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Rhodococcus Equi Infection And Interferon-Gamma Regulation In Foals, Lingshuang Sun

Theses and Dissertations--Veterinary Science

Rhodococcus equi (R. equi) is one of the most serious causes of pneumonia in young foals. The clinical disease is of great concern to breeding farms worldwide due to the impact of mortality on economic losses. While adult horses are resistant to R. equi, foals exhibit a distinct age-associated susceptibility. The mechanism underlying this susceptibility in foals is not well understood. Interferon-gamma (IFNg) plays an important role in the clearance of R. equi, but its expression is impaired in neonatal foals. Moreover, the regulation of this age-related IFNg expression in foals remains unknown. In humans, IFNg …

Effects On Semen Quality And On Establishment Of Persistent Equine Arteritis Virus (Eav) Infection In Stallions Following Experimental Challenge With The Kentucky 84 (Ky84) Strain, Juliana Roberta Campos

Theses and Dissertations--Veterinary Science

Equine arteritis virus (EAV) is the causal agent of equine viral arteritis (EVA), a disease of equids. Following EAV infection, up to 70% of stallions may become carriers and continuously shed the virus in their semen for varying time periods. The long-term carrier stallion has an important role in the transmission and maintenance of EAV in horse populations. Recently, it has been demonstrated a correlation between in vitro susceptibility of CD3⁺ T lymphocytes to EAV infection and establishment of long-term persistent infection among stallions following natural infections. In this study, we investigated whether stallions with in vitro EAV susceptible …

Needlestick Resistance Of Protective Gloves: Development Of A Test Method, Toan Vu-Khanh, Patricia Dolez, C.Thang Nguyen, Chantal Gauvin, Jaime Lara

Rapports de recherche scientifique

Cliquez ici pour la version française de ce rapport

La piqûre par les aiguilles médicales constitue un type de risque auquel un nombre croissant de travailleurs sont confrontés. En complément ultime aux autres stratégies de maîtrise des risques, en particulier les techniques d'ingénierie et les mesures administratives, il est nécessaire que soient disponibles des vêtements de protection efficaces contre la piqûre par les aiguilles médicales et, en particulier, des gants de protection.

La recherche s'est effectuée suite à des demandes paritaires visant à identifier des gants de protection adaptés au risque de piqûre par les aiguilles médicales. Ces demandes provenaient …

Singapore’S Chinatown: Nation Building And Heritage Tourism In A Multiracial City, Brenda S. A. Yeoh, Lily Kong

Research Collection School of Social Sciences

This paper focuses on the pivotal role played by the state in refashioning the Chinatown landscape as part of both nation-building and heritage tourism projects, and the ensuing cultural politics. After a brief history of the creation of Singapore’s Chinatown, the paper discusses, first, Chinatown’s place in Singapore’s post-independence nation-building project and, second, the reconfiguration of the Chinatown landscape as a tourism asset. The final section reflects on the changing politics of place as Chinatown gains legitimacy in state discourses on heritage, tourism and multiculturalism, as well as in the popular imagination as an ethnic precinct par excellence.

The Politics Of Physical Education Reform, Ari Zyskind

CMC Senior Theses

The purpose of the paper is to determine why today's youth are so physically inactive by examining the role and efforts of physical education, and the state and federal governments responsibility in supporting these programs, in fighting today's obesity epidemic by creating generations of healthy and physically active children. Research led to the determination that states have failed to maintain and improve physical education resulting in a physically inactive youth. Therefore, the nation should look to federal legislation to support state-led physical education, which this paper found to be constitutional if the enactments followed the provisions established in South Dakota …

A Survey Assessing The Contributing Factors To Substance Abuse Treatment In U.S. Corrections Settings, Michael Soule

