Digital Commons Network^™

Viral Receptor Trafficking Regulated By Gabarap, Cendy Valle Oseguera, Carolyn C. Tu, Jie Sun, Kathleen Arnolds, Juliet V. Spencer

Creative Activity and Research Day - CARD

Human cytomegalovirus (HCMV) is a widespread pathogen that can be life-threatening to immune-compromised patients but rarely causes disease in healthy individuals. Previous work using the yeast two-hybrid system found that GABARAP (γ-aminobutyric-acid-receptor-associated-protein) binds to HCMV US27. US27 is similar to human chemokine receptors, but is localized intracellularly instead of on the surface. Here, we examined the US27-GABARAP interaction in human cells and identified a four amino acid motif (WXXL) that mediates GABARAP binding to US27 and its localization to endosomal compartments. Since GABARAP regulates cellular receptor trafficking, these results show that viral US27 is also controlled by a cellular protein.

Role Of Human Cytomegalovirus In Breast Cancer, Cendy Valle Oseguera, Juliet V. Spencer

Creative Activity and Research Day - CARD

Cancer results from unregulated cell growth that invades neighboring tissues. While there are many known risk factors for cancer, one area that remains largely unexplored is the impact of infectious disease. Human cytomegalovirus (HCMV) is highly prevalent in the population and has also been found in several types of tumors. We are investigating the possibility that a viral protein released from infected cells, cmvIL-10, promotes tumor metastasis by enhancing the invasive potential of breast cancer cells. These results will clarify the role of HCMV in breast cancer progression and could have broad implications for the diagnosis and treatment of cancer.

Establishment Of An Efficient Method For The Synthesis Of Srh, An Important Molecule In Bacterial Quorum Sensing, Emily Showell-Rouse, Ruoyi Liu

Creative Activity and Research Day - CARD

Quorum sensing (QS) is a process of bacterial communication that regulates the expression of virulence genes in many bacteria. The study of QS, could lead to new treatments for bacterial diseases. Interspecies bacterial communication utilizes the signaling molecule autoinducer-2 (AI-2). The LuxS enzyme converts S-ribosyl-L-homocysteine (SRH) into 4(S),5-dihydroxypentane-2,3-dione (DPD), the precursor of AI-2. LuxS inhibitors could prevent QS by halting conversion of SRH. We have developed an efficient synthesis of SRH from D-ribose and L-homocystine. This procedure provides us with both a supply of SRH for biochemical assays and a foundation for the synthesis of SRH analogs …

Loneliness In Middle Childhood: Social Connectedness And Genetic Relatedness, Taryn Larribas, Margaret Gross, Meenakshi Palaniappan, Helena Karnilowics, Shannon Mccarthy

Creative Activity and Research Day - CARD

The evolutionary approach argues that genetic similarity contributes to greater social similarity due to their desire to protect their genes. The social perspective model argues that loneliness is impacted by social relationships. It is hypothesized that MZ twins will show support for the evolutionary perspective, having the closest levels of loneliness, and will have levels comparable to FFs (Segal, 2000). It is hypothesized that loneliness means will show the following pattern: MZ < DZ = FS < VT with MZ = FF. Additionally, it is hypothesized that there will be a gender difference in loneliness in that M > F (Junttila & Vauras, 2009).

Participants were 300 pairs of children (8-12 years), who took part in the TAPS Study. The hypothesis was examined using 54 pairs of …

Data Studio Opens At Kennedy Library On April 26, Public Affairs Office

Press Releases

No abstract provided.

Gsu View, 2012-04-16, Office Of Marketing And Communications

GSU View

Newsletter published by Governors State University 2007-current.

Lanthorn, Vol. 46, No. 58, April 16, 2012, Grand Valley State University

Volume 46, July 14, 2011 - June 18, 2012

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Spartan Daily April 16, 2012, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 138, Issue 38

The Statesman, V. 55, I. 26, Stony Brook University

Stony Brook Statesman-Sucolian

v. 55, i. 26

Synthesis And Dna Functionalization Of Cdse/Cds (Core/Shell) Quantum Dots, Braden Lawrence

