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Increased Water Current Induces Micro-Architectural Changes To The Vertebral Bone Of Juvenile Rainbow Trout (Oncorhynchus Mykiss), Mag Owen, B Eynon, S Woodgate, Sj Davies, S Fox

School of Biomedical Sciences

No abstract provided.

Palaeolimnological Evidence For An East-West Climate See-Saw In The Mediterranean Since Ad 900, Neil Roberts, Ana Moreno, Bl Valero-Garces, Corella J Pablo, Matthew Jones, Samantha Allcock, Jessie Woodbridge, M Morellon, Juerg Luterbacher, Elena Xoplaki, M Turkes

More Faculty of Science and Engineering Research

No abstract provided.

Oral Health And Pathology: A Macrophage Account., Rebecca Merry, Louise Belfield, Paul Mcardle, Andrew Mclennan, Stjohn Crean, Andrew Foey

School of Biomedical Sciences

Macrophages are present in healthy oral mucosa and their numbers increase dramatically during disease. They can exhibit a diverse range of phenotypes characterised as a functional spectrum from pro-inflammatory to anti-inflammatory (regulatory) subsets. This review illustrates the role of these subsets in the oral inflammatory disease lichen planus, and the immunosuppressive disease oral squamous cell carcinoma (SCC). We conclude that the role of macrophages in driving progression in oral disease identifies them as potential therapeutic targets for a range of oral pathologies.

Speech Development: Toddlers Don't Mind Getting It Wrong, Piers Messum, Ian S. Howard

School of Engineering, Computing and Mathematics

No abstract provided.

Guided Self-Help Concreteness Training As An Intervention For Major Depression In Primary Care: A Phase Ii Randomized Controlled Trial., E. R. Watkins, R. S. Taylor, R. Byng, C. Baeyens, R. Read, K. Pearson, L. Watson

Peninsula Medical School

BACKGROUND: The development of widely accessible, effective psychological interventions for depression is a priority. This randomized trial provides the first controlled data on an innovative cognitive bias modification (CBM) training guided self-help intervention for depression. METHOD: One hundred and twenty-one consecutively recruited participants meeting criteria for current major depression were randomly allocated to treatment as usual (TAU) or to TAU plus concreteness training (CNT) guided self-help or to TAU plus relaxation training (RT) guided self-help. CNT involved repeated practice at mental exercises designed to switch patients from an unhelpful abstract thinking habit to a helpful concrete thinking habit, thereby targeting …

The Role Of Insulin-Like Growth Factors Signaling In Merlin-Deficient Human Schwannomas., Sylwia Ammoun, M. Caroline Schmid, Natalia Ristic, Lu Zhou, David Hilton, Emanuela Ercolano, Camille Carroll, C. Oliver Hanemann

Peninsula Medical School

Loss of the tumor suppressor merlin causes development of the tumors of the nervous system, such as schwannomas, meningiomas, and ependymomas occurring spontaneously or as part of a hereditary disease Neurofibromatosis Type 2 (NF2). Current therapies, (radio) surgery, are not always effective. Therefore, there is a need for drug treatments for these tumors. Schwannomas are the most frequent of merlin-deficient tumors and are hallmark for NF2. Using our in vitro human schwannoma model, we demonstrated that merlin-deficiency leads to increased proliferation, cell-matrix adhesion, and survival. Increased proliferation due to strong activation of extracellular-signal-regulated kinase 1/2 (ERK1/2) is caused by overexpression/activation …

Iterative Orthology Prediction Uncovers New Mitochondrial Proteins And Identifies C12orf62 As The Human Ortholog Of Cox14, A Protein Involved In The Assembly Of Cytochrome C Oxidase, R Szklarczyk, Bfj Wanschers, Td Cuypers, Jj Esseling, Et Al

School of Biomedical Sciences

BACKGROUND: Orthology is a central tenet of comparative genomics and ortholog identification is instrumental to protein function prediction. Major advances have been made to determine orthology relations among a set of homologous proteins. However, they depend on the comparison of individual sequences and do not take into account divergent orthologs. RESULTS: We have developed an iterative orthology prediction method, Ortho-Profile, that uses reciprocal best hits at the level of sequence profiles to infer orthology. It increases ortholog detection by 20% compared to sequence-to-sequence comparisons. Ortho-Profile predicts 598 human orthologs of mitochondrial proteins from Saccharomyces cerevisiae and Schizosaccharomyces pombe with 94% …

An Instructional Pyramid: Expanding Coach Wooden's "Pyramid Of Success" To Guide P.E.T.E. Professionals, Robert Christenson, David C. Barney

Faculty Publications

What in the teaching-learning process can PETE (Physical Education Teacher Education) faculty identify as being effective and a critical part of this multifaceted practice? Which of the physical activity learning experiences best serves the student? Finally, how does a future-professional physical education teacher, who is inexperienced and intimidated by their first job circumstances, wade through all the information and responsibilities to perform up to expectations? As described by Veal (2011), "Teachers operate in an intensely complicated and demanding world. They face 30 or more students at once – each one different from the other, demanding individualized attention and treatment. Teachers …

