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2012

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Articles 16621 - 16650 of 22929

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Visualizing Quranic Words With Parallel Plot, R.J.R. Yuso, R. Zainuddin, M.S. Baba, N. Jomhari, Z.M. Yusoff Jan 2012

Visualizing Quranic Words With Parallel Plot, R.J.R. Yuso, R. Zainuddin, M.S. Baba, N. Jomhari, Z.M. Yusoff

Research Publications (2011 to 2015)

Parallel plot is a relatively new type of plot in comparison to scatter plot. The aim of this paper is to find out the effectiveness of parallel plot visualization in comparison to the scatter plot for novice users. Comparison through literature shows that parallel and scatter plot visualization techniques offer similar visualization features. A study was conducted based on the parallel plot in Parallel Coordinate for the Qur'an (PaCQ) interface using a relational model, Goals Operators Methods and Selection Rules (GOMS) analysis and user performance evaluation. Based on the GOMS analysis, the subtasks and operation time involved in exploring data …

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Waste Recycling: Feasibility Of Saw Dust Based Spent Mushroom Substrate And Goat Manure In Vermicomposting, A.A. Jamaludin, Noor Zalina Mahmood, N. Abdullah Jan 2012

Waste Recycling: Feasibility Of Saw Dust Based Spent Mushroom Substrate And Goat Manure In Vermicomposting, A.A. Jamaludin, Noor Zalina Mahmood, N. Abdullah

Research Publications (2011 to 2015)

Vermicomposting for 140 days by using Lumbricus rubellus was conducted after 21 days of natural pre-composting. Five treatments in different ratio of goat manure: spent mushroom substrate were prepared as feed materials with four replicates for each treatment namely; 20:80 (TA), 40:60 (TB), 50:50 (TC), 60:40 (TD) and 80:20 (TE). As for control, each treatment without earthworm was prepared. On the basis of nutrient elements, goat manure and spent mushroom substrate can be decomposed through both methods of vermicomposting and natural composting. Findings of this study indicated that the higher usage of goat manure with longer duration resulted in the …

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Whole-Genome Sequences And Comparative Genomics Of Salmonella Enterica Serovar Typhi Isolates From Patients With Fatal And Nonfatal Typhoid Fever In Papua New Guinea, Ramani Baddam, Kwai Lin Thong, Tiruvayipati Suma Avasthi, Sabiha Shaik, Kien Pong Yap, Cindy Shuan Ju Teh, Lay Ching Chai, Narender Kumarasamy, Niyaz Ahmed Jan 2012

Whole-Genome Sequences And Comparative Genomics Of Salmonella Enterica Serovar Typhi Isolates From Patients With Fatal And Nonfatal Typhoid Fever In Papua New Guinea, Ramani Baddam, Kwai Lin Thong, Tiruvayipati Suma Avasthi, Sabiha Shaik, Kien Pong Yap, Cindy Shuan Ju Teh, Lay Ching Chai, Narender Kumarasamy, Niyaz Ahmed

Research Publications (2011 to 2015)

Many of the developing countries of the Southeast Asian region are significantly affected by endemic typhoid fever, possibly as a result of marginal living standards. It is an important public health problem in countries such as Papua New Guinea, which is geographically close to some of the foci of endemicity in Asia. The severity of the disease varies in different regions, and this may be attributable to genetic diversity among the native strains. Genome sequence data on strains from different countries are needed to clearly understand their genetic makeup and virulence potential. We describe the genomes of two Salmonella Typhi …

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The Effects Of Simulated Rainfall On Immature Population Dynamics Of Aedes Albopictus And Female Oviposition, H. Dieng, G.M.S. Rahman, A. Abu Hassan, M.R. Che Salmah, T. Satho, F. Miake, M. Boots, Sazaly Abubakar Jan 2012

The Effects Of Simulated Rainfall On Immature Population Dynamics Of Aedes Albopictus And Female Oviposition, H. Dieng, G.M.S. Rahman, A. Abu Hassan, M.R. Che Salmah, T. Satho, F. Miake, M. Boots, Sazaly Abubakar

