Digital Commons Network^™

Full Issue: Vol. 66, No. 1

Sci-Tech News

No abstract provided.

Unh: The Magazine Of The University Of New Hampshire, Winter 2012, Unh Magazine

UNH Magazine

Archived version of web content originally found at https://unhmagazine.unh.edu/pastissues.html

2011-2012 Annual Report, Southern Illinois University Board Of Trustees

Annual Report Archive

No abstract provided.

Accessing High-Quality Instructional Strategies, Edmund T. Hamann, Jenelle Reeves

Department of Teaching, Learning, and Teacher Education: Faculty Publications

Instructional strategies figure centrally in what happens in classrooms, are critical to educational outcomes, and central to the narrowing of achievement gaps. However, broad improvement of schools, including the narrowing of these gaps, will depend on changes in instructional strategy and improved student access to educators using these strategies. Much of the research on instructional strategies identifies universal aspects of effective instruction that pertain across subject matter, grade level and student characteristics. Other important findings from instructional strategy research are not as broadly applicable. These second kind of findings, are more specific to particular grade levels, topics of instruction, students’ …

Infusing Disability Sport Into The Sport Management Curriculum, Deborah R. Shapiro, Brenda G. Pitts, Mary A. Hums, Jimmy Calloway

Faculty Articles

Disability sport is growing around the world with momentum and is described as a "movement" (Bailey, 2008; DePauw & Gavron, 2005). While there are more similarities than differences with sport management for able-bodied athletes and those with disabilities, there are additional needs and considerations for persons with disabilities (DePauw & Gavron, 2005). The noticeable visibility of individuals with disabilities in society, including sport, raises concerns about the degree to which sport management academic programs have modified their curricula to ensure that individuals working in the sport management field are prepared to deal with the uniqueness of disability sport. This paper …

Bo40-1-Web.Pdf, Bird Observer

Bird Observer

No abstract provided.

Bo40-2-Web.Pdf, Bird Observer

Bird Observer

No abstract provided.

Bo40-3-Web.Pdf, Bird Observer

Bird Observer

No abstract provided.

Bo40-5-Web.Pdf, Bird Observer

Bird Observer

No abstract provided.

Separation, Deportation, Termination, Marcia A. Yablon-Zug

Faculty Publications

There is a growing practice of separating immigrant children from their deportable parents. Parental fitness is no longer the standard with regard to undocumented immigrant parents. Increasingly, fit undocumented parents must convince courts and welfare agencies that continuing or resuming parental custody is in their child’s best interest. This requirement is unique to immigrant parents and can have a disastrous impact on their ability to retain custody of their children. Best interest decisions are highly subjective and courts and agencies increasingly base their custody determinations on subjective criteria such as negative perceptions regarding undocumented immigrants and their countries of origin, …

Lesion-Specific Dna-Binding And Repair Activities Of Human O⁶-Alkylguanine Dna Alkyltransferase, Manana Melikishvili, Michael G. Fried

Center for Structural Biology Faculty Publications

Binding experiments with alkyl-transfer-active and -inactive mutants of human O⁶-alkylguanine DNA alkyltransferase (AGT) show that it forms an O⁶-methylguanine (6mG)-specific complex on duplex DNA that is distinct from non-specific assemblies previously studied. Specific complexes with duplex DNA have a 2:1 stoichiometry that is formed without accumulation of a 1:1 intermediate. This establishes a role for cooperative interactions in lesion binding. Similar specific complexes could not be detected with single-stranded DNA. The small difference between specific and non-specific binding affinities strongly limits the roles that specific binding can play in the lesion search process. Alkyl-transfer kinetics with …

Cell Wall Antibiotics Provoke Accumulation Of Anchored Mcherry In The Cross Wall Of Staphylococcus Aureus, Wenqi Yu, Friedrich Götz

Molecular Biosciences Faculty Publications

A fluorescence microscopy method to directly follow the localization of defined proteins in Staphylococcus was hampered by the unstable fluorescence of fluorescent proteins. Here, we constructed plasmid (pCX) encoded red fluorescence (RF) mCherry (mCh) hybrids, namely mCh-cyto (no signal peptide and no sorting sequence), mCh-sec (with signal peptide), and mCh-cw (with signal peptide and cell wall sorting sequence). The S. aureus clones targeted mCh-fusion proteins into the cytosol, the supernatant and the cell envelope respectively; in all cases mCherry exhibited bright fluorescence. In staphylococci two types of signal peptides (SP) can be distinguished: the +YSIRK motif SPlip and the −YSIRK …

