Digital Commons Network^™

Foreword: The Intersection Of Race, Corporate Law, And Economic Development, Leonard M. Baynes

St. John's Law Review

No abstract provided.

Federalism And The Contrivances Of Public Law, Paul Boudreaux

St. John's Law Review

No abstract provided.

Starting Over: The Heuristics Of Family Relocation Decision Making, Lucy S. Mcgough

St. John's Law Review

No abstract provided.

Substantially Limited Justice?: The Possibilities And Limits Of A New Rawlsian Analysis Of Disability-Based Discrimination, Elizabeth A. Pendo

St. John's Law Review

No abstract provided.

Portrayal Of Interactions Between Humans And Coyotes (Canis Latrans): Content Analysis Of Canadian Print Media (1998-2010), Shelley M. Alexander, Michael S. Quinn

Cities and the Environment (CATE)

Print media is one form of public discourse that provides a means to examine human-coyote interactions. We conducted a content analysis of 453 articles addressing coyote events reported in the Canadian print media between 1998 and 2010. We found 119 articles about human-coyote interactions, of which 32 involved a report of coyote biting (26) or attempting to bite (6) a person. 108 articles were about coyote-dogs and 32 about coyotes-cat interactions. Remaining articles were on topics unrelated to interactions (e.g. culls). Basing our analysis in grounded theory, we identified important descriptive and emotional themes surrounding these events. The most common …

Spatial And Temporal Variation Of Coyote (Canis Latrans) Diet In Calgary, Alberta, Victoria M. Lukasik, Shelley M. Alexander

Cities and the Environment (CATE)

We examined the diet of a portion of Calgary’s urban coyotes to provide baseline data on feeding ecology, to determine spatial and seasonal effects on diet, and to assess whether anthropogenic food sources (primarily garbage) and domestic cats or dogs were part of coyote diet. Bi-weekly surveys of seven study sites were conducted between August 2006 and September 2007. We analyzed 484 coyote scats. The top five prey types consumed by the coyotes studied were small mammals (84.71%), herbaceous plants (44.63%), crabapples (33.88%), woody plants (16.94%) and anthropogenic food sources (14.05%). Domestic animals – cats (Felis catus) and …

Commonwealth Times 2012-02-23

Commonwealth Times, 1969-

No abstract provided.

Assembly And Regulation Of The Membrane Attack Complex Based On Structures Of C5b6 And Sc5b9, Michael A. Hadders, Doryen Bubeck, Pietro Roversi, Svetlana Hakobyan, Federico Forneris, B. Paul Morgan, Michael K. Pangburn, Oscar Llorca, Susan M. Lea, Piet Gros

School of Medicine Faculty Publications and Presentations

Activation of the complement system results in formation of membrane attack complexes (MACs), pores that disrupt lipid bilayers and lyse bacteria and other pathogens. Here, we present the crystal structure of the first assembly intermediate, C5b6, together with a cryo-electron microscopy reconstruction of a soluble, regulated form of the pore, sC5b9. Cleavage of C5 to C5b results in marked conformational changes, distinct from those observed in the homologous C3-to-C3b transition. C6 captures this conformation, which is preserved in the larger sC5b9 assembly. Together with antibody labeling, these structures reveal that complement components associate through sideways alignment of the central MAC-perforin …

2011-12 Series - Art Caplan, University Center For The Humanities

University Center for the Humanities Events

Some argue that we can avoid rationing health care. Dr. Caplan will use demographics that prove this view is simply wrong, and will take up practical questions. If we must ration, how ought we do so? And if we do so, who should ration and what principles ought they to follow?

