Digital Commons Network^™

Interdisciplinary Approaches To Climate Change Research And Training: Possible Funding Opportunities, Kathryn Docherty

Research and Dessert

NSF Transforming Undergraduate Education in Science, Technology, Engineering and Mathematics (TUES)

Dept. of Education Graduate Assistance in Areas of National Need (GAANN)

NSF Discovery Research K‐12 (DRK‐12)

Packard Foundation – Conservation and Science

Gates Foundation – College‐Ready Education, Early Learning, Post‐secondary Education, Empowering Communities

Dow Foundation

NIH Science Education Partnership Award (SEPA)

NIH‐National Institute of Allergy and Infectious Diseases (NIAID) Science Education Award (R25)

NSF Partnerships for International Research and Education (PIRE)

NSF International Research Experiences for Students (IRES)

NSF Catalyzing New International Collaborations

NSF Partnerships for Enhanced Engagement in Research (PEER) Science

NSF Directorate for Social, Behavioral and Economic …

College Of Health Sciences Newsletter, November 2012, College Of Health Sciences

Ellmer College of Health Sciences Newsletters

November 2012 issue of Old Dominion University's College of Health Sciences Newsletter.

Pharmacy Matters - November 2012, University Of Mississippi. School Of Pharmacy

Pharmacy Matters Newsletters

Featured stories: "Alumnus turns his pharmacy into a multimillion-dollar business," "$10 million grant to expand UM's neuroscience research," "Assistant professor discusses diabetes care at D.C. forum," "Professor serves on Medicaid Drug Utilization Review Board," "Professor picks up national award for dispensing good advice," "Student team to compete in national clinical skills competition"

Other Funding Opportunities For An Interdisciplinary Climate Change Project, David Karowe, Kathryn Docherty, Carla Koretsky

Research and Dessert

No abstract provided.

Personal Environmental Information: The Promise And Perils Of The Emerging Capacity To Identify Individual Environmental Harms, Katrina Fischer Kuh

Vanderbilt Law Review

A variety of modern technologies reveal individual behaviors that have environmental consequences with increasing clarity. Smart meters and related technologies detect detailed information about when and how individuals use electricity within the home. Radio frequency identification ("RFID") chips embedded in recycling collection bins track household recycling behaviors, including everything from whether the household is recycling to whether its members properly separate their recyclables. Regulators use aerial imagery and geographic information systems ("GIS") technology to detect violations of local building codes and the illegal filling of wetlands. Interactive "ecomaps" allow city residents to compare environmental performance by zip code. Even information …

Information On Small Populations With Significant Health Disparities: A Report On Data Collected On The Health Of Asian Americans In Massachusetts, Carolyn Wong, Hannah Hosotani, John Her

Institute for Asian American Studies Publications

An analysis of publicly available sources of data on Asian Americans in Massachusetts with recommendations on ways to improve this collection of data.

Our report begins with a discussion of the important issues of data collection and reporting and then discusses the particular challenges of collecting and reporting on data in Massachusetts. Profiles of major datasets based on records for administrative entities are presented such as the Massachusetts Cancer Registry, hospital discharges, MassHealth, and Medicare, and mortality and natality records. This is followed by a description of major datasets based on population surveys such as the Behavioral Risk Factor Surveillance …

The Marginalization Of Women In Anambra State Of Nigeria As A Risk Factor In Hiv/Aids Transmission, Godson Ezejiofor

African Journal of Criminology and Justice Studies

This paper examines how different types of cultural marginalization and subservient treatment of women have become major factors in transmission of HIV/AIDS to Nigerian women with core study being on Anambra state women of Nigeria. Research findings from this study conducted at Nwafor Orizu College of Education, Nsugbe, Anambra State, indicated that as a result of the long standing maleness culture and patriarchal society in Anambra state, power, and authority are disproportionately held by men Subsequently, women are subjugated and relegated by men to secondary roles in the socio-cultural and economic matrix of Anambra state. The maleness syndrome, which is …