College of Arts and Sciences Poster Presentations

In recent years, colloidal semiconductor nanocrystals, commonly known as quantum dots, have gained much attention in fields such as materials chemistry, bioengineering, chemical and biomedical engineering. These semiconductor nanocrystals display unique optical, electrical, and chemical properties unlike any bulk material or individual molecule. Areas of particular interest in the field of quantum dots include biofunctionalization. Recently, advances in biology and medicine indicate successful bioconjugate functionalization of biomolecules such as peptides, antibodies, nucleic acids, or small-molecules for labeling and intracellular tracking.This research is focused on the multistep synthesis of CdSe/CdS core-shell nanoparticles as well as employment of two different solubilization methods—lipid …

April 16, 2012 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

2011-12 Faculty Senate - April 16, 2012 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Out With The Old And In With The New: A Comparison Between Molecular And Traditional Techniques To Identify Parasitized Birds, Christian Guerrero

College of Arts and Sciences Poster Presentations

Traditionally, the identification of blood parasites has been based on visual examination of blood smears. This approach depends on individual expertise in making blood smears and identifying parasites, which can vary widely from person to person. Recent work has shown that reading blood smears is significantly less sensitive than using molecular studies in identification. Thus, the accuracy of the data can fluctuate greatly. This project compares the ability of investigators to identify infected birds using microscopes and blood smears with their ability to identify infected birds through molecular analysis of blood from the same sample.

During fall migration (September – …

See No, Smell No, Taste No Evil: How Sage-Grouse Detect Toxic Sagebrush, K. Gehlken, B. Robb, S. Agafonov, J. Forbey

College of Arts and Sciences Poster Presentations

There is increasing evidence that sage-grouse selectively consume individual and species of sagebrush that have the lowest concentrations of chemical defenses, or toxins. We propose that this selection requires the ability to see, smell or taste specific chemicals or groups of chemicals that vary quantitatively and qualitatively in sagebrush available throughout the winter range of sage-grouse. We are developing methods to determine if and how selected and avoided sagebrush may differ in color, smell and taste. We used ultraviolet and near infrared detectors to determine the variation in the "color" of phenolics in sagebrush. We used gas chromatography to determine …

Daily Eastern News: April 16, 2012, Eastern Illinois University

April

No abstract provided.

Current, April 16, 2012, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

Grad Students Set To Host Second Girls In Science Day, Tyler Greer

Browse All News

No abstract provided.

20 Profs Presented Excellence In Mentorship Awards, Tyler Greer

Browse All News

No abstract provided.

Using An Experimental Mixture Design To Identify Experimental Regions With High Probability Of Creating A Homogeneous Monolithic Column Capable Of Flow, Charles C. Willden

Theses and Dissertations

Graduate students in the Brigham Young University Chemistry Department are working to develop a filtering device that can be used to separate substances into their constituent parts. The device consists of a monomer and water mixture that is polymerized into a monolith inside of a capillary. The ideal monolith is completely solid with interconnected pores that are small enough to cause the constituent parts to pass through the capillary at different rates, effectively separating the substance. Although the end objective is to minimize pore sizes, it is necessary to first identify an experimental region where any combination of input variables …

Modeling The Potential Effects Of Plasmodium Infection On The Galapagos Penguin (Spheniscus Mendiculus), Robert James Meile

Theses

The recently discovered presence of a species of Plasmodium infecting the endangered Galapagos penguin (Spheniscus mendiculus) potentially threatens their long-term persistence. However, not much information is available on the transmission dynamics of Plasmodium in Galapagos or the impact of the parasite on infected penguins. The present work takes the model of the Galapagos penguin population devised by Vargas et al. (2007)—which did not include any impacts from disease—and adds a simple model of infection. Two variables—the probability of an individual becoming infected each year, and the increase in annual mortality caused by infection—define the dynamics of the disease …

The Scope Of The Malnutrition Epidemic In Guatemala: Its Implications On The Development Of The Child And Of The Nation, Rebekah M. Zello

Senior Honors Theses

Research reveals that malnutrition is a severe problem in the nation of Guatemala, as it is the country with the highest rate of malnutrition in Latin America and the Western hemisphere, and the fourth highest rate in the world. The epidemic of malnutrition in Guatemala not only inhibits the development of each child, but also the development of the nation as a whole. The causes and effects of child malnutrition both on the individual and on Guatemalan society will be explored. Infant malnutrition in Guatemala is an injustice which manifests itself severely through the cognitive, physical, and psychosocial shortcomings in …

