysia, screening them for the presence of virulence genes. Their genetic relatedness was determined by accessory gene regulator (agr) types, PCR-restriction fragment length polymorphism (RFLP) of the coa gene, pulsed-field gel electrophoresis (PFGE), S. aureus protein A (spa), and multilocus-sequence typing (MLST). …

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Comparison Of Predicted Susceptibility Between Genotype And Virtual Phenotype Hiv Drug Resistance Interpretation Systems Among Treatment-Naive Hiv-Infected Patients In Asia: Taser-M Cohort Analysis, A. Jiamsakul, R. Kantor, P.C. Li, S. Sirivichayakul, T. Sirisanthana, P. Kantipong, C.K. Lee, A. Kamarulzaman, W. Ratanasuwan, R. Ditangco, T. Singtoroj, S. Sungkanuparph Jan 2012

Comparison Of Predicted Susceptibility Between Genotype And Virtual Phenotype Hiv Drug Resistance Interpretation Systems Among Treatment-Naive Hiv-Infected Patients In Asia: Taser-M Cohort Analysis, A. Jiamsakul, R. Kantor, P.C. Li, S. Sirivichayakul, T. Sirisanthana, P. Kantipong, C.K. Lee, A. Kamarulzaman, W. Ratanasuwan, R. Ditangco, T. Singtoroj, S. Sungkanuparph

Research Publications (2011 to 2015)

Background: Accurate interpretation of HIV drug resistance (HIVDR) testing is challenging, yet important for patient care. We compared genotyping interpretation, based on the Stanford University HIV Drug Resistance Database (Stanford HIVdb), and virtual phenotyping, based on the Janssen Diagnostics BVBA’s vircoTYPE™ HIV-1, and investigated their level of agreement in antiretroviral (ARV) naive patients in Asia, where non-B subtypes predominate. Methods: Sequences from 1301 ARV-naive patients enrolled in the TREAT Asia Studies to Evaluate Resistance – Monitoring Study (TASER-M) were analysed by both interpreting systems. Interpretations from both Stanford HIVdb and vircoTYPE™ HIV-1 were initially grouped into 2 levels: susceptible and …

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Computational Intelligence Based Technique In Multiple Facts Devices Installation For Power System Security, S.A. Jumaat, I. Musirin, M.M. Othman, Hazlie Mokhlis Jan 2012

Computational Intelligence Based Technique In Multiple Facts Devices Installation For Power System Security, S.A. Jumaat, I. Musirin, M.M. Othman, Hazlie Mokhlis

Research Publications (2011 to 2015)

This paper presents a study on optimal location and sizing of multiple FACTS devices based on Particle Swarm Optimization (PSO) for minimization of transmission losses, and voltage profile improvement, which takes into account the cost of installation. In this study, Static Var Compensator (SVC) and Thyristor Controlled Series Compensator (TCSC) are chosen as the compensating device for the purposes of maintaining security in power system. Simulations for various loading conditions at several load buses have been conducted in order to evaluate its robustness and feasibility for broad implementation. In addition, installation of several FACTS devices into the system has been …

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Cucurbitacin L 2-O-Β-Glucoside Demonstrates Apoptogenesis In Colon Adenocarcinoma Cells (Ht-29): Involvement Of Reactive Oxygen And Nitrogen Species Regulation, S.I. Abdelwahab, L.E. Hassan, A.M. Abdul Majid, S.M. Yagi, S. Mohan, M.M. Elhassan Taha, S. Ahmad, C.S. Chuen, P. Narrima, M.M. Rais, S. Syam, B.A. Moharam, A.H. Hadi Jan 2012

Cucurbitacin L 2-O-Β-Glucoside Demonstrates Apoptogenesis In Colon Adenocarcinoma Cells (Ht-29): Involvement Of Reactive Oxygen And Nitrogen Species Regulation, S.I. Abdelwahab, L.E. Hassan, A.M. Abdul Majid, S.M. Yagi, S. Mohan, M.M. Elhassan Taha, S. Ahmad, C.S. Chuen, P. Narrima, M.M. Rais, S. Syam, B.A. Moharam, A.H. Hadi

Research Publications (2011 to 2015)

Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. Cucurbitacins are a group of highly oxygenated triterpenes. Many plants used in folk medicine to treat cancer have been found to contain cucurbitacins displaying potentially important anti-inflammatory actions. The current study was designed to investigate the anti-ROS and -RNS effects of cucurbitacin L 2-O-β-glucoside (CLG) and the role of these signaling factors in the apoptogenic effects of CLG on human colon cancer cells (HT-29). This natural cucurbitacin was isolated purely from Citrullus lanatus var. citroides (Cucurbitaceae). The results …

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Cytokine Expression Profile Of Dengue Patients At Different Phases Of Illness, A. Rathakrishnan, S.M. Wang, Y.L. Hu, A.M. Khan, S. Ponnampalavanar, L.C.S. Lum, R. Manikam, S.D. Sekaran Jan 2012

Cytokine Expression Profile Of Dengue Patients At Different Phases Of Illness, A. Rathakrishnan, S.M. Wang, Y.L. Hu, A.M. Khan, S. Ponnampalavanar, L.C.S. Lum, R. Manikam, S.D. Sekaran

Research Publications (2011 to 2015)

Background: Dengue is an important medical problem, with symptoms ranging from mild dengue fever to severe forms of the disease, where vascular leakage leads to hypovolemic shock. Cytokines have been implicated to play a role in the progression of severe dengue disease; however, their profile in dengue patients and the synergy that leads to continued plasma leakage is not clearly understood. Herein, we investigated the cytokine kinetics and profiles of dengue patients at different phases of illness to further understand the role of cytokines in dengue disease. Methods and Findings: Circulating levels of 29 different types of cytokines were assessed …

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Denguetools: Innovative Tools And Strategies For The Surveillance And Control Of Dengue, Annelies Wilder-Smith, Karl Erik Renhorn, Hasitha Tissera, Sazaly Abubakar, Luke Alphey, Pattamaporn Kittayapong, Steve Lindsay, James Logan, Christoph Hatz, Paul Reiter, Joacim Rocklöv, Peter Byass, Valerie R. Louis, Yesim Tozan, Eduardo Massad, Antonio Tenorio, Christophe Lagneau, Gregory L'Ambert, David Brooks, Johannah Wegerdt, Duane Gubler Jan 2012

Denguetools: Innovative Tools And Strategies For The Surveillance And Control Of Dengue, Annelies Wilder-Smith, Karl Erik Renhorn, Hasitha Tissera, Sazaly Abubakar, Luke Alphey, Pattamaporn Kittayapong, Steve Lindsay, James Logan, Christoph Hatz, Paul Reiter, Joacim Rocklöv, Peter Byass, Valerie R. Louis, Yesim Tozan, Eduardo Massad, Antonio Tenorio, Christophe Lagneau, Gregory L'Ambert, David Brooks, Johannah Wegerdt, Duane Gubler

Research Publications (2011 to 2015)

Dengue fever is a mosquito-borne viral disease estimated to cause about 230 million infections worldwide every year, of which 25,000 are fatal. Global incidence has risen rapidly in recent decades with some 3.6 billion people, over half of the world's population, now at risk, mainly in urban centres of the tropics and subtropics. Demographic and societal changes, in particular urbanization, globalization, and increased international travel, are major contributors to the rise in incidence and geographic expansion of dengue infections. Major research gaps continue to hamper the control of dengue. The European Commission launched a call under the 7th Framework Programme …

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Descriptions Of Two New Species Of Simulium (Simulium) (Diptera: Simuliidae) From Tioman Island, Peninsular Malaysia, H. Takaoka, Mohd Sofian-Azirun, D.M. Belabut Jan 2012

Descriptions Of Two New Species Of Simulium (Simulium) (Diptera: Simuliidae) From Tioman Island, Peninsular Malaysia, H. Takaoka, Mohd Sofian-Azirun, D.M. Belabut

Research Publications (2011 to 2015)