Discovery Of Marinopyrrole A (Maritoclax) As A Selective Mcl-1 Antagonist That Overcomes Abt-737 Resistance By Binding To And Targeting Mcl-1 For Proteasomal Degradation*, Kenichiro Doi, Rongshi Li, Shen-Shu Sung, Hongwei Wu, Yan Liu, Wanda Manieri, Gowdahalli Krishnegowda, Andy Awwad, Alden Dewey, Xin Liu, Shantu Amin, Chunwei Cheng, Yong Qin, Ernst Schonbrunn, Gary W. Daughdrill, Thomas P. Loughran Jr., Said M. Sebti, Hong-Gang Wang

Molecular Biosciences Faculty Publications

The anti-apoptotic Bcl-2 family of proteins, including Bcl-2, Bcl-XL and Mcl-1, are well-validated drug targets for cancer treatment. Several small molecules have been designed to interfere with Bcl-2 and its fellow pro-survival family members. While ABT-737 and its orally active analog ABT-263 are the most potent and specific inhibitors to date that bind Bcl-2 and Bcl-XL with high affinity but have a much lower affinity for Mcl-1, they are not very effective as single agents in certain cancer types because of elevated levels of Mcl-1. Accordingly, compounds that specifically target Mcl-1 may overcome this resistance. In this study, we identified …

Global Kentucky (Winter 2012), University Of Kentucky International Center

Global Kentucky

No abstract provided.

The Role Of Epigenetics In Evolution: The Extended Synthesis, Aaron W. Schrey, Christina L. Richards, Victoria Meller, Vincent Sollars, Douglas M. Ruden

Integrative Biology Faculty and Staff Publications

No abstract provided.

Epigenetic Variation May Compensate For Decreased Genetic Variation With Introductions: A Case Study Using House Sparrows (Passer Domesticus) On Two Continents, Aaron W. Schrey, Courtney A. C. Coon, Michael T. Grispo, Mohammed Awad, Titus Imboma, Earl D. Mccoy, Henry R. Mushinsky, Christina L. Richards, Lynn B. Martin

Integrative Biology Faculty and Staff Publications

Epigenetic mechanisms impact several phenotypic traits and may be important for ecology and evolution. The introduced house sparrow (Passer domesticus) exhibits extensive phenotypic variation among and within populations. We screened methylation in populations from Kenya and Florida to determine if methylation varied among populations, varied with introduction history (Kenyan invasion < 50 years old, Florida invasion ~150 years old), and could potentially compensate for decrease genetic variation with introductions. While recent literature has speculated on the importance of epigenetic effects for biological invasions, this is the first such study among wild vertebrates. Methylation was more frequent in Nairobi, and outlier loci suggest that populations may be differentiated. Methylation diversity was similar between populations, in spite of known lower genetic diversity in Nairobi, which suggests that epigenetic variation may compensate for decreased genetic diversity as a source of phenotypic variation during introduction. Our results suggest that methylation differences may be common among house sparrows, but research is needed to discern whether methylation impacts phenotypic variation.

Regulation Of Platelet Exoctosis And Its Role In Diseases, Rania A. Al Hawas

Theses and Dissertations--Health and Clinical Sciences

In addition to their role in hemostasis, platelets appear to contribute to vascular inflammatory diseases. Platelets achieve this through the secretion of various prothrombotic and pro-inflammatory molecules. Platelet secretion is mediated by integral membrane proteins called Soluble NSF Attachment protein REceptors (SNAREs). SNAREs come from both granule/vesicle membranes (v-SNAREs) and target membranes (t-SNAREs) to form a trans-bilayer complex that promotes membrane fusion and subsequent granule cargo release. The work described in this dissertation dissects various, yet related aspects of platelet secretion in both physiological relevant and pathological circumstances.