Yale Medicine Thesis Digital Library

In light of the dramatic rise in incarceration due to the "War on Drugs," we explored the contributing factors to substance abuse treatment (SAT) programming - in particular, evidence-based treatments like medication assisted therapy (MAT) - implementation in United States correctional settings (including jails, prisons, and community corrections facilities). We hypothesized that current funding availability would be the primary factor preventing and contributing to program implementation, but further hypothesized that an array of secondary factors such as overcrowding, geographic location, facility type, and attitudes and knowledge about MAT would also play a role. We mailed a survey to an enriched …

Medicine@Yale June 2012 Volume 8, Issue 3, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Rethinking The New Public Health, Lindsay F. Wiley

Washington and Lee Law Review

This Article contributes to an emerging theoretical debate over the legitimate scope of public health law by linking it to a particular doctrinal debate in public nuisance law. State and local governments have been largely stymied in their efforts to use public nuisance litigation against harmful industries to vindicate collectively-held, common law rights to non-interference with public health and safety. The ways in which this litigation has failed are instructive for a broader movement in public health that is only just beginning to take shape. In response to evolving scientific understanding about the determinants of health, public health advocates are …

Bio-Cultural Knowledge And The Challenges Of Intellectual Property Rights Regimes For African Development, Ikechi Mgbeoji

Articles & Book Chapters

African states have, since the colonial encounter, been part of the international regimes on intellectual property rights. Formal accession to various treaties and conventions on intellectual property rights instruments should not be mistaken for actual internalization of the policies, structures and norms required for reaping the promised benefits of participation in such regimes. There is ample evidence showing that most African states do not have the requisite structures for fruitful engagement with international intellectual property rights regimes. Until this anomaly is rectified, African states' engagement with international intellectual property regimes will remain structurally flawed and inimical to the human development …

African/Black Psychology: A Qualitative Investigation Of Distinguished Black Psychologists, Nichole J. Mckenzie

Theses and Dissertations

Over the past 40 years, researchers have made numerous attempts to document and expand upon the literature surrounding the development of African/Black psychology. Yet little is known about the contextual factors that might have influenced individual decisions to become involved in the movement. This study examined the early life experience of 13 Black psychologists whose autobiographies were published in Robert Williams (2008) book, History of the Association of Black Psychologists: Profiles of Outstanding Black Psychologists. Data for this study were analyzed utilizing a qualitative research approach. Themes that arose from the analysis included: (a) direct exposure/awareness of oppressive social, political, …

Choosing Home For Someone Else: Guardian Residential Decision-Making, Naomi Karp, Erica Wood

Utah Law Review

Sue had lived in her own home for fifty years but recently lost it due to financial exploitation by her daughter. She wanted to live as independently as possible and to avoid living in a nursing home. The public guardianship program found her an affordable apartment in a senior residence, and arranged for in-home care, transportation, and visiting nurses when needed. Several elderly tenants in the same building used the same in-home care staff, so the hours were easier to work out. The guardianship program also sought restitution from the daughter. A fifty-three-year-old man with an intellectual disability was injured …

A Rare Presentation Of Brucellosis: Polyradiculopathy And Peripheral Neuritis, Günay Ertem, Gülni̇hal Kutlu, Çi̇ğdem Ataman Hati̇poğlu, Cemal Bulut, Ali̇ Pekcan Demi̇röz

Turkish Journal of Medical Sciences

To present 8 patients with polyradiculopathy or polyradiculoneuritis caused by brucellosis. Polyradiculopathy or polyradiculoneuritis are occasional neurological involvements of brucellosis. Materials and methods: The diagnosis was made with clinical, serological and/or cerebrospinal fluid, and electromyographic examinations. Results: All of the patients except one improved quickly after specific antimicrobial treatment. Furthermore, electrophysiological examinations revealed normal findings in 6 patients. Conclusion: This clinical form of brucellosis is mostly reversible if it is diagnosed earlier and treated effectively.

Laboratory Criteria For Severe Crimean-Congo Haemorrhagic Fever : Letter To The Editor, Mesut Ortatatli, Serdar Ümi̇t Sarici

Turkish Journal of Medical Sciences

No abstract provided.

