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Development And Promotion In Translational Medicine: Perspectives From 2012 Sino-American Symposium On Clinical And Translational Medicine, Mengjia Qian, Duojiao Wu, Ena Wang, Francesco Marincola, Wei Wang, William Rhodes, Michael Liebman, Chunxue Bai, Ching-Wan Lam, Gyorgy Marko-Varga, Thomas Fehniger, Roland Andersson, Xiangdong Wang

Research outputs 2012

Background Clinical translational medicine (CTM) is an emerging area comprising multidisciplinary research from basic science to medical applications and entails a close collaboration among hospital, academia and industry. Findings This Session focused discussing on new models for project development and promotion in translational medicine. The conference stimulated the scientific and commercial communication of project development between academies and companies, shared the advanced knowledge and expertise of clinical applications, and created the environment for collaborations. Conclusions Although strategic collaborations between corporate and academic institutions have resulted in a state of resurgence in the market, new cooperation models still need time to …

Promoting Mitochondrial Biogenesis With The Sirti Activator Srt1720 To Improve Mitochondrial And Renal Function After Acute Kidney Injury, Jason Allen Funk

MUSC Theses and Dissertations

Mitochondrial dysfunction is a primary pathological consequence of acute kidney injury (AKI). Induction of mitochondrial biogenesis via the nuclear coactivator of transcription PPARγ-coactivator-1α (PGC-1α), the master regulator of mitochondrial biogenesis, rescues mitochondrial function in renal cells after oxidant injury. The primary goal of this project was to evaluate the recovery of mitochondrial function after in vivo AKI, and to determine the influence of mitochondrial biogenesis during the repair process. Deacetylation of PGC-1α by the class III HDAC SIRT1 produces a more active form of the protein and stimulates mitochondrial biogenesis. The potent SIRT1 activator SRT1720 induced deacetylation of PGC-1α, increased …

Global Stability And Traveling Wave Solutions For Some Epidemiological Models, Siroj Kansakar

Dissertations

No abstract provided.

Thorns Also And Thistles, Warren A. Shipton

Journal of the Adventist Theological Society

No abstract provided.

Section 1: Bio-Medical/Bioengineering, Asme Ectc Coordinating Committee

Early Career Technical Journal (ECTJ)

Proceedings of the ASME Early Career Technical Conference, November 4-5, 2011. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia

pp. 1-44

Study Of Tuberculosis Spread In Clinical Settings In Resource-Constrained Countries Using Computational Fluid Dynamics (Cfd), Adeel Khalid

Early Career Technical Journal (ECTJ)

Proceedings of the ASME Early Career Technical Conference, November 4-5, 2011. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia

Section 1: Bio-Medical/Bioengineering; pp. 3-10

Asme Early Career Technical Journal (Complete Issue), Asme Ectc Coordinating Committee

Early Career Technical Journal (ECTJ)

Proceedings of the ASME Early Career Technical Conference, November 4-5, 2011. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia

The Color Of Water: Observations Of A Brown Buffalo On Water Law And Policy In Ten Stanzas, Tom I. Romero

Water Law Review

No abstract provided.

Police Crime & Less-Than-Lethal Coercive Force: A Description Of The Criminal Misuse Of Tasers, Philip M. Stinson, Bradford W. Reyns, John Liederbach

Criminal Justice Faculty Publications

This study explores and describes the nature and character of cases that involve the criminal misuse of TASERs by police officers through a content analysis of newspaper articles. The news-based content analysis identified 24 police officers who were arrested for crimes that involved inappropriate use of TASERs over a 65 month period from January 2005 through May 2010. Data on these cases are presented in terms of: a) the arrested officer, b) victim characteristics, and c) the situational context of these events. The news-based content analyses were used to identify and describe some factors that were common among these events, …

Pond-Level Risk Factors Associated With Columnaris Disease On Mississippi Commercial Catfish Farms, Fred L. Cunningham, Skip W. Jack, David Hardin, Robert W. Wills

