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The Vegf Quadruplex-Forming Sequence Inhibits Lung Cancer Cell Growth., Edward David Muench 1987-

Electronic Theses and Dissertations

Vascular endothelial growth factor (VEGF), a commonly overexpressed oncogene in a variety of malignancies including non-small cell lung cancer (NSCLC), is a key regulator of angiogenesis promoting tumor survival, growth, and metastasis. The promoters of several cancer-related genes, including VEGF, contain disproportionate sequences within nuclease hypersensitivity regions capable of forming quadruplex (fourstranded) DNA. The specific quadruplex forming sequence of interest is the 20 base pair polyG/polyC tract that codes for the VEGF promoter (VEGFq), which is located in the proximal promoter region upstream of the transcription initiation site. This oligonucleotide has been shown to have significant growth hindering effects when …

Analysis Of Eeg Rhythms Using Custom-Made Matlab Application For Processing Of Data Collected During Neurofeedback Training In Adhd Subjects., Brent Hillard

Electronic Theses and Dissertations

INTRODUCTION: Attention Deficit/Hyperactivity Disorder (ADHD) is a disorder that is prevalent throughout the world. It is believed that 5% of school aged children suffer from ADHD, with some estimates indicating as high as 10% may suffer from the disorder. Primarily, three subtypes of ADHD have been associated with certain electroencephalographic (EEG) abnormalities. The most common treatment for ADHD is medication. However, neurofeedback is considered an efficacious treatment for ADHD. It is proposed that neurofeedback training aimed to mitigate inattention and low arousal in ADHD will be accompanied by changes in EEG bands' relative power. DATA COLLECTION: Patients were 18 children …

Counselor Beliefs And Perceived Knowledge Regarding Clients With Learning Disabilities, Tamekia R. Bell

Counseling & Human Services Theses & Dissertations

Clients with learning disabilities constitute a cultural group that has not been extensively studied. The professional literature has found that counselors have reported the need for additional training in working with clients with disabilities. This study explored counselors' beliefs and perceived knowledge regarding counseling clients with learning disabilities. Participants in this study were college counselors, mental health counselors, and school counselors who were members of the following professional counseling associations: the American College Counseling Association (ACCA), the American Mental Health Counselors Association (AMCHA), and the American School Counselor Association (ASCA). These counselors were assessed to determine their perceived competency regarding …

Modeling The Dispersion Of Eastern Oyster Larvae (Crassostrea Virginica) And Its Effects On The Movement Of Disease Resistant Genes In The Delaware Bay Estuary, Diego A. Narvaez

OES Theses and Dissertations

This study combines several models to address two primary research questions. How does the interaction of larval biology and environmental variability determine the spatial distribution of oyster larvae in Delaware Bay? What is the role of larval dispersion in the transference of disease-resistant genes? The particle-tracking module in the Regional Ocean Modeling System (ROMS) was converted into an Individual-Based model representing Eastern oyster larvae that has growth and vertical migration. Exchange of larvae between natural oyster reefs was estimated and used in an Individual-Based genetic model that simulates the genetic structure of eastern oysters. Particles were released from a number …

Alternative Therapy And Treatment Of Type 2 Diabetes, Carmine R. Grieco

Human Movement Studies & Special Education Theses & Dissertations

The rise in prevalence and incidence of type 2 diabetes mellitus (T2D) in the developing world continues unabated. Current treatment strategies, however, fall short of achieving optimal glycemic control. The aim of project I was to investigate the effect of an acute bout of a yogic breathing exercise on heart rate variability (HRV) in individuals with T2D. Project II was designed to assess the effectiveness of the neurohormone melatonin in lowering short- and long-term glucose levels, lipids and oxidative stress in T2D. Project III investigated the differential effects of two different styles of aerobic exercise on postprandial glycemia, mood and …

Teaching Effective Strategies Of Communication Within Blended Families, Pamela S. Bell

All Capstone Projects

Project explored communication in step families (blended families). A literature review was conducted, and workshop developed.