Impacts Of A Parenting Newsletter On Fathers Of Kindergarten Children, Sean E. Brotherson, Erin Kramer Holmes, Christopher J. Bouwhuis

Faculty Publications

This study is the first assessment of the perceived effectiveness of a parenting newsletter written specifically for fathers or father figures. The Father Times newsletter was distributed weekly for six weeks to all families of kindergarten children at a local school. Once hundred seventy-seven fathers responded to a self-report questionnaire regarding usage of the parenting newsletter, perceptions of the newsletter as a resource, and impacts of fathers' attitudes, knowledge, behaviors, and father–child relationship quality. Two-thirds of fathers in the sample reported changing at least "somewhat" in all nine outcomes explored. Neither father age nor number of children in the home …

Establishing A Foundation For Automated Human Credibility Screening, Jay F. Nunamaker Jr, Judee K. Burgoon, Nathan W. Twyman, Jeffrey Gainer Proudfoot, Ryan M. Schuetzler, Justin Scott Giboney

Faculty Publications

Automated human credibility screening is an emerging research area that has potential for high impact in fields as diverse as homeland security and accounting fraud detection. Systems that conduct interviews and make credibility judgments can provide objectivity, improved accuracy, and greater reliability to credibility assessment practices, need to be built. This study establishes a foundation for developing automated systems for human credibility screening

Association Between C-Reactive Protein And Cognitive Deficits In Elderly Men And Women: A Meta-Analysis, Bruce L. Brown, Dawson W. Hedges, Thomas J. Farrer

Faculty Publications

Abstract

Background: Certain risk factors for cognitive decline appear modifiable. A potentially modifiable marker of inflammation, C-reactive protein may be associated with cognitive deficits, although not all studies have found a relationship between C-reactive protein and cognitive ability. Further, few research papers have examined whether gender may affect any association between C-reactive protein and cognitive deficit.

Methods: To better understand the association between C-reactive protein, cognitive deficit, and gender in elderly people, we meta-analyzed cross-sectional studies that reported cognitive ability assessed by the Mini-Mental State Examination or an equivalent measure, C-reactive protein concentrations, and gender.

Results: While we identified no …

Forgiveness And Relationship Satisfaction: Mediating Mechanisms, Scott R. Braithwaite, Edward A. Selby, Frank D. Fincham

Faculty Publications

Although the ability to forgive transgressions has been linked to overall relationship satisfaction, the mechanisms that mediate this association have not been established. We propose that the tendency to forgive a romantic partner increases relationship satisfaction via increased relational effort and decreased negative conflict. In two studies, we used structural equations modeling to examine these variables as potential mechanisms that drive this association. In Study 1 (N = 523) and Study 2 (N = 446) we found that these variables significantly mediated the association between forgiveness and relationship satisfaction. The findings were robust when examined concurrently and longitudinally, across multiple …

Examining A Brief Suicide Screening Tool In Older Adults Engaging In Risky Alcohol Use, Scott R. Braithwaite, Jessica D. Ribeiro, Jon J. Peaff, Thomas E. Joiner

Faculty Publications

Alcohol misuse increases risk of suicidal behavior in older adults. TheDepressive Symptom Inventory-Suicidality Subscale (DSI-SS; Metalsky & Joiner,1997) and its relation to suicide attempt history was examined to see if it differedfor older adults as a function of their alcohol use. Structural equation modelingwas used in a sample (N= 1,061) of older adult outpatients to examine the scale’smeasurement invariance and population heterogeneity and its relation to suicideattempt history. Analyses supported the equivalence of the DSI-SS in risky andnonrisky drinkers. The DSI-SS significantly predicted past suicide attempts. Find-ings support the viability of the DSI-SS as suicide screening tool for older adults.

Subliminal Activation Of Social Ties Moderates Cardiovascular Reactivity During Acute Stress, Wendy C. Birmingham, Mckenzie Carlisle, Bert N. Uchino, David M. Sanbonmatsu, Timothy W. Smith, Matthew R. Cribbet, Kathleen C. Light, Allison A. Vaughn

Faculty Publications

Objective—The quality of one’s personal relationships has been reliably linked to important physical health outcomes, perhaps through the mechanism of physiological stress responses. Most studies of this mechanism have focused on whether more conscious interpersonal transactions influence cardiovascular reactivity. However, whether such relationships can be automatically activated in memory to influence physiological processes has not been determined. The primary aims of this study were to examine if subliminal activation of relationships could influence healthrelevant physiological processes, and to examine this question in the context of a more general relationship model that incorporates both positive and negative dimensions. Method—We randomly assigned …