Two new species of black flies, Simulium (Simulium) jasmoni and S. (S.) tiomanense, are described on the basis of adult, pupal and larval specimens collected from Tioman Island, Pahang, Malaysia, and are placed in the tuberosum species-group in the subgenus Simulium (Simulium) Latreille. Simulium (S.) jasmoni, new species, is characterised by the female tarsal claw with a minute subbasal projection, an unusual characteristic within the species-group, and S. (S.) tiomanense, new species, is striking in having a dichoptic male head, a characteristic rarely recorded in the family Simuliidae, as well as the pupal thoracic integument with a pit-like organ near …

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Determining The Optimal Concentration Of Mannose As An Effective Selection Agent For Transformed Oil Palm Cells Using The Phosphomannose Isomerase (Pmi) Gene As A Positive Selectable Marker, B. Bahariah, G.K.A. Parveez, N. Khalid Jan 2012

Determining The Optimal Concentration Of Mannose As An Effective Selection Agent For Transformed Oil Palm Cells Using The Phosphomannose Isomerase (Pmi) Gene As A Positive Selectable Marker, B. Bahariah, G.K.A. Parveez, N. Khalid

Research Publications (2011 to 2015)

The elimination of antibiotic or herbicide resistance gene usage in genetically modified plants is being encouraged due to public concern. In response to this, alternative selection systems for the recovery of transgenic oil palm were developed using positive selectable markers. To establish a selection system that utilises the phosphomannose isomerase (pmi) gene for oil palm transformation, we first determined the optimal mannose concentration for selecting the transformed cells. Non-transformed embryogenic calli were cultured on media containing various combinations and concentrations of mannose and a usable source of carbon, i.e. sucrose, ranging in content from 0 to 30 g litre . …

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Different Wavelengths Light To Induce Physiological Changes Callus For The Biosynthesis Of Gymnemic Acid In Gymnema Sylvestre, A.B.A. Ahmed, A.S. Rao, M.V. Rao, R.M. Taha Jan 2012

Different Wavelengths Light To Induce Physiological Changes Callus For The Biosynthesis Of Gymnemic Acid In Gymnema Sylvestre, A.B.A. Ahmed, A.S. Rao, M.V. Rao, R.M. Taha

Research Publications (2011 to 2015)

A callus culture of Gymnema sylvestre was cultivated under different light conditions (blue, white, red and green light). Green-white coloured gymnemic acid containing cell groups were formed on the surface of the callus culture under blue light respectively. The phytohormone kinetin enhanced the gymnemic acid formation in blue light, but was unable to induce gymnemic acid in darkness. The phytohormone 2,4-D induced the formation gymnemic acid under all light conditions studied. Analysis of the callus growth phase under all treatments revealed that gymnemic acid accumulation was maximum (12.22 mg/g d.w) in the callus during stationary phase of 45 days, grown …

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Diversity Of Malaysian Moray Eels (Anguilliformes: Muraenidae), K.H. Loh, S.H. Muhammad Ali, V.C. Chong, A. Sasekumar Jan 2012

Diversity Of Malaysian Moray Eels (Anguilliformes: Muraenidae), K.H. Loh, S.H. Muhammad Ali, V.C. Chong, A. Sasekumar

Research Publications (2011 to 2015)

No abstract provided.

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Domiciliary Cockroaches Found In Restaurants In Five Zones Of Kuala Lumpur Federal Territory, Peninsular Malaysia, J. Jeffery, S. Sulaiman, P. Oothuman, S. Vellayan, P. Zainol-Ariffin, S. Paramaswaran, A. Razak, M. Muslimin, O.B. Kamil-Ali, M. Rohela, N.M. Abdul-Aziz Jan 2012

Domiciliary Cockroaches Found In Restaurants In Five Zones Of Kuala Lumpur Federal Territory, Peninsular Malaysia, J. Jeffery, S. Sulaiman, P. Oothuman, S. Vellayan, P. Zainol-Ariffin, S. Paramaswaran, A. Razak, M. Muslimin, O.B. Kamil-Ali, M. Rohela, N.M. Abdul-Aziz

Research Publications (2011 to 2015)