Detection Of Folate Receptor From Fr+ Cells, Gopikrishna Pinnaka

All Capstone Projects

Targeted drug delivery is a newer and less explored arena that has potential scope in tumor targeting because the regular chemotherapy has lethal effects on the normal cells also. Our present Work was an attempt to specifically target receptors on cancerous cells, especially the Folate Receptor (FR). Folate is important for cells for DNA synthesis and the tissues that rapidly divide require folate, cancer cells are no exceptions for this. To cope with the increased demand for the folate the cancer cells express greater FR on the cell surface. This very fact was our basis for the construction of our …

Folate Nanoparticle Conjugates, Safwat A. Masood

All Capstone Projects

The folate receptor is overexpressed on the surface of numerous cancer cell types including those of the breast, lung, kidney, ovary, and brain. Recent interest has exploded in the use of folate to deliver payloads and imaging agents to folate receptor positive cancer cells based on several positive clinical trials including phase III trials of EC-145, which is poised to become the first folate targeted, FDA approved drug. Given the success of EC-145 and numerous other agents in the pharmaceutical pipeline, there remains a great interest in the exploitation of this technology in the delivery of nanoscale agents to folate …

Using Photoactive Nanoparticles As Photodynamic Antimicrobial Chemotherapeutic (Pact) Agent To Treat Chronic Wounds, Chaitanya Poola

All Capstone Projects

The purpose of this study is to use photoactive vitamin nanoparticles as photodynamic antimicrobial chemotherapeutic agent to treat patients with chronic wounds. Chronic wounds are considered as a pandemic health problem which affects millions of people and increases ~10 % annually. According to the American Academy of Dermatology, the expense of treating chronic wounds constitutes over half of the total cost for all skin diseases. The main cause of chronic wounds is due to the existence of biofilms. Biofilms are complex microbial communities containing and are reported to be major factor contributing to multiple chronic inflammatory diseases. Owing to bacterial …

Tumor Bed Boost Radiotherapy In Breast Cancer. A Review Of Current Techniques., Yasir A. Bahadur, Camelia T. Constantinescu

Saudi Medical Journal

Various breast boost irradiation techniques were studied and compared. The most commonly used techniques are external beam radiation therapy (EBRT) (photons or electrons) and high dose rate (HDR) interstitial brachytherapy, but recent studies have also revealed the use of advanced radiotherapy techniques, such as intensity modulated radiation therapy (IMRT), intra-operative radiation therapy (IORT), tomotherapy, and protons. The purpose of this study is to systematically review the literature concerning breast boost radiotherapy techniques, and suggest evidence based guidelines for each. A search for literature was performed in the National Library of Medicine9s (PubMed) database for English-language articles published from 1st January …

Procalcitonin Is A Good Tool To Guide Duration Of Antibiotic Therapy In Patients With Severe Acute Pancreatitis. A Randomized Prospective Single-Center Controlled Trial., Rong Qu, Yan Ji, Yun Ling, Chu-Yang Ye, Si-Ming Yang, Yan-Yuan Liu, Ri-Yan Yang, Yu-Feng Luo, Zhi Guo

Saudi Medical Journal

OBJECTIVES: To investigate the clinical usefulness of procalcitonin (PCT) for guiding duration of antibiotic therapy in patients with severe acute pancreatitis (SAP). METHODS: A total of 71 patients with confirmed severe acute pancreatitis from March 2009 to September 2011 in the Department of Critical Care Medicine of Huizhou Municipal Central Hospital, Guangdong, China were enrolled in this study. Procalcitonin was measured daily by a semi-quantitative immunoassay in the study group. Patients were randomly assigned into 2 groups including a PCT-guided group (study group) and a prophylactic antibiotic therapy (control group). Antibiotic therapy in the study group was not applied until …

Is It Feasible To Perform Coronary Chronic Total Occlusion Intervention With Conventional Angioplasty Equipment., Ahmet Karabulut, Mahmut Cakmak, Bulent Uzunlar