Risk Factors And Prognosis In Children Hospitalized Due To Pandemic H1n1 Influenza A Virus Infection In Ankara, Turkey*, Medi̇ne Ayşi̇n Taşar, Yildiz Bi̇lge, Özge Uysal Soyer, Şükran Yildirim, Mustafa Taşar, Fatma İnci̇ Arikan

Turkish Journal of Medical Sciences

To describe the demographic characteristics and clinical features in children with influenza A (H1N1) virus infection and to identify risk factors for severe disease or poor prognosis. Following the first tourist-imported case in Turkey on 16 May 2009, the influenza A (H1N1) virus has spread throughout the country. Materials and methods: Children under 18 years of age who were hospitalized for at least 24 h with an influenza-like illness and who had confirmed influenza A (H1N1) virus infection were included in the study. Demographic factors, clinical signs and symptoms, laboratory results, radiographic findings, treatments, and follow-up periods were noted. Results: …

Serum Interleukin-8 Levels May Predict Relapse In Brucellosis, Nazlim Aktuğ Demi̇r, Onur Ural

Turkish Journal of Medical Sciences

To investigate whether cytokines are effective in predicting relapses among patients with acute brucellosis. Materials and methods: This trial was conducted in 42 patients who were being followed-up with diagnosis of acute brucellosis. Serum samples were obtained on days 0 and 45. In patients whose clinical symptoms recurred within a year of treatment and exhibited infectious parameters in compliance with brucellosis, a Rivanol standard tube agglutination (STA) test was performed and the diagnosis of relapse was based on brucella immunoglobulin M (IgM). Serum samples were evaluated for various parameters, namely tumor necrosis factor-alpha (TNF-\alpha), interferon-gamma (IFN-\gamma), interleukin 2 (IL-2), IL-4, …

Biological Screening Of Various Medicinal Plant Extracts For Antibacterial And Antitumor Activities, Fatma Pehli̇van Karakaş, Arzu Yildirim, Arzu Türker

Turkish Journal of Biology

Bioassays of 2 types (antibacterial and antitumor) were performed to show the biological activities of 16 different plants grown in Bolu, Turkey: Clinopodium vulgare L. subsp. vulgare L., Salvia verticillata L. subsp. amasiaca (Frey & Bornm.) Bornm., Salvia tomentosa Mill., Mentha pulegium L., Melilotus officinalis (L.) Desr., Melilotus alba Desr., Medicago lupulina L., Galega officinalis L., Xeranthemum annuum L., Cichorium intybus L., Plantago lanceolata L., Plantago major L. subsp. major, Fumaria officinalis L., Galium palustre L., Echium vulgare L., and Sambucus nigra L. For each plant, 3 different extracts (aqueous, ethanol, and methanol) were obtained, and a total of 48 …

Genetic Structure And Disease Prevalence Of Boreal Toads (Bufo Boreas) In Glacier National Park, Brett Rebekah Addis

Graduate Student Theses, Dissertations, & Professional Papers

Amphibians are more threatened than any other vertebrate group, with 41% of species experiencing declines. The causes of most declines are not well understood, though many declines have been linked to the emerging infectious disease chytridiomycosis. Additionally, amphibians are physiologically constrained to moist habitats and considered poor dispersers; thus, they may suffer genetic consequences of population isolation. To address threats to the persistence of boreal toads (Bufo boreas) in Glacier National Park, USA, I genotyped 551 individuals at 11 microsatellite loci and used spatially independent (STRUCTURE) and spatially explicit (GENELAND) Bayesian methods to describe population genetic structure and identify barriers …

The Rise And Fall Of Crassostrea Virginica Oyster Reefs: The Role Of Disease And Fishing In Their Demise And A Vignette On Their Management, Eric N. Powell, John M. Klinck, Kathryn Ashton-Alcox, Eileen E. Hofmann, Jason Morson