Atherosclerosis is a leading cause of death in the westernized countries and …

Trends In Hospital Admissions For Myocardial Infarcts For Women In Arizona, Florida And Maryland In 2000 To 2010, Rebecca Farmer Mcintyre

MUSC Theses and Dissertations

Coronary arterial disease is the leading cause of death and morbidity in developing countries. Acute myocardial infarction (AMI) has traditionally been considered a disease affecting mostly men, yet women are increasingly at risk due to obesity and diabetes. However, current trends in the AMI risk for women are not well understood. This study used archival data on hospital discharges from three states within the USA to examine the 10-year trend in presentations of patients to emergency rooms (ER) with a presenting diagnosis of chest pain and AMI, to document rate changes by gender over time. We observed a decreasing number …

Symptom Intrusiveness, Chronic Conditions And Health-Related Quality Of Life: Development Of Conceptual And Measurement Models, Jill Marie Monfre

MUSC Theses and Dissertations

Background: The number of patients in the United States living with chronic conditions is increasing as patients are surviving conditions that were previously fatal. This increase in survival has resulted in a shift in the disease burden in the United States from infectious to chronic diseases. Many patients with chronic conditions experience associated symptoms that impact their health-related quality of life more significantly than those without associated symptoms. To enable patients to achieve what they determine to be an acceptable state of wellbeing, health care providers must first be aware of the factors and the relationships among the factors that …

Activation Of Protein Phosphatase 2c By Ceramide And Essential Role Of Acid Sphingomyelinase In Interleukin-6 Synthesis, David Mark Perry

MUSC Theses and Dissertations

Since their discovery over a century ago, sphingolipids have riddled and fascinated the scientific community with benchmarks of progress including the identification of the enzymatic defects in the lysosomal storage diseases and the discovery of their involvement in cellular processes. Excluding sphingosine-1-phosphate with its associated G-protein coupled receptors, a staggering gap still persists in our understanding of the mechanisms related to the functions of the sphingolipids, ceramide and sphingosine. Moreover, in spite of the impressive amount of literature implicating ceramide in biological processes, precise and well-documented roles in biology for specific ceramide-producing enzymes are surprisingly rare. To further investigate the …

Modeling Count Outcomes From Hiv Risk Reduction Interventions: A Comparison Of Competing Statistical Models For Count Responses, Yinglin Xia, Dianne Morrison-Beedy, Jingming Ma, Changyong Feng, Wendi Cross, Xin Tu

Nursing Faculty Publications

Modeling count data from sexual behavioral outcomes involves many challenges, especially when the data exhibit a preponderance of zeros and overdispersion. In particular, the popular Poisson log-linear model is not appropriate for modeling such outcomes. Although alternatives exist for addressing both issues, they are not widely and effectively used in sex health research, especially in HIV prevention intervention and related studies. In this paper, we discuss how to analyze count outcomes distributed with excess of zeros and overdispersion and introduce appropriate model-fit indices for comparing the performance of competing models, using data from a real study on HIV prevention intervention. …

Annual Report 2011-2012, University Of South Florida. College Of Education

College of Education Publications

No abstract provided.

The Influence Of Breastfeeding On Postpartum Weight Retention, Mariam Girguis

Public Health Theses

Background:your words Weight gained during pregnancy and not lost postpartum has been identified as a contributor to increased obesity risk among women of childbearing age.

Objective: To determine the influence of "any" and exclusive breastfeeding duration on postpartum weight retention (PPWR).

Design: Women were selected from the longitudinal Infant Feeding Practices Study II (IFPS II) . All women who reported both their pre-pregnancy weight and at least one postpartum weight were included in the analyses. Multivariate logistic and linear regression models were used to examine the association between "any" and exclusive breastfeeding duration and PPWR at 3 (n=2254), 6 (n=1966), …

Disrupting The Dyad: Effects Of Parenting Stress On Infant Social-­Emotional Development, Anna L. Zonderman

Public Health Theses

BACKGROUND. Social-­emotional development in infancy can be compromised by exposure to violence, parental mental illness and other factors that interfere with a caregiver's ability to anticipate and respond to an infant's needs. Parenting stress may influence social­emotional development in the same way. In the context of disturbances to parental care, stress on the caregiver is known to adversely affect infant social-­emotional development. However, there is limited empirical evidence explicitly examining the impact of parenting stress (as it is measured in this analysis).

