Digital Commons Network^™

Acute Otitis Media: Antibiotic Length, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Priority Without Progress: The Fda's Neglected Tropical Disease Voucher Program After 18 Years, Maple Goh, Kevin Outterson, Aaron Kesselheim

Faculty Scholarship

Introduction: To incentivize drug and vaccine development for neglected tropical diseases (NTDs), US Congress created the Priority Review Voucher (PRV) program in 2007. Sponsors that obtain Food and Drug Administration (FDA) approval for an eligible product receive a voucher redeemable to accelerate review of another product.

Methods: We reviewed the program’s public health impact by examining all 14 vouchers awarded for NTD products between 2007 and 2024, including the timing of FDA approval relative to World Health Organization (WHO) Prequalification, Essential Medicines List inclusion, first use in endemic countries, and voucher disposition.

Results: Eight (57%) achieved WHO …

Utilization Of Intensive Care Interventions In Critically Ill Patients With Candidemia Versus Bacteremia: A Multicenter Retrospective Cohort Study, Mary North Jones, Masayuki Nigo, Stefano Casarin, James Kurian, Aarjav Sanghvi, Enshuo Hsu, Stephen L Jones, Ashton Connor, David B Corry, Cesar A Arias, Max W Adelman

Faculty, Staff and Students Publications

Objectives: Candida species are one of the most common causes of ICU-onset bloodstream infection (BSI). Yet, there is no robust guidance on when to initiate empiric antifungals for ICU patients suspected of BSI. We compared patients with ICU-onset candidemia vs. ICU-onset bacteremia to determine which patients may benefit from empiric antifungals.

Design: We compared characteristics between patients with bacteremia vs. candidemia at time of culture. We determined risk factors for death and constructed a multivariable regression to determine if candidemia is an independent risk factor for death.

Setting/patients: We included ICU patients from a hospital system in Houston, Texas (n …

Diagnostic Evaluation And Treatment Of Utis In Children With Neurogenic Bladder, Jacqueline G Holden, Sowdhamini Wallace, Pearl W Chang, Stephanie Davis-Rodriguez, Rana F Hamdy, John M Morrison, Michael J Tchou, Victor Trevisanut, Vijaya Vemulakonda, Catherine S Forster

Faculty, Staff and Students Publications

Objective: Children with neurogenic bladder (NGB) are at increased risk for urinary tract infections (UTIs), but there is a lack of guidelines to assist clinicians in diagnosing and treating these children. Our objective was to describe the presentation and treatment of provider diagnosed UTIs in children with NGB compared to children with vesicoureteral reflux (VUR) and to assess the proportion of children with NGB who met a consortium definition of UTI.

Study design: We included children < 18 years old with either VUR or NGB who were diagnosed in the emergency department with a febrile UTI in our multicenter retrospective cohort study. We extracted and compared UTI symptoms and urinalysis results specific to children with NGB to children with VUR. We measured the proportion of UTI diagnoses concordant with the Urologic Management to Preserve Initial Renal Function (UMPIRE) consensus definition of UTI, defined as ≥ 100,000 CFU/mL of 1 or 2 organisms, pyuria, and ≥ two symptoms of UTI.

Results: The most common symptom among all children in the cohort was vomiting (38.8 %). Of the 215 children with NGB, 41.3 % met …

Association Of Sleep Disturbance With Survival After Colorectal Cancer Diagnosis: Results From The Colocare Study, Anita R Peoples, Adetunji T Toriola, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Sleep problems are common among cancer patients. The relationship between sleep disruption and clinical outcomes after colorectal cancer (CRC) diagnosis remains poorly understood. We investigated associations of sleep disruption with survival and recurrence in patients with CRC.