CCPO Publications

We describe a model designed to simulate the shell carbonate budget of an oyster reef.We identify five parameters descriptive of basic characteristics of the shell carbonate budget of a reef that limit simulation accuracy. Two describe the TAZ (taphonomically-active zone) and the distribution of shell carbonate within it. One is the taphonomic rate in the TAZ. Two determine the volume contribution of shell carbonate and the taphonomic loss rate within the reef framework. For Mid-Atlantic estuaries, model simulations suggest that reef accretion only occurs if oyster abundance is near carrying capacity. Simulations further suggest that reef accretion is infeasible for …

Circulation And Behavior Controls On Dispersal Of Eastern Oyster (Crassostrea Virginica) Larvae In Delaware Bay, Diego A. Narvaez, John M. Klinck, Eric N. Powell, Eileen E. Hofmann, John Wilkin, Dale B. Haidvogel

CCPO Publications

The degree of genetic connectivity among populations in a metapopulation has direct consequences for species evolution, development of disease resistance, and capacity of a metapopulation to adapt to climate change. This study used a metapopulation model that integrates population dynamics, dispersal, and genetics within an individual-based model framework to examine the mechanisms and dynamics of genetic connectivity within a metapopulation. The model was parameterized to simulate four populations of oysters (Crassostrea virginica) from Delaware Bay on the mid-Atlantic coast of the United States. Differences among the four populations include a strong spatial gradient in mortality, a spatial gradient …

The Distribution Of Cyphoma Gibbosum (Mollusca Gastropoda: Cypraeoidea: Ovulidae) (The Flamingo Tongue Gastropod) In Relation To The Presence Of The Fungal Disease Aspergillosis On Gorgonia Spp. (Anthozoa: Cnidaria: Octocorallia: Gorgoniidae), Julie Christina Krzykwa

Theses & ETDs

The fungal disease Aspergillosis has been an ongoing epizootic in the Caribbean since its identification in 1995. Further investigation into the environmental or biological vectors of Aspergillosis is of great interest, as this disease has had a considerable impact on coral reefs in the Caribbean. The gastropod Cyphoma gibbosum is able to pass viable spores of Aspergillus sydowii (Ascomycota: Eurotiomycetes: Eurotiales: Trichocomaceae), the fungus thought to cause the disease, and previous field studies noted an increased presence of C. gibbosum during Aspergillosis outbreaks. These observations suggest that C. gibbosum may be a biological vector of Aspergillosis. This study looked at …

Berhane Hewan ('Light For Eve'): Increasing Opportunities To Delay Marriage And Promote Schooling, Annabel Erulkar, Eunice N. Muthengi

Poverty, Gender, and Youth

This policy brief describes the findings of a pilot study on girls’ experience of early marriage, education, and sexual behavior in rural Amhara Region, Ethiopia. The brief also discusses efforts in the region to delay marriage and promote girls’ schooling. The Amhara Bureau of Women, Children and Youth Affairs and the Population Council pilot-tested a program to delay marriage and support schooling in rural Amhara Region. The program, entitled Berhane Hewan (Amharic for “Light for Eve”), included community conversations, support for remaining in school, and conditional cash transfers if girls remained unmarried and in school for the duration of the …

Dispatch From The Culture War: Virginia's Failed Hpv Vaccination Mandate, Rachel Reynolds

Richmond Public Interest Law Review

coverage seems to have become overshadowed. This paper will inquire into what makes Gardasil different from other vaccines, and how that impacts its administration. Part I will describe the specifics of the HPV vaccine: how it works and how Virginia decided to promote its usage. Part II will examine the ways in which jurisdictions have traditionally understood vaccination policy, and contrast it with the ways in which they have handled the HPV vaccine. Part III will examine the disadvantages of continuing the mandate's ineffective political war of attrition, and suggest a coalition-building strategy to effect policy that honors communal values …

The Constitutionality Of Current Legal Barriers To Telemedicine In The United States: Analysis And Future Directions Of Its Relationship To National And International Health Care Reform, Amar Gupta, Deth Sao

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Catching Flies With Vinegar: A Critique Of The Centers For Medicare And Medicaid Self-Disclosure Program, Jean Wright Veilleux

Health Matrix: The Journal of Law-Medicine

No abstract provided.