Research Publications (2011 to 2015)

Larvae of Aedes albopictus Skuse typically inhabit natural and artificial containers. Since these larval habitats are replenished by rainfall, Ae. albopictus may experience increased loss of immature stages in areas with high levels of rainfall. In this study, we investigated the effects of rainfall and container water level on population density, and oviposition activity of Ae. albopictus. In field and laboratory experiments, we found that rainfall resulted in the flushing of breeding habitats. Excess rain negatively impacted larval and pupal retention, especially in small habitats. When filled with water to overflowing, container habitats were significantly repellent to ovipositing females. Taken …

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(E,E)-1,2-Bis3-(Prop-2-Yn-1-Yloxy)Benzylidenehydrazine, W.N.A. Al-Mehana, Rosiyah Yahya, F. Sonsudin, K.M. Lo Jan 2012

(E,E)-1,2-Bis3-(Prop-2-Yn-1-Yloxy)Benzylidenehydrazine, W.N.A. Al-Mehana, Rosiyah Yahya, F. Sonsudin, K.M. Lo

Research Publications (2011 to 2015)

The molecule of the title compound, C 20H 16N 2O 2, is centrosymmetric, the inversion center being located at the mid-point of the central azine bond. The conformation around the C=N bond is E. The whole molecule (except for the H atoms) is essentially planar, with an r.m.s. deviation of 0.07 �. In the crystal, molecules are linked head-to-tail by pairs of C - H�O hydrogen bonds, forming inversion dimers, and resulting in the formation of chains propagating along 011.

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1 '- Acetoxychavicol Acetate Inhibits Growth Of Human Oral Carcinoma Xenograft In Mice And Potentiates Cisplatin Effect Via Proinflammatory Microenvironment Alterations, L.L.A. In, N.M. Arshad, H. Ibrahim, M.N. Azmi, Khalijah Awang, Noor Hasima Nagoor Jan 2012

1 '- Acetoxychavicol Acetate Inhibits Growth Of Human Oral Carcinoma Xenograft In Mice And Potentiates Cisplatin Effect Via Proinflammatory Microenvironment Alterations, L.L.A. In, N.M. Arshad, H. Ibrahim, M.N. Azmi, Khalijah Awang, Noor Hasima Nagoor

Research Publications (2011 to 2015)

Background: Oral cancers although preventable, possess a low five-year survival rate which has remained unchanged over the past three decades. In an attempt to find a more safe, affordable and effective treatment option, we describe here the use of 1'S-1'-acetoxychavicol acetate (ACA), a component of Malaysian ginger traditionally used for various medicinal purposes. Methods: Whether ACA can inhibit the growth of oral squamous cell carcinoma (SCC) cells alone or in combination with cisplatin (CDDP), was explored both in vitro using MTT assays and in vivo using Nu/Nu mice. Occurrence of apoptosis was assessed using PARP and DNA fragmentation assays, while …

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2245g/A Polymorphism Of The Receptor For Advanced Glycation End-Products (Rage) Gene Is Associated With Diabetic Retinopathy In The Malaysian Population, Zhi Xiang Ng, Umah Rani Kuppusamy, Iqbal Tajunisah, Kenneth Choong Sian Fong, Adrian Choon Aun Koay, Kek Heng Chua Jan 2012

2245g/A Polymorphism Of The Receptor For Advanced Glycation End-Products (Rage) Gene Is Associated With Diabetic Retinopathy In The Malaysian Population, Zhi Xiang Ng, Umah Rani Kuppusamy, Iqbal Tajunisah, Kenneth Choong Sian Fong, Adrian Choon Aun Koay, Kek Heng Chua

Research Publications (2011 to 2015)

Background/aims The receptor for advanced glycation end-products (RAGE) has been implicated in the pathogenesis of diabetic microvascular complications. The aim of this study was to investigate the association between 2245G/A gene polymorphism of the RAGE gene and retinopathy in Malaysian type 2 diabetic patients. Methods 342 unrelated type 2 diabetic patients (171 with retinopathy (DR), 171 without retinopathy (DNR)) and 235 unrelated healthy subjects from all over Malaysia were recruited for this study. Genomic DNA was isolated from 3â��ml samples of whole blood using a modified conventional DNA extraction method. The genotype and allele frequencies of 2245G/A were studied using …