The following domiciliary cockroaches were collected from restaurants in five zones of Kuala Lumpur Federal Territory, Malaysia using IL glass beaker traps baited with ground mouse-pellets: Periplaneta americana (Linnaeus) (n = 820), Periplaneta brunnea Burmeister (n = 46), Blattella germanica (Linnaeus) (n = 12504), Supella longipalpa (Fabricius) (n = 321), Symploce pallens Stephens (n = 29) and Neostylopyga rhombifolia (Stoll) (n = 5). The following bacteria were isolated from 10 cockroach specimens: Enterobacter cloacae, Klebsiella pneumoniae ssp. pneumoniae, Klebsiella pneumoniae ssp. rhinoscleromatis and Serratia liquefaciens from 5 B. germanica; Acinetobacter calcoaceticus var. anitratus, Citrobacter diversus/amalonaticus, Escherichia vulneris and K.p. pneumoniae …

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Eeg Feature Extraction Using Parametric And Non-Parametric Models, F. Shiman, S.H. Safavi, F.M. Vaneghi, M. Oladazimi, M.J. Safari, F. Ibrahim Jan 2012

Eeg Feature Extraction Using Parametric And Non-Parametric Models, F. Shiman, S.H. Safavi, F.M. Vaneghi, M. Oladazimi, M.J. Safari, F. Ibrahim

Research Publications (2011 to 2015)

We have conducted extensive review on parametric and nonparametric methods for EEG feature extraction and application. We believe that this is the first attempt to compare all methods. Our findings indicate that parametric method does not provide good performance for EEG signal while non-parametric method lack of detail information on the EEG analysis. © 2012 IEEE.

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Effect Of Mucuna Pruriens Seed Extract Pretreatment On The Responses Of Spontaneously Beating Rat Atria And Aortic Ring To Naja Sputatrix (Javan Spitting Cobra) Venom, Shin Yee Fung, Nget Hong Tan, Si Mui Sim, John C. Aguiyi Jan 2012

Effect Of Mucuna Pruriens Seed Extract Pretreatment On The Responses Of Spontaneously Beating Rat Atria And Aortic Ring To Naja Sputatrix (Javan Spitting Cobra) Venom, Shin Yee Fung, Nget Hong Tan, Si Mui Sim, John C. Aguiyi

Research Publications (2011 to 2015)

Mucuna pruriens Linn. (velvet bean) has been used by native Nigerians as a prophylactic for snakebite. Rats pretreated with M. pruriens seed extract (MPE) have been shown to protect against the lethal and cardiovascular depressant effects of Naja sputatrix (Javan spitting cobra) venoms, and the protective effect involved immunological neutralization of the venom toxins. To investigate further the mechanism of the protective effect of MPE pretreatment against cobra venom toxicity, the actions of Naja sputatrix venom on spontaneously beating rat atria and aortic rings isolated from both MPE pretreated and untreated rats were studied. Our results showed that the MPE …

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Effect Of Phenotypic Switching On The Biological Properties And Susceptibility To Chlorhexidine In Candida Krusei Atcc 14243, M.H. Arzmi, Fathilah Abdul Razak, M.Y. Musa, W. Harun Jan 2012

Effect Of Phenotypic Switching On The Biological Properties And Susceptibility To Chlorhexidine In Candida Krusei Atcc 14243, M.H. Arzmi, Fathilah Abdul Razak, M.Y. Musa, W. Harun

Research Publications (2011 to 2015)

Phenotypic switching is characterized as a virulence factor of Candida spp. This study was carried out to evaluate the phenotypic switching ability of C. krusei ATCC 14243 and to determine its effect on the biological properties, adherence capacity and susceptibility towards chlorhexidine digluconate (CHX). To induce switched generations C. krusei was cultured under nitrogen-depleted growth conditions by adding phloxine B. These phenotypically switched colonies were designated as the 1st generation. Subsequent sub-culturing was performed to produce the 2nd, 3rd and 4th switched generations. The recovery of the 3rd generation was the highest at 85.7 while that of the 4th generation …

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Effects Of Biomass, Cod And Bicarbonate Concentrations On Fermentative Hydrogen Production From Pome By Granulated Sludge In A Batch Culture, P. Mohammadi, S. Ibrahim, M.S. Mohamad Annuar Jan 2012

Effects Of Biomass, Cod And Bicarbonate Concentrations On Fermentative Hydrogen Production From Pome By Granulated Sludge In A Batch Culture, P. Mohammadi, S. Ibrahim, M.S. Mohamad Annuar

