Digital Commons Network^™

Drug Safety: It's A Learning Process, Vanessa Eng

Journal of Civil Rights and Economic Development

No abstract provided.

Birth Of A New Age: A Comprehensive Review Of New York Inheritance Law Responding To Advances In Reproductive Technology, Catherine Belfi

Journal of Civil Rights and Economic Development

No abstract provided.

When Ethical Principles And Feminist Jurisprudence Collide: An Unorthodox Reading Of "A Jury Of Her Peers", Sara D. Schotland

Journal of Civil Rights and Economic Development

No abstract provided.

Bryant University Research And Engagement Day Program

Bryant REDay (Research and Engagement Day)

No abstract provided.

The Antelope, University Of Nebraska At Kearney

The Antelope

No abstract provided.

The Fierce Green Fire: Vol. 2 Issue 23, Wofford College Environmental Studies Program

The Fierce Green Fire

No abstract provided.

Volume 103 Issue 22, Southwestern Oklahoma State University

The Southwestern - Archive

No abstract provided.

Survival Motor Neuron Protein Deficiency Impairs Myotube Formation By Altering Myogenic Gene Expression And Focal Adhesion Dynamics, Katherine V. Bricceno, Tara Martinez, Evgenia Leikina, Stephanie Duguez, Terence A. Partridge, Leonid V. Chernomordik, Kenneth H. Fischbeck, Charlotte J. Sumner, Barrington G. Burnett

Pediatrics Faculty Publications

While spinal muscular atrophy (SMA) is characterized by motor neuron degeneration, it is unclear whether and how much survival motor neuron (SMN) protein deficiency in muscle contributes to the pathophysiology of the disease. There is increasing evidence from patients and SMA model organisms that SMN deficiency causes intrinsic muscle defects. Here we investigated the role of SMN in muscle development using muscle cell lines and primary myoblasts. Formation of multinucleate myotubes by SMN-deficient muscle cells is inhibited at a stage preceding plasma membrane fusion. We found increased expression and reduced induction of key muscle development factors, such as MyoD and …

Easterner, Vol. 63, No. 23, April 18, 2012, Associated Students Of Eastern Washington University

Student Newspapers

This issue of the Easterner contains articles about the Associated Students (ASEWU) primary elections, a campus talk by Washington Secretary of State Sam Reed, the EWU World Cup, a strategic planning luncheon, the dean of students search, the upcoming Clean Sweep event for Earth Day, Get Lit!, women's tennis, track athlete Taylor Walker, and seniors entering the NFL draft.

Water Purification Device For A Developing Country Constructed From Local Materials, Martina L. Houmann

Capstone Research Projects

No abstract provided.

Synthesis Of Some New Fluorinated Hexahydroquinoline And Acridinedione Derivatives In Trifluoroethanol, Cosmas O. Okoro, Mumiye A. Ogunwale, Tasneem Siddiquee

Chemistry Faculty Research

This article describes one-pot synthesis of new fluorinated hexahydroquinoline derivatives via unsymmetric Hantzsch reaction involving 5-trifluoromethyl-1,3-cyclohexanedione, aldehydes, acetoacetate ester, and ammonium acetate in trifluoroethanol (TFE). The reaction is simple and rapid with high yield.

"The Crescent" Student Newspaper, April 18, 2012, George Fox University Archives

"The Crescent" Student Newspaper

Student newspaper of George Fox University.

The Anchor, Volume 125.21: April 18, 2012, Hope College

The Anchor: 2012

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Natural Reward Experience Alters Ampa And Nmda Receptor Distribution And Function In The Nucleus Accumbens, Kyle K. Pitchers, Susanne Schmid, Andrea R. Di Sebastiano, Xu Wang, Steven R. Laviolette, Michael N. Lehman, Lique M. Coolen

Anatomy and Cell Biology Publications

Natural reward and drugs of abuse converge upon the mesolimbic system which mediates motivation and reward behaviors. Drugs induce neural adaptations in this system, including transcriptional, morphological, and synaptic changes, which contribute to the development and expression of drug-related memories and addiction. Previously, it has been reported that sexual experience in male rats, a natural reward behavior, induces similar neuroplasticity in the mesolimbic system and affects natural reward and drug-related behavior. The current study determined whether sexual experience causes long-lasting changes in mating, or ionotropic glutamate receptor trafficking or function in the nucleus accumbens (NAc), following 3 different reward abstinence …

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.

High And Persistent Hiv Seroincidence In Men Who Have Sex With Men Across 47 U.S. Cities, Marta-Louise Ackers, Alan E. Greenberg, Carol Y. Lin, Bradford N. Bartholow, Adrian Hirsch Goodman, Michael Longhi, Marc Gurwith

Epidemiology Faculty Publications

Objective

To provide HIV seroincidence data among men who have sex with men (MSM) in the United States and to identify predictive factors for seroconversion.