METHODS: CRC patients with stages I-IV (N = 895) were included in this study. Self-reported sleep disturbance was assessed presurgery using the sleep item from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core-30 and classified into "no/mild" or "moderate/severe" sleep disturbance. Cox-proportional hazard models were computed (HRs and 95% confidence intervals) to investigate associations of sleep disturbance …

A Scalable Organoid Model Of Urothelial Aging For Metabolic Interrogation, Infection Modeling, And Reversal Of Age-Associated Changes, Adwaita R Parab, Arnold M Salazar, Steven J Bark, Margarita Divenko, Vasanta Putluri, D'Feau J Lieu, Aadya S Singh, Nagireddy Putluri, Indira U Mysorekar

Faculty, Staff and Students Publications

Aging leads to a progressive decline in overall bladder function resulting in lower urinary tract symptoms and increased susceptibility to infections. However, tissue-specific mechanisms of aging, specifically the contributions of the urothelium, remain elusive. Here, we introduce mouse bladder epithelium-derived organoids (mBEDOs) as a scalable platform to model urothelial aging. mBEDOs from aged mice recapitulate key features of age-associated cellular reprogramming, including oxidative stress, senescence, and DNA damage. We demonstrate the utility of mBEDOs for modeling Uropathogenic Escherichia coli (UPEC) infection, generating assembloids between mBEDOs and macrophages to model epithelial-immune interactions, and genetic perturbation. Using the mBEDO platform, we also …

Nasal Microbiome And Phageome Profiles Are Associated With Prospective Respiratory Viral Infection Risk In School-Age Children, Michael S Kelly, Ching-Ying Huang, Minsik Kim, Dastan Haghnazari, Aribah Baig, Ye Sun, Bryan R Lenneman, Michael J Tisza, Amparito Cunningham, Diane Gold, Wanda Phipatanakul, Peggy S Lai

Faculty, Staff and Students Publications

Background: Respiratory viral infections are common and can trigger asthma exacerbations in children. The roles of the nasal microbiome and phageome (viruses that infect microbes) are not well understood.

Objective: We sought to characterize the epidemiology of respiratory viral infections and the interplay between the nasal microbiome, phageome, and viral infections in school-age children with asthma.

Methods: We performed metagenomic sequencing and quantitative RT-PCR detection of respiratory viruses on 375 nasal samples from 227 school-age children with asthma collected routinely 3 times over a year. Surveys on parent-reported cold and asthma symptoms were administered routinely every 2 months. We evaluated …

Cressent: A Bioinformatics Toolkit To Explore And Improve Ssdna Virus Annotation, Ricardo R Pavan, Matthew B Sullivan, Michael J Tisza

Faculty, Staff and Students Publications

ssDNA viruses are important components of diverse ecosystems; however, it remains challenging to systematically identify and classify them. This is partly due to their broad host range and resulting genomic diversity, structure and rapid evolutionary rates. In addition, distinguishing genuine ssDNA genomes from contaminating sequences in metagenomic datasets (e.g. from commercial kits) has been an unresolved issue for years. Here, we present CRESSENT (CRESS-DNA Extended aNnotation Toolkit), a comprehensive and modular bioinformatic pipeline focused on ssDNA virus 'genome-to-analysis' and annotation. The pipeline integrates multiple functionalities organized into several modules: sequence dereplication, decontamination, phylogenetic analysis, …

Phenofit: A Framework For Determining Computable Phenotyping Algorithm Fitness For Purpose And Reuse, Laura K Wiley, Luke V Rasmussen, Rebecca T Levinson, Jennnifer Malinowski, Sheila M Manemann, Melissa P Wilson, Martin Chapman, Jennifer A Pacheco, Theresa L Walunas, Justin B Starren, Suzette J Bielinski, Rachel L Richesson

2020-Current year OA Pubs

BACKGROUND: Computational phenotyping from electronic health records (EHRs) is essential for clinical research, decision support, and quality/population health assessment, but the proliferation of algorithms for the same conditions makes it difficult to identify which algorithm is most appropriate for reuse.

OBJECTIVE: To develop a framework for assessing phenotyping algorithm fitness for purpose and reuse.

FITNESS FOR PURPOSE: Phenotyping algorithms are fit for purpose when they identify the intended population with performance characteristics appropriate for the intended application.

FITNESS FOR REUSE: Phenotyping algorithms are fit for reuse when the algorithm is implementable and generalizable-that is, it identifies the same intended population …

Plasma Ceramides Levels In Severe Covid-19 Disease: Correlations With Survival, Tri Pham, Andrea M Heredia Castillo, Andrew Atkinson, Linda R Peterson, M Cristina Vazquez Guillamet

2020-Current year OA Pubs

BACKGROUND: Dysregulated inflammatory processes have been associated with severe COVID-19 disease. Ceramides, bioactive lipids involved in inflammatory signaling, have been utilized to predict outcomes in chronic cardiometabolic diseases and pancreatic cancer, but their role in COVID-19 remains unknown.