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2,2'-Diethoxy-4,4'-(E, E)-Hydrazinediyl- Idenebis(Methanylylidene)Diphenol, W.N.A. Al-Mehana, Rosiyah Yahya, F. Sonsudin, I.N.A. Al-Mehana, K.M. Lo Jan 2012

2,2'-Diethoxy-4,4'-(E, E)-Hydrazinediyl- Idenebis(Methanylylidene)Diphenol, W.N.A. Al-Mehana, Rosiyah Yahya, F. Sonsudin, I.N.A. Al-Mehana, K.M. Lo

Research Publications (2011 to 2015)

The complete molecule of the title compound, C 18H 20N 2O 4, is generated by inversion symmetry. The conformation around the C=N bond is E. With the exception of the ethoxy substituent, the molecule is essentially planar with an r.m.s. deviation of 0.0455 �. In the crystal, molecules are linked by O - H·· ·N hydrogen bonds into a two-dimensional supra-molecular network parallel to the bc plane.

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A Brief Review On Anti Diabetic Plants: Global Distribution, Active Ingredients, Extraction Techniques And Acting Mechanisms, C.H. Chan, G.C. Ngoh, R. Yusoff Jan 2012

A Brief Review On Anti Diabetic Plants: Global Distribution, Active Ingredients, Extraction Techniques And Acting Mechanisms, C.H. Chan, G.C. Ngoh, R. Yusoff

Research Publications (2011 to 2015)

A study has been conducted with the aim to provide researchers with general information on anti diabetic extracts based on relevant research articles collected from 34 reliable medical journals. The study showed that Asian and African continents have 56 and 17 share of the worldwide distribution of therapeutic herbal plants, respectively. In Asia, India and China are the leading countries in herbal plants research, and there has been an increase in medicinal research on plants extract for diabetes treatment since 1995 in these regions. The information collected shows that plant leaves are about 20 more favorable for storing active ingredients, …

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7 Alpha-Hydroxy-Beta-Sitosterol From Chisocheton Tomentosus Induces Apoptosis Via Dysregulation Of Cellular Bax/Bcl-2 Ratio And Cell Cycle Arrest By Downregulating Erk1/2 Activation, Mohammad Tasyriq, Ibrahim A. Najmuldeen, Lionel L.A. In, Khalit Mohamad, Khalijah Awang, Noor Hasima Nagoor Jan 2012

7 Alpha-Hydroxy-Beta-Sitosterol From Chisocheton Tomentosus Induces Apoptosis Via Dysregulation Of Cellular Bax/Bcl-2 Ratio And Cell Cycle Arrest By Downregulating Erk1/2 Activation, Mohammad Tasyriq, Ibrahim A. Najmuldeen, Lionel L.A. In, Khalit Mohamad, Khalijah Awang, Noor Hasima Nagoor

Research Publications (2011 to 2015)

In continuation of our interest towards the elucidation of apoptotic pathways of cytotoxic phytocompounds, we have embarked upon a study on the anticancer effects of 7 alpha-hydroxy-beta-sitosterol (CT1), a rare natural phytosterol oxide isolated from Chisocheton tomentosus. CT1 was found to be cytotoxic on three different human tumor cell lines with minimal effects on normal cell controls, where cell viability levels were maintained >= 80 upon treatment. Our results showed that cell death in MCF-7 breast tumor cells was achieved through the induction of apoptosis via downregulation of the ERK1/2 signaling pathway. CT1 was also found to increase proapoptotic Bax …

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A Comparative Approach To Ecg Feature Extraction Methods, F.M. Vaneghi, M. Oladazimi, F. Shiman, A. Kordi, M.J. Safari, F. Ibrahim Jan 2012

A Comparative Approach To Ecg Feature Extraction Methods, F.M. Vaneghi, M. Oladazimi, F. Shiman, A. Kordi, M.J. Safari, F. Ibrahim

Research Publications (2011 to 2015)

This paper discusses six most frequent methods used to extract different features in Electrocardiograph (ECG) signals namely Autoregressive (AR), Wavelet Transform (WT), Eigenvector, Fast Fourier Transform (FFT), Linear Prediction (LP), and Independent Component Analysis (ICA). The study reveals that Eigenvector method gives better performance in frequency domain for the ECG feature extraction. © 2012 IEEE.