Faculty Senate Executive Committee Agenda, April 16, 2012, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• FDDE Annual Report - Christopher Neale
• Committee on Committees Annual Report - Flora Shrode
• Calendar Committee Report - Michelle Larson
• Continuing USU-Eastern Integration - Glenn McEvoy
• Open Access - Flora Shrode, Richard Clement
• EPC Items - Larry Smith
• HR Code Changes: 369 Organ Donor Leave, 350 Educational Benefits,357 Long Term Disability, 307 Conflicts of Interest - BrandE Faupell
• PRPC Code Changes Section 405.7.2(1) and 405.8.3(1) (for Second Reading). - Terry Peak
• Post-Tenure Review Task Force Issues #2 - Glenn McEvoy

Solvation Of Organic Cations In The Gas Phase And Within Molecular Clusters, Ahmed Hamid

Theses and Dissertations

The role of the solvent in ionic and ion-molecule interactions is of fundamental importance in kinetics and thermodynamics of solution chemistry. However, the study of the ionic interactions in the presence of a large number of solvent molecules is very challenging. Therefore, the gas-phase is the appropriate medium to study such reactions on a molecular level where the ion-solvent interaction can be examined by studying ions surrounded with a cluster of solvent molecules in the complete absence of the any interference caused by the bulk of the solvent. In nature, organic ions can form hydrogen bonds with solvents. An insight …

An Ethnographic Analysis Of The Struggles And Priorities Of Medical Missionaries Serving In The Dominican Republic, Randi Hafele

Honors Theses

No abstract provided.

April 16, 2012, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

An Exploration Of Undeclared Students' Expectations Of Experiences For Faculty Interactions And Co-Curricular Involvement, Lorie Anne Kittendorf

USF Tampa Graduate Theses and Dissertations

Student persistence and achievement are areas of significant concern for institutions of higher education. With national college graduation rates hovering in the 50% range, it is important for colleges and universities to understand which student characteristics and campus environments lead to greater success, as well as the expectations students have of the college experience.

Research on undeclared students is vast and dates back more than 70 years, and many of the seminal studies and respected research data have led to the perception that they are at higher risk of attrition and have lower levels of academic achievement than their declared …

Design And Biophysicochemical Properties Of Chitosan-Collagen-Calcium Phosphate Microparticles And Scaffolds For Bone Tissue Regeneration, Monica Viorica Zugravu

Electronic Theses and Dissertations Archive

Due to limitations of bone autografts and allografts there is much research directed at designing synthetic bone grafts. In this work, collagen-chitosan-calcium phosphate microparticles and microparticle-based scaffolds were compared to their counterparts without collagen in terms of degradation, cytocompatibility (porosity and stiffness only for scaffolds). Microparticles exhibited 20% decrease in mass over 6 weeks and provided an optimal environment for 3-5 fold cell proliferation over 7 days-culture period. Although there was no effect of collagen addition to microparticles, all the formulations may be suitable as bone tissue fillers. Further, there was no difference between control and collagen scaffolds. In general, …

Food Availability As A Determinant Of Weight Gain Among Renal Transplant Recipients, Robin Frances Bloodworth

Electronic Theses and Dissertations Archive

Renal transplantation is the treatment of choice for End Stage Renal Disease (ESRD), but one of the risks associated with this treatment is excessive weight gain. Several potential causes of this increased risk have been evaluated, but environmental factors have not yet been explored. This study used Geographic Information Systems (GIS) to evaluate the effect of number and ratio (number of one compared to all) of food sources (fast food restaurants, convenience stores, and grocery stores) within a one, two, and three mile buffer around transplant recipients' residences (n = 484) on BMI change during the first year post-transplant. Multiple …

Sanderson Named To Endowed Professorship In Cancer Pathobiology, Staff

Browse All News

No abstract provided.

General Neural Networks Dynamics Are A Superposition Of Gradient-Like And Hamiltonian-Like Systems, Chaouki T. Abdallah, James W. Howse, Gregory L. Heileman

Electrical & Computer Engineering Faculty Publications

This report presents a formalism that enables the dynamics of a broad class of neural networks to be understood. A number of previous works have analyzed the Lyapunov stability of neural network models. This type of analysis shows that the excursion of the solutions from a stable point is bounded. The purpose of this work is to present a model of the dynamics that also describes the phase space behavior as well as the structural stability of the system. This is achieved by writing the general equations of the neural network dynamics as the sum of gradient-like and Hamiltonian-like systems. …