The Chicken Challenge – What Contemporary Studies Of Fowl Mean For Science And Ethics, Carolynn L. Smith, Jane Johnson

Between the Species

Studies with captive fowl have revealed that they possess greater cognitive capacities than previously thought. We now know that fowl have sophisticated cognitive and communicative skills, which had hitherto been associated only with certain primates. Several theories have been advanced to explain the evolution of such complex behavior. Central to these theories is the enlargement of the brain in species with greater mental capacities. Fowl present us with a conundrum, however, because they show the behaviors anticipated by the theories but do not have the expected changes in the brain. Consequently fowl present two challenges of interest to us here. …

The Scarlet - Volume Xcii, No. 16 (February 23, 2012), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The February 23, 2012 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

Minutes, Arts & Sciences Faculty Meeting, Thursday, Feb. 23, 2012, Arts & Sciences Faculty

The College of Liberal Arts Faculty Minutes

No abstract provided.

Siting Study For A Hydrokinetic Energy Project Located Offshore Southeastern Florida: Protocols For Survey Methodology For Offshore Marine Hydrokinetic Energy Projects, Charles Vinick, Charles Messing, Brian K. Walker, John K. Reed, Stephanie Rogers

Marine & Environmental Sciences Faculty Reports

Dehlsen Associates, LLC was awarded a grant by the United States Department of Energy (DOE) Golden Field Office for a project titled “Siting Study Framework and Survey Methodology for Marine and Hydrokinetic Energy Project in Offshore Southeast Florida,” corresponding to DOE Grant Award Number DE-EE0002655 resulting from DOE funding Opportunity Announcement Number DE-FOA- 0000069 for Topic Area 2, and it is referred to herein as “the project.”

The purpose of the project was to enhance the certainty of the survey requirements and regulatory review processes for the purpose of reducing the time, efforts, and costs associated with initial siting efforts …

Daily Eastern News: January 23, 2012, Eastern Illinois University

January

No abstract provided.

The Pan American (2012-02-23), Reynaldo Leal, Nadia Tamez-Robledo

UTPA Archives - The Pan American Newspaper

Vol. 68, No. 19

Chanticleer | Vol 60, Issue 18, Jacksonville State University

Chanticleer

No abstract provided.

The Advocate, February 23, 2012, Minnesota State University Moorhead

The Advocate

No abstract provided.

The Alestle - Vol. 64 No. 23 - 02/23/2012, Southern Illinois University Edwardsville

The Alestle

Vol. 64 No. 23

The Parthenon, February 23, 2012, Crystal Myers

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

Fuel For The Future, Kristin Duisberg

UNH Today Archive

No abstract provided.

Active Site Mutations Change The Cleavage Specificity Of Neprilysin., Travis Sexton, Lisa J. Hitchcook, David W. Rodgers, Luke H. Bradley, Louis B. Hersh

Molecular and Cellular Biochemistry Faculty Publications

Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of physiological peptides. We have generated a series of neprilysin variants containing mutations at either one of two active site residues, Phe⁵⁶³ and Ser⁵⁴⁶. Among the mutants studied in detail we observed changes in their activity towards leucine⁵-enkephalin, insulin B chain, and amyloid β_1-40. For example, NEP^F563I displayed an increase in preference towards cleaving leucine⁵-enkephalin relative to insulin B chain, while mutant NEP^S546E was less discriminating …

The Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University for February 23-29, 2012. Vol. 90, No. 7.

Early Versus Delayed Decompression For Traumatic Cervical Spinal Cord Injury: Results Of The Surgical Timing In Acute Spinal Cord Injury Study (Stascis), Michael G. Fehlings, Alexander Vaccaro, Jefferson R. Wilson, Anoushka Singh, David W. Cadotte, James S. Harrop, Bizhan Aarabi, Christopher Shaffrey, Marcel Dvorak, Charles Fisher, Paul Arnold, Eric M. Massicotte, Stephen Lewis, Raja Rampersaud

Department of Neurosurgery Faculty Papers

Background: There is convincing preclinical evidence that early decompression in the setting of spinal cord injury (SCI) improves neurologic outcomes. However, the effect of early surgical decompression in patients with acute SCI remains uncertain. Our objective was to evaluate the relative effectiveness of early (,24 hours after injury) versus late ($24 hours after injury) decompressive surgery after traumatic cervical SCI.