Saudi Medical Journal

OBJECTIVES: To demonstrate feasibility of coronary chronic total occlusion (CTO) procedures with conventional interventional equipment. METHODS: Ninety-five subsequent CTO patients were analyzed retrospectively. Patients who met the inclusion criteria were intervented with standard angioplasty catheters, guidewires, and balloon catheters. The procedural success rate of the interventions was discussed according to clinical and demographic characteristics of patients and equipment used for intervention. This study was carried out in Istanbul Medicine Hospital, Istanbul, Turkey between January 2007 and June 2011. RESULTS: Successful revascularization was achieved in 80% of patients, and all patients were discharged on the day after the procedure without complication. …

Relationships Between Educators' Organizational Commitment, Job Satisfaction, And Administrators' Gender, Stephanie Potter

Doctoral Dissertations and Projects

The purpose of this quantitative, causal-comparative study was to examine the differences between teachers' mean job satisfaction scores based on the administrators' gender and examine the relationship between the administrators' gender and teachers' organizational commitment plans in Tennessee middle schools. Job satisfaction and organizational commitment was measured by the Tennessee Teaching, Empowering, Leading and Learning (TELL) Survey that was administered online and completed by Tennessee teachers voluntarily and anonymously. A stratified random selection of schools based on the administrator's gender (female, n = 85; male, n = 85) was selected (N = 170) from those achieving the predetermined response criteria …

Attitudes And Perceptions Of Local Residents And Tourists Toward The Protected Area Of Retezat National Park, Romania, Andrea Blanka Szell

Masters Theses

Despite the fact that there has been a significant increase in interest in the sustainable management of protected areas (PAs), many of them still fail to meet conservation goals. Considering that the availability of financial resources and the general public's interest toward environmental conservation play such an important role in the successful performance of PAs, it is of great importance to investigate local residents' and visitors' attitudes and perceptions regarding PAs. This will help gain knowledge of the level of financial and social support they would be willing to give to environmental conservation in PAs. To elicit attitudes and perceptions, …

By-Laws Of The Faculty Of The School Of Medicine, School Of Medicine Faculty Senate.

Administrative Documents

No abstract provided.

A Call To Reject The Neurological Standard In The Determination Of Death And Abandon The Dead Donor Rule, Lauren J. Riley

Notre Dame Law Review

The article presents information on the adoption of law "Uniform Determination of Death Act (UDDA)" by the U.S. government that defines the criteria for determining death. It discusses the neurological standard for determining death that is the cessation of integrative functioning of the brain, the cardiopulmonary system, and the respiratory system. It further discusses the use of legal fictions to retain both the neurological criterion and the dead donor rule.

Creation Of Large Scale Face Dataset Using Single Training Image, Qun Wang

Electrical & Computer Engineering Theses & Dissertations

Face recognition (FR) has become one of the most successful applications of image analysis and understanding in computer vision. The learning-based model in FR is considered as one of the most favorable problem-solving methods to this issue, which leads to the requirement of large training data sets in order to achieve higher recognition accuracy. However, the availability of only a limited number of face images for training a FR system is always a common problem in practical applications. A new framework to create a face database from a single input image for training purposes is proposed in this dissertation research. …

Treatment Of Aortic Heart Valve Conduit With Glutamine And Heat Shock As A Means To Deter The Constituent Cellular Population From Becoming Apoptotic, Alyce Marie Linthurst Jones

Theses and Dissertations in Biomedical Sciences

Cryopreserved allograft heart valves represent the best solution for a patient with a failing heart valve. However, the constituent cells become apoptotic and within months of transplant the heart valve becomes acellular and the recipient's cells do not repopulate the allograft (3, 51). A strategy to prevent this situation would be to minimize or prevent apoptosis from occurring by strategically altering steps during heart valve processing. Recently it has been demonstrated that: 1) Heat shock protein 70 is a negative modulator of the apoptotic cascade; 2) Cells in culture exposed to hypothermic conditions produce heat shock protein 70 upon rewarming; …