METHODS: This observational study prospectively enrolled patients with COVID-19 disease who required intubation and mechanical ventilation at a Midwestern academic hospital between August 2020 and March 2021. Plasma ceramides 16:0 (C16), 22:0 (C22), and 24:0 (C24) and inflammatory markers (CRP, ESR, D-Dimer, and ferritin) were collected and organized weekly from symptom onset for up to 6 weeks. Patients were grouped by in-hospital …

A Systemic Selective Modified Mrna Delivery Platform For Preventing Chemotherapy-Induced Cardiotoxicity, Jimeen Yoo, Mengcheng Shen, Et Al.

2020-Current year OA Pubs

Doxorubicin (Dox) is a widely employed chemotherapeutic agent, but its use is clinically limited by dose-accumulative cardiotoxicity. More specifically, Dox induces oxidative stress and causes pro-apoptotic ceramide accumulation in cardiomyocytes (CMs). Acid ceramidase (AC) modified mRNA (modRNA) has been shown to reduce ceramide levels and protect the heart following ischemic injury; however, therapeutic modRNA applications have been hindered by the need for invasive delivery. Here, we present a platform for minimally intrusive transmission of modRNA to the heart. This CM-selective modRNA translational system (cmSMRTs) is encapsulated in lipid nanoparticles for intravenous (IV) delivery to enable systemic administration with high cardiac …

Dual Tyk2/Jak1 Inhibition By Brepocitinib Reprograms Synoviocyte Pathobiology: Mechanistic Insights Into Targeted Therapy For Rheumatoid Arthritis, Umar Saeed, Zahra Zahid Piracha, Andromeda M. Nauli, Surya M. Nauli

Pharmacy Faculty Articles and Research

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial hyperplasia, persistent inflammation, and joint destruction. Targeted inhibition of intracellular signaling pathways, such as JAK-STAT, has improved RA treatment outcomes, though safety and selectivity remain as concerns. Brepocitinib, a dual TYK2/JAK1 inhibitor, has shown clinical efficacy in the management of autoimmune diseases, yet its mechanistic impact on synoviocytes remains underexplored.

Objectives:

To investigate the molecular and functional effects of brepocitinib on MH7A and RA-FLS synoviocytes, a key effector cell type in RA pathogenesis.

Methods:

MH7A and RA-FLS cells were treated with brepocitinib (0.5 µM, 1 µM, and 5 …

Private Sector Healthcare Investment In Indonesia: Leveraging Australia-Indonesia Partnerships For Health System Transformation, Susan Josephine Neuhaus

Journal of Indonesian Health Policy and Administration

Australia and Indonesia are strategic partners with expanding bilateral trade valued at AUD 26.7 billion (2022-23). Health care partnerships between the two countries offer significant opportunities for private sector engagement. Indonesia’s large population, rapidly growing middle class, and implementation of Universal Health Coverage (UHC) through the Jaminan Kesehatan Nasional (JKN) present partnership opportunities to strengthen health system capacity, address infrastructure gaps and workforce shortages, and contribute to shared economic and prosperity goals. This study explores how Australian private healthcare investment can complement government initiatives in supporting Indonesia’s UHC while advancing Australia’s regional engagement. A descriptive qualitative analysis was conducted using …

Analysis Of Coverage Of Tuberculosis Prevention Therapy (Tpt): Literature Review, Septia Rahmalina, Ede Surya Darmawan

Journal of Indonesian Health Policy and Administration

Tuberculosis Preventive Therapy (TPT) is a crucial intervention for tuberculosis (TB) control, particularly among high-risk groups such as household contacts of TB patients and people living with Human Immunodeficiency Virus (HIV). Despite being recommended by the World Health Organization (WHO), TPT implementation still faces challenges at the primary care level. This study employed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method to review 11 articles published between 2021 and 2025 that were relevant to TPT implementation in various high-TB burden countries, including Indonesia. The main barriers identified were input (logistics, training), process (tracing, education, monitoring), and output …

Prophylactic Antibiotic Analysis In Obs-Gyn, Orthopedics, Gastrointestinal Surgery At A South Tangerang Hospital, January-March 2024, Evelina Endang Nurjaman, Helen Andriani

