Specificities Of Aortic Stenosis In Women – From Diagnosis To Management, Yasser Harb, Fadi Tohme, Hadi Ossaili, Karim Halabi, Ali Kanso, Elie Chammas, Samer Nasr, Mohammad Tahini, Nicole Karam

Saudi Medical Journal

Aortic stenosis (AS) is the most common valvular heart disease worldwide, with pathophysiology, clinical presentation, and management differing widely according to sex. Women demonstrate predominantly fibrotic valve modifications and less calcifications for given hemodynamic severity, with left ventricular concentric hypertrophy and smaller cavity size leading to a higher prevalence of paradoxical low-flow, low-gradient AS. These sex differences are modulated by hormonal changes, inflammatory and metabolic pathways, as well as genetic and epigenetic regulators. Atypical symptoms and hemodynamic specificities on echocardiography all combine to create diagnostic challenges that contribute to delayed recognition and intervention. Multimodality imaging, particularly the use of sex-specific …

Women’S Cardiovascular Health In 2025: Advancements Achieved, Challenges Ahead, Jamilah S. Alrahimi

Saudi Medical Journal

Cardiovascular disease (CVD) is the leading cause of death among women globally. Recognition of sex-specific risk factors, pathophysiology, and clinical presentations has established women's cardiovascular health as a research and clinical priority. Pregnancy complications, premature menopause, and autoimmune disease, are now identified as long-term contributors to cardiovascular risk, while female-predominant syndromes such as ischemia with non-obstructive coronary arteries and heart failure with preserved ejection fraction are increasingly acknowledged. Novel therapies and updated guidelines emphasize psychosocial determinants, reproductive history, and postpartum risk assessment in prevention and management. Despite these advances, women remain underdiagnosed, undertreated, and underrepresented in clinical trials. Diagnostic delays …

Investigating The Use Of Antidepressants In Treating Major Depressive Disorder: Insights From A Retrospective Study In Saudi Arabia, Hassan A Alsaad, Wajd A Alfaraj, Maryam M Alrababi, Ali M Sonbaa, Dalal M Albakr, Ali Saleh Abensaad, Fadhel A Alomar

Saudi Medical Journal

Objectives: To investigate patterns of antidepressant prescribing and continuation rates among patients with major depressive disorder (MDD) in Saudi Arabia and to identify factors associated with treatment persistence. Method: A retrospective study was conducted at King Fahad Hospital of the University between May 2023 and February 2025. Data on patients' demographic characteristics, diagnostic information, and prescribed medications were collected. Initial antidepressant therapy and treatment continuation were evaluated, and potential influencing factors were analyzed. Results: Selective serotonin reuptake inhibitors (SSRIs) accounted for most first-line prescriptions (71%), followed by SSRI/atypical combinations (11%) and serotonin–norepinephrine reuptake inhibitors (SNRIs) (5%). Of the 220 patients …

Prognostic Significance Of Lymphovascular Invasion In Breast Cancer: Insights From A Retrospective Analysis At A Tertiary Care Center, Nora Trabulsi, Shayma Alotaibi, Mohammed Bahabri, Hussain A. Alkhalifah, Ghady D. Alshehri, Sultan K. Alshali, Ali Farsi, Marwan Alhajeili, Hassan Al-Turki, Salma Sait, Alaa Shabkah, Rana Ajaboor, Hessa Aljhdali

Saudi Medical Journal

Objective: To explore the relationship between lymphovascular invasion (LVI) and outcomes across different histopathological subtypes, tumor grades, clinical stages, hormone receptor profiles, and treatment modalities. Lymphovascular invasion is a well-recognized histopathological feature associated with tumor dissemination in breast cancer. However, its prognostic weight is under-reported in Middle Eastern cohorts. Methods: We retrospectively reviewed data from 828 women treated for invasive breast carcinoma at King Abdulaziz University Hospital from 2010 to 2020. Clinicopathologic variables, treatments, and outcomes were extracted. Overall survival (OS) and event-free survival (EFS) were estimated and tested using Kaplan–Meier curves; independent predictors were identified with stepwise Cox models. …

Sleep Disorder Phenotypes And The Risk Of Incident Heart Failure: A Meta-Analysis With Mendelian Randomization Validation, Fang Yan, Lihua Fan, Yunhu Chen