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A Numerical Analysis Of Electric Field Strength Over Planar Microarray Dot Electrode For Dielectrophoretic Lab-On-Chip Device, Bashar Yafouz, Nahrizul Adib Kadri, Fatimah Ibrahim Jan 2012

A Numerical Analysis Of Electric Field Strength Over Planar Microarray Dot Electrode For Dielectrophoretic Lab-On-Chip Device, Bashar Yafouz, Nahrizul Adib Kadri, Fatimah Ibrahim

Research Publications (2011 to 2015)

Dielectrophoresis (DEP) has been proven as a method of manipulating and analyzing the electrophysiological properties of bioparticles by applying non-uniform electric fields generated through special electrodes. Various electrode geometries have been developed to address different applications. Simulation of the electric field strength over electrodes is essential in order to optimize the generated DEP force for enhancing cell manipulation. This paper describes the study of electric field distribution over planar multiple microarray dot electrode using numerical modeling of Comsol Multiphysics 4.2a®. Results show that the electric field strength is axisymmetrical around the centre of the dot aperture and that is higher …

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A Study On The Energy Source In The Developing Embryo Of The Mangrove Horseshoe Crab, Carcinoscorpius Rotundicauda (Latreille), T.C. Srijaya, P.J. Pradeep, F. Shaharom, A. Chatterji Jan 2012

A Study On The Energy Source In The Developing Embryo Of The Mangrove Horseshoe Crab, Carcinoscorpius Rotundicauda (Latreille), T.C. Srijaya, P.J. Pradeep, F. Shaharom, A. Chatterji

Research Publications (2011 to 2015)

The mangrove horseshoe crab, Carcinoscorpius rotundicauda, is an Asian species found in Malaysia. This ancient arthropod has a long incubational period during which it depends on various energy sources for both embryogenesis and organogenesis. This study describes the trend of energy utilization from the endogenous reserves by the developing embryos from 0 to 40 days of incubation (until the hatching of the larvae). The dry weight, insoluble protein, carbohydrate, glycogen and lipid showed a declining trend from 0 to 40 days of incubation, whereas the wet weight, water content, ash content and soluble protein showed an increasing trend. Selected micro-elements …

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Acute Oral Toxicity Evaluations Of Some Zinc(Ii) Complexes Derived From 1-(2-Salicylaldiminoethyl)Piperazine Schiff Bases In Rats, Muhammad Saleh Salga, Hapipah Mohd Ali, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwahab Jan 2012

Acute Oral Toxicity Evaluations Of Some Zinc(Ii) Complexes Derived From 1-(2-Salicylaldiminoethyl)Piperazine Schiff Bases In Rats, Muhammad Saleh Salga, Hapipah Mohd Ali, Mahmood Ameen Abdulla, Siddig Ibrahim Abdelwahab

Research Publications (2011 to 2015)

The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, H-1 NMR, C-13 NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not …

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Acute Toxicity And Gastroprotective Effect Of The Schiff Base Ligand ¹H-Indole-3-Ethylene-5-Nitrosalicylaldimine And Its Nickel (Ii) Complex On Ethanol Induced Gastric Lesions In Rats, M.M. Ibrahim, Hapipah Mohd Ali, M.A. Abdullah, P. Hassandarvish Jan 2012

Acute Toxicity And Gastroprotective Effect Of The Schiff Base Ligand ¹H-Indole-3-Ethylene-5-Nitrosalicylaldimine And Its Nickel (Ii) Complex On Ethanol Induced Gastric Lesions In Rats, M.M. Ibrahim, Hapipah Mohd Ali, M.A. Abdullah, P. Hassandarvish