Journal of Indonesian Health Policy and Administration

Inappropriate use of prophylactic antibiotics (PAs) remains a primary driver of antimicrobial resistance (AMR); however, global adherence to established prescribing guidelines remains suboptimal. This study aimed to analyze the compliance and rationality of PA prescription and to evaluate the underlying causes of physician non-adherence in obstetrics, orthopedic, and gastrointestinal surgeries at a hospital in South Tangerang City, Indonesia. Adopting a mixed-methods approach, this investigation combined a quantitative assessment of 208 surgical patient records (January–March 2024) with qualitative exploratory interviews conducted with three specialist peer group heads. This design allowed the triangulation of prescribing data with underlying clinical perspectives. PA rationality …

Salivary Protein Quantity, Ionic Value, And Protein Movement In Stunted And Non-Stunted Children In Indonesia, Munifah Abdat, Sri Rezeki, Putri N. Zulkifli, Mela R. Adinda, Ardiansyah S. Pawinru, Eka Setyawardana

Journal of Dentomaxillofacial Science

Objective: This study aimed to analyze total salivary protein quantity, ionic activity, and protein molecular movement in children with and without stunting.

Material and Method: Saliva samples were collected from 30 children aged 4-6years (15stunted and15 non-stunted). Proteins were extracted using 0.1 M HCI. The total protein quantity was determined using the Bradford assay and Fourier Transform Infrared (FTIR) spectroscopy. Salivary ionic activity (dissolved oxygen, conductivity, and total dissolved solids) and salivary viscosity were measured using an ionic meter and an Ostwald viscometer, respectively. Statistical analyses included independent t-tests, Kruskal-Wallis tests, and Spearman correlation analyses (a=0.05).

Results: Stunted children had …

Effects Of Freeze-Dried Homologous Platelet-Rich Plasma On Type I Collagen Expression In Mg-63 Cells: An In Vitro Study, Kwartarini Murdiastuti, Niken Olivia

Journal of Dentomaxillofacial Science

Objective: This study investigated the osteoinductive activity effects of freeze-dried homologous platelet-rich plasma (FD HPRP) by assessing its effects on type I collagen expression in MG-63 cells.

Material and Method: HPRP was obtained from a blood bank and subjected to freeze-drying and y-radiation (20 and 25 kGy) for sterilization. Osteoblasts (MG63 cells) were cultured to confluence and then divided into three groups. Group 1 was an untreated control, and groups 2 and 3 were treated with FD HPRP at 20 and 25 kGy, respectively. Type I collagen expression was examined using immunohistochemistry on day14.The data were analyzed by one-way analysis …

The Archaeology Of Alienation: Representation Of Death For The Mentally Illness In Lawang, Malang, Aninda Diandra Rahmadewi, Irmawati Marwoto Imj

International Review of Humanities Studies

Alienation as a novelty in archaeological research which in this study aims to explain how mentally illness patients are buried at Lawang Mental Hospital as an alienation and how the representation of the graves of patients with mentally illness. Alienation is a form of experience by individuals who are marginalized from society, one of which is people with mentally illness. Alienation in mentally illness does not only occur during their lifetime, but continues until they die. Lawang Mental Hospital, built in 1884, is the only mental hospital that has a special cemetery for mentally illness patients. The method used focuses …

Novel R Shiny Tool For Survival Analysis With Time-Varying Covariate In Oncology Studies: Overcoming Biases And Enhancing Collaboration, Yimei Li, Yang Qiao, Fei Gao, Jordan Gauthier, Qiang Ed Zhang, Jenna Voutsinas, Wendy Leisenring, Ted Gooley, Corinne Summers, Alexandre Hirayama, Cameron Turtle, Rebecca Gardner, Jarcy Zee, Qian Vicky Wu

Wills Eye Hospital Papers

PURPOSE: Our study is motivated by evaluating the role of hematopoietic cell transplantation (HCT) after chimeric antigen receptor T-cell (CAR-T) therapy for ALL, a debated topic. Because patients may receive HCT at different times after CAR-T infusion or never, HCT post-CAR-T should be considered as a time-varying covariate (TVC).