Saudi Medical Journal

Objectives: To quantify how specific sleep-disorder phenotypes are related to incident heart failure (HF) using a meta-analysis of cohort data and to probe causal relevance via 2-sample Mendelian randomization (MR). Methods: Fourteen cohorts comprised of participants without HF at baseline were pooled (49,501 exposed; 337,317 controls). A random effects meta-analysis produced pooled hazard ratios (HRs) with 95% confidence intervals (CIs). A bidirectional two-sample MR was used to evaluate the causal effects of sleep phenotypes on HF. Results: Overall, sleep disorders were linked to a higher incidence of HF (pooled HR 1.46; 95% CI 1.30–1.63; pp < 0.001), whereas insomnia was not independently associated with HF (pooled HR 1.11; 95% CI 0.75–1.62; p = 0.609). The …

Addendum No. 5: Fog Integration, Vesa Olavi Lius

Defensive Publications Series

Abstract

Addendum 4 analysed ALLFROMAIR® system performance under clear-sky conditions using passive radiative cooling. A critical operational extension is fog — a phenomenon occurring several hours per day across a wide range of climates, including coastal deserts. During fog periods, the wire-forest electrode structure already present in the system functions directly as a high-efficiency fog collector, while the DEP field actively directs droplets toward the electrode surface and vibration-desorption ensures continuous drainage.

Calculations show that ALLFROMAIR® v2 achieves 0.26–0.97 L/m²/h during fog periods (Q = η × LWC_median × v × 3.6, η = 0.72), compared with 0.07–0.35 L/m²/h for …

Addendum No. 4: Radiative Hybrid Cooling, Vesa Olavi Lius

Defensive Publications Series

Abstract

This addendum introduces a critical architectural extension of the ALLFROMAIR® system: the integration of passive radiative cooling directly into the electrode structure. Analysis of the original wire-forest configuration demonstrated that the Modified Kelvin-Thomson (MKT) effect at operational field strengths (E ≈ 1.67 MV/m) produces a vapour-pressure reduction of approximately 0.0007% — insufficient as the sole condensation driving force in sub-saturated air. The solution presented here is to supply a temperature gradient through passive infrared radiative cooling of the electrode surface, requiring no moving parts and consuming no electrical energy.

Calculations demonstrate that a SiO₂/HfO₂ selective radiative coating on an …

Existence Of Positive Periodic Solutions For A First-Order Semilinear Functional Differential Equation With An Iterative Source Term, Ahlème Bouakkaz, Rabah Khemis

Turkish Journal of Mathematics

In this paper, we will establish the existence of positive periodic solutions for a class of first order iterative functional differential equations by using a powerful and effective technique based on the Krasnoselskii fixed point theorem together with some useful properties of a Green's function. The obtained results that complement some previous works, are illustrated with an example.

A Non-Newtonian Approach To Screw Motion And Dual Numbers, Esra Parlak, Zehra Özdemi̇r

Turkish Journal of Mathematics

In this paper, we define multiplicative dual numbers, multiplicative dual vectors, scalars, and vector products associated with the multiplicative dual numbers. We give the base elements of multiplicative dual elliptic quaternions and their operational properties. We explain the rotation and translation motions in multiplicative dual elliptical quaternions. We provide the matrix representations of the screw motion using multiplicative dual elliptical quaternions. Thanks to these multiplicative dual elliptical quaternions, we explain the screw motion along with rotation and translation with theorems and proofs. We visualize this screw motion with mathematical programs by applying screw-ruled surfaces.

Counseling Satisfaction In Lgbtq Clients: The Roles Of Perceived Counselor Religiosity And Perceived Discrimination, Karen Cain Culbertson

Doctoral Dissertations and Projects

LGBTQ individuals experience mental health issues more frequently than the heterosexual population (Benz et al., 2019; Hinton et al., 2024; Nakamura & Logie, 2020). It appears that they often face unique challenges when seeking mental health care (Makadon et al., 2015). These may become complex when working with Christian counselors when there are conflicting beliefs between their religious views and their counseling standards (Lane, 2021). Although previous research has identified barriers to care for the LGBTQ community and the psychological impact of non-affirming religious settings, there is little research on how these dynamics unfold specifically within a Christian counseling relationship …

The Impact Of Covid-19 On Women Caregivers Of The Sandwich Generation, Keri L. Burns

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to describe female members of the sandwich generation’s experiences as care providers during and post-COVID-19 in Central Florida. At this research stage, female members of the sandwich generation are understood as women in midlife who occupy dual caregiving roles for dependent children and aging parents, and whose lived experiences offer insight into caregiving experiences during a global pandemic. (Steiner & Fletcher, 2017). As life expectancy has increased and financial insecurity has been a concern for all generations, the sandwich generation caregivers, specifically women, have become more focused on providing varying levels of care …