United States Department of Agriculture Wildlife Services: Staff Publications

A large commercial catfish enterprise encompassing over 500 food fish ponds from five farms covering multiple counties in the Mississippi Delta was included in this analysis of columnaris risk factors. A gram-negative bacterium, Flavobacterium columnare, is the cause of columnaris disease and is considered the second-most prevalent bacterial disease in farm-raised catfish. The objective of this study was to determine if pond-level risk factors reported by farm personnel were associated with columnaris disease mortalities. To identify risk factors affecting susceptibility of farm-raised channel catfish Ictalurus punctatus to columnaris disease, a Catfish Management database was developed. Logistic regression was used …

Antibodies To Avian Influenza Viruses In Canada Geese (Branta Canadensis): A Potential Surveillance Tool?, Whitney M. Kistler, David E. Stallknecht, Thomas J. Deliberto, Seth Swafford, Kerri Pedersen, Kyle Van Why, Paul C. Wolf, Jerry A. Hill, Darren L. Brunning, James C. Cumbee, Randall M. Mickley, Carl W. Betsill, Adam R. Randall, Roy D. Berghaus, Michael J. Yabsley

United States Department of Agriculture Wildlife Services: Staff Publications

Traditionally, the epidemiology of avian influenza viruses (AIVs) in wild birds has been defined by detection of virus or viral RNA through virus isolation or reverse-transcription polymerase chain reaction. Our goals were to estimate AIV antibody prevalence in Canada geese (Branta canadensis) and measure effects of age and location on these estimates. We collected 3,205 samples from nine states during June and July 2008 and 2009: Georgia, Massachusetts, Minnesota, Mississippi, New Jersey, North Carolina, Pennsylvania, Washington, and West Virginia. Serum samples were tested for AIV antibodies with the use of a commercial blocking enzyme-linked immunosorbent assay. Overall, 483 …

The Role Of The National Wildlife Disease Program In Wildlife Disease Surveillance And Emergency Response, Kerri Pedersen, John A. Baroch, Dale L. Nolte, Tom Gidlewski, Thomas J. Deliberto

United States Department of Agriculture Wildlife Services: Staff Publications

The National Wildlife Disease Program (NWDP), overseen by the U.S. Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services (WS), was established in 2003 to develop a nationally coordinated wildlife disease surveillance and emergency response system. Since its inception, the NWDP has developed collaborations with over 200 national and international partners. The national partners include state, tribal, federal, and private organizations. These partnerships have resulted in surveillance and management of over 100 pathogens, toxins, and disease syndromes affecting wildlife, domestic animals, and humans. Several of these pathogens, including avian influenza, plague, tularemia, bluetongue, and 10 pathogens carried by …

Detection Of Volatile Organic Compounds In Cattle Naturally Infected With Mycobacterium Bovis, Nir Peled, Radu Ionescu, Pauline Nol, Orna Barash, Matt Mccollum, Kurt C. Vercauteren, Matthew Koslow, Randal S. Stahl, Jack Rhyan, Hossam Haick

United States Department of Agriculture Wildlife Services: Staff Publications

We report here on a novel methodology in detecting Mycobacterium bovis (M. bovis) infection in cattle, based on identifying unique volatile organic compounds (VOCs) or a VOC profile in the breath of cattle. The study was conducted on an M. bovis-infected dairy located in southern Colorado, USA, and on two tuberculosis-free dairies from northern Colorado examined as negative controls. Gaschromatography/ mass-spectrometry analysis revealed the presence of 2 VOCs associated with M. bovis infection and 2 other VOCs associated with the healthy state in the exhaled breath of M. bovis-infected and not infected animals, yielding distinctly different VOC patterns …