Research Publications (2011 to 2015)

The present study was performed to evaluate the gastroprotective activity of Schiff base ligand derived from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats. The compounds were orally administered with low (30 mg/kg) and high (60 mg/kg) doses to ulcer-induced Sprague-Dawley rats. Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either cimetidine or TNS and its nickel (II) complex each resulted in significant protection against gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with TNS and …

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Acute Toxicity And Gastroprotective Effect Of The Schiff Base Ligand 1h-Indole-3-Ethylene-5-Nitrosalicylaldimine And Its Nickel (Ii) Complex On Ethanol Induced Gastric Lesions In Rats, M.A. Abdullah, M.M. Ibrahim, Hapipah Mohd Ali, P. Hassandarvish Jan 2012

Acute Toxicity And Gastroprotective Effect Of The Schiff Base Ligand 1h-Indole-3-Ethylene-5-Nitrosalicylaldimine And Its Nickel (Ii) Complex On Ethanol Induced Gastric Lesions In Rats, M.A. Abdullah, M.M. Ibrahim, Hapipah Mohd Ali, P. Hassandarvish

Research Publications (2011 to 2015)

The present study was performed to evaluate the gastroprotective activity of Schiff base ligand derived from the condensation reaction of tryptamine (an indole derivative) and 5-nitrosalicylaldehyde (TNS) and its nickel (II) complex against ethanol-induced gastric ulcer in rats. The compounds were orally administered with low (30 mg/kg) and high (60 mg/kg) doses to ulcer-induced Sprague-Dawley rats.Macroscopically, the ulcer control group exhibited severe mucosal injury, whereas pre-treatment with either cimetidine or TNS and its nickel (II) complex each resulted in significant protection against gastric mucosal injury. Flattening of gastric mucosal folds was also observed in rats pretreated with TNS and its …

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An Exploration Of Knowledge, Attitudes And Behaviours Of Young Multiethnic Muslim-Majority Society In Malaysia In Relation To Reproductive And Premarital Sexual Practices, L.P. Wong Jan 2012

An Exploration Of Knowledge, Attitudes And Behaviours Of Young Multiethnic Muslim-Majority Society In Malaysia In Relation To Reproductive And Premarital Sexual Practices, L.P. Wong

Research Publications (2011 to 2015)

Background: The increasing trend of premarital sexual experience and unintended pregnancies in Malaysia warrants sustained and serious attention. The sensitivities of sex-related issues in a Muslim-majority country create various types of barriers to sexual and reproductive health information, support and practices. This study aims to gain understanding of knowledge, attitudes and behaviours of young women in Malaysia concerning reproductive, contraception and premarital sexual practices. Methods: A cross-sectional study was performed, using an anonymous self-administered questionnaire carried out among 1695 female university students in a public university in Malaysia. Results: Respondents had low scores for knowledge of reproduction and pregnancy (median=4, …

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An Oral Cancer Biobank Initiative: A Platform For Multidisciplinary Research In A Developing Country, R.B. Zain, V. Athirajan, W.M.N. Ghani, I.A. Razak, R.J. Raja Latifah, S.M. Ismail, A.A. Sallam, A.Z. Bustam, Z.A.A. Rahman, A. Hussien, N. Talib, S.C. Cheong, A. Jallaludin Jan 2012

An Oral Cancer Biobank Initiative: A Platform For Multidisciplinary Research In A Developing Country, R.B. Zain, V. Athirajan, W.M.N. Ghani, I.A. Razak, R.J. Raja Latifah, S.M. Ismail, A.A. Sallam, A.Z. Bustam, Z.A.A. Rahman, A. Hussien, N. Talib, S.C. Cheong, A. Jallaludin

Research Publications (2011 to 2015)

Identification of diagnostic markers for early detection and development of novel and therapeutic agents for effective patient management are the main motivation for cancer research. Biological specimens from large cohort and case-control studies which are crucial in providing successful research outcomes are often the limiting factor that hinders research efforts, especially in developing countries. Therefore, the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) were established to systematically collect large number of samples with comprehensive sociodemographic, clinicopathological, management strategies, quality of life and associated patient follow-up data to facilitate oral cancer research in Malaysia. The MOCDTBS also promotes sharing …