A Transcendental Phenomenological Study Of Cognitive Overload In Manufacturing Engineers During Online Training In An Industrial Environment, Sarah J. May

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore experiences of cognitive overload among engineers in manufacturing during digital training in industrial environments. Engineers in manufacturing manage substantial physical and cognitive demands in order to maintain safe and efficient industrial environments. In addition to these responsibilities, engineers are often expected to engage in digital training within active work settings, frequently without physical or cognitive separation from job-related tasks. A qualitative research design was employed, with data collected from 10 participants and analyzed through triangulation and thematic coding. Data collection methods included a qualitative questionnaire, individual interviews, and a letter-writing …

Infusing Indigenous Knowledge Into Eurocentric Educational Systems In Sub-Saharan Africa: A Hermeneutical Phenomenology, Assane Ba Faye

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study is to explore the lived experiences of participants from Mills Elementary School and the Kao-Kao School District (pseudonyms) regarding the integration of pre-colonial traditional pedagogies into post-colonial Eurocentric education systems in sub-Saharan Africa. The guiding theory for this research is Jean Piaget’s constructivist theory, which emphasizes active learner involvement and knowledge development based on prior experience. The main research question asks: What are the lived experiences of community members at Mills Elementary School and the Kao-Kao School District (pseudonyms) concerning the effects of incorporating Indigenous pedagogies into Eurocentric education systems in sub-Saharan Africa? …

Cis-Regulatory Evolution Of Wnt Family Genes Contributes To A Morphological Difference Between Silkworm Species, Kenta Tomihara, Ana Pinharanda, Young Mi Kwon, Andrew M. Taverner, Laura S. Kors, Matthew L. Aardema, Julia C. Holder, Lin Poyraz, Takashi Kiuchi, Peter Andolfatto

Department of Biology Faculty Scholarship and Creative Works

Closely related species often exhibit distinct morphologies that can contribute to species-specific adaptations and reproductive isolation. One example is Lepidopteran caterpillar appendages, such as the “caudal horn” of Bombycoidea moths, which have evolved substantial morphological diversity among species in this group. Using interspecific crosses, we identify the genetic basis of the caudal horn size difference between Bombyx mori and its closest relative Bombyx mandarina. The three largest of eight QTL account for one third the mean horn length difference between the species. The largest of these, on chromosome 4, encompasses a conserved Wnt family gene cluster, key upstream regulators …

Minutes, Curriculum Committee Meeting, Tuesday, March 10, 2026, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.

Evaluating Eastern Wild Turkey (Meleagris Gallopavo Silvestris) Behavioral Ecology In The Southeastern United States, Chad Argabright

LSU Doctoral Dissertations

The wild turkey (Meleagris gallopavo spp.) is a game bird species in North America who are one of the great success stories in restoration and conservation. Wild turkeys were extirpated from most of their range in the early 20th century, but through habitat restoration and translocation efforts the population was restored to the point of being sustainably harvested in 49 U.S. States by the late 20th century. However recent declines in wild turkey population indices have necessitated ongoing research on the behavioral ecology of wild turkeys to help counteract these declines. East Texas specifically for the past century has …

On The Spot: "What Is Your Opinion On The Campus Carry Bill?", Tess Kujawa

Digital Edition

No abstract provided.

Potency-Related Effects Of Smoked Cannabis On Simulated Driving Performance: A Randomized, Controlled Crossover Trial, Bruna Brands, Adam Zaweel, Madison Wright, Patricia Di Ciano, Christine M. Wickens, Justin Matheson, Andrew Fares, Omer S. M. Hasan, Marcos Sanches, Beth Sproule, Marilyn A. Huestis, Timothy L. Brown, Bernard Le Foll

Institute of Emerging Health Professions Faculty Papers

Given the increasing availability of high-potency Δ9-tetrahydrocannabinol (Δ9-THC) products, understanding potency-related effects of Δ9-THC on driving performance is an important public safety issue. This randomized, double-blind, placebo-controlled, within-subjects trial examined the effects of smoked cannabis with varying Δ9-THC concentrations on simulated driving. Adults aged 19–45 who regularly used cannabis and held valid driver’s licenses completed simulated driving tasks after smoking placebo, or cannabis containing low (6.25%/47 mg Δ9-THC), medium (12.5%/94 mg Δ9-THC), or high (22%/165 mg Δ9-THC) Δ9-THC levels. The primary outcome was mean speed (km/h); secondary measures included maximum speed, standard deviation of lateral position (SDLP), reaction time (RT), …