METHODS: Standard Cox models and Kaplan-Meier (KM) curves (naïve method) assume that TVC status is known and fixed at baseline, which can yield biased estimates. Landmark analysis is a popular alternative but depends on a chosen landmark time. Time-dependent (TD) Cox model is better suited for TVC although visualizing survival curves …

Institute For Global Health And Development : Annual 2025, Institute For Global Health And Development

IGHD Newsletters

• Message From the Director
• Workshops & Conferences
• Climate Change and The Built Environment
• Supporting Women in Science (SWIS)
• Field Immersion & Community Engagement
• Global & Regional Engagements
• Climate, Health & Equity Engagements
• Capacity Building & Research Strengthening
• Webinars Hosted by IGHD
• Research Contributions & Global Recognition
• Media Stories, Awards & Achievements
• Policy Advocacy & National Dialogues
• Looking Ahead: Commitment to Equity & Impact
• Shining Light on Achievement
• Climate Change and Maternal Health: Dr. Jai Das Featured in The Economist
• Pakistan Urged to Make Bold Nutrition Pledges
• N4G Summit 2025
• Climate Change Disproportionately Affects Women and Children
• National Seminar Advances Agenda …

High Prevalence Of Cerebrovascular Calcifications And Clinical Correlates In Indigenous Bolivian Forager‐Horticulturalists: A Population‐Based Observational Study, Giuseppe Barisano, Bavrina Bigjahan, Grant Schleifer, Maria Ashna, Wendy J. Mack, M. Linda Sutherland, James D. Sutherland, Helena C. Chui, Meng Law, Thomas J. Fischbach, Andrei Irimia, Nikhil N. Chaudhari, Daniel K. Cummings, Paul L. Hooper, Jacob E. Aronoff, Ellen E. Walters, Daniel Eid Rodriguez, Raul Quispe Gutierrez, Jesus Bani Cuata, Kenneth Buetow, Caleb E. Finch, Michael D. Gurven, Jonathan Stieglitz, Gregory S. Thomas, Randall C. Thompson, Benjamin Trumble, Hillard Kaplan, Margaret Gatz

ESI Publications

Background

Methods

Rapid Diagnosis Of Staphylococcus Aureus Using The Lamp Method, Hadeel Abdul-Amir, Thair Al-Kelabi

AUIQ Conference Proceedings

Methicillin-resistant Staphylococcus aureus (MRSA), a genetically distinct strain of S. aureus, poses a significant health problem in humans and animals. MRSA is responsible for various difficult-to-treat illnesses in humans and animals. The loop-mediated isothermal amplification (LAMP) experiment was performed using four unique primers developed for six distinct mecA and femA gene sequences. The LAMP test was completed in 45 minutes at 62.5°C and visualized by gel electrophoresis. Moreover, the LAMP test has better sensitivity than conventional PCR, detecting genomic DNA at 64.8 pg/μL, which is hundreds of times more sensitive than conventional PCR.  The LAMP test is an …

Defective Viral Genomes: Emerging Therapeutic Tools For Animal Viral Infections, Saad Hashem Ghmeiss, Ali Abdul-Jassim Alwan

AUIQ Conference Proceedings

Defective Viral Genomes (DVGs), which are viral genomes that are defective in some way, are naturally occurring byproducts of viral replication in numerous RNA viruses, notably Orthomyxoviridae (Influenza virus), Filoviridae (Ebola and dengue), and Paramyxoviridae (Respiratory Syncytial). They have three well-defined functions: interference with regular virus replication, immunostimulation, and virus persistence. DVGs are defective viral genomes that can hijack the replication cycle of wild-type viruses, leading to partial or complete suppression of viral populations. A variety of new DVGs are created through infection of the host by one of these viruses. The researchers devised a strategy for identifying those most …

Optic Neuritis And Neuroretinitis In Cat-Scratch Disease: An Updated Systematic Review, Sara Urdiales-Sánchez, José-Ramiro González-Montaña, Pilar Alonso-Alonso, Javier Urdiales-Urdiales

Journal of Pediatric Neurology

This study provides a systematic review of optic neuritis and neuroretinitis associated with cat scratch disease (CSD) caused by Bartonella henselae. CSD, commonly transmitted through cat scratches or bites, can lead to visual complications, particularly in children, who are more frequently exposed to cats. A comprehensive literature search identified 10 relevant studies from an initial pool of 521 articles. Typical CSD manifests with regional lymphadenopathy, but severe complications like hepatosplenomegaly and encephalitis can occur, especially in younger patients. Atypical presentations, such as neuroretinitis, often begin as optic neuritis with papillary edema, progressing to a macular star pattern. Pediatric patients may …