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Antibacterial Evaluation Of Some Schiff Bases Derived From 2-Acetylpyridine And Their Metal Complexes, N.S. Gwaram, H.M. Ali, H. Khaledi, M.A. Abdulla, A.H.A. Hadi, Kwai Lin Thong, C.L. Ching, C.L. Ooi Jan 2012

Antibacterial Evaluation Of Some Schiff Bases Derived From 2-Acetylpyridine And Their Metal Complexes, N.S. Gwaram, H.M. Ali, H. Khaledi, M.A. Abdulla, A.H.A. Hadi, Kwai Lin Thong, C.L. Ching, C.L. Ooi

Research Publications (2011 to 2015)

A series of Schiff bases derived from 2-acetylpyridne and their metal complexes were characterized by elemental analysis, NMR, FT-IR and UV-Vis spectral studies. The complexes were screened for anti-bacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumanni (AC), Klebsiella pneumonie (KB) and Pseudomonas aeruginosa (PA) using the disc diffusion and micro broth dilution assays. Based on the overall results, the complexes showed the highest activities against MRSA while a weak antibacterial activity was observed against A. baumanii and P. aeruginosa.

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Antioxidant Activity, Phenolic And Flavonoid Contents In The Leaves Of Different Varieties Of Sweet Potato (Ipomoea Batatas), S.M. Hue, A.N. Boyce, C. Somasundram Jan 2012

Antioxidant Activity, Phenolic And Flavonoid Contents In The Leaves Of Different Varieties Of Sweet Potato (Ipomoea Batatas), S.M. Hue, A.N. Boyce, C. Somasundram

Research Publications (2011 to 2015)

The study of antioxidants from natural sources has gained popularity in the recent years. Six Ipomoea batatas leafy varieties namely Batu Kelantan, Batu Biasa, Biru Putih, Oren, Vitato and Indon were compared to assess the total phenols, flavonoids, reducing power and antioxidant activity. In this study, the Indon variety showed the highest level of total phenolic contents at 5.35 ± 0 g GAE/100 g DW. The flavonoid contents in the leaves ranged from 96 ± 47.6 μg/ g in Indon variety to 263.5 ± 43.5 μg/g in Batu Biasa variety. 1,1-diphenyl-2-picryl hydrazyl (DPPH) was used to determine the radical scavenging …

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Antioxidant And Hypoglycemic Activities Of Leaf Extracts Of Three Popular Terminalia Species, A. Arya, S. Nyamathulla, M.I. Noordin, M.A. Mohd Jan 2012

Antioxidant And Hypoglycemic Activities Of Leaf Extracts Of Three Popular Terminalia Species, A. Arya, S. Nyamathulla, M.I. Noordin, M.A. Mohd

Research Publications (2011 to 2015)

This study aimed to ascertain the antioxidant and hypoglycemic activity of methanolic extracts of the leaves of Terminalia arjuna, T. bellerica, and T. chebula. Extracts were evaluated for total phenolic, flavonoid, and tannin content, and in vitro antioxidant potential with DPPH, ORAC, and FRAP assays. The extracts' hypoglycemic activities were evaluated by hypoglycemic screening and an oral glucose tolerance test (OGTT) in normal rats. The methanolic extracts of T. chebula leaves exhibited the highest quantity of total phenolic and flavonoid content, followed by those of T. bellerica and T. arjuna. T. arjuna contained more tannin than T. bellerica did, but …

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Antipsychotic-Like Activity Of Noni (Morinda Citrifolia Linn.) In Mice, V. Pandy, M. Narasingam, Z. Mohamed Jan 2012

Antipsychotic-Like Activity Of Noni (Morinda Citrifolia Linn.) In Mice, V. Pandy, M. Narasingam, Z. Mohamed

Research Publications (2011 to 2015)