Undergraduate Science Writing Performance And Perceptions Following An Online Guided Writing Module, Amanda Gunlefinger, Hannah Smith, Jeffrey Klemens, Nanette Tomicek

College of Life Sciences Faculty Papers

Undergraduate students often struggle with scientific communication, particularly in writing clear and concise lab reports. A retrospective cohort study was conducted in a multi-section Anatomy and Physiology laboratory course to examine patterns in student writing performance and perceptions of science writing following the implementation of an online guided writing module. The module, developed in Nearpod integrated with Canvas, provided task-specific instruction and embedded questions with immediate feedback focused on authoring a results section for a lab report assignment. Student enrolled during the 2024 implementation term who completed the module (n = 278) demonstrated higher lab report writing scores compared to …

Individual Differences In Alexithymia Modulate Cognition-Emotion Interactions In Daily Life Ongoing Experiences, Anqi Lei, Md Faysal, Louis Chitiz, Raven Wallace, Samyogita Hardikar, Brontë Mckeown, Jonathan Smallwood, Elizabeth Jefferies, Robert Leech, Nerissa Ho

School of Psychology

Individual differences modulate our thoughts and emotional experiences, yet how thought and emotion interact in daily life remains largely unclear. We leverage alexithymia, a trait reflecting atypical emotional awareness, to reveal these interactions in naturalistic settings. Using multi-dimensional experiencesampling via smartphones, we captured moment-to-moment thought patterns and concurrent affective states (valence, arousal, stress) in people’s daily life (N = 190 undergraduate students, age range = 18 to 36, 159 females). Using Principal Component Analysis and Linear Mixed Models, we identified four thought dimensions that relate differently to these affective states: future-self orientation, intrusive distraction, sensory engagement, and task-focus. Alexithymia modulated …

Enhancing Seventh-Grade Students’ Scientific Literacy Through The Science-Poly Game, Shita Dhiyanti, Imra’Atul Mufidah, Dyne Rizki Puspitasari, Siti Zubaidah

Journal of Innovation and Teacher Professionalism

This study aims to improve seventh-grade junior high school students’ scientific literacy through the use of the science-poly game on the topic of motion. The learning process was implemented using the lesson study approach, which consists of three stages: plan, do, and see. In the planning stage, teachers collaboratively designed learning activities and literacy-based questions integrated into the science-poly game. During the implementation stage, students participated in the game while engaging with scientific problems that required them to analyze questions, identify key scientific terms, and formulate conclusions. In the reflection stage, teachers discussed the learning outcomes and evaluated the effectiveness …

The Influence Of Diorama Learning Media On Science Learning Outcomes For Class Iii Elementary Schools, Sunya Tiara Putri, Dya Ayu Agustina Putri

Journal of Innovation and Teacher Professionalism

Education plays a crucial role in shaping intellectually capable and well-prepared generations, which necessitates the use of effective and engaging learning media at the elementary school level. This study aims to examine the influence of diorama-based learning media on science learning outcomes of third-grade elementary school students, particularly on the topic of butterfly metamorphosis. A quantitative approach employing a quasi-experimental design with a nonequivalent control group was used. The sample consisted of Grade III students selected purposively, involving an experimental group taught using diorama media and a control group receiving conventional instruction. Learning outcomes were measured using a 20-item achievement …

Transnational Private Environmental Regulation: Are States Striking Back?, Errol E. Meidinger

Contributions to Books

Published as Chapter 11 in Research Handbook on Environmental Regulation, David Williamson, Gary Lynch-Wood & Agne Prochorskaite, eds.

Rapid global trade expansion beginning in the 1990s spawned a parallel expansion in non-state (‘private’) environmental regulatory (PER) programs. They issue regulatory standards, monitor and judge performance, sanction poor performance, and sometimes regulate state activities. PER programs constitute extensive and complex transnational governance agglomerations encompassing environmental certification, corporate social responsibility, and environment-society-governance programs, typically intertwined with governmental and intergovernmental regulatory programs.