Inactivation Of Bacterial Opportunistic Skin Pathogens By Nonthermal Dc-Operated Afterglow Atmospheric Plasma, L. C. Heller, C. M. Edelblute, A. M. Mattson, X. Hao, J. F. Kolb

Bioelectrics Publications

AIMS: Multidrug-resistant opportunistic pathogens are clinically significant and require the development of new antimicrobial methods. In this study, Acinetobacter baumannii, Pseudomonas aeruginosa and Staphylococcus aureus cells were exposed to atmospheric plasma on agar plates and in vitro on porcine skin for the purpose of testing bacterial inactivation.

METHODS AND RESULTS: Microbial inactivation at varying exposure durations was tested using a nonthermal plasma jet generated with a DC voltage from ambient air. The observed reduction in colony forming units was quantified as log₁₀ reductions.

CONCLUSIONS: Direct plasma exposure significantly inactivated seeded bacterial cells by approx. 6 log_{10 …}

Sheep Skin Odor Improves Trap Captures Of Mosquito Vectors Of Rift Valley Fever, David P. Tchouassi, Rosemary Sang, Catherine L. Sole, Armanda D.S. Bastos, Klaus Mithoefer, Baldwyn Torto

All Peer-Reviewed Publications

In recent years, the East African region has seen an increase in arboviral diseases transmitted by blood-feeding arthropods. Effective surveillance to monitor and reduce incidence of these infections requires the use of appropriate vector sampling tools. Here, trapped skin volatiles on fur from sheep, a known preferred host of mosquito vectors of Rift Valley fever virus (RVFV), were used with a standard CDC light trap to improve catches of mosquito vectors. We tested the standard CDC light trap alone (L), and baited with (a) CO2 (LC), (b) animal volatiles (LF), and (c) CO2 plus animal volatiles (LCF) in two highly …

From Fenway Park To The Mall Of America: A Multi-Collaborative Approach To Teaching And Learning, Micah L. Berman, Michael Freiberg, Julie Ralston Aoki

University of Dayton Law Review

Special issue: Articles on legal research and writing

Mitigation Of Radiation Induced Pulmonary Vascular Injury By Delayed Treatment With Captopril, Robert C. Molthen, Qingping Wu, Brian L. Fish, John E. Moulder, Elizabeth R. Jacobs, Meetha M. Medhora

Biomedical Engineering Faculty Research and Publications

Background and Objective: A single dose of 10 Gy radiation to the thorax of rats results in decreased total lung angiotensin-converting enzyme (ACE) activity, pulmonary artery distensibility and distal vascular density while increasing pulmonary vascular resistance (PVR) at 2 months post-exposure. In this study, we evaluate the potential of a renin-angiotensin system (RAS) modulator, the ACE inhibitor captopril, to mitigate this pulmonary vascular damage.

Methods: Rats exposed to 10 Gy thorax only irradiation and age-matched controls were studied 2 months after exposure, during the development of radiation pneumonitis. Rats were treated, either immediately or 2 weeks after radiation exposure, with …

Group Testing Regression Models, Boan Zhang

Department of Statistics: Dissertations, Theses, and Student Research

Group testing, where groups of individual specimens are composited to test for the presence or absence of a disease (or some other binary characteristic), is a procedure commonly used to reduce the costs of screening a large number of individuals. Statistical research in group testing has traditionally focused on a homogeneous population, where individuals are assumed to have the same probability of having a disease. However, individuals often have different risks of positivity, so recent research has examined regression models that allow for heterogeneity among individuals within the population. This dissertation focuses on two problems involving group testing regression models. …

Breast Cancer Vaccine: Are We There Yet?, Lipika Chablani

Pharmacy Faculty/Staff Publications

In lieu of an abstract, here is the article's first paragraph:

Breast cancer is the most fatal form of cancer for female population worldwide. National Cancer Institute (NCI) estimates 226,870 females and 2,190 males to be diagnosed with breast cancer in the United States by the end of 2012. The estimated death toll for this year includes 39,510 females and 410 males, as reported by NCI. Statistics state that 1 in every 8 females will be diagnosed with breast cancer during her lifetime. These alarming numbers have provoked a large number of scientists to contribute towards the fight against breast …

Expanding Delivery System Research In Public Health Settings: Lessons From Practice-Based Research Networks, Glen P. Mays, Rachel A. Hogg

Health and Clinical Sciences Faculty Publications

BACKGROUND: Delivery system research to identify how best to organize, finance, and implement health improvement strategies has focused heavily on clinical practice settings, with relatively little attention paid to public health settings-where research is made more difficult by wide heterogeneity in settings and limited sources of existing data and measures. This study examines the approaches used by public health practice-based research networks (PBRNs) to expand delivery system research and evidence-based practice in public health settings.

METHODS: Practice-based research networks employ quasi-experimental research designs, natural experiments, and mixed-method analytic techniques to evaluate how community partnerships, economic shocks, and policy changes impact …

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Against the Grain

No abstract provided.

Jihadist Cells And "Ied" Capabilities In Europe: Assessing The Present And Future Threat To The West, Jeffrey M. Bale Dr.

Books, Monographs & Collaborative Studies

The first of two interrelated security threats is multifaceted inasmuch as it stems from a complex combination of religious, political, historical, cultural, social, and economic motivational factors caused by the growing predilection for carrying out mass casualty terrorist attacks inside the territories of “infidel” Western countries by clandestine operational cells that are inspired by, and sometimes linked to, various jihadist networks with a global agenda. The second threat is more narrowly technical: the widespread fabrication of increasingly sophisticated and destructive improvised explosive devices (IEDs) by those very same jihadist groups. These devices, if properly constructed, are capable of causing extensive …

Chronic Hepatitis B And C Co-Infection Increased All-Cause Mortality In Haart-Naive Hiv Patients In Northern Thailand, N. Tsuchiya, P. Pathipvanich, A. Rojanawiwat, N. Wichukchinda, I. Koga, M. Koga, W. Auwanit, P. E. Kilgore, K. Ariyoshi, P. Sawanpanyalert

Department of Pharmacy Practice

A total of 755 highly active antiretroviral therapy (HAART)-naive HIV-infected patients were enrolled at a government hospital in Thailand from 1 June 2000 to 15 October 2002. Census date of survival was on 31 October 2004 or the date of HAART initiation. Of 700 (92.6%) patients with complete data, the prevalence of hepatitis B virus (HBV) surface antigen and anti-hepatitis C virus (HCV) antibody positivity was 11.9% and 3.3%, respectively. Eight (9.6%) HBV co-infected patients did not have anti-HBV core antibody (anti-HBcAb). During 1166.7 person-years of observation (pyo), 258 (36.9%) patients died [22.1/100 pyo, 95% confidence interval (CI) 16.7–27.8]. HBV …

Personal Environmental Information: The Promise And Perils Of The Emerging Capacity To Identify Individual Environmental Harms, Katrina Fischer Kuh

Hofstra Law Faculty Scholarship

The article discusses personal environmental information, privacy rights, and the possibility of identifying individual environmental harms as of November 2012. Emerging technologies are addressed in relation to customer opt-out and privacy policies, as well as the Fourth Amendment to the U.S. Constitution. Radio frequency identification (RFID) chips and geographic information systems (GIS) technology are mentioned, along with Global Positioning System (GPS) devices and U.S. environmental law.

Bandemia With Normal White Blood Cell Counts Associated With Infection., Marci Drees, Narrani Kanapathippillai, Marc T Zubrow

Department of Medicine Faculty Papers

OBJECTIVE: Measuring immature white blood cell forms ("bands") has been considered clinically unnecessary. We performed this study to determine whether elevated band counts, with normal total white blood cells on admission, were associated with infection or in-hospital death.