Background: Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders. The present investigation was designed to evaluate the antipsychotic effect of noni fruits (Morinda citrifolia Linn.) using mouse models of apomorphine-induced climbing behaviour and methamphetamine-induced stereotypy (licking, biting, gnawing and sniffing).Methods: In acute study, the methanolic extract of Morinda citrifolia (MMC) at different doses 1, 3, 5, 10 g/kg was administered orally one hour prior to apomorphine (5 mg/kg, i.p) and methamphetamine …

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Antipsychotic-Like Activity Of Noni (Morinda Citrifolia Linn.) In Mice, P. Vijayapandi, M. Narasingam, Z. Mohamed Jan 2012

Antipsychotic-Like Activity Of Noni (Morinda Citrifolia Linn.) In Mice, P. Vijayapandi, M. Narasingam, Z. Mohamed

Research Publications (2011 to 2015)

Background: Noni fruit is widely consumed in tropical regions of Indonesia to the Hawaiian Islands. The noni plant has a long history of use as a medicinal plant to treat a wide variety of ailments including CNS disorders. The present investigation was designed to evaluate the antipsychotic effect of noni fruits (Morinda citrifolia Linn.) using mouse models of apomorphine-induced climbing behaviour and methamphetamine-induced stereotypy (licking, biting, gnawing and sniffing). Methods: In acute study, the methanolic extract of Morinda citrifolia (MMC) at different doses 1, 3, 5, 10 g/kg was administered orally one hour prior to apomorphine (5 mg/kg, i.p) and …

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Antiviral Activity Of Baicalein And Quercetin Against The Japanese Encephalitis Virus, Jefree Johari, Aynaz Kianmehr, Mohd Rais Mustafa, Sazaly Abubakar, Keivan Zandi Jan 2012

Antiviral Activity Of Baicalein And Quercetin Against The Japanese Encephalitis Virus, Jefree Johari, Aynaz Kianmehr, Mohd Rais Mustafa, Sazaly Abubakar, Keivan Zandi

Research Publications (2011 to 2015)

Japanese encephalitis (JE), a mosquito-borne viral disease, is endemic to the entire east and southeast Asia, and some other parts of the world. Currently, there is no effective therapeutic available for JE; therefore, finding the effective antiviral agent against JEV replication is crucial. In the present study, the in vitro antiviral activity of baicalein and quercetin, two purportedly antiviral bioflavonoids, was evaluated against Japanese encephalitis virus (JEV) replication in Vero cells. Anti-JEV activities of these compounds were examined on different stages of JEV replication cycle. The effects of the compounds on virus replication were determined by foci forming unit reduction …

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Apoptosis Induction, Cell Cycle Arrest And In Vitro Anticancer Activity Of Gonothalamin In A Cancer Cell Lines, A.M. Alabsi, R. Ali, A.M. Ali, S.A.R. Al-Dubai, H. Harun, N.H. Abu Kasim, A. Alsalahi Jan 2012

Apoptosis Induction, Cell Cycle Arrest And In Vitro Anticancer Activity Of Gonothalamin In A Cancer Cell Lines, A.M. Alabsi, R. Ali, A.M. Ali, S.A.R. Al-Dubai, H. Harun, N.H. Abu Kasim, A. Alsalahi

Research Publications (2011 to 2015)

Cancer is one of the major health problems worldwide and its current treatments have a number of undesired adverse side effects. Natural compounds may reduce these. Currently, a few plant products are being used to treat cancer. In this study, goniothalamin, a natural occurring styryl-lactone extracted from Goniothalamus macrophyllus, was investigated for cytotoxic properties against cervical cancer (HeLa), breast carcinoma (MCF-7) and colon cancer (HT29) cells as well as normal mouse fibroblast (3T3) using MTT assay. Fluorescence microscopy showed that GTN is able to induce apoptosis in HeLa cells in a time dependent manner. Flow cytometry further revealed HeLa cells …

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Are Intertidal Mudflat Communities (Fish And Shrimp) Affected By Cockle Culture?, L.L. Soon, C.C. Ving, H.L. Kar, T. Yurimoto Jan 2012

Are Intertidal Mudflat Communities (Fish And Shrimp) Affected By Cockle Culture?, L.L. Soon, C.C. Ving, H.L. Kar, T. Yurimoto

Research Publications (2011 to 2015)

No abstract provided.