The Burden Of Breast Cancer In Italy: Mastectomies And Quadrantectomies Performed Between 2001 And 2008 Based On Nationwide Hospital Discharge Records., Prisco Piscitelli, Maddalena Barba, Massimo Crespi, Massimo Di Maio, Antonio Santoriello, Massiliamo D'Aiuto, Alfredo Fucito, Arturo Losco, Francesca Pentimalli, Pasquale Maranta, Giovanna Chitano, Alberto Argentiero, Cosimo Neglia, Alessandro Distante, Gian Luca Di Tanna, Maria Luisa Brandi, Alfredo Mazza, Ignazio R Marino, Antonio Giordano

Department of Surgery Faculty Papers

BACKGROUND: Where population coverage is limited, the exclusive use of Cancer Registries might limit ascertainment of incident cancer cases. We explored the potentials of Nationwide hospital discharge records (NHDRs) to capture incident breast cancer cases in Italy.

METHODS: We analyzed NHDRs for mastectomies and quadrantectomies performed between 2001 and 2008. The average annual percentage change (AAPC) and related 95% Confidence Interval (CI) in the actual number of mastectomies and quadrantectomies performed during the study period were computed for the full sample and for subgroups defined by age, surgical procedure, macro-area and singular Region. Re-admissions of the same patients were separately …

Perceptions And Experiences Of Women In Karachi, Pakistan Regarding Secondary Infertility: Results From A Community-Based Qualitative Study, Neelofar Sami, Tazeen S. Ali

Community Health Sciences

Background: The prevalence of infertility in Pakistan is 22% with primary infertility at 4% and secondary infertility at 18%. This study explored perceptions and experiences of women in Karachi, Pakistan regarding the causes, treatment-seeking behavior for and consequences of secondary infertility.
Methods: Focus group discussions and in-depth interviews with married women explored their perceptions and experiences for issues related to secondary infertility.
Results: The knowledge of women about the causes and scientific treatment options for infertility was limited resulting in inclination for traditional unsafe health care. Infertility was stated to result in marital instability, stigmatization and abuse specially for women …

Infection Models Of Intracellular Staphylococcus Aureus And The Impact Of Interleukin 12 On Macrophage Killing Activity, Therwa Hamza

Graduate Theses, Dissertations, and Problem Reports (ETD)

Staphylococcus aureus (S. aureus) is the predominant cause of bone and joint infections worldwide. These infections may lead to severe bone and joint destruction and high mortality. Treatment of bone infections frequently requires long-term hospitalization for repeated debridement and prolonged antibiotic treatment. Bacteria including S. aureus, however, are often surprisingly successful in overcoming both host defense mechanisms and antibiotic treatments resulting in chronic and recurrent bone infections. Indeed, a high rate of recurrence or relapse of bone infections has been reported where ∼17% of infections related to traumatic extremity injuries recur or relapse. One thought is that bacteria like S. …

Dynamics Of Vibrio With Virulence Genes Detected In Pacific Harbor Seals (Phoca Vitulina Richardii) Off California: Implications For Marine Mammal Health, Stephanie Nichole Hughes

Master's Theses

Given their coastal site fidelity and opportunistic foraging behavior, harbor seals (Phoca vitulina) may serve as sentinels for coastal ecosystem health. Seals using urbanized coastal habitat can acquire enteric bacteria, including Vibrio, that may affect their health. To understand Vibrio dynamics in seals, demographic and environmental factors were tested for predicting potentially virulent Vibrio in free-ranging and stranded Pacific harbor seals (P. v. richardii) off the coast of California. Vibrio prevalence did not vary with season and was greater in free-ranging seals (29%, n = 319) compared with stranded seals (17%, n = 189). Of …

Vol. 40, No. 4: Full Issue, Denver Journal Of International Law & Policy

Denver Journal of International Law & Policy

No abstract provided.