Research Publications (2011 to 2015)

Effects of three selected variables viz. biomass concentration, initial chemical oxygen demand (COD) concentration and initial bicarbonate alkalinity (BA) on biological hydrogen production from palm oil mill effluent (POME) using the granulated sludge in batch culture were investigated. The experimental results were analyzed and modeled using a central composite design (CCD) of response surface methodology (RSM). In order to carry out a comprehensive analysis of the biohydrogen production process, indicative parameters namely hydrogen yield (Y H), specific hydrogen production rate (SHPR), and COD removal efficiency were studied as the process responses. Maximum hydrogen yield (124.5 mmol H 2/g COD removed) …

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Effects Of Pithecellobium Jiringa Ethanol Extract Against Ethanol-Induced Gastric Mucosal Injuries In Sprague-Dawley Rats, M.A. Abdulla, I.A.A. Ibrahim, S.W. Qader, A.R. Nimir, S.I. Abdelwahab, F.H. Al-Bayaty Jan 2012

Effects Of Pithecellobium Jiringa Ethanol Extract Against Ethanol-Induced Gastric Mucosal Injuries In Sprague-Dawley Rats, M.A. Abdulla, I.A.A. Ibrahim, S.W. Qader, A.R. Nimir, S.I. Abdelwahab, F.H. Al-Bayaty

Research Publications (2011 to 2015)

Current anti-gastric ulcer agents have side effects, despite the progression and expansion of advances in treatment. This study aimed to investigate the gastroprotective mechanisms of Pithecellobium jiringa ethanol extract against ethanol-induced gastric mucosal ulcers in rats. For this purpose, Sprague Dawley rats were randomly divided into five groups: Group 1 (normal control) rats were orally administered with vehicle (carboxymethyl cellulose), Group 2 (ulcer control) rats were also orally administered with vehicle. Group 3 (positive control) rats were orally administered with 20 mg/kg omeprazole, Groups 4 and 5 (experimental groups) received ethanol extract of Pithecellobium jiringa ethanol extract at a concentration …

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Electro-Acupuncture (Ea) As An Adjunct Therapy To Methadone Maintenance Treatment (Mmt) In Heroin Addiction: A Study Of 2d Eeg Power Spectral Topography And Morlet Wavelet, F. Shiman, F. Molaei, M. Oladazimi, R. Abd Rashid, H. Habil, F. Ibrahim Jan 2012

Electro-Acupuncture (Ea) As An Adjunct Therapy To Methadone Maintenance Treatment (Mmt) In Heroin Addiction: A Study Of 2d Eeg Power Spectral Topography And Morlet Wavelet, F. Shiman, F. Molaei, M. Oladazimi, R. Abd Rashid, H. Habil, F. Ibrahim

Research Publications (2011 to 2015)

The present study investigates the efficiency of electro acupuncture (EA) as an adjunct therapy to methadone maintenance treatment (MMT) in heroin dependents. Time-frequency analysis, based on Morlet wavelet transform together with 2D spectral power topography were applied to demonstrate different brain dynamics in subjects being acupunctured as compared to controls. A significant decrease of delta activity in right hemisphere together with an increase of alpha activity in central areas was observed in subjects who underwent acupuncture which may indicate the modulatory effects of electro-acupuncture as a treatment to improve the conditions of opioid dependency. © 2012 IEEE.

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Entomologic Investigation Of Plasmodium Knowlesi Vectors In Kuala Lipis, Pahang, Malaysia, A. Jiram, I. Vythilingam, Y. Noorazian, Y. Yusof, A. Azahari, M.Y. Fong Jan 2012

Entomologic Investigation Of Plasmodium Knowlesi Vectors In Kuala Lipis, Pahang, Malaysia, A. Jiram, I. Vythilingam, Y. Noorazian, Y. Yusof, A. Azahari, M.Y. Fong

Research Publications (2011 to 2015)