Methods: We performed a multicenter, international, prospective cohort study (Surgical Timing in Acute Spinal Cord Injury Study: STASCIS) in adults aged 16–80 with cervical SCI. Enrolment occurred between 2002 and 2009 at 6 North American centers. The primary outcome was …

Auf1/Hnrnp D Represses Expression Of Vegf In Macrophages, Abigail Fellows, Mary E. Griffin, Brenda L. Petrella, Lihui Zhong, Fatemeh P. Parvin-Nejad, Roy Fava, Peter Morganelli, R. Brooks Robey, Ralph C. Nichols

Dartmouth Scholarship

Vascular endothelial growth factor (VEGF) is a regulator of vascularization in development and is a key growth factor in tissue repair. In disease, VEGF contributes to vascularization of solid tumors and arthritic joints. This study examines the role of the mRNA-binding protein AUF1/heterogeneous nuclear ribonucleoprotein D (AUF1) in VEGF gene expression. We show that overexpression of AUF1 in mouse macrophage-like RAW-264.7 cells suppresses endogenous VEGF protein levels. To study 3′ untranslated region (UTR)–mediated regulation, we introduced the 3′ UTR of VEGF mRNA into a luciferase reporter gene. Coexpression of AUF1 represses VEGF-3′ UTR reporter expression in RAW-264.7 cells and in …

Anti-Malarial Activity Of Geldanamycin Derivatives In Mice Infected With Plasmodium Yoelii, Rubul Mout, Zhi-Dong Xu, Angela Kh Wolf, Vincent J. Davisson, Gotam K. Jarori

Borch Department of Medicinal Chemistry and Molecular Pharmacology Faculty Publications

Background

Geldanamycin (GA), a benzoquinone ansamycin antibiotic has been shown in vitro to possess anti-plasmodial activity. Pharmacological activity of this drug is attributed to its ability to inhibit PfHSP90. The parasite growth arrest has been shown to be due to drug-induced blockage of the transition from ring to trophozoite stage. To further evaluate the consequences of this pharmacodyamic feature, the anti-malarial activity of GA analogs with enhanced drug properties in a Plasmodium-infected animal model have been evaluated for their capacity to induce clearance of the parasite. In the process, a hypothesis was subsequently tested regarding the susceptibility of the …

Pathobiological Implications Of The Expression Of Egfr, Pakt, Nf-Κb And Mic-1 In Prostate Cancer Stem Cells And Their Progenies., Murielle Mimeault, Sonny L. Johansson, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

The progression of prostate cancers (PCs) to locally invasive, androgen-independent and metastatic disease states is generally associated with treatment resistance and disease relapse. The present study was undertaken to establish the possibility of using a combination of specific oncogenic products, including epidermal growth factor receptor (EGFR), pAkt, nuclear factor-kappaB (NF-κB) and macrophage inhibitory cytokine-1 (MIC-1) as biomarkers and therapeutic targets for optimizing the management of patients with localized PC at earlier disease stages. The immunohistochemical and immunofluorescence data have revealed that the expression levels of EGFR, Ser(473)-pAkt, NF-κB p65 and MIC-1 proteins were significantly enhanced in the same subset of …

Epidemiology And Management Of Depression Following Coronary Heart Disease Diagnosis In Women, Siqin Ye, Ellen-Ge Denton, Lauren T. Wasson, Karina W. Davidson

Publications and Research

Coronary heart disease (CHD) and depression are both highly prevalent in women. Importantly, depression is associated with significantly elevated morbidity and mortality in women with CHD. There are intriguing speculations about biological mechanisms underlying this association, such as endothelial dysfunction, subclinical atherosclerosis, inflammation, and autonomic dysregulation. Social and behavioral mechanisms, such as lack of social support and physical inactivity, have also been shown to play important roles. Unfortunately, many randomized clinical trials of counseling and pharmacologic interventions for depression in patients with CHD have failed to improve cardiovascular outcomes, and in fact have raised the possibility that interventions might be …

The Prospector, February 23, 2012, Utep Student Publications

The Prospector

Headline: Candidates Fighting For Congressional Seat

The Eastern Echo, February 23, 2012, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

The Eastern Echo, February 23, 2012, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.