Electrokinetic Transport Phenomena In Nanofluidic Devices, Mingkan Zhang

Mechanical & Aerospace Engineering Theses & Dissertations

Nanofluidic devices have wide potential applications in biology, chemistry and medicine, and have been proven to be very valuable in sensing biological particles (e.g., DNA and proteins) due to their efficiency, sensitivity and portability. Electrokinetic control of ion, fluid, and particle transport by using only electric field is the most popular method employed in nanofluidic devices. A comprehensive understanding of the electrokinetic ion, fluid, and particle transport in nanofluidics is essential for developing nanofluidic devices for the detection of single molecules, such as the next generation nanopore-based DNA sequencing technology. This research explored numerical simulation of electrokinetic ion and fluid …

Gender Performativity In The Community College: A Case Study Of Female Backline Classified Staff, Samantha Rose Powers

Educational Leadership & Workforce Development Theses & Dissertations

This case study explored the gendered performances of five female backline classified staff members who work in non-traditional fields within a community college. More specifically, this study defined gendered behaviors at a community college, and explored how these behaviors have affected the identities of women working in non-traditional fields at the community college. This study indicated through documents, observations, and interviews that there was mixed evidence of the degree to which gendered behavior is cultivated at a community college in Washington. Document review, interview, and observation findings showed that women at the community college reported expectations of gendered behavior, gender …

Strategies For Improving Lter Network Data Availability, Long Term Ecological Research

Long Term Ecological Research Network

A memorandum entailing current issues affected network data availability and citing goals for the IM Exec.

Citation Pattern Of The Nigerian Journal Of Horticultural Science From 1990-2005, Bolanle Oluyemisi Fagbola, Mary Adefunke Adejoro

Library Philosophy and Practice (e-journal)

Introduction

The essence of academic journal publishing is to report research findings and to contribute to the field of knowledge. Journals are the most current channel of dissemination of new ideas, knowledge and breakthroughs in scientific development. Academic journals play a significant role in academic scholarship (Xiao and Smith, 2006). The present study therefore is undertaken on one of the renowned subject specialized academic journals, with the aim of analyzing citations cited in the various articles published therein.

Citation analysis examines bibliographic data from journal articles, monographs, published bibliographies, theses and electronic indexes in order to understand researchers' specific information …

Patients' Information Needs In Affiliated Hospitals Of Tehran University Of Medical Sciences, Moosa Majidi, Hodeiseh Mahdavi, Hasan Siamian

Library Philosophy and Practice (e-journal)

Introduction

Information seeking theories often refer to the concept of information needs, a presumed cognitive state wherein an individual's need state triggers the search behavior characteristic of information seeking in a given context. With the growth of electronic information and the increasing availability of health information, the idea of the 'informed patient' has become prominent. On the one hand, this has resulted in concerns about associated changes in the doctor-patient relationship and health outcomes [1]; on the other, it has given rise to visions of timely, high quality, accessible, understandable, reliable, and relevant information for patients and care-providers [2] Certainly, …

Academic Libraries' External Environment And Environmental Scanning By Managers Of Central Libraries Of Islamic Azad Universities Of Iran, Fahimeh Babalhavaeji, Mohammad Reza Farhadpoor

Library Philosophy and Practice (e-journal)

Introduction

Academic libraries such as other libraries and information centers and organizations operate within the context of two environments- internal and external. Both of these environments are interconnected. Whilst, internal context of library consists organizational structure and functions and the way they are configured in pursuit of specified organizational objectives; each library operates in complex and changing external environments, which frequently produces new challenges which must be controlled to ensure the library’s future survival and success. Their impact is a two-way process. Changes in the external environment affect the organization’s internal environment, whilst decisions made at managerial level will impact …

Citation Analysis Of Phd Theses In Psychology Of Selected Universities In Andhra Pradesh, India, N. Zafrunnisha

Library Philosophy and Practice (e-journal)

Introduction

The exponential growth of scientific literature, interdisciplinary nature of research, and trend towards specialization have posed many problems both to the scientists and librarians. The extensive investigations and the abundance of literature being published and contributed to immense escalation of cost for the libraries, as the acquisition of published literature became an increasingly difficult task. To maintain a reasonable collection of periodicals, at least in broad fields, it is necessary for the librarians to know the characteristics of subject literature used by the users. Information is not only increasing exponentiality but the growth rates also differ from one discipline …

Managing Ict Waste: The Case Of Delta State University Abraka, Nigeria, Monday Obaidjevwe Ogbomo, Alex Ozoemelem Obuh, Elizabeth Ibolo

Library Philosophy and Practice (e-journal)

Introduction

Information and communication technology (ICT) are modern tools and equipments that are used for the processing, storing, disseminating and utilization of information. Information and communication technology include computers, monitors, modern, keyboard, mice, scanner and printers etc. According to Aina (2004), information and communication technology is concerned with the technology used in handling, acquiring, processing, storing and disseminating information.