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Assessing The Value Of Dna Barcodes For Molecular Phylogenetics: Effect Of Increased Taxon Sampling In Lepidoptera, J.J. Wilson Jan 2012

Assessing The Value Of Dna Barcodes For Molecular Phylogenetics: Effect Of Increased Taxon Sampling In Lepidoptera, J.J. Wilson

Research Publications (2011 to 2015)

Background: A common perception is that DNA barcode datamatrices have limited phylogenetic signal due to the small number of characters available per taxon. However, another school of thought suggests that the massively increased taxon sampling afforded through the use of DNA barcodes may considerably increase the phylogenetic signal present in a datamatrix. Here I test this hypothesis using a large dataset of macrolepidopteran DNA barcodes. Methodology/Principal Findings: Taxon sampling was systematically increased in datamatrices containing macrolepidopteran DNA barcodes. Sixteen family groups were designated as concordance groups and two quantitative measures; the taxon consistency index and the taxon retention index, were …

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Assessing Toxicities Of Industrial Effluents And 1,4-Dioxane Using Sulphur-Oxidising Bacteria In A Batch Test, A. Gurung, S.H. Kim, J.H. Joo, M. Jang, S.E. Oh Jan 2012

Assessing Toxicities Of Industrial Effluents And 1,4-Dioxane Using Sulphur-Oxidising Bacteria In A Batch Test, A. Gurung, S.H. Kim, J.H. Joo, M. Jang, S.E. Oh

Research Publications (2011 to 2015)

In this study, the qualities of the final effluents from nine different industries (A, B, C, D, E, F, G, H and I) discharging 1,4-dioxane mainly as effluents were assessed using sulphur-oxidising bacteria (SOB) as a test micro-organism in batch mode. Results showed that effluent from industry 'B' was the most toxic of all the effluents tested, followed by E, C and A effluents. An EC50 value of 13 was obtained for effluent from B, whereas with E, C and A effluents, the EC50 values of 23, 25 and 29 were found, respectively. Similarly, batch tests were performed in order …

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Assessment Of Upper Body Muscle Activity During Salat And Stretching Exercise: A Pilot Study, F. Ibrahim, S.A. Ahmad Jan 2012

Assessment Of Upper Body Muscle Activity During Salat And Stretching Exercise: A Pilot Study, F. Ibrahim, S.A. Ahmad

Research Publications (2011 to 2015)

Salat is the practice of formal prayer for Muslims. It involves with both spiritual and physical acts. This paper presents electromyography (EMG) output during the "takbeeratul-ihram (TI)", one of the postures in Salat and stretching exercise. Comparisons on EMG outputs between TI and stretching exercise are discussed. Ten healthy participants (five males and five females) were recruited for the investigation. The EMG signals were recorded from back scapula, upper trapezius, biceps brachii and pectoralis major muscles. The results showed that higher EMG signals in pectoralis major and biceps during performing the stretching posture. However, for TI posture, the EMG activities …

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Auditing Scholarly Journals Published In Malaysia And Assessing Their Visibility, A.N. Zainab, S.A. Sanni, N.N. Edzan, A.P. Koh Jan 2012

Auditing Scholarly Journals Published In Malaysia And Assessing Their Visibility, A.N. Zainab, S.A. Sanni, N.N. Edzan, A.P. Koh

Research Publications (2011 to 2015)

The problem with the identification of Malaysian scholarly journals lies in the lack of a current and complete listing of journals published in Malaysia. As a result, librarians are deprived of a tool that can be used for journal selection and identification of gaps in their serials collection. This study describes the audit carried out on scholarly journals, with the objectives (a) to trace and characterized scholarly journal titles published in Malaysia, and (b) to determine their visibility in international and national indexing databases. A total of 464 titles were traced and their yearly trends, publisher and publishing characteristics, bibliometrics …

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