ABSTRACT: BACKGROUND: The first natural infection of Plasmodium knowlesi in humans was recorded in 1965 in peninsular Malaysia. Extensive research was then conducted and it was postulated that it was a rare incident and that simian malaria will not be easily transmitted to humans. However, at the turn of the 21st century, knowlesi malaria was prevalent throughout Southeast Asia and is life threatening. Thus, a longitudinal study was initiated to determine the vectors, their seasonal variation and preference to humans and macaques. METHODS: Monthly mosquito collections were carried out in Kuala Lipis, Pahang, peninsular Malaysia, using human-landing collection and monkey-baited …

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Epidemiological And Genetic Data Supporting The Transmission Of Ancylostoma Ceylanicum Among Human And Domestic Animals, R. Ngui, Y. A. L. Lim, R. Traub, R. Mahmud, M. S. Mistam Jan 2012

Epidemiological And Genetic Data Supporting The Transmission Of Ancylostoma Ceylanicum Among Human And Domestic Animals, R. Ngui, Y. A. L. Lim, R. Traub, R. Mahmud, M. S. Mistam

Research Publications (2011 to 2015)

Background: Currently, information on species-specific hookworm infection is unavailable in Malaysia and is restricted worldwide due to limited application of molecular diagnostic tools. Given the importance of accurate identification of hookworms, this study was conducted as part of an ongoing molecular epidemiological investigation aimed at providing the first documented data on species-specific hookworm infection, associated risk factors and the role of domestic animals as reservoirs for hookworm infections in endemic communities of Malaysia. Methods/Findings: A total of 634 human and 105 domestic canine and feline fecal samples were randomly collected. The overall prevalence of hookworm in humans and animals determined …

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Ethnic Differences In Survival After Breast Cancer In South East Asia, N. Bhoo-Pathy, M. Hartman, C.H. Yip, N. Saxena, N.A. Taib, S.E. Lim, P. Iau, H.O. Adami, A.M. Bulgiba, S.C. Lee Jan 2012

Ethnic Differences In Survival After Breast Cancer In South East Asia, N. Bhoo-Pathy, M. Hartman, C.H. Yip, N. Saxena, N.A. Taib, S.E. Lim, P. Iau, H.O. Adami, A.M. Bulgiba, S.C. Lee

Research Publications (2011 to 2015)

BACKGROUND: The burden of breast cancer in Asia is escalating. We evaluated the impact of ethnicity on survival after breast cancer in the multi-ethnic region of South East Asia. METHODOLOGY/PRINCIPAL FINDINGS: Using the Singapore-Malaysia hospital-based breast cancer registry, we analyzed the association between ethnicity and mortality following breast cancer in 5,264 patients diagnosed between 1990 and 2007 (Chinese: 71.6, Malay: 18.4, Indian: 10.0). We compared survival rates between ethnic groups and calculated adjusted hazard ratios (HR) to estimate the independent effect of ethnicity on survival. Malays (nâ��=â��968) presented at a significantly younger age, with larger tumors, and at later stages …

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Gastroprotective Activity Of Polygonum Chinense Aqueous Leaf Extract On Ethanol-Induced Hemorrhagic Mucosal Lesions In Rats, Mahmood Ameen Abdulla, I.F. Ismail, S. Golbabapour, P. Hassandarvish, M. Hajrezaie, Nazia Abdul Majid, F.A. Kadir, F. Al-Bayaty, K. Awang, H. Hazni Jan 2012

Gastroprotective Activity Of Polygonum Chinense Aqueous Leaf Extract On Ethanol-Induced Hemorrhagic Mucosal Lesions In Rats, Mahmood Ameen Abdulla, I.F. Ismail, S. Golbabapour, P. Hassandarvish, M. Hajrezaie, Nazia Abdul Majid, F.A. Kadir, F. Al-Bayaty, K. Awang, H. Hazni

Research Publications (2011 to 2015)

Polygonum chinense is aMalaysian ethnic plant with various healing effects. This study was to determine preventive effect of aqueous leaf extract of P. chinense against ethanol-induced gastric mucosal injury in rats. Sprague Dawley rats were divided into seven groups. The normal and ulcer control groups were orally administered with distilled water. The reference group was orally administered with 20mg/kg omeprazole. The experimental groups received the extracts 62.5, 125, 250, and 500 mg/kg, accordingly. After sixty minutes, distilled water and absolute ethanol were given (5 mL/kg) to the normal control and the others,respectively. In addition to histology, immunohistochemical and periodic acid …