Performance Of The Mean, Highest, And Admission Day Pediatric Sequential Organ Failure Assessment (Psofa) Scores As Outcome Predictors In A Pediatric Intensive Care Unit: A Prospective Observational Study, Debasis Maity, Moumita Samanta, Sandipan Sen, Tapan Kumar Sinha Mahapatra, Asim Kumar Mallick

Journal of Pediatric Intensive Care

Objectives: The Pediatric Sequential Organ Failure Assessment score (pSOFA) has been recently validated from its adult version having included the six clinical and biochemical parameters of organ dysfunction (respiratory, coagulation, cardiovascular, neurological, hepatic, and renal) and adapting age-adjusted cutoffs. Our goal was to find out which among the pSOFA scores (recorded on admission, highest score, and the mean score i.e., pSOFA1, pSOFAh, and pSOFAm respectively) performed better to predict mortality among the patients admitted in our pediatric intensive care unit (PICU). Methods: This prospective observational study was conducted on 104 patients (1 month to 12 years of age) admitted in …

The Expansion Of Exposure Notification Software To Enhance Disease Surveillance And Ring Vaccination, Julia Felton

URGENT Matters

No abstract provided.

Combined Glycoprotein Mutations In Rabies Virus Promote Astrocyte Tropism And Protective Cns Immunity In Mice, Mirjam Anna Rita Bertoune, Corinna Kolbe, Ann-Cathrin Werner, Maren Steinmetz, Bernhard Dietzschold, Eberhard Weihe

Department of Microbiology and Immunology Faculty Papers

Rabies virus (RABV) causes fatal encephalitis once it invades the central nervous system (CNS), and treatment options are extremely limited at this stage. We investigated the recombinant RABV variants SPBN, SPBNGA (glycoprotein substitution R333E), SPBNGAK (R333E plus N194K), SPBNGAS (R333E plus N194S), and TriGAS (three copies of the R333E/N194S glycoprotein). We evaluated their cellular tropism and immune activation in an intracerebral mouse infection model using immunohistochemistry and confocal immunofluorescence. SPBNGAK (R333E/N194K) resulted in mixed neuronal and astrocytic infection and lethal disease. In contrast, the R333E/N194S mutations in the GAS variants were associated with reduced neuronal infection and apparent astrocyte-restricted infection …

Partial Versus Full Revision In Cementless Single-Stage Exchange For Hip Periprosthetic Joint Infection: A Multicenter Comparative Study With 10-Year Survivorship Analysis, Wenbo Mu, Atthakorn Jarusriwanna, Boyong Xu, Scot A. Brown, Xiaogang Zhang, Alexander Dawes, Javad Parvizi Md, Li Cao

Rothman Institute Papers

BACKGROUND: Periprosthetic joint infection (PJI) is one of the most challenging complications following total hip arthroplasty (THA). Traditional management typically involves full revision to ensure comprehensive infection eradication. However, for patients with well-fixed implants, partial revision in a single-stage cementless approach may provide a viable alternative, potentially preserving bone stock and reducing operative time. The relative efficacy of this approach compared with full revision remains to be fully explored. This multicenter study aims to determine whether partial revision in cementless single-stage exchange surgery offers comparable infection control outcomes to full revision for select patients with well-fixed implants.

METHODS: We conducted …

The Cowl - V. 89 N. 12 - January 29, 2026

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 12 - January 29, 2026. 16 pages.

Shingles: A Case Report, Michele White Dds, Ryan Vahdani Dds, Mha, Gary Frey Dds, Ben Warner Ms, Dds, Md

The Journal of the Michigan Dental Association

This case report details a 58-year-old male who presented at a dental urgent care clinic with oral pain and a facial rash. The report identifies the condition as shingles (herpes zoster), caused by the reactivation of the varicella-zoster virus. It explores the clinical presentation, differential diagnosis—distinguishing it from Ramsay Hunt Syndrome and Bell’s palsy—and emphasizes the importance of early antiviral treatment. Furthermore, the source highlights the role of dental practitioners in identifying infectious diseases and promoting vaccination. It serves as an educational tool for medical and dental clinicians to enhance collaborative care and expedite treatment through better recognition of shingles …