Antimalarials From Plant Pathogenic Fungi, Mallika Kumarihamy

Electronic Theses and Dissertations

The purpose of this study was to discover antimalarial compounds from necrotropic plant pathogenic fungi. Various phytotoxins released by necrotropic plant pathogenic fungi may inhibit the plant-like metabolic pathways in the apicoplast, a chloroplast-like organelle, essential for the survival of apicomplexan parasites, such as Plasmodium which cause malaria in humans. This dissertation describes the isolation, characterization, and biological evaluation of secondary metabolites of eight fungal strains. In addition to the antiplasmodial assay, all the extracts were subjected to phytotoxic, antimicrobial, and cytotoxic bioassays. Isolation of metabolites was performed by chromatographic methods and identification was carried out by spectroscopic and spectrometric …

Facilitating Client Centred Learning, Registered Nurses' Association Of Ontario

General Submissions: Community and Population-based Materials

The aim of this guideline is to provide evidence-based recommendations for Registered Nurses, Registered Practical Nurses and other health-care providers to facilitate client centred learning that promotes and enables clients to take action for their health.

"Human Babesiosis": An Emerging Transfusion Dilemma, Helieh S. Oz, Karin N. Westlund

Physiology Faculty Publications

Babesiosis, a common disease of animals, can infect humans via vector "tick bite", particularly in endemic areas. The recent reports of fatal cases in Hepatitis C and postliver transplant patients resulting from transfusion of contaminated blood should alert the medical profession regarding this emerging dilemma in endemic as well as nonendemic areas and the need for accurate blood screening for transfusion. Here, we illustrate different stages of the parasite lifecycle, progression of babesiosis in animal model, some aspects of pathologic outcomes, ongoing therapeutic modalities, and a feasible Acridine Orange fluorescent methodology for the diagnostic evaluation of blood samples.

Nutrition, Inflammation, And Infectious Disease, Helieh S. Oz, Sung-Ling Yeh

Physiology Faculty Publications

No abstract provided.

Publications And Reports: Research And Extension 2011 Annual Summary, Department Of Natural Resource Management, South Dakota State University

Natural Resource Management Faculty Publications

Table of Contents:
[Page] 3 Introduction
[Page] 4 Department Faculty List
[Page] 5 Departmental Graduate Students
[Page] 9 Peer-reviewed publications
[Page] 15 Publications in proceedings and other journals
[Page] 17 Books or book chapters
[Page] 19 Extension reports
[Page] 21 Other reports (e.g., agency reports, completion records)
[Page] 24 popular records

Public Perceptions Of Wildlife-Associated Disease: Risk Communication Matters, Daniel J. Decker, William F. Siemer, Darrick T. N. Evenson, Richard C. Stedman, Katherine A. Mccomas, Margaret A. Wild, Kevin T. Castle, Kirsten M. Leong

Human–Wildlife Interactions

Wildlife professionals working at the interface where conflicts arise between people and wild animals have an exceptional responsibility in the long-term interest of sustaining society’s support for wildlife and its conservation by resolving human–wildlife conflicts so that people continue to view wildlife as a valued resource. The challenge of understanding and responding to people’s concerns about wildlife is particularly acute in situations involving wildlife-associated disease and may be addressed through One Health communication. Two important questions arise in this work: (1) how will people react to the message that human health and wildlife health are linked?; and (2) will wildlife-associated …

Are Probiotics Safe And Effective In Reducing The Incidence Of Diarrhea In Hiv-Positive Individuals?, Christina K. Horvath

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not probiotics are safe and effective in reducing the incidence of diarrhea in HIV-positive individuals.

Study Design: Systematic review of three English language primary studies, published in 1998, 2007, and 2008.

Data Sources: Three double-blind, randomized, controlled trials published after 1996, comparing administration of probiotics with placebo, were obtained using EBSCOhost, PubMed, and Cochrane databases.