Information and communication technology has benefited educational institutions in several ways. Haag, Cummings and Dawkins, (2000) summarize the benefit in the following three (3) areas; the area of information processing task (such as online registration of courses, payment of school fees …

The Effect Of European Starlings And Ambient Air Temperature On Salmonella Enterica Contamination Within Cattle Feed Bunks, James C. Carlson, Jeremy W. Ellis, Shelagh K. Tupper, Alan B. Franklin, George M. Linz

United States Department of Agriculture Wildlife Services: Staff Publications

European starlings (Sturnus vulgaris) are a known risk factor for the occurrence of microorganisms that are pathogenic to cattle and humans in concentrated animal feeding operations (CAFOs). Starling use of CAFOs is known to vary in response to weather; starling control operations on CAFOs often are timed to coincide with favorable environmental conditions to maximize take. The totality of this information suggests that disease risks in CAFOs associated with starlings may be influenced by environmental factors, such as temperature. In this study, we assessed the risk of Salmonella enterica contamination of cattle feed by modeling the interaction between …

Management Of Double-Crested Cormorants To Improve Sport Fi Sheries In Michigan: Three Case Studies, Brian S. Dorr, Shauna L. Hanisch, Peter H. Butchko, David G. Fielder

United States Department of Agriculture Wildlife Services: Staff Publications

Impacts of double-crested cormorants (Phalacrocorax auritus) to fisheries have been documented, but evaluation of the process and outcomes of cormorant management to reduce impacts on fisheries is lacking. We provide a synthesis of adaptive management of double-crested cormorants in the Les Cheneaux Islands (LCI), Brevoort Lake, and Drummond Island, Michigan from 2004 to 2007. The LCI management focused on reducing numbers of nesting cormorants in the region as a means of improving the yellow perch (Perca flavescens) population and fishery. At Brevoort Lake and Drummond Island, management focused on lethal and nonlethal harassment of spring migrating …

Using Radio-Telemetry To Assess The Risk European Starlings Pose In Pathogen Transmission Among Feedlots, Shannon M. Gaukler, H. Jeffrey Homan, George M. Linz, William J. Bleier

United States Department of Agriculture Wildlife Services: Staff Publications

We monitored site-use and movements of 102 radio-tagged European starlings (Sturnus vulgaris) during the winter months at 2 concentrated animal feeding operations (feedlots) in central Kansas. Our research investigated the spatial ecology of wintering starlings as part of a broad epidemiological study on the possible role of starlings in pathogen transmission at feedlots. Site fidelity was 0.677 and 0.552 (days at capture-site per total days tagged) for feedlots A and B, respectively. Minimal exchange (9%) occurred between feedlots A and B and was often followed by a roost-site change. Starlings rarely abandoned the feedlot where they were captured, …

Apparent Prevalence Of Swine Brucellosis In Feral Swine In The United States, Kerri Pedersen, Sarah N. Bevins, Brandon S. Schmit, Mark W. Lutman, Michael P. Milleson, Clint T. Turnage, Troy T. Bigelow, Thomas J. Deliberto

United States Department of Agriculture Wildlife Services: Staff Publications

Samples were collected in 35 states as part of a national monitoring system to detect multiple diseases in feral swine (Sus scrofa). During March 2009 through December 2010, we collected serum samples from 4,479 feral swine from 13 states, and 159 animals tested were seropositive for brucellosis. No difference in likelihood of infection was found between males and females, but adults were more likely than sub-adults or juveniles to be exposed to brucellosis. Feral swine sampled during winter months also were more likely to be seropositive than animals sampled during other seasons. Apparent prevalence varied among states, and …