OBJECTIVES. To examine the effect of maternal parenting stress on the social-­emotional development of infants born to young, …

2012 Commencement Program, Seattle University

Commencement Programs

No abstract provided.

Supplementing Gestating Beef Cows Grazing Cornstalk Residue, Jason M. Warner, Jeremy L. Martin, Zachary C. Hall Hall, Luke M. Kovarik, Kathryn J. Hanford, Richard J. Rasby, Mark Dragastin

Nebraska Beef Cattle Reports

A 5-year study evaluated the effects of protein supplementation to beef cows grazing cornstalks in late gestation on both cow and calf weight, and the reproductive performance of heifer progeny. Supplementation improved cow BCS at the end of cornstalk grazing. Calf weight, cow pregnancy rates, and reproductive traits of subsequent heifer progeny were not impacted by supplementation. Supplementing mid- to late-gestation beef cows grazing cornstalks has minimal impact on cow performance or fetal programming of heifer progeny.

Effect Of Corn Stalk Grazing And Baling On Cattle Performance And Irrigation Needs, Simon Van Donk, Adam L. Mcgee, Terry J. Klopfenstein Klopfenstein, L. Aaron Stalker

Nebraska Beef Cattle Reports

The effects of removing corn residue by grazing and baling on continuous corn production were investigated. Initial data showed a trend toward keeping more water in the soil in the treatment with the most residue left on the field (no grazing or baling), but there was no effect of either grazing or baling on subsequent corn yield. Water conservation resulting from maintaining residue on the field may help reduce pumping costs or increase yields when water is limited. However, this benefit is likely to be outweighed by feed cost savings or grazing rental income, and good cow performance.

Use Of Complete-Feed Diets Ramp™ And Test Starter For Receiving Cattle, Cody J. Schneider, Brandon J. Nuttelman, Kelsey M. Rolfe Rolfe, William A. Griffin, David R. Smith, Terry J. Klopfenstein, Galen E. Erickson

Nebraska Beef Cattle Reports

Performance of newly arrived 576 lb steer calves, fed two complete feeds or a control ration was evaluated. Treatment diets were fed for 30 or 31 days and includeda control receiving diet consisting of alfalfa hay, Sweet Bran^® , dry-rolled corn, and supplement or one of two complete feeds: RAMP and Test Starter which contained a high level of Sweet Bran and a minimal amount of forage. RAMP increased ADG when compared with the control diet. Cattle fed Test Starter had similar performance to the control receiving diet.

Feedlot Manure Utilization As Influenced By Application Scheme And Diet, Andrea K. Watson, Galen E. Erickson, Terry J. Klopfenstein Klopfenstein, Richard K. Koelsch, Raymond E. Massey, Joseph H. Harrison

Nebraska Beef Cattle Reports

The BFNMP$ program was utilized to study effects of dietary nitrogen (N) and phosphorus (P), and N volatilization on economics of manure utilization. Feeding high CP (18.7%) and P (0.5%) diets increased manure net value $6.92/ head compared to manure with a traditional diet (13.3% CP and 0.3% P) being fed. Spreading this manure on a four-year P basis is economical and environmentally friendly.

2012 Nebraska Beef Cattle Report (Complete)

Nebraska Beef Cattle Reports

Cow/Calf

Supplementing Gestating Beef Cows Grazing Cornstalk Residues

Effect of Corn Stalk Grazing and Baling on Cattle Performance and Irrigation Needs

Nutritive Value and Amount of Corn Plant Parts

Wheat Straw, Distillers Grains, and Beet Pulp for Late Gestation Beef Cows

Influence of Weaning Date and Pre-partum Nutrition on Cow-Calf Productivity

Effect of Calving Period on Heifer Progeny

Evaluating Conventional and Sexed Semen in a Commercial Beef Heifer Program

Late Gestation Supplementation Impacts Primiparous Beef Heifers and Progeny

Nutritional Regime and Antral Follicle Count Impact Reproductive Characteristics in Heifers

Vascular Endothelial Growth Factor A(VEGFA) in Ovulatory Follicles

Oocyte mRNA and …