Methods

From 1998–2002, 4684 high-risk MSM, age 18–60 years, participated in a randomized, placebo-controlled HIV vaccine efficacy trial at 56 U.S. clinical trial sites. Demographics, behavioral data, and HIV status were assessed at baseline and 6 month intervals. Since no overall vaccine efficacy was detected, data were combined from both trial arms to calculate HIV incidence based on person-years (py) of follow-up. Predictors of seroconversion, adjusted hazards ratio (aHR), were evaluated using a Cox proportional …

Iron Deficiency Causes A Shift In Amp-Activated Protein Kinase (Ampk) Catalytic Subunit Composition In Rat Skeletal Muscle, John Merrill

Theses and Dissertations

To determine effects of iron deficiency on AMPK activation and signaling, as well as the AMPKα subunit composition in skeletal muscle, rats were fed a control (C=50-58 mg/kg Fe) or iron deficient (ID=2-6 mg/kg Fe) diet for 6-8 wks. Their respective hematocrits were 47.5% ± 1.0 and 16.5% ± 0.6. Iron deficiency resulted in 28.3% greater muscle fatigue (p<0.01) in response to 10 min of stimulation (1 twitch/sec) and was associated with a greater reduction in phosphocreatine (C: Resting 24.1 ± 0.9 micromol/g, Stim 13.1 ± 1.5 micromol/g; ID: Resting 22.7 ± 1.0 micromol/g, Stim 3.2 ± 0.7 micromol/g; p<0.01) and ATP levels (C: Resting 5.89 ± 0.48 micromol/g, Stim 6.03 ± 0.35 micromol/g; ID: Resting 5.51 ± 0.20 micromol/g, Stim 4.19 ± 0.47 micromol/g; p<0.05). AMPK activation increased with stimulation in muscles of C and ID animals. A reduction in Cytochrome c and other iron-dependent mitochondrial proteins was observed in ID animals (p<0.01). The AMPK catalytic subunit (alpha) was also examined because both isoforms are known to play different roles in responding to energy challenges. In ID animals, AMPK alpha2 subunit protein content was reduced to 71.6% of C (p<0.05), however this did not result in a significant difference in resting AMPK alpha2 activity. AMPK alpha1 protein was unchanged, however an overall increase in AMPK alpha1 activity was observed (C: 0.91 pmol/mg/min; ID: 1.63 pmol/mg/min; p<0.05). Resting phospho Acetyl CoA Carboxylase (pACC) was unchanged. This study indicates that chronic iron deficiency causes a shift in the expression of AMPK alpha subunit composition and potentially altered sensitivity to cellular energy challenges.

The Lumberjack, April 18, 2012, The Lumberjack Staff

2012

The student newspaper of Humboldt State University

Spectrum, Volume 28, Issue 21, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Student commons dedicated to McMahon -- Dance team places fifth at Nationals -- Minor makes books come to life with illustrations -- Professors and students mixed on iPad updates and improvements -- U.S. hopes of diplomacy fade with North Korea launch -- From Facebook friends to acquaintances -- Protesting the Protest

Campus Chronicle, C.J. Eilers, Nevin Cornwell, Mo Powell Eckstein, Jon Rothfus, Ariel Curtis, Dakota Lancaster, Paige Rothfus, Scott Rentz, Andy Langager

Campus Chronicle

No abstract provided.

An Analysis Of Uriay Culture And Gospel Presentation To The Uriay Tribe, Kaitlin R. Sones

Senior Honors Theses

The Uriay people group in Papua New Guinea is a remote animistic tribe that has just recently heard the Gospel. This people group is just one of the thousands of distinct cultures in this world, many of which have not yet received the good news of Jesus Christ. This thesis opens by analyzing culture and animism and culminates with an ethnographic description of the Uriay tribe based on personal observation and information collected from missionaries who have lived among the Uriay people for over ten years. The purpose of this thesis is to provide research on this remote people group …

April 18, 2012 Cal Poly Report, Public Affairs Office

Cal Poly Report

No abstract provided.

Laissez-Faire Individualism And Its Descent Into Ideology In The Us, From The Interwar Period To 1960, Darren Barany

The Journal of Public and Professional Sociology

The origins of the American conservative movement lie in several strands of political and economic thought. The contemporary narrative about free and unfettered markets, i.e. neoliberalism, had been adopted from the early laissez-faire individualism of the American Old Right. In light of the recent political ascent of “Tea Party Conservatism” in the United States and its misappropriation of laissez-faire ideas, this paper traces the development of this one aspect of the American conservative tradition, what is now commonly referred to as libertarianism.[i]

This article is not meant to be an exhaustive review of laissez-faire individualist thought during this period …

Transmission Of Triticum Mosaic Virus And Its Impact On The Biology Of The Wheat Curl Mite Aceria Tosichella Keifer (Eriophyidae), And An Evaluation Of Management Tactics For The Wheat Curl Mite And The Wheat–Mite–Virus Complex, Anthony J. Mcmechan

Department of Entomology: Dissertations, Theses, and Student Research

The wheat-mite-virus complex is an important production constraint to winter wheat production in the Great Plains, and consists of three viruses; wheat streak mosaic (WSMV), wheat mosaic (WMoV) and Triticum mosaic virus (TriMV). Synergistic interactions between these viruses have resulted in increased rates of replication and transmission of viruses, thus increasing the potential impact on wheat yields. The wheat curl mite (WCM), Aceria tosichella Keifer is the only known vector of the viruses within the wheat-mite-virus complex.