METHODS: We performed a retrospective cohort study including all patients admitted to the Christiana Care Health System 2-hospital, 1100-bed community-based academic health system in 2009 with normal white blood cells (3800-10,800 per mm(3)) on admission who had manual differentials performed. We defined our band groups as normal (≤10% bands and other immature cells), moderate (11%-19%), or high (≥20%). Via chart review, we …

Comparative Study Of Influenza Virus Replication In Mdck Cells And In Primary Cells Derived From Adenoids And Airway Epithelium, Natalia A. Ilyushina, Mine R. Ikizler, Yoshihiro Kawaoka, Larisa G. Rudenko

Dartmouth Scholarship

Although clinical trials with human subjects are essential for determination of safety, infectivity, and immunogenicity, it is de- sirable to know in advance the infectiousness of potential candidate live attenuated influenza vaccine strains for human use. We compared the replication kinetics of wild-type and live attenuated influenza viruses, including H1N1, H3N2, H9N2, and B strains, in Madin-Darby canine kidney (MDCK) cells, primary epithelial cells derived from human adenoids, and human bron- chial epithelium (NHBE cells). Our data showed that despite the fact that all tissue culture models lack a functional adaptive im- mune system, differentiated cultures of human epithelium exhibited …

Regulatory T-Cells And Associated Pathways In Metastatic Renal Cell Carcinoma (Mrcc) Patients Undergoing Dc-Vaccination And Cytokine-Therapy, Adrian Schwarzer, Benita Wolf, Jan L. Fisher, Thomas Schwaab, Sven Olek, Udo Baron, Craig R. Tomlinson, John D. Seigne, Nancy A. Crosby, Jiang Gui, Thomas H. Hampton, Camilo E. Fadul, John A. Heaney, Marc S. Ernstoff

Dartmouth Scholarship

Purpose: To evaluate CD4+CD25+FOXP3+ T regulatory cells (TREG) and associated immune-regulatory pathways in peripheral blood lymphocytes (PBL) of metastatic renal cell carcinoma (mRCC) patients and healthy volunteers. We subsequently investigated the effects of immunotherapy on circulating TREG combining an extensive phenotype examination, DNA methylation analysis and global transcriptome analysis.

Design: Eighteen patients with mRCC and twelve volunteers (controls) were available for analysis. TREG phenotype was examined using flow cytometry (FCM). TREG were also quantified by analyzing the epigenetic status of the FOXP3 locus using methylation specific PCR. As a third approach, RNA of the PBL was hybridized to Affymetrix GeneChip …

Barriers To The Effective Implementation Of Immunization Information Systems In A Private Provider Setting, Echezona E. Ezeanolue, Ineada Jack, William Downey, Benjamin Hart, Chad L. Cross

Nevada Journal of Public Health

One of the goals of Healthy People 2010 is to increase the proportion of children less than 6 years of age with two or more vaccinations recorded in a fully operational population-based immunization information system to 95%. In 2008, we piloted the Nevada web-based immunization information system (WEBIZ) in a large private pediatric clinic in north-west Las Vegas. Our objectives were: (1) to determine compliance with the recommendation that all vaccine providers report immunization activities to the WEBIZ without a state mandate and (2) to determine perceived barriers to compliance and suggestions on how to overcome expressed barriers. We documented …

Prevalence And Antimicrobial Susceptibility Of Methicillin-Resistant Staphylococcus Aureus In Pregnant Women And Their Newborns In Las Vegas, Nevada, Mark P. Buttner, Echezona E. Ezeanolue, Patricia Cruz, Joanne L. Henry, Ineada Jack, Chad L. Cross

Nevada Journal of Public Health

Colonization and infection by resistant strains of Staphylococcus aureus are being reported in epidemic proportions. The goal of this study was to determine the local prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization in pregnant women in southern Nevada and how it correlates with colonization and infection of their neonates. Signed consent was obtained, and a brief questionnaire was administered by the medical staff to each pregnant woman to collect demographic data and pertinent medical, family and social history. Nasal and vaginal specimens were obtained from pregnant women at ≥35 weeks gestation, and nasal and umbilicus specimens were obtained from their …

Cruel But Not So Unusual: Farmer V. Brennan And The Devolving Standards Of Decency, Stacy Lancaster Cozad

Pepperdine Law Review

No abstract provided.