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Gelam Honey Has A Protective Effect Against Lipopolysaccharide (Lps)-Induced Organ Failure, M. Kassim, M. Mansor, N. Al-Abd, K.M. Yusoff Jan 2012

Gelam Honey Has A Protective Effect Against Lipopolysaccharide (Lps)-Induced Organ Failure, M. Kassim, M. Mansor, N. Al-Abd, K.M. Yusoff

Research Publications (2011 to 2015)

Gelam honey exerts anti-inflammatory and antioxidant activities and is thought to have potent effects in reducing infections and healing wounds. The aim of this study was to investigate the effects of intravenously-injected Gelam honey in protecting organs from lethal doses of lipopolysaccharide (LPS). Six groups of rabbits (N = 6) were used in this study. Two groups acted as controls and received only saline and no LPS injections. For the test groups, 1 mL honey (500 mg/kg in saline) was intravenously injected into two groups (treated), while saline (1 mL) was injected into the other two groups (untreated); after 1 …

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Gelam Honey Scavenges Peroxynitrite During The Immune Response, M. Kassim, M. Mansor, A. Suhaimi, G. Ong, K.M. Yusoff Jan 2012

Gelam Honey Scavenges Peroxynitrite During The Immune Response, M. Kassim, M. Mansor, A. Suhaimi, G. Ong, K.M. Yusoff

Research Publications (2011 to 2015)

Monocytes and macrophages are part of the first-line defense against bacterial, fungal, and viral infections during host immune responses; they express high levels of proinflammatory cytokines and cytotoxic molecules, including nitric oxide, reactive oxygen species, and their reaction product peroxynitrite. Peroxynitrite is a short-lived oxidant and a potent inducer of cell death. Honey, in addition to its well-known sweetening properties, is a natural antioxidant that has been used since ancient times in traditional medicine. We examined the ability of Gelam honey, derived from the Gelam tree (Melaleuca spp.), to scavenge peroxynitrite during immune responses mounted in the murine macrophage cell …

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Genetic Association Of Snps In The Fto Gene And Predisposition To Obesity In Malaysian Malays, Y.D. Apalasamy, M.F. Ming, S. Rampal, A. Bulgiba, Z. Mohamed Jan 2012

Genetic Association Of Snps In The Fto Gene And Predisposition To Obesity In Malaysian Malays, Y.D. Apalasamy, M.F. Ming, S. Rampal, A. Bulgiba, Z. Mohamed

Research Publications (2011 to 2015)

The common variants in the fat mass- and obesity-associated (FTO) gene have been previously found to be associated with obesity in various adult populations. The objective of the present study was to investigate whether the single nucleotide polymorphisms (SNPs) and linkage disequilibrium (LD) blocks in various regions of the FTO gene are associated with predisposition to obesity in Malaysian Malays. Thirty-one FTO SNPs were genotyped in 587 (158 obese and 429 non-obese) Malaysian Malay subjects. Obesity traits and lipid profiles were measured and single-marker association testing, LD testing, and haplotype association analysis were performed. LD analysis of the FTO SNPs …

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Genome Sequence And Comparative Genomics Analysis Of A Vibrio Cholerae O1 Strain Isolated From A Cholera Patient In Malaysia, Abdulrazak Osama, Han Ming Gan, Cindy Shuan Ju Teh, Kien Pong Yap, Kwai Lin Thong Jan 2012

Genome Sequence And Comparative Genomics Analysis Of A Vibrio Cholerae O1 Strain Isolated From A Cholera Patient In Malaysia, Abdulrazak Osama, Han Ming Gan, Cindy Shuan Ju Teh, Kien Pong Yap, Kwai Lin Thong

Research Publications (2011 to 2015)

The genome sequence analysis of a clinical Vibrio cholerae VC35 strain from an outbreak case in Malaysia indicates multiple genes involved in host adaptation and a novel Na+-driven multidrug efflux pump-coding gene in the genome of Vibrio cholerae with the highest similarity to VMA_001754 of Vibrio mimicus VMA223.

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