Outcomes Measured: Frequency and consistency of stools. Daily or weekly questionnaires allowed subjects to report perceived severity of symptoms using scales containing descriptive words and figures with corresponding numeric values. Subjects were …

Is Ceftobiprole A Safe And Effective Treatment For Skin And Skin Structure Infections?, Laura Thompson

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine whether or not ceftobiprole is a safe and effective treatment for complicated skin and skin structure infections

STUDY DESIGN: Review of all English language primary randomized controlled trials from 1996-2010

DATA SOURCES: Three randomized controlled trials were found using Pubmed and Cochrane databases

OUTCOMES MEASURES: Skin or skin-structure infection cure with ceftobiprole intervention and adverse effects of this new pharmaceutical. Cure or failure to cure skin infection was determined based on both clinical and microbiological assessment. Adverse events were measured based on patient reports, clinician reports, labs, and vital sign …

Development And Evaluation Of An Instrument To Measure Mother-Infant Togetherness After Childbirth, Carol Lawrence

Electronic Theses and Dissertations

No existing measure to date captures mother-infant togetherness. A valid measure of togetherness is essential to engage in evidence-based practice, evaluate obstetric delivery models and nursing interventions, and measure the level of togetherness which promotes optimal maternal-infant outcomes. When together and in close proximity, a women and her infant have access to one another to allow for mutual caregiving or caregiving on cue. A new measure entitled the Mother-Infant Togetherness Scale (MITS) was developed based on a review of the literature and conceptual framework of Mother-Newborn Mutual Caregiving. The MITS is a 35- item instrument composed of four subscales that …

Use Of Methionine Sulfoximine To Dissect The Role Of Glutamine Synthetase And Glutamine In Progression Of Acute Liver Failure, Amruta Anil Jambekar

Wayne State University Dissertations

Methionine sulfoximine (MSO) is a modified amino acid and a well characterized irreversible inhibitor of glutamine synthetase (GS) enzyme. Glutamine is synthesized by GS enzyme and it is the most abundant amino acid in the body. Glutamine is required by immune cells for generation, propagation and maintenance of an immune response.

To induce acute liver failure (ALF) in mice, animals were given intraperitoneal injections of E. coli lipopolysaccharides (LPS) and sugar D-galactosamine (D-GalN). When these animals were pretreated with MSO, 80% of the animals were completely rescued from liver failure. Moreover, when we characterized the immune response generated during ALF …

Examining Autoimmune Sequelae During Cancer Immunotherapy In A Combined Autoimmune Thyroiditis And Tumor Mouse Model, Suresh Kari

Wayne State University Dissertations

Some clinical trials of immunotherapeutic agents against cancers have resulted in the development of autoimmune sequelae, including autoimmune thyroiditis. It has been suggested that the immunotherapy resulted in an alteration in the immunoregulatory mechanism(s). Using experimental autoimmune thyroiditis (EAT), a mouse model of Hashimoto's thyroiditis (HT), the importance of regulatory T cells (Tregs) has been well established; inhibition of Tregs leads to enhanced thyroiditis with repeated doses of mouse thyroglobulin (mTg) without adjuvant. To simulate cancer patients, we developed a combined EAT and tumor model in our EAT-susceptible mice (CBA/J). In first establishing the tumor model, we found Treg depletion …

Membrane-Bound Immunomodulators As Adjuvants In A Cell Culture-Based Avian Influenza Vaccine, David Daniel Fischer

Wayne State University Dissertations

Inactivated viral vaccines often generate suboptimal immune responses. Adjuvants are incorporated into vaccines to increase their immunogenicity, however currently available adjuvants have shortcomings which have limited their use in human and veterinary medicine. This necessitates the development of new adjuvants and delivery systems. Cytokines have been extensively tested as adjuvants in vaccines but challenges such as diffusion from antigen, short half-lives and production costs have been encountered. To address this, we developed a technology that efficiently produces inactivated, whole-virus influenza vaccine bearing membrane-bound cytokines. Tethering the cytokine to the antigen of interest keeps the immunomodulator in close contact with the …