Using forestry and climate change examples, this article analyzes key features of PER programs, how they may be growing empirically more …

Cultural Influences On Mental Health Help-Seeking: A Comparative Study Of Haiti And The United States, Luther-King Jean-Baptiste

Doctoral Dissertations and Projects

Mental health stigma and help-seeking behaviors vary across cultural contexts and are shaped by shared beliefs, values, and social expectations. This qualitative study examined how cultural meaning systems influenced mental health help-seeking behaviors in Haiti and the United States. Using surveys and semi-structured interviews, data were collected from 30 participants (15 from each country) who reported a history of psychological distress or mental health challenges. Findings indicated that help-seeking behaviors were not determined solely by symptom severity but were embedded within cultural, relational, spiritual, and structural frameworks. In Haiti, help-seeking was largely collective and shaped by family validation, community norms, …

The Benefits Of A Holistic Biblical Approach To Adolescent Substance Use Treatment And Prevention, Amberlin D. Salas

Doctoral Dissertations and Projects

Adolescent addiction is increasingly problematic in the United States, including substance use and other addictive behaviors that carry a risk of continued adult addiction if not resolved effectively. Current treatment models are primarily limited to meeting the mental, emotional, and physical needs, but have gaps in treating areas such as spirituality and healthy parental relationships. From a biblical standpoint, Christian principles are relevant to all areas of need in the addicted individual, and considering a holistic biblical approach to address all areas of life could fill the gaps left by conventional addiction interventions. To understand the possible implications of a …

Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R Sean Norman M.Sc., Ph.D., Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge

Faculty Publications

Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …

Moderate-Temperature Hydrothermal Treatment Removes Detectable Dna And Antibiotic Resistance Genes From Municipal Sludge While Preserving Resource Value, R. Sean Norman, Mirza Isanovic, Gabrielle Kartzmark, Nicole Berge

Faculty Publications

Wastewater treatment plants (WWTPs) are key reservoirs of antibiotic resistance genes (ARGs), with municipal sludge containing high bacterial densities and diverse ARGs that may spread through land application. Hydrothermal treatment (HT) is a process that inactivates pathogens and stabilizes biomass, but its performance at moderate temperatures is less understood. We evaluated HT (100°C–250°C; 2–24 h) for degrading bacterial DNA and ARGs in dewatered municipal sludge. DNA was quantified by fluorometry, bacterial presence confirmed by 16S rRNA gene PCR, and ARGs profiled by qPCR targeting 84 clinically and environmentally relevant genes. HT up to 250°C produced modest carbon densification, high solids …

The Association Of P27 With Prostate Cancer Outcomes: A Secondary Analysis Of Nrg/Rtog 8610 And 9202, Krishnan Patel, Stephanie Pugh, Jeffry Simko, Anthony Zietman, Michelangelo Fiorentino, David Paul D'Souza, Seth Rosenthal, Adam Currey, Adam Dicker, Bradley Stish, Eric Horwitz, Tyler Robin, Michael Dominello, Christopher Peters, Kwang Choi, Jason Efstathiou, Samir Narayan, George Daniel Grass, Zaker Rana, Phuoc Tran, Massimo Loda, Paul Nguyen

Kimmel Cancer Center Faculty Papers

PURPOSE: The cyclin-dependent kinase inhibitor p27 is a well-profiled modulator of cell cycle progression. Low nuclear p27 levels have been demonstrated to have a negative prognostic impact on outcomes in patients undergoing prostatectomy. The prognostic value of p27 after radiation therapy (RT) for prostate cancer is unknown.

METHODS AND MATERIALS: Levels of p27 were evaluated in pre-RT prostate biopsy samples from 2 randomized, phase 3 trials, NRG/RTOG 8610 and 9202, which treated patients with RT with or without androgen deprivation therapy (ADT). Nuclear p27 was analyzed using immunohistochemistry and quantified using automated imaging analysis. The association of p27 as both …

Underexplored Maternal Microbiomes: Immune, Metabolic, And Microbial Pathways Shaping Pregnancy Outcomes, Rafael Tomoya Michita, Nicole Jimenez, Melissa M Herbst-Kralovetz, Indira U Mysorekar

Faculty, Staff and Students Publications

Maternal microbial ecosystems play critical roles in shaping reproductive physiology and pregnancy outcomes. During the pre-conception and prenatal periods, these communities modulate maternal physiology by regulating immune tolerance, nutrient metabolism, and susceptibility to pregnancy complications such as preterm birth, hypertensive disorders, and gestational diabetes. While the gut microbiota has been extensively studied, the roles of cervicovaginal, urinary, respiratory, oral, and upper reproductive tract microbiomes remain less clear. In this minireview, we synthesize current knowledge on these underexplored maternal microbiomes, with an emphasis on the cervicovaginal and urinary microbiota and their interactions with the placenta and fetus. We discuss cross-niche microbial …

Multiple Persistent Nodular Lesions In An Infant: Diagnosing Disseminated Juvenile Xanthogranuloma, Kourtney Kelly

Biochemistry and Molecular Biology

No abstract provided.