Currently, three colonies of WCM have been characterized by differential responses to mite resistant genes (biotypes) in wheat and differential transmission of WMoV. …

Expression Of The Pair-Rule Gene Homologs Runt, Pax3/7, Even-Skipped-1 And Even-Skipped-2 During Larval And Juvenile Development Of The Polychaete Annelid Capitella Teleta Does Not Support A Role In Segmentation, Elaine C. Seaver, Emi Yamaguchi, Gemma S. Richards, Néva P. Meyer

Biology

Background: Annelids and arthropods each possess a segmented body. Whether this similarity represents an evolutionary convergence or inheritance from a common segmented ancestor is the subject of ongoing investigation.Methods: To investigate whether annelids and arthropods share molecular components that control segmentation, we isolated orthologs of the Drosophila melanogaster pair-rule genes, runt, paired (Pax3/7) and eve, from the polychaete annelid Capitella teleta and used whole mount in situ hybridization to characterize their expression patterns.Results: When segments first appear, expression of the single C. teleta runt ortholog is only detected in the brain. Later, Ct-runt is expressed in the ventral nerve cord, …

Species Identification And Strain Attribution With Unassembled Sequencing Data, Owen Eric Francis

Theses and Dissertations

Emerging sequencing approaches have revolutionized the way we can collect DNA sequence data for applications in bioforensics and biosurveillance. In this research, we present an approach to construct a database of known biological agents and use this database to develop a statistical framework to analyze raw reads from next-generation sequence data for species identification and strain attribution. Our method capitalizes on a Bayesian statistical framework that accommodates information on sequence quality, mapping quality and provides posterior probabilities of matches to a known database of target genomes. Importantly, our approach also incorporates the possibility that multiple species can be present in …

Neuromusicology And Combat-Induced Traumatic Brain Injury, Brittany L. Neuser

Honors Theses

The number of reported cases of combat-induced traumatic brain injury (TBI) among American veterans is rapidly increasing. The results of TBI are often a combination of deficits in cognitive, physical, emotional, and behavioral functions. Each case poses unique challenges for all involved—soldiers, their families, and health care personnel. Though each case is unique, common symptoms include impaired gross and fine motor, speech and language, memory, attention, visual, auditory, and emotional functioning (Davis, Gfeller, Thaut, 2008).

Due to the holistic nature of TBI symptoms, finding an effective yet cost-efficient treatment modality proves to be a difficult task. Previous research has suggested …

An Analysis Of Virginia Transfer Policy And Articulation Agreements: A Comparative Study Of Community College Transfer And Native Students--Enrollments And Outcomes In A Teacher Preparation Program, Michael C. Huffman

Theses and Dissertations

Transfer articulation is an important policy issue in Virginia. With increasing economic strains on federal and state budgets, pressure on key actors in higher education, and critical teacher shortages, an opportunity presented itself to investigate state transfer policy and articulation agreements designed to facilitate student transfer. Articulation agreements are policy instruments designed to facilitate a seamless transfer of both students and credits from the community college system into senior institutions. Over the last decade increased articulation activity has taken place in the Commonwealth of Virginia driven by higher education costs and articulation specific to teacher preparation due to teacher shortages. …

Neuromusicology And Combat-Induced Traumatic Brain Injury, Elisabeth C. Spinniken

Honors Theses

The number of reported cases of combat-induced traumatic brain injury (TBI) among American veterans is rapidly increasing. The results of TBI are often a combination of deficits in cognitive, physical, emotional, and behavioral functions. Each case poses unique challenges for all involved—soldiers, their families, and health care personnel. Though each case is unique, common symptoms include impaired gross and fine motor, speech and language, memory, attention, visual, auditory, and emotional functioning (Davis, Gfeller, Thaut, 2008).

Due to the holistic nature of TBI symptoms, finding an effective yet cost-efficient treatment modality proves to be a difficult task. Previous research has suggested …

Neuromusicology And Combat-Induced Traumatic Brain Injury, Brittany Neuser

Honors Theses

The number of reported cases of combat-induced traumatic brain injury (TBI) among American veterans is rapidly increasing. The results of TBI are often a combination of deficits in cognitive, physical, emotional, and behavioral functions. Each case poses unique challenges for all involved—soldiers, their families, and health care personnel. Though each case is unique, common symptoms include impaired gross and fine motor, speech and language, memory, attention, visual, auditory, and emotional functioning (Davis, Gfeller, Thaut, 2008).

Due to the holistic nature of TBI symptoms, finding an effective yet cost-efficient treatment modality proves to be a difficult task. Previous research has suggested …