Evaluative Threat And Ambulatory Blood Pressure: Cardiovascular Effects Of Social Stress In Daily Experience, Wendy C. Birmingham, Timothy W. Smith, Bert N. Uchino

Faculty Publications

Objective—Physiological effects of social evaluation are central in models of psychosocial influences on physical health. Experimental manipulations of evaluative threat evoke substantial cardiovascular and neuroendocrine responses in laboratory studies, but only preliminary evidence is available regarding naturally-occurring evaluative threats in daily life. In such non-experimental ambulatory studies, it is essential to distinguish effects of evaluative threat from related constructs known to alter stress, such as ability perceptions and concerns about appearance. Methods—94 married, working couples (mean age 29.2 years) completed a one-day (8am to 10pm) ambulatory blood pressure (ABP) protocol with random interval-contingent measurements using a Suntech monitor and Palm …

Psychological Pathways Linking Social Support To Health Outcomes: A Visit With The “Ghosts” Of Research Past, Present, And Future, Wendy C. Birmingham, Bert N. Uchino, Kimberly Bowen, Mckenzie Carlisle

Faculty Publications

Contemporary models postulate the importance of psychological mechanisms linking perceived and received social support to physical health outcomes. In this review, we examine studies that directly tested the potential psychological mechanisms responsible for links between social support and health-relevant physiological processes (1980s to 2010). Inconsistent with existing theoretical models, no evidence was found that psychological mechanisms such as depression, perceived stress, and other affective processes are directly responsible for links between support and health. We discuss the importance of considering statistical/design issues, emerging conceptual perspectives, and limitations of our existing models for future research aimed at elucidating the psychological mechanisms …

Specific Dimensions Of Perceived Support And Ambulatory Blood Pressure: Which Support Functions Appear Most Beneficial And For Whom?, Wendy C. Birmingham, Kimberly S. Bowen, Bert N. Uchino, Mckenzie Carlisle, Timothy W. Smith, Kathleen C. Light

Faculty Publications

Perceived support has been related to lower cardiovascular morbidity and mortality. However, little is known about the specific functional components of support responsible for such links. We tested if emotional, informational, tangible, and belonging support predicted ambulatory blood pressure (ABP) and interpersonal interactions (e.g., responsiveness), and if such links were moderated by gender. In this study, 94 married couples underwent 12 h of ABP monitoring during daily life which included a night at home with their spouse. They completed a short-form of the interpersonal support evaluation list that provides information on total (global) support, as well as specific dimensions of …

Knowing Your Partner Is Not Enough: Spousal Importance Moderates The Link Between Attitude Familiarity And Ambulatory Blood Pressure, Wendy C. Birmingham, Bert N. Uchino, David M. Sanbonmatsu

Faculty Publications

Close relationships have been linked to cardiovascular morbidity and mortality. More research is needed, however, on the social and biological processes responsible for such links. In this study, we examined the role of relationship-based attitudinal processes (i.e., attitude familiarity and partner importance) on ambulatory blood pressure during daily life. Forty-seven married couples completed a questionnaire regarding their own attitudes, perceptions of their partner’s attitudes, and perceptions of partner importance. They also underwent a 1-day ambulatory assessments of daily spousal interactions and blood pressure. Partner importance was related to better interpersonal functioning (e.g., partner responsiveness) and lower ambulatory systolic blood pressure. …

Performance Monitoring Following Conflict: Internal Adjustments In Cognitive Control?, Scott A. Baldwin, Michael J. Larson, Peter E. Clayson

Faculty Publications

The purpose of this study was to investigate the effects of strategic conflict-related adjustments in cognitive control processes on indices of performance monitoring. Previous research has examined the ability of parametric task-related manipulations to bias attention to errors; however, the present study sought to elucidate the effects of internal adjustments in control mediated by the anterior cingulate cortex on error-related conflict processing. High-density event-related potentials (ERPs) were obtained from 124 healthy individuals (68 female, 66 male) during a modified Eriksen flanker task. Behavioral measures (i.e., error rates, response times [RTs]) and N2 amplitudes showed significant conflict adaptation (i.e., previous-trial congruencies …

How Does Noise Affect Amplitude And Latency Measurement Of Event-Related Potentials (Erps)? A Methodological Critique And Simulation Study, Scott A. Baldwin, Peter E. Clayson, Michael J. Larson

Faculty Publications

There is considerable variability in the quantification of event-related potential (ERP) amplitudes and latencies. Weexamined susceptibility of ERP quantification measures to incremental increases in background noise through publishedERP data and simulations. Measures included mean amplitude, adaptive mean, peak amplitude, peak latency, andcentroid latency. Results indicated mean amplitude was the most robust against increases in background noise. Theadaptive mean measure was more biased, but represented an efficient estimator of the true ERP signal particularly forindividual-subject latency variability. Strong evidence is provided against using peak amplitude. For latency measures,the peak latency measure was less biased and less efficient than the centroid latency …