Ivermectin Inhibits Growth Of Chlamydia Trachomatis In Epithelial Cells, Matthew A. Pettengill, Verissa W. Lam, Ikechukwu Ollawa, Camila Marques-Da-Silva, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans. However, ivermectin has never been shown to be effective against bacterial pathogens. Here we show that ivermectin also inhibits infection of epithelial cells by the bacterial pathogen, Chlamydia trachomatis, at doses that could be envisioned clinically for sexually-transmitted or ocular infections by Chlamydia.

Cultivation Of Whipple Bacillus: The Irony And The Ecstasy, David N. Fredricks, David A. Relman

United States Department of Veterans Affairs: Publications

For 90 years investigators (including George Whipple) have been unable to propagate the microbe responsible for Whipple’s disease, despite many published and probably many more unpublished attempts.¹ Evidence that a bacterium causes Whipple’s disease has accumulated in recent decades. Light and electron microscopy show rod-shaped bacilli in the affected tissues of these patients, usually free in the lamina propria of the small bowel but also as partly degraded structures within macrophage vacuoles.² On the basis of histology, investigators have suggested that these organisms propagate extracellularly,³ although intact organisms have been detected within several types of cells.^{4 …}

Bragdon V. Abbott: The Supreme Court's Anti-Discrimination Advocacy And The Reopening Of Pandora's Box , Brett D. Watson

Pepperdine Law Review

No abstract provided.

Montana Kaimin, October 26, 2012, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Constitutive Type Vi Secretion System Expression Gives Vibrio Cholerae Intra- And Interspecific Competitive Advantages, Daniel Unterweger, Maya Kitaoka, Sarah T. Miyata, Verena Bachmann, Teresa M. Brooks, Jessica Moloney, Oscar Sosa, David Silva, Jorge Duran-Gonzalez, Daniele Provenzano

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

The type VI secretion system (T6SS) mediates protein translocation across the cell membrane of Gram-negative bacteria, including Vibrio cholerae - the causative agent of cholera. All V. cholerae strains examined to date harbor gene clusters encoding a T6SS. Structural similarity and sequence homology between components of the T6SS and the T4 bacteriophage cell-puncturing device suggest that the T6SS functions as a contractile molecular syringe to inject effector molecules into prokaryotic and eukaryotic target cells. Regulation of the T6SS is critical. A subset of V. cholerae strains, including the clinical O37 serogroup strain V52, express T6SS constitutively. In contrast, pandemic strains …

Acute Haematogenous Community-Acquired Methicillin-Resistant Staphylococcus Aureus Osteomyelitis In An Adult: Case Report And Review Of Literature, A. Dhanoa, V.A. Singh, A. Mansor, M.Y. Yusof, K.T. Lim, Kwai Lin Thong

Research Publications (2011 to 2015)

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) has of late emerged as a cause of community-acquired infections among immunocompetent adults without risk factors. Skin and soft tissue infections represent the majority of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clinical presentations, whilst invasive and life-threatening illness like necrotizing pneumonia, necrotizing fasciitis, pyomyositis, osteomyelitis and sepsis syndrome are less common. Although more widely described in the pediatric age group, the occurrence of CA-MRSA osteomyelitis in adults is an uncommonly reported entity. CASE PRESENTATION: We describe an invasive CA-MRSA infection in a 28 year-old previously healthy male, manifesting with bacteraemia, osteomyelitis of femur, pyomyositis and septic …