High Crimes, Not Misdemeanors: Deterring The Production Of Unsafe Food, Rena Steinzor

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Down-Modulation Of Mica On Malignant Glioma Cells By Herpes Simplex Virus, Carl Irwin Odom

All ETDs from UAB

Glioblastoma Multiforme is a primary malignancy of the central nervous system and is fatal for patients despite surgical resection and radiotherapy. Oncolytic Herpes Simplex Virus (oHSV) vectors deleted of the γ134.5 neurovirulence gene are potential therapies for treating glioblastoma tumors. Although replication in permissive cells is considered the primary mechanism of oHSV mediated tumor clearance, there is evidence that the immune system is part of the tumor clearance mechanism during treatment with oncolytic viruses. Specifically, natural killer (NK) cells may be important for tumor clearance during oHSV therapy. NK cell activation relies partially on the stimulation of activating or inhibitory …

Making Informed Consent Work In Nigerian Health Care, Oluchukwu Jacinta Aniaka

LLM Theses

The notion of informed consent to medical treatment is a fundamental precept in law. It recognizes autonomy and the right to personal inviolability, irrespective of nationality, socio-economic situation and ideological orientation. A full realization of autonomy in the Nigerian legal system is severely constricted by sociological and cultural factors. Of particular concern is the impact of oppression which may arise from socialization, arbitrary disclosure practice by physicians, or as a result of legislative enactment. To remedy the elemental defects in the Nigerian Code of Medical Ethics, without addressing the impediments posed by the social environment from which a patient operates, …

Situation Analysis Of Behavior Change Communication Activities In Bihar: A Step Towards Developing A Comprehensive Bcc Strategy, M.E. Khan, Isha Bhatnagar, Avishek Hazra, Mukesh Kumar

Reproductive Health

A situation analysis undertaken by the Population Council in Bihar, India assessed a number of contributing factors to a behavior change communication (BCC) strategy. Social norms and practices can be changed if appropriate messages are delivered through a combination of communication channels including mass, mid-, and other media, coupled with improved interactions between frontline healthcare workers and target populations at family and community levels. The analysis notes that effective BCC strategy should be measured in terms of actual behavior change. Impact of BCC activities can be measured by immediate outputs and intermediate and final outcomes depending on implementation duration. The …

Critical Issues For Integrating Srh And Hiv/Aids Services To Provide Dual Protection Against Unintended Pregnancy And Hiv/Sti Acquisition, Population Council

Reproductive Health

This document reports on a one-day symposium that was held by the STEP UP (Strengthening Evidence for Programming on Unintended Pregnancy) Research Program Consortium, coordinated by the Population Council. STEP UP generates policy-relevant research to promote an evidence-based approach for improving access to family planning and safe abortion in Bangladesh, Ghana, India, Kenya, and Senegal. The symposium’s objectives were to review and discuss critical and emerging issues around integrating SRH and HIV and AIDS services to enable dual protection, including new directions in dual protection technology and behaviour change interventions. The meeting also provided an opportunity to discuss the programmatic …

Dynamic Changes In Serum Monocyte Chemoattractant Protein-1, And Regulated Upon Activation, Normal T Cell Expressed And Secreted Levels In Patients With Minor Intracerebral Hemorrhage, Zhendong Li, Shijian Luo, Yuhua Fan, Huabin Sun

Neurosciences

OBJECTIVE: To investigate the time expression profile of serum monocyte chemoattractant protein (MCP)-1, and regulated upon activation, normal T cell expressed and secreted (RANTES) after minor intracerebral hemorrhage (ICH). METHODS: This study was carried out in the Department of Neurology in the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China. Fifteen consecutive hospitalized patients with minor ICH were enrolled from July 2008 to December 2008. The patients’ serum levels of MCP-1 and RANTES were measured by enzyme-linked immunosorbent assay (ELISA) on days 1-3, 7, 14, and 30 after the onset of ICH, and